TDR Targets

Basic information

Technical information

TDR Targets ID: 736219
Name: 2-(3-acetylpyridin-1-ium-1-yl)-1-phenylethano ne
MW: 240.277 | Formula: C15H14NO2+
H donors: 0 H acceptors: 2 LogP: 2.18 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1)C[n+]1cccc(c1)C(=O)C
InChi: 1S/C15H14NO2/c1-12(17)14-8-5-9-16(10-14)11-15(18)13-6-3-2-4-7-13/h2-10H,11H2,1H3/q+1
InChiKey: BGUAPJQBDFVVHK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(3-acetylpyridin-1-ium-1-yl)-1-phenyl-ethanone
2-(3-acetyl-1-pyridin-1-iumyl)-1-phenylethanone
2-(3-ethanoylpyridin-1-ium-1-yl)-1-phenyl-ethanone
CBMicro_006639
ZINC02923796

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable reductase	0.0189	0.2531	0.8868
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0058	0.0531	0.0815
Echinococcus multilocularis	nuclear receptor nhr 48	0.0028	0.0057	0.0057
Schistosoma mansoni	RAR-like nuclear receptor	0.0058	0.0531	0.0476
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0518	0.0463
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0028	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0108	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0528	0.0811
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0075	0.0265
Brugia malayi	Pre-SET motif family protein	0.0406	0.5866	1
Onchocerca volvulus	Bile acid receptor homolog	0.0058	0.0531	0.071
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0031	0.0108	0.0051
Brugia malayi	Pre-SET motif family protein	0.0058	0.0528	0.0811
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0029	0.0075	0.0265
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0028	0.0057	0.0057
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0029	0.0075	0.0265
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0188	0.2513	0.4227
Echinococcus granulosus	thioredoxin glutathione reductase	0.0083	0.0912	0.0912
Loa Loa (eye worm)	thioredoxin reductase	0.0083	0.0904	0.1458
Brugia malayi	photoreceptor-specific nuclear receptor	0.0058	0.0531	0.0815
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.4025	0.5983
Onchocerca volvulus		0.0463	0.6727	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0029	0.0075	0.0265
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0189	0.2531	0.8868
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0058	0.0531	0.0476
Brugia malayi	Steroid receptor seven-up type 2	0.0058	0.0531	0.0815
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0058	0.0531	0.0531
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0528	0.0474
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0058	0.0531	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0531	0.0815
Giardia lamblia	Fructose-bisphosphate aldolase	0.0286	0.4025	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0189	0.2531	0.8868
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0188	0.2513	0.6172
Leishmania major	trypanothione reductase	0.0083	0.0904	0.322
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0058	0.0531	0.0815
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0081	0.0883	0.0883
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0029	0.0075	0.0297
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0083	0.0912	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0531	0.0815
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0029	0.0075	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0531	0.0815
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0058	0.0531	0.0815
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0029	0.0075	0.0265
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0058	0.0528	0.5468
Schistosoma mansoni	coup transcription factor	0.0058	0.0531	0.0476
Onchocerca volvulus		0.0081	0.0883	0.1239
Echinococcus granulosus	histone lysine methyltransferase setb	0.0058	0.0528	0.0528
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0056	0.0495	0.0495
Schistosoma mansoni	retinoic acid receptor RXR	0.0058	0.0531	0.0476
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0189	0.2531	0.8868
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0058	0.0518	0.0518
Onchocerca volvulus		0.0058	0.0531	0.071
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0058	0.0531	0.0531
Brugia malayi	jmjC domain containing protein	0.0058	0.0518	0.0793
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0188	0.2513	0.4227
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.4025	0.5983
Toxoplasma gondii	thioredoxin reductase	0.0083	0.0904	1
Brugia malayi	glutathione reductase	0.0083	0.0904	0.1458
Trypanosoma brucei	hypothetical protein, conserved	0.0207	0.2809	1
Plasmodium vivax	SET domain protein, putative	0.0058	0.0528	0.5468
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0058	0.0531	0.0531
Echinococcus multilocularis	microtubule associated protein 2	0.0676	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0058	0.0531	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0531	0.0815
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0188	0.2513	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0058	0.0518	0.0518
Leishmania major	DNA polymerase eta, putative	0.0031	0.0107	0.0381
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0028	0.0057	0.0057
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0058	0.0531	0.0815
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0075	0.0265
Brugia malayi	Nuclear hormone receptor-like 1	0.0058	0.0531	0.0815
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0518	0.0793
