Detailed information for compound 715074

Basic information

Technical information
  • TDR Targets ID: 715074
  • Name: 3-(2,3-dichlorophenyl)-1-(2-ethoxyphenyl)urea
  • MW: 325.19 | Formula: C15H14Cl2N2O2
  • H donors: 2 H acceptors: 1 LogP: 4.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1NC(=O)Nc1cccc(c1Cl)Cl
  • InChi: 1S/C15H14Cl2N2O2/c1-2-21-13-9-4-3-7-11(13)18-15(20)19-12-8-5-6-10(16)14(12)17/h3-9H,2H2,1H3,(H2,18,19,20)
  • InChiKey: ULYRCJHGVQEQAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00609875
  • IVK/1635680

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus peregrin 0.0032 0.0165 0.0331
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0401 0.1532
Echinococcus multilocularis lamin dm0 0.0053 0.0683 0.154
Brugia malayi PHD-finger family protein 0.0028 0.0083 0.0038
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.011 0.0334
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0423 0.0199
Echinococcus multilocularis peregrin 0.0032 0.0165 0.0331
Schistosoma mansoni hypothetical protein 0.0028 0.0083 0.0105
Loa Loa (eye worm) hypothetical protein 0.0034 0.0223 0.0223
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.2007 0.541
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.1594 0.1557
Loa Loa (eye worm) acetyltransferase 0.0141 0.2784 0.2784
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0822 0.1801
Onchocerca volvulus 0.0151 0.3021 0.2963
Toxoplasma gondii hypothetical protein 0.0049 0.0573 0.679
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0822 0.2144
Onchocerca volvulus 0.0053 0.0683 0.0606
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2189 0.2189
Giardia lamblia PHD finger protein 15 0.0028 0.0083 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1594 0.7824
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.011 0.5
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0986 0.1088
Brugia malayi jmjC domain containing protein 0.0034 0.0225 0.0181
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0822 0.1864
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.3212 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0986 0.2247
Echinococcus granulosus intermediate filament protein 0.0053 0.0683 0.154
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0986 0.0986
Schistosoma mansoni ap endonuclease 0.0037 0.0297 0.0697
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0822 0.0829
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.2007 0.27
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0091 0.0047
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0225 0.047
Schistosoma mansoni kinase 0.0046 0.0519 0.1308
Loa Loa (eye worm) hypothetical protein 0.0151 0.3021 0.3021
Onchocerca volvulus 0.0053 0.0683 0.0606
Mycobacterium ulcerans hypothetical protein 0.0159 0.3212 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0473 0.0431
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.066 0.066
Echinococcus granulosus lamin dm0 0.0053 0.0683 0.154
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.011 0.0843
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.011 0.5
Brugia malayi 6-phosphofructokinase 0.0109 0.2007 0.1971
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0986 0.0946
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0297 0.9243
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0401 0.1532
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.2784 0.7553
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.1594 0.1594
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0347 0.0755
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0401 0.458
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.2007 0.5866
Echinococcus multilocularis lamin 0.0053 0.0683 0.154
Loa Loa (eye worm) hypothetical protein 0.005 0.06 0.06
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0401 0.458
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.011 0.0423
Trypanosoma brucei polo-like protein kinase 0.0091 0.1594 0.2048
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.2007 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0986 0.2247
Echinococcus multilocularis musashi 0.0053 0.0683 0.154
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0423 0.0199
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0297 0.0639
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0822 0.1801
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0423 0.0199
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0225 0.047
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2007 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0822 0.2144
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0083 0.0491
Echinococcus multilocularis muscleblind protein 0.0149 0.298 0.6899
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.663 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0023
Plasmodium falciparum phd finger protein, putative 0.0028 0.0083 0.1396
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.2007 0.4629
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.1594 0.2048
Brugia malayi phosphofructokinase 0.0109 0.2007 0.1971
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0083
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0986 0.1088
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.2007 0.4629
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0347 0.0755
Loa Loa (eye worm) hypothetical protein 0.0053 0.0683 0.0683
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0473 0.105
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0225 0.0225
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.1594 0.2048
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.2007 0.27
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0423 0.0199
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0683 0.0683
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0091 0.0091
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.269 0.6222
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0083 0.0105
Schistosoma mansoni ap endonuclease 0.0037 0.0297 0.0697
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0473 0.0473
Brugia malayi hypothetical protein 0.0151 0.3021 0.299
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2007 1
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0683 0.0642
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0297 0.0987
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0225 0.0497
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.2007 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0822 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.011 0.2397
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0401 1
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0683 0.0683
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1594 0.7824
