TDR Targets

Basic information

Technical information

TDR Targets ID: 73469
Name: 1-[3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-4H- imidazo[1,5-a]quinoxalin-5-yl]-2,2,2-trifluor oethanone
MW: 375.305 | Formula: C17H12F3N5O2
H donors: 0 H acceptors: 4 LogP: 2.25 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(F)(F)F)N1Cc2c(ncn2c2c1cccc2)c1noc(n1)C1CC1
InChi: 1S/C17H12F3N5O2/c18-17(19,20)16(26)24-7-12-13(14-22-15(27-23-14)9-5-6-9)21-8-25(12)11-4-2-1-3-10(11)24/h1-4,8-9H,5-7H2
InChiKey: HASWZFFTZZAHTK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-4H-imidazo[1,5-a]quinoxalin-5-yl]-2,2,2-trifluoro-ethanone
1-[3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-4H-imidazo[5,1-c]quinoxalin-5-yl]-2,2,2-trifluoroethanone
1-[3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-4H-imidazo[5,1-c]quinoxalin-5-yl]-2,2,2-trifluoro-ethanone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	GABA-A receptor; anion channel	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	468 aa	28.6 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	434 aa	26.7 %
Brugia malayi	Cation transporter family protein	GABA-A receptor; anion channel	467 aa	453 aa	28.5 %
Echinococcus granulosus	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	439 aa	29.6 %
Echinococcus granulosus	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	454 aa	30.4 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	461 aa	27.8 %
Echinococcus multilocularis	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Echinococcus multilocularis	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	478 aa	28.7 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	446 aa	29.1 %
Onchocerca volvulus	Gamma-aminobutyric acid receptor subunit beta homolog	GABA-A receptor; anion channel	467 aa	433 aa	34.6 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	435 aa	29.7 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	GABA-A receptor; anion channel	467 aa	379 aa	19.3 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	GABA-A receptor; anion channel	467 aa	496 aa	26.0 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	441 aa	33.8 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	375 aa	21.9 %
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	GABA-A receptor; anion channel	467 aa	479 aa	29.2 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	GABA-A receptor; anion channel	467 aa	418 aa	19.6 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	494 aa	25.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	446 aa	28.0 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	454 aa	29.5 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	GABA-A receptor; anion channel	467 aa	384 aa	19.5 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	447 aa	25.7 %
Onchocerca volvulus	Eukaryotic initiation factor 4A-III homolog	GABA-A receptor; anion channel	467 aa	453 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	heterochromatin protein 1	0.0033	0.0555	1
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.0555	0.4803
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0107	0.03
Echinococcus granulosus	cathepsin b	0.0147	0.3574	0.3574
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0277	0.0277
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0555	0.1552
Echinococcus multilocularis	cathepsin L	0.0016	0.0107	0.0107
Brugia malayi	hypothetical protein	0.0033	0.0555	0.1552
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0405	0.086
Trichomonas vaginalis	hypothetical protein	0.0033	0.0555	0.4803
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0405	0.1135
Entamoeba histolytica	hypothetical protein	0.0033	0.0555	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0033	0.0555	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0023	0.0277	0.0277
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0405	0.7309
Toxoplasma gondii	cathepsin B	0.0051	0.1039	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Echinococcus multilocularis	Chromo domain	0.0033	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.002	0.0202	0.0566
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0405	0.086
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0023	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0405	0.0405
Echinococcus granulosus	cathepsin L	0.0016	0.0107	0.0107
Echinococcus multilocularis	nAChR subunit	0.0023	0.0277	0.0277
Loa Loa (eye worm)	ctsf protein	0.0027	0.0405	0.1135
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0027	0.0405	0.6664
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0147	0.3574	0.3574
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0277	0.0774
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0555	0.1552
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Brugia malayi	Cathepsin L-like precursor	0.002	0.0202	0.0566
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0023	0.0277	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.3574	0.3574
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Brugia malayi	Protein cec-1.	0.0033	0.0555	0.1552
Loa Loa (eye worm)	hypothetical protein	0.002	0.0202	0.0566
Echinococcus multilocularis	cathepsin b	0.0147	0.3574	0.3574
Onchocerca volvulus		0.0027	0.0405	0.7309
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0277	0.0277
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0405	0.086
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0555	0.1552
