Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.6408 | 0.6568 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1036 | 0.1036 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.9756 | 0.9728 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.1841 | 0.1887 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.3348 | 0.3432 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.1036 | 0.1036 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.1036 | 0.1036 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.3348 | 0.258 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.1036 | 0.1036 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.1036 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.1036 | 0.1036 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.3348 | 1 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0006 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.1036 | 0.1036 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.1036 | 0.1036 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.1036 | 0.1036 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.1036 | 0.1036 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.9756 | 0.9756 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.3348 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1036 | 0.1036 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.3348 | 0.3432 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.1841 | 0.1887 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.3348 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.1036 | 0.1036 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.1036 | 0.1036 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.6408 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.1036 | 0.1036 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.3348 | 0.258 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.3348 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.9756 | 0.9728 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.1036 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.1036 | 0.1036 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.3348 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.1841 | 0.1887 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1036 | 0.1036 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.1036 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.3348 | 0.3432 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.1036 | 0.1036 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.1036 | 0.1036 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.3348 | 0.3432 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.3348 | 0.258 |
Onchocerca volvulus | 0.001 | 0.1036 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.3348 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.1036 | 0.1036 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.9756 | 0.9756 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.3348 | 0.3348 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.1036 | 0.1036 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.9756 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.9756 | 0.9756 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.1036 | 0.1036 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.9756 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.6408 | 0.6568 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.3348 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.3348 | 0.3348 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1036 | 0.1036 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.3348 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.1841 | 0.1887 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.9756 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.1036 | 0.1036 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.3348 | 0.258 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.1036 | 0.1036 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.1841 | 0.1887 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.3348 | 0.3348 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.1036 | 0.1036 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.3348 | 0.3432 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.1036 | 0.1036 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.3348 | 0.3348 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.1036 | 0.1036 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.1036 | 0.1036 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.