Detailed information for compound 734708

Basic information

Technical information
  • TDR Targets ID: 734708
  • Name: 2-(2,4-dichlorophenoxy)-N-pyrimidin-2-ylaceta mide
  • MW: 298.125 | Formula: C12H9Cl2N3O2
  • H donors: 1 H acceptors: 3 LogP: 2.67 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ncccn1)COc1ccc(cc1Cl)Cl
  • InChi: 1S/C12H9Cl2N3O2/c13-8-2-3-10(9(14)6-8)19-7-11(18)17-12-15-4-1-5-16-12/h1-6H,7H2,(H,15,16,17,18)
  • InChiKey: LBQURLWBGPIXCS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,4-dichlorophenoxy)-N-pyrimidin-2-yl-acetamide
  • 2-(2,4-dichlorophenoxy)-N-(2-pyrimidinyl)acetamide
  • 2-(2,4-dichlorophenoxy)-N-pyrimidin-2-yl-ethanamide
  • IVK/6217581
  • CBKinase1_000379
  • ZINC00334720
  • 2-(2,4-Dichloro-phenoxy)-N-pyrimidin-2-yl-acetamide
  • BAS 01215292
  • Oprea1_448407
  • AG-690/09626048
  • Oprea1_030027
  • CBKinase1_012779