Echinococcus granulosus	nuclear receptor nhr 48	0.0028	0.0057	0.0057
Trypanosoma cruzi	trypanothione reductase, putative	0.0029	0.0075	0.0265
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0188	0.2513	0.3735
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0058	0.0531	0.0531
Onchocerca volvulus	Protein ultraspiracle homolog	0.0058	0.0531	0.071
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.4025	0.5983
Brugia malayi	hypothetical protein	0.0031	0.0108	0.0087
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0058	0.0522	0.0776
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0029	0.0075	0.0075
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0058	0.0531	0.0476
Trypanosoma brucei	DNA polymerase eta, putative	0.0044	0.0307	0.085
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0028	0.0057	0.0057
Schistosoma mansoni	DNA polymerase eta	0.0044	0.0307	0.0251
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.4025	0.5983
Brugia malayi	steroid hormone receptor	0.0058	0.0531	0.0815
Plasmodium vivax	glutathione reductase, putative	0.0083	0.0904	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0083	0.0904	0.3168
Plasmodium vivax	thioredoxin reductase, putative	0.0083	0.0904	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0108	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0531	0.0815
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0058	0.0531	0.0476
Trypanosoma cruzi	DNA polymerase eta, putative	0.0031	0.0107	0.0381
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0031	0.0108	0.0108
Treponema pallidum	fructose-bisphosphate aldolase	0.0286	0.4025	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0058	0.0531	0.0531
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0028	0.0057	0.0057
Echinococcus granulosus	thyroid hormone receptor alpha	0.0028	0.0057	0.0057
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.014	0.1779	0.708
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0531	0.0815
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0286	0.4025	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0058	0.0531	0.0815
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0058	0.0531	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0531	0.0815
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0058	0.0528	0.0474
Leishmania major	hypothetical protein, conserved	0.0058	0.0522	0.1858
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0058	0.0531	0.0815
Trichomonas vaginalis	glutathione reductase, putative	0.0029	0.0075	0.0111
Schistosoma mansoni	jumonji domain containing protein	0.0058	0.0518	0.0463
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0058	0.0531	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0108	0.0087
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0058	0.0531	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0307	0.043
Schistosoma mansoni	thyroid hormone receptor	0.0058	0.0531	0.0476
Trypanosoma cruzi	trypanothione reductase, putative	0.0083	0.0904	0.322
Echinococcus granulosus	FTZ F1 alpha	0.0058	0.0531	0.0531
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0058	0.0531	0.0531
Echinococcus granulosus	dna polymerase eta	0.0044	0.0307	0.0307
Trichomonas vaginalis	mercuric reductase, putative	0.0029	0.0075	0.0111
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0058	0.0528	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0108	0.0087
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0058	0.0531	0.0531
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0286	0.4025	1
Schistosoma mansoni	nuclear hormone receptor	0.0058	0.0531	0.0476
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0188	0.2513	0.3735
Brugia malayi	nuclear hormone receptor	0.0058	0.0531	0.0815
Echinococcus granulosus	ecdysone induced protein 78C	0.0058	0.0531	0.0531
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0189	0.2531	0.6994
Trypanosoma cruzi	hypothetical protein, conserved	0.0207	0.2809	1
Onchocerca volvulus		0.0058	0.0528	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0883	0.1422
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0029	0.0075	0.003
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0058	0.0531	0.0476
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0058	0.0531	0.0815
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0058	0.0531	0.0815
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0081	0.0883	0.0831
Leishmania major	DNA polymerase eta, putative	0.0044	0.0307	0.1093
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.021	0.2854	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0058	0.0531	0.0531
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0075	0.0265
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0108	0.0087
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.0307	0.043
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0058	0.0531	0.0815
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0029	0.0075	0.0261
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.014	0.1779	0.6233
Brugia malayi	nuclear receptor NHR-88	0.0058	0.0531	0.0815
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0189	0.2531	0.8868
Brugia malayi	Thioredoxin reductase	0.0083	0.0904	0.1458
Loa Loa (eye worm)	steroid hormone receptor	0.0058	0.0531	0.0815
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0528	0.0474
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0058	0.0531	0.071