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0405	0.3201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.1039	0.1039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0555	0.1552
Loa Loa (eye worm)	LGC-31 protein	0.0023	0.0277	0.0774
Brugia malayi	Heterochromatin protein 1	0.0033	0.0555	0.1552
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0033	0.0555	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0023	0.0277	0.0774
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0023	0.0277	0.0277
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0033	0.0555	0.4803
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.0405	0.0405
Onchocerca volvulus		0.0023	0.0277	0.4987
Loa Loa (eye worm)	heterochromatin protein 1	0.0033	0.0555	0.1552
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0033	0.0555	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0277	0.0277
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.3574	0.3574
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0277	0.0774
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0033	0.0555	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0033	0.0555	0.4803
Onchocerca volvulus		0.0023	0.0277	0.4987
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0555	0.1552
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0405	0.1135
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0051	0.1039	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0405	0.1135
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0277	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Brugia malayi	Cation transporter family protein	0.0023	0.0277	0.0774
Brugia malayi	Associated with TFs and helicases family protein	0.0033	0.0555	0.1552
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0023	0.0277	0.0774
Loa Loa (eye worm)	helicase	0.0033	0.0555	0.1552
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0405	0.1135
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0023	0.0277	0.0774
Brugia malayi	chromobox protein homolog 3	0.0033	0.0555	0.1552
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Brugia malayi	Cathepsin L-like precursor	0.002	0.0202	0.0566
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0033	0.0555	0.0555
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0107	0.03
Echinococcus multilocularis	chromobox protein 1	0.0033	0.0555	0.0555
Onchocerca volvulus	Putative nachr subunit	0.0023	0.0277	0.4987
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0277	0.0277
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0023	0.0277	0.0774
Giardia lamblia	Cathepsin B precursor	0.0051	0.1039	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Onchocerca volvulus		0.0023	0.0277	0.4987
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0033	0.0555	0.4803
Echinococcus multilocularis	cathepsin b	0.0147	0.3574	0.3574
Plasmodium vivax	vivapain-2	0.0027	0.0405	0.6664
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0277	0.0774
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0033	0.0555	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0405	0.0405
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Onchocerca volvulus		0.0023	0.0277	0.4987
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0033	0.0555	0.4803
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0202	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0555	0.1552
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0033	0.0555	0.4803
Loa Loa (eye worm)	cathepsin B	0.0051	0.1039	0.2907
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0405	0.0405
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0405	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0405	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0405	0.1135
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0405	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0277	0.0774
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0023	0.0277	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0405	0.1135
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0277	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Echinococcus multilocularis	chromobox protein 2	0.0389	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0277	0.0774
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Schistosoma mansoni	chromobox protein	0.0389	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0033	0.0555	0.4803
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0277	0.0277
Onchocerca volvulus		0.0027	0.0405	0.7309
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.0405	0.0405
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0277	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0405	0.3201
Brugia malayi	Cation transporter family protein	0.0023	0.0277	0.0774
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0277	0.0774
Echinococcus granulosus	cathepsin l1	0.0027	0.0405	0.0405
Entamoeba histolytica	hypothetical protein	0.0033	0.0555	1
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0033	0.0555	0.1552
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0405	0.7309
Schistosoma mansoni	nAChR subunit	0.0023	0.0277	0.0277
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0033	0.0555	0.2356
Onchocerca volvulus		0.0033	0.0555	1
Giardia lamblia	Cathepsin B precursor	0.0051	0.1039	0.5
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.0555	0.4803
Onchocerca volvulus		0.0033	0.0555	1
Plasmodium vivax	vivapain-2	0.0027	0.0405	0.6664
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0405	0.3201