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide receptor A26 0.0496 0.6959 0.6959
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0249 0.0249
Brugia malayi hypothetical protein 0.0037 0.0204 0.0487
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.012 0.0625
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0043 0.016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.1532 0.5
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0249 0.1294
Loa Loa (eye worm) hypothetical protein 0.0152 0.1902 0.4208
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.1532 0.1532
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.1532 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.1532 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3533 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0065 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2203 0.6236
Entamoeba histolytica hypothetical protein 0.0025 0.0034 0.137
Schistosoma mansoni hypothetical protein 0.0173 0.2203 0.2203
Loa Loa (eye worm) hypothetical protein 0.0256 0.3432 0.7593
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.1532 0.5721
Schistosoma mansoni microtubule-associated protein tau 0.0703 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0043 0.0223
Echinococcus multilocularis muscleblind protein 1 0.0152 0.1902 0.1902
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3533 1
Onchocerca volvulus Huntingtin homolog 0.0256 0.3432 0.7947
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2203 0.6236
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.012 0.0625
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.1532 0.7976
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2203 0.6236
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0249 0.1294
Echinococcus multilocularis carboxylesterase 5A 0.0074 0.0756 0.0756
Brugia malayi DNA topoisomerase I 0.0205 0.2678 0.639
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0249 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2203 0.6236
Brugia malayi Carboxylesterase family protein 0.0074 0.0756 0.1804
Echinococcus granulosus lamin dm0 0.0056 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0095
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0249 0.0249
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0074 0.0756 0.0756
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.1532 0.5
Schistosoma mansoni hypothetical protein 0.0037 0.0204 0.0204
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0249 0.0704
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.035 0.035
Plasmodium falciparum topoisomerase I 0.0205 0.2678 1
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.1532 0.1532
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0034 0.0177
Echinococcus multilocularis neuropeptide s receptor 0.0496 0.6959 0.6959
Echinococcus multilocularis microtubule associated protein 2 0.0703 1 1
Echinococcus granulosus snurportin 1 0.033 0.452 0.452
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0249 0.0249
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0065 0.0065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.035 0.035
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.452 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0204 0.0204
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0249 0.0704
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3533 1
Schistosoma mansoni lamin 0.0056 0.0494 0.0494
Echinococcus granulosus neuropeptide s receptor 0.0496 0.6959 0.6959
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.234 0.6622
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2203 0.6236
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.1532 0.1532
Leishmania major DNA topoisomerase type IB small subunit 0.0051 0.0422 0.2198
Echinococcus multilocularis lamin dm0 0.0056 0.0494 0.0494
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0034 0.0096
Plasmodium vivax topoisomerase I, putative 0.0205 0.2678 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0043 0.0223
Brugia malayi Muscleblind-like protein 0.0152 0.1902 0.4539
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2203 0.6236
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.234 0.6622
Loa Loa (eye worm) hypothetical protein 0.0056 0.0494 0.1094
Loa Loa (eye worm) hypothetical protein 0.0256 0.3432 0.7593
Echinococcus granulosus neuropeptide receptor A26 0.0496 0.6959 0.6959
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3533 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0043 0.016
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0494 0.1094
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0204 0.0204
Echinococcus granulosus acetylcholinesterase 0.0074 0.0756 0.0756
Schistosoma mansoni DNA topoisomerase type I 0.0153 0.1921 0.1921
Schistosoma mansoni hypothetical protein 0.033 0.452 0.452
Echinococcus granulosus DNA topoisomerase 1 0.0205 0.2678 0.2678
Entamoeba histolytica hypothetical protein 0.0037 0.0204 0.8211
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.3533 0.7815
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0034 0.0096
Onchocerca volvulus Huntingtin homolog 0.0256 0.3432 0.7947
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.0111
Leishmania major hypothetical protein, conserved 0.0026 0.0043 0.0223
Leishmania major DNA topoisomerase IB, large subunit 0.0153 0.1921 1
Schistosoma mansoni lamin 0.0056 0.0494 0.0494
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0249 0.0249
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0249 0.0249
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0494 0.118
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0249 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0249 0.0593
Brugia malayi hypothetical protein 0.0308 0.4191 1
Echinococcus granulosus lamin 0.0056 0.0494 0.0494
Schistosoma mansoni hypothetical protein 0.0173 0.2203 0.2203
Leishmania major importin beta-1 subunit, putative 0.0025 0.0034 0.0177
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0249 0.0249
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0043 0.0223
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0249 0.1294
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.035 0.0775
Onchocerca volvulus 0.0308 0.4191 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0204 0.0204
Echinococcus multilocularis geminin 0.0173 0.2203 0.2203
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.035 0.035
Plasmodium falciparum importin beta, putative 0.0031 0.012 0.0448
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0249 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0145
Brugia malayi hypothetical protein 0.0026 0.0043 0.0102
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.012 0.0448
Echinococcus granulosus carboxylesterase 5A 0.0074 0.0756 0.0756
Toxoplasma gondii DNA topoisomerase I, putative 0.0205 0.2678 1
Brugia malayi intermediate filament protein 0.0056 0.0494 0.118
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0153 0.1921 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.012 0.0448
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.035 0.0836
Echinococcus granulosus acetylcholinesterase 0.0074 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.0152 0.1902 0.4208
Brugia malayi Importin beta-1 subunit 0.0031 0.012 0.0286
Loa Loa (eye worm) DNA topoisomerase I 0.0205 0.2678 0.5925
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0249 0.1294
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0055 0.0479 0.106
Brugia malayi hypothetical protein 0.0256 0.3432 0.8189
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.3533 0.8429
Schistosoma mansoni intermediate filament proteins 0.0056 0.0494 0.0494
Echinococcus granulosus intermediate filament protein 0.0056 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0308 0.4191 0.9272
Echinococcus multilocularis lamin 0.0056 0.0494 0.0494
Echinococcus multilocularis acetylcholinesterase 0.0074 0.0756 0.0756
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.1532 0.1532
Echinococcus multilocularis muscleblind protein 0.0152 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0031 0.012 0.0266
Loa Loa (eye worm) hypothetical protein 0.0074 0.0756 0.1672
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3533 1
Entamoeba histolytica hypothetical protein 0.0037 0.0204 0.8211
Loa Loa (eye worm) hypothetical protein 0.004 0.0249 0.055
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0153 0.1921 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0034 0.0096
Schistosoma mansoni DNA topoisomerase type I 0.0205 0.2678 0.2678
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.035 0.035
Echinococcus multilocularis musashi 0.0056 0.0494 0.0494
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.2203 0.4621
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0043 0.016
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0249 0.0704
Entamoeba histolytica hypothetical protein 0.0037 0.0204 0.8211
Brugia malayi RNA, U transporter 1 0.0088 0.0959 0.2287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.035 0.035
Schistosoma mansoni importin beta-1 0.0031 0.012 0.012
Brugia malayi Carboxylesterase family protein 0.0074 0.0756 0.1804
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.2203 0.6236
Loa Loa (eye worm) acetylcholinesterase 1 0.0074 0.0756 0.1672
Echinococcus multilocularis importin subunit beta 1 0.0031 0.012 0.012
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0109 0.0261
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0043 0.016
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0494 0.1094
Loa Loa (eye worm) hypothetical protein 0.0074 0.0756 0.1672
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.035 0.035
Echinococcus multilocularis snurportin 1 0.033 0.452 0.452
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0051 0.0422 0.2198
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0051 0.0422 0.2198
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.3533 1
Echinococcus granulosus importin subunit beta 1 0.0031 0.012 0.012
Schistosoma mansoni DNA topoisomerase type I 0.0153 0.1921 0.1921
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.035 0.035
Entamoeba histolytica hypothetical protein 0.0037 0.0204 0.8211
Echinococcus multilocularis acetylcholinesterase 0.0074 0.0756 0.0756
Echinococcus multilocularis DNA topoisomerase 1 0.0205 0.2678 0.2678
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0109 0.0242
Echinococcus granulosus geminin 0.0173 0.2203 0.2203
Loa Loa (eye worm) carboxylesterase 0.0074 0.0756 0.1672
Echinococcus granulosus muscleblind protein 0.0152 0.1902 0.1902

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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