Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0021 | 0.0051 | 0.0051 |
Loa Loa (eye worm) | doublecortin family protein | 0.0021 | 0.0051 | 0.0361 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0042 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0244 | 0.1415 | 0.9982 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0202 | 0.2117 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0153 | 0.5 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0021 | 0.0051 | 0.5 |
Echinococcus granulosus | neuropeptide s receptor | 0.0482 | 0.2863 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0051 | 0.0179 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.023 | 0.2415 |
Brugia malayi | Doublecortin family protein | 0.0021 | 0.0051 | 0.0361 |
Brugia malayi | follicle stimulating hormone receptor | 0.0244 | 0.1415 | 0.9982 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.0649 | 0.4578 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0051 | 0.0538 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0136 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0051 | 0.0179 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.0181 | 0.1276 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0016 | 0.0021 | 0.0072 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.1418 | 0.4953 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0153 | 0.1077 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0136 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0051 | 0.0538 |
Schistosoma mansoni | loxhd1 | 0.0021 | 0.0051 | 0.0538 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0051 | 0.0361 |
Brugia malayi | hypothetical protein | 0.0245 | 0.1418 | 1 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0051 | 0.0361 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0021 | 0.0051 | 0.0179 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0016 | 0.0021 | 0.0218 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0952 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0153 | 0.1603 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.1319 | 0.797 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0952 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0016 | 0.0021 | 0.0146 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0021 | 0.0051 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0016 | 0.0021 | 0.0218 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0016 | 0.0021 | 0.0021 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0482 | 0.2863 | 0.2863 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0153 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0021 | 0.0146 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0042 | 0.0181 | 0.0632 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0016 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.0649 | 0.4578 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 0.0202 | 0.2117 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.023 | 0.2415 |
Schistosoma mansoni | polycystin 1-related | 0.0021 | 0.0051 | 0.0538 |
Echinococcus granulosus | voltage gated potassium channel | 0.0016 | 0.0021 | 0.0072 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.1319 | 0.797 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0482 | 0.2863 | 0.2863 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0153 | 0.1603 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0051 | 0.0361 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.0649 | 0.4578 |
Onchocerca volvulus | 0.005 | 0.023 | 1 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0123 | 0.0677 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0051 | 0.0361 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0051 | 0.0538 |
Schistosoma mansoni | lipoxygenase | 0.0123 | 0.0677 | 0.7104 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0051 | 0.0051 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.1418 | 0.1418 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0153 | 0.0153 |
Echinococcus granulosus | geminin | 0.0168 | 0.0952 | 0.3327 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.023 | 0.1622 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.0451 | 0.4731 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0042 | 0.0181 | 0.1276 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1418 | 1 |
Echinococcus multilocularis | geminin | 0.0168 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0151 | 0.1066 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0153 | 0.5 |
Echinococcus granulosus | RUN | 0.0021 | 0.0051 | 0.0179 |
Echinococcus multilocularis | RUN | 0.0021 | 0.0051 | 0.0051 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0153 | 0.0533 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0153 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0123 | 0.0677 | 0.2363 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0482 | 0.2863 | 1 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.1319 | 0.797 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0051 | 0.0051 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.1319 | 0.797 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.