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0107	0.1933
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Schistosoma mansoni	nAChR subunit	0.0023	0.0277	0.0277
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0277	0.0277
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0023	0.0277	0.0277
Onchocerca volvulus		0.0027	0.0405	0.7309
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0033	0.0555	0.4803
Onchocerca volvulus		0.0027	0.0405	0.7309
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0277	0.0277
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0033	0.0555	0.0555
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.0555	0.4803
Echinococcus granulosus	Chromo domain	0.0033	0.0555	0.0555
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0033	0.0555	0.0555
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0033	0.0555	0.2356
Echinococcus multilocularis	chromobox protein 1	0.0033	0.0555	0.0555
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0555	1
Loa Loa (eye worm)	CHromoDomain protein family member	0.0033	0.0555	0.1552
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0277	0.0774
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0033	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Loa Loa (eye worm)	fibroinase	0.0027	0.0405	0.1135
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0405	0.3201
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0023	0.0277	0.0774
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0277	0.0277
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.0555	0.4803
Brugia malayi	CHD4 protein	0.0033	0.0555	0.1552
Onchocerca volvulus		0.0023	0.0277	0.4987
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0277	0.0774
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0023	0.0277	0.0277
Onchocerca volvulus		0.0033	0.0555	1
Plasmodium vivax	heterochromatin protein 1, putative	0.0033	0.0555	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0027	0.0405	0.6664
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0202	0.0202
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0023	0.0277	0.0774
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0023	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Echinococcus granulosus	nAChR subunit	0.0023	0.0277	0.0277
Onchocerca volvulus		0.0027	0.0405	0.7309
Brugia malayi	cathepsin L-like precursor	0.002	0.0202	0.0566
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0277	0.0277
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0277	0.0277
Onchocerca volvulus	Cathepsin F homolog	0.0027	0.0405	0.7309
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0405	0.7309
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0277	0.0774
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.002	0.0202	0.0274
Brugia malayi	excitatory GABA receptor EXP-1A	0.0023	0.0277	0.0774
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0033	0.0555	0.0555
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0277	0.0774
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0277	0.0277
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0033	0.0555	0.4803
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Onchocerca volvulus		0.002	0.0202	0.3644
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0555	1
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0033	0.0555	0.0555
Schistosoma mansoni	hypothetical protein	0.0033	0.0555	0.0555
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0405	0.7309
Brugia malayi	M-phase phosphoprotein, mpp8	0.0033	0.0555	0.1552
Echinococcus granulosus	cathepsin L cysteine protease	0.0016	0.0107	0.0107
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0016	0.0107	0.0107
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0405	0.3201
Entamoeba histolytica	cysteine proteinase 2	0.0016	0.0107	0.1933
Echinococcus granulosus	cathepsin b	0.0147	0.3574	0.3574
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0277	0.0277
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0033	0.0555	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Echinococcus granulosus	cysteine protease	0.0016	0.0107	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0405	0.086
Loa Loa (eye worm)	cysteine protease	0.0027	0.0405	0.1135
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0023	0.0277	0.0774
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0405	0.3201
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.002	0.0202	0.0566
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0016	0.0107	0.0107
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0051	0.1039	1
Entamoeba histolytica	hypothetical protein	0.0033	0.0555	1
Schistosoma mansoni	chromobox protein	0.0033	0.0555	0.0555
Echinococcus granulosus	chromobox protein 1	0.0033	0.0555	0.0555
Schistosoma mansoni	nAChR subunit	0.0023	0.0277	0.0277
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0277	0.0277
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0405	0.1135
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0147	0.3574	1
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.0555	0.4803
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0033	0.0555	0.0555
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.3574	0.3574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0405	0.7309
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0405	0.0405
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0023	0.0277	0.0277
Onchocerca volvulus		0.0027	0.0405	0.7309