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.1594 0.2048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0473 0.1182
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0473 0.105
Brugia malayi intermediate filament protein 0.0053 0.0683 0.0642
Brugia malayi MH2 domain containing protein 0.0116 0.2189 0.2154
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0223 0.0179
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0986 0.1088
Schistosoma mansoni lamin 0.0053 0.0683 0.1761
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0822 0.1801
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.011 0.0843
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.011 0.184
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.1594 0.3666
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.2007 0.541
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0473 0.105
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0083 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1594 0.7824
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.1594 0.1524
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0297 0.1631
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.06 0.0558
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.2007 0.27
Echinococcus multilocularis Protein lozenge 0.0056 0.0736 0.1664
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0645 0.055
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0322 0.0696
Schistosoma mansoni hypothetical protein 0.0034 0.0223 0.0491
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.049 0.2004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0565 0.0565
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0473 0.1182
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.663 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.1594 0.3666
Giardia lamblia Kinase, PLK 0.0091 0.1594 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.1618 0.3721
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.06 0.06
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.1594 0.7897
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1594 0.7824
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.2826 0.3993
Loa Loa (eye worm) phosphofructokinase 0.0109 0.2007 0.2007
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0318 0.1765
Echinococcus granulosus muscleblind protein 0.0149 0.298 0.6899
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.2007 0.2007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0297 0.0297
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1594 0.7824
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.1594 0.4273
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2007 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0401 0.0881
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.2826 0.3993
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2007 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.298 0.298
Brugia malayi jmjC domain containing protein 0.0092 0.1618 0.1581
Loa Loa (eye worm) hypothetical protein 0.0443 1 1
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0322 0.0696
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0473 0.105
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.2007 0.2007
Schistosoma mansoni jumonji domain containing protein 0.0073 0.1164 0.3086
Loa Loa (eye worm) hypothetical protein 0.0149 0.298 0.298
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0822 0.1801
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0297 0.0254
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0297 0.0987
Echinococcus multilocularis muscleblind protein 1 0.0149 0.298 0.6899
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0083 0.0491
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.049 0.2004
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.2784 0.2752
Schistosoma mansoni hypothetical protein 0.0178 0.3672 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0822 0.1864
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.011 0.0843
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0083 0.0138
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0297 0.5
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0297 0.1288
Brugia malayi 6-phosphofructokinase 0.0109 0.2007 0.1971
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.011 0.184
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.2784 0.6443
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.06 0.0558
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0225 0.0497
Echinococcus granulosus lamin 0.0053 0.0683 0.154
Brugia malayi Bromodomain containing protein 0.0032 0.0165 0.0121
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0083 0.1072
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0083 0.0083
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0318 0.1394
Schistosoma mansoni intermediate filament proteins 0.0053 0.0683 0.1761
Loa Loa (eye worm) hypothetical protein 0.0443 1 1
Echinococcus granulosus kinesin family 1 0.0205 0.4309 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1594 0.7824
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.663 1
Loa Loa (eye worm) kinesin-like protein KLP2 0.0027 0.0044 0.0044
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0297 0.0987
Brugia malayi Muscleblind-like protein 0.0149 0.298 0.2949
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0297 0.7097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0473 0.1182
Schistosoma mansoni lamin 0.0053 0.0683 0.1761
Schistosoma mansoni lozenge 0.0056 0.0736 0.1908
Echinococcus multilocularis kinesin family 1 0.0205 0.4309 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.011 0.2397
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1594 0.7824
Loa Loa (eye worm) runx1 0.0056 0.0736 0.0736
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.2007 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.2007 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.663 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0986 0.4799
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0986 0.2596
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.2007 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.2826 0.3993
Onchocerca volvulus 0.0443 1 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.2007 0.5866
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.1618 0.3721
Toxoplasma gondii exonuclease III APE 0.0037 0.0297 0.3251
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0986 0.1088
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0297 0.0639
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2189 0.2189

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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