Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.1044 | 0.6759 | 0.666 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0296 | 0.0296 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0404 | 0.234 | 0.234 |
Schistosoma mansoni | hexokinase | 0.1513 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0509 | 0.3063 | 0.2937 |
Echinococcus multilocularis | hexokinase | 0.1513 | 1 | 1 |
Trypanosoma brucei | beta lactamase | 0.0141 | 0.052 | 0.0231 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0509 | 0.3063 | 0.2937 |
Entamoeba histolytica | hexokinase 2 | 0.1513 | 1 | 1 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0141 | 0.052 | 0.0064 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0509 | 0.3063 | 0.2852 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0509 | 0.3063 | 0.3063 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0132 | 0.0461 | 0.017 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0076 | 0.0076 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0132 | 0.0461 | 0.017 |
Treponema pallidum | hexokinase (hxk) | 0.1513 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0468 | 0.2783 | 0.2783 |
Echinococcus granulosus | hexokinase | 0.1513 | 1 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.1044 | 0.6759 | 0.5 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0132 | 0.0461 | 0.0175 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.1089 | 0.7068 | 0.7187 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.0076 | 0.0076 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0682 | 0.4258 | 0.4083 |
Echinococcus multilocularis | hexokinase | 0.1513 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1513 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1146 | 0.7463 | 0.7386 |
Mycobacterium ulcerans | glutaminase | 0.1473 | 0.9718 | 1 |
Echinococcus granulosus | hexokinase | 0.1513 | 1 | 1 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.1044 | 0.6759 | 0.6759 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0404 | 0.234 | 0.234 |
Onchocerca volvulus | Hexokinase homolog | 0.0949 | 0.6106 | 0.5987 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0509 | 0.3063 | 0.2852 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.2872 | 0.2872 |
Brugia malayi | MH2 domain containing protein | 0.0519 | 0.3135 | 0.3135 |
Schistosoma mansoni | kinase | 0.0259 | 0.1335 | 0.1335 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0296 | 0.0296 |
Trypanosoma brucei | hexokinase | 0.1513 | 1 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.1473 | 0.9718 | 0.9718 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0682 | 0.4258 | 0.4102 |
Onchocerca volvulus | 0.0949 | 0.6106 | 0.5987 | |
Loa Loa (eye worm) | hexokinase | 0.1513 | 1 | 1 |
Echinococcus granulosus | caspase 3 | 0.0296 | 0.1594 | 0.1594 |
Toxoplasma gondii | hexokinase | 0.1513 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1513 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0949 | 0.6106 | 0.6106 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0293 | 0.1571 | 0.6983 |
Trypanosoma brucei | hexokinase, putative | 0.1513 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0141 | 0.052 | 0.0371 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0519 | 0.3135 | 0.3135 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0132 | 0.0461 | 0.017 |
Trypanosoma brucei | polo-like protein kinase | 0.0509 | 0.3063 | 0.2852 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.1089 | 0.7068 | 0.7187 |
Plasmodium falciparum | hexokinase | 0.1513 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0509 | 0.3063 | 0.2937 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.1044 | 0.6759 | 0.666 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0509 | 0.3063 | 0.3063 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.1044 | 0.6759 | 0.6759 |
Brugia malayi | Hexokinase family protein | 0.1513 | 1 | 1 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0362 | 0.2051 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.1044 | 0.6759 | 0.666 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0252 | 0.1289 | 0.1054 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0509 | 0.3063 | 0.2937 |
Trypanosoma cruzi | hexokinase, putative | 0.1513 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.1473 | 0.9718 | 0.9718 |
Echinococcus multilocularis | caspase 8 | 0.0108 | 0.0296 | 0.0296 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0509 | 0.3063 | 0.3063 |
Echinococcus multilocularis | hexokinase | 0.1513 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0509 | 0.3063 | 0.2852 |
Loa Loa (eye worm) | glutaminase | 0.1473 | 0.9718 | 0.9718 |
Echinococcus multilocularis | caspase 3 | 0.0296 | 0.1594 | 0.1594 |
Echinococcus granulosus | caspase 2 | 0.0108 | 0.0296 | 0.0296 |
Echinococcus multilocularis | caspase 2 | 0.0108 | 0.0296 | 0.0296 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.0076 | 0.0076 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0293 | 0.1571 | 0.1199 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0509 | 0.3063 | 0.2937 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0519 | 0.3135 | 0.3135 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.1089 | 0.7068 | 1 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0336 | 0.1869 | 0.1622 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0509 | 0.3063 | 0.2937 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0346 | 0.1939 | 0.1693 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.1044 | 0.6759 | 0.6759 |
Trypanosoma brucei | hypothetical protein, conserved | 0.1146 | 0.7463 | 0.7386 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.1089 | 0.7068 | 0.6979 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0404 | 0.234 | 0.234 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.1044 | 0.6759 | 0.6759 |
Onchocerca volvulus | 0.1513 | 1 | 1 | |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0108 | 0.0296 | 0.0296 |
Echinococcus granulosus | caspase | 0.0404 | 0.234 | 0.234 |
Trichomonas vaginalis | glutaminase, putative | 0.1473 | 0.9718 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0468 | 0.2783 | 0.2783 |
Entamoeba histolytica | hexokinase 1 | 0.1513 | 1 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.1044 | 0.6759 | 0.6804 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0509 | 0.3063 | 0.2852 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0509 | 0.3063 | 0.301 |
Loa Loa (eye worm) | glutaminase 2 | 0.1473 | 0.9718 | 0.9718 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0141 | 0.052 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1032 | 0.6677 | 0.6677 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.1089 | 0.7068 | 0.7187 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0132 | 0.0461 | 0.0461 |
Brugia malayi | Cell death protein 3 precursor | 0.0108 | 0.0296 | 0.0296 |
Plasmodium vivax | hexokinase, putative | 0.1513 | 1 | 1 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0108 | 0.0296 | 0.0296 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0509 | 0.3063 | 0.3063 |
Trypanosoma brucei | hexokinase | 0.1513 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0509 | 0.3063 | 0.2937 |
Onchocerca volvulus | 0.1513 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.1513 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.1513 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.1513 | 1 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0108 | 0.0296 | 0.0296 |
Echinococcus multilocularis | caspase | 0.0404 | 0.234 | 0.234 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.1089 | 0.7068 | 0.6979 |
Leishmania major | hexokinase, putative | 0.1513 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0076 | 0.0076 |
Leishmania major | hypothetical protein, conserved | 0.1146 | 0.7463 | 0.7386 |
Echinococcus granulosus | hexokinase type 2 | 0.1513 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0252 | 0.1289 | 0.1054 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.1089 | 0.7068 | 0.6979 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0404 | 0.234 | 0.234 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.0076 | 0.0076 |
Brugia malayi | Hexokinase family protein | 0.0949 | 0.6106 | 0.6106 |
Brugia malayi | hexokinase type II | 0.0481 | 0.2872 | 0.2872 |
Onchocerca volvulus | 0.1513 | 1 | 1 | |
Echinococcus granulosus | caspase 8 | 0.0108 | 0.0296 | 0.0296 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.1044 | 0.6759 | 0.6759 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0132 | 0.0461 | 0.0461 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0509 | 0.3063 | 0.3063 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.2872 | 0.2872 |
Echinococcus multilocularis | hexokinase type 2 | 0.1513 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1146 | 0.7463 | 0.7386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.