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0405	0.1135
Brugia malayi	SET domain containing protein	0.0033	0.0555	0.1552
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0107	0.1933
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0277	0.0774
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0405	0.3201
Brugia malayi	Cathepsin L-like cysteine proteinase	0.002	0.0202	0.0566
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Schistosoma mansoni	nAChR subunit	0.0023	0.0277	0.0277
Schistosoma mansoni	chromobox protein	0.0033	0.0555	0.0555
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.0555	0.4803
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0023	0.0277	0.0277
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0023	0.0277	0.0774
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0033	0.0555	1
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0405	0.3201
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0033	0.0555	0.4803
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0027	0.0405	0.6664
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0555	0.1552
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0405	0.0405
Echinococcus granulosus	chromobox protein 1	0.0033	0.0555	0.0555
Schistosoma mansoni	nAChR subunit	0.0023	0.0277	0.0277
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Entamoeba histolytica	cysteine proteinase 1, putative	0.0016	0.0107	0.1933
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0555	0.0555
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0051	0.1039	1
Echinococcus granulosus	cathepsin l1	0.002	0.0202	0.0202
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0033	0.0555	0.2356
Onchocerca volvulus		0.0027	0.0405	0.7309
Schistosoma mansoni	chromobox protein	0.0033	0.0555	0.0555
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.0555	0.4803
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0033	0.0555	0.4803
Echinococcus granulosus	Chromobox protein 3	0.0033	0.0555	0.0555
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0277	0.0277
Brugia malayi	cathepsin B-like cysteine proteinase	0.0147	0.3574	1
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0107	0.1933
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Schistosoma mansoni	nAChR subunit	0.0023	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0147	0.3574	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Trichomonas vaginalis	Heterochromatin protein, putative	0.0033	0.0555	0.4803
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0023	0.0277	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Onchocerca volvulus		0.0023	0.0277	0.4987
Giardia lamblia	Cathepsin B precursor	0.0051	0.1039	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0555	0.1552
Echinococcus multilocularis	cysteine protease	0.0027	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0277	0.0277
Echinococcus multilocularis	Chromobox protein 3	0.0033	0.0555	0.0555
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0033	0.0555	0.4803
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0555	0.4803
Schistosoma mansoni	nAChR subunit	0.0023	0.0277	0.0277
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0107	0.1933
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0405	0.0405
Echinococcus multilocularis	cysteine protease	0.0027	0.0405	0.0405
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0405	0.3201
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0277	0.0277
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0051	0.1039	0.2688
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0033	0.0555	0.0555
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0023	0.0277	0.0774
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0016	0.0107	0.0107
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0405	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0202	0.1018
Brugia malayi	Valyl-tRNA synthetase	0.0033	0.0555	0.1552
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0405	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0405	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0277	0.0277
Brugia malayi	Cation transporter family protein	0.0023	0.0277	0.0774
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0277	0.0277
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0107	0.1933
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0033	0.0555	0.4803
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0033	0.0555	0.4803
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0405	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0202	0.1018

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 35 mg kg-1	Antagonistic activity of the compound against metrazole-induced clonic convulsions in rat after ip injection	ChEMBL.	8568803
Ki (binding)	= 143 nM	Inhibition of [3H]-flunitrazepam binding to GABA-A receptor of rat cortical membranes	ChEMBL.	8568803
Ki (binding)	= 143 nM	Inhibition of [3H]-flunitrazepam binding to GABA-A receptor of rat cortical membranes	ChEMBL.	8568803
[35S] TBPS shift (binding)	= 0.73	In vitro inhibition of [35S]-TBPS binding in rat brain membranes, activity expressed as [35S]-TBPS shift value	ChEMBL.	8568803
[35S] TBPS shift (binding)	= 0.73	In vitro inhibition of [35S]-TBPS binding in rat brain membranes, activity expressed as [35S]-TBPS shift value	ChEMBL.	8568803

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL440478
PubChem: 11793852

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 73469