Plasmodium falciparum	glutathione reductase	0.0083	0.0904	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.4025	0.5983
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.4025	0.5983
Echinococcus granulosus	lysine specific demethylase 5A	0.0058	0.0518	0.0518
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.0307	0.1093
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0058	0.0531	0.0815
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0081	0.0883	0.1422
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0029	0.0075	0.0265
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0107	0.0392
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0029	0.0075	0.0017
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0031	0.0108	0.0051
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0028	0.0057	0.0057
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0188	0.2513	0.3735
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0058	0.0531	0.0815
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0029	0.0075	0.0297
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0031	0.0108	0.0108
Onchocerca volvulus		0.0188	0.2513	0.3682
Mycobacterium tuberculosis	Probable oxidoreductase	0.021	0.2854	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0058	0.0531	0.0476
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0058	0.0531	0.0531
Echinococcus multilocularis	FTZ F1 alpha	0.0058	0.0531	0.0531
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0522	0.1858
Schistosoma mansoni	thyroid hormone receptor	0.0058	0.0531	0.0476
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0029	0.0075	0.5
Loa Loa (eye worm)	glutathione reductase	0.0083	0.0904	0.1458
Schistosoma mansoni	microtubule-associated protein tau	0.0676	1	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0058	0.0518	0.0463
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0075	0.0265
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0058	0.0531	0.0476
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0058	0.0522	0.0776
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.0522	0.1858
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0058	0.0531	0.0815
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0058	0.0531	0.0815
Brugia malayi	nuclear receptor RXR	0.0031	0.0108	0.0087
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.4025	0.5983
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0108	0.0087
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.013	0.1625	0.5694
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0406	0.5866	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0028	0.0057	0.0057
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0029	0.0075	0.0297
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0028	0.0057	0.0057
Trichomonas vaginalis	set domain proteins, putative	0.0463	0.6727	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0188	0.2513	0.3735
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0531	0.0815
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0058	0.0531	0.0531
Trypanosoma cruzi	hypothetical protein, conserved	0.0207	0.2809	1
Brugia malayi	jmjC domain containing protein	0.0058	0.0518	0.0793
Trypanosoma brucei	trypanothione reductase	0.0083	0.0904	0.3035
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0058	0.0531	0.0815
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0028	0.0057	0.0057
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0058	0.0522	0.1636
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0058	0.0531	0.0815
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0058	0.0531	0.0531
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0075	0.0265
Plasmodium falciparum	thioredoxin reductase	0.0083	0.0904	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0058	0.0528	0.0474
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0029	0.0075	0.0265
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.021	0.2854	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0058	0.0531	0.0815
Echinococcus granulosus	L aminoadipate semialdehyde	0.0081	0.0883	0.0883
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0029	0.0075	0.0075
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0058	0.0531	0.0531
Brugia malayi	hypothetical protein	0.0031	0.0108	0.0087
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.021	0.2854	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0058	0.0531	0.0815
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0029	0.0075	0.5
Leishmania major	hypothetical protein, conserved	0.0207	0.2809	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0058	0.0518	0.0518
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0058	0.0531	0.0815
Echinococcus multilocularis	dna polymerase eta	0.0044	0.0307	0.0307
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0031	0.0108	0.0087
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0108	0.0087
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	0.4025	0.5983
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0188	0.2513	0.3735
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0058	0.0531	0.0476
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0058	0.0528	0.0528
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0029	0.0075	0.5
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0189	0.2531	0.8868
Brugia malayi	ecdysteroid receptor	0.0058	0.0531	0.0815
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0188	0.2513	0.3735

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 736219