Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase | 0.0234 | 0.3829 | 0.3829 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0184 | 0.2797 | 0.2105 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0424 | 0.7754 | 0.7525 |
Entamoeba histolytica | hexokinase 1 | 0.0234 | 0.3829 | 1 |
Echinococcus multilocularis | hexokinase | 0.0234 | 0.3829 | 0.2358 |
Echinococcus multilocularis | hexokinase | 0.0234 | 0.3829 | 0.2358 |
Trypanosoma brucei | hexokinase | 0.0234 | 0.3829 | 0.2083 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.02 | 0.3121 | 0.0978 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0424 | 0.7754 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.2292 | 0.2292 |
Echinococcus multilocularis | hexokinase type 2 | 0.0234 | 0.3829 | 0.2358 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0184 | 0.2797 | 0.2797 |
Leishmania major | hexokinase, putative | 0.0234 | 0.3829 | 0.2083 |
Echinococcus granulosus | hexokinase type 2 | 0.0234 | 0.3829 | 0.2358 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.044 | 0.8088 | 0.7905 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.02 | 0.3121 | 0.0978 |
Loa Loa (eye worm) | glutaminase | 0.0533 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0233 | 0.38 | 0.38 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0175 | 0.2619 | 0.2619 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0184 | 0.2797 | 0.0347 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0184 | 0.2797 | 0.2797 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0424 | 0.7754 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0184 | 0.2797 | 0.2105 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0184 | 0.2797 | 0.2105 |
Schistosoma mansoni | hexokinase | 0.0234 | 0.3829 | 0.3199 |
Echinococcus granulosus | hexokinase | 0.0234 | 0.3829 | 0.2358 |
Brugia malayi | Hexokinase family protein | 0.0147 | 0.2027 | 0.2027 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0424 | 0.7754 | 0.7754 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0184 | 0.2797 | 0.427 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0424 | 0.7754 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0147 | 0.2027 | 0.2027 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.02 | 0.3121 | 0.2419 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0415 | 0.7559 | 0.9606 |
Brugia malayi | MH2 domain containing protein | 0.0233 | 0.38 | 0.38 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0424 | 0.7754 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0184 | 0.2797 | 0.2105 |
Brugia malayi | Hexokinase family protein | 0.0072 | 0.049 | 0.049 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0184 | 0.2797 | 0.1657 |
Loa Loa (eye worm) | hexokinase type II | 0.0234 | 0.3829 | 0.3829 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.044 | 0.8088 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.02 | 0.3121 | 0.0978 |
Leishmania major | hexokinase, putative | 0.0234 | 0.3829 | 0.2083 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0424 | 0.7754 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.044 | 0.8088 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0415 | 0.7559 | 0.9672 |
Mycobacterium ulcerans | glutaminase | 0.0533 | 1 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0424 | 0.7754 | 0.575 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0184 | 0.2797 | 0.0347 |
Brugia malayi | Hexokinase family protein | 0.0234 | 0.3829 | 0.3829 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.044 | 0.8088 | 0.7905 |
Onchocerca volvulus | 0.0234 | 0.3829 | 1 | |
Brugia malayi | hexokinase type II | 0.0074 | 0.0531 | 0.0531 |
Trypanosoma cruzi | hexokinase, putative | 0.0234 | 0.3829 | 0.3395 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0424 | 0.7754 | 1 |
Brugia malayi | hexokinase | 0.0234 | 0.3829 | 0.3829 |
Leishmania major | hypothetical protein, conserved | 0.0415 | 0.7559 | 0.9606 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.044 | 0.8088 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0072 | 0.049 | 0.049 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.02 | 0.3121 | 0.0978 |
Echinococcus granulosus | hexokinase | 0.0234 | 0.3829 | 0.2358 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0184 | 0.2797 | 0.2105 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.02 | 0.3121 | 0.0613 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0184 | 0.2797 | 0.1657 |
Entamoeba histolytica | hexokinase 2 | 0.0234 | 0.3829 | 1 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0175 | 0.2619 | 0.2619 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.044 | 0.8088 | 0.7905 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0233 | 0.38 | 0.38 |
Onchocerca volvulus | 0.0234 | 0.3829 | 1 | |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0147 | 0.2032 | 0.5 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0424 | 0.7754 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0184 | 0.2797 | 0.2061 |
Echinococcus granulosus | hexokinase | 0.0234 | 0.3829 | 0.2358 |
Trypanosoma cruzi | hexokinase, putative | 0.0234 | 0.3829 | 0.3395 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0424 | 0.7754 | 0.7754 |
Trypanosoma brucei | hexokinase | 0.0234 | 0.3829 | 0.2083 |
Schistosoma mansoni | glutaminase | 0.0533 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0234 | 0.3829 | 0.2083 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0415 | 0.7559 | 0.9672 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0184 | 0.2797 | 0.2105 |
Onchocerca volvulus | 0.0234 | 0.3829 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0234 | 0.3829 | 0.3829 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.3121 | 0.3121 |
Trichomonas vaginalis | glutaminase, putative | 0.0533 | 1 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.044 | 0.8088 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0533 | 1 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0277 | 0.4715 | 0.3209 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0184 | 0.2797 | 0.2105 |
Echinococcus multilocularis | hexokinase | 0.0234 | 0.3829 | 0.2358 |
Toxoplasma gondii | hexokinase | 0.0234 | 0.3829 | 0.1426 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0531 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0531 | 0.0531 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.014 | 0.1896 | 0.0142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.