Detailed information for compound 736244

Basic information

Technical information
  • TDR Targets ID: 736244
  • Name: 2-(2-hydroxyethyl)-5-[2-(2-hydroxyethyl)-1,3- dioxoisoindol-5-yl]oxyisoindole-1,3-dione
  • MW: 396.35 | Formula: C20H16N2O7
  • H donors: 2 H acceptors: 6 LogP: 0.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1C(=O)c2c(C1=O)cc(cc2)Oc1ccc2c(c1)C(=O)N(C2=O)CCO
  • InChi: 1S/C20H16N2O7/c23-7-5-21-17(25)13-3-1-11(9-15(13)19(21)27)29-12-2-4-14-16(10-12)20(28)22(6-8-24)18(14)26/h1-4,9-10,23-24H,5-8H2
  • InChiKey: VVLFUCAJJOFCCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-hydroxyethyl)-5-[2-(2-hydroxyethyl)-1,3-dioxo-isoindolin-5-yl]oxy-isoindoline-1,3-dione
  • 2-(2-hydroxyethyl)-5-[[2-(2-hydroxyethyl)-1,3-dioxo-5-isoindolinyl]oxy]isoindoline-1,3-dione
  • 2-(2-hydroxyethyl)-5-[2-(2-hydroxyethyl)-1,3-diketo-isoindolin-5-yl]oxy-isoindoline-1,3-quinone
  • 2-(2-hydroxyethyl)-5-[2-(2-hydroxyethyl)-1,3-dioxo-isoindol-5-yl]oxy-isoindole-1,3-dione
  • BAS 03421490
  • A0516/0023890
  • Oprea1_139325
  • Oprea1_450214
  • EU-0034446
  • ZINC00911854

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.0189 0.5
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.003 0.0007 0.0003
Onchocerca volvulus 0.003 0.0007 0.0008
Mycobacterium tuberculosis Probable dehydrogenase 0.0288 0.3296 0.8894
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0402 0.0542
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.7371 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0014 0.0012
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.003 0.0007 0.0009
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0044 0.0189 0.0251
Echinococcus multilocularis potassium channel subfamily K 8 0.003 0.0007 0.0002
Plasmodium vivax potassium channel, putative 0.003 0.0007 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0014 0.0012
Giardia lamblia NADH oxidase lateral transfer candidate 0.0044 0.0189 0.025
Plasmodium vivax thioredoxin reductase, putative 0.0126 0.1238 1
Schistosoma mansoni hypothetical protein 0.003 0.0007 0.0003
Brugia malayi Pre-SET motif family protein 0.0209 0.2293 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.003 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0272 0.3092 0.4219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.7371 1
Plasmodium falciparum potassium channel 0.003 0.0007 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0865 0.1175
Onchocerca volvulus 0.003 0.0007 0.0008
Echinococcus multilocularis small conductance calcium activated potassium 0.0605 0.7322 0.7321
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0044 0.0189 0.0258
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0189 0.1475
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0189 0.1475
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0044 0.0189 0.1475
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.003 0.0007 0.0009
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0865 0.1165
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0865 0.1165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0189 0.1475
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0288 0.3296 0.8894
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0609 0.7371 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Plasmodium falciparum thioredoxin reductase 0.0126 0.1238 1
Leishmania major trypanothione reductase 0.0126 0.1238 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0044 0.0189 0.149
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.003 0.0007 0.0002
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.003 0.0007 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0189 0.1475
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0189 0.1475
Schistosoma mansoni twik family of potassium channels-related 0.003 0.0007 0.0003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0288 0.3296 0.8894
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0865 0.1165
Echinococcus multilocularis potassium channel subfamily K 8 0.003 0.0007 0.0002
Onchocerca volvulus 0.003 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Onchocerca volvulus 0.0238 0.2661 1
Treponema pallidum fructose-bisphosphate aldolase 0.0609 0.7371 1
Plasmodium vivax glutathione reductase, putative 0.0126 0.1238 1
Toxoplasma gondii NADPH-glutathione reductase 0.0044 0.0189 0.149
Echinococcus granulosus peregrin 0.0029 0.0005 0.0007
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0865 0.6966
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0853 0.1165
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0865 0.3237
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2293 0.3127
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0865 0.6966
Trypanosoma brucei polo-like protein kinase 0.0097 0.0865 0.6966
Plasmodium falciparum glutathione reductase 0.0044 0.0189 0.149
Schistosoma mansoni calcium-activated potassium channel 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0044 0.0189 0.0533
Toxoplasma gondii ion channel protein 0.003 0.0007 0.0018
Brugia malayi glutathione reductase 0.0126 0.1238 0.539
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.7371 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0283 0.1214
Loa Loa (eye worm) hypothetical protein 0.0303 0.3488 0.4759
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0044 0.0189 0.0533
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0283 0.1214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.7371 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0127 0.1252 0.1247
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0283 0.038
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0189 0.1475
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0044 0.0189 0.149
Schistosoma mansoni twik family of potassium channels-related 0.003 0.0007 0.0003
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0044 0.0189 0.149
Echinococcus granulosus calcium activated potassium channel variant 0.003 0.0007 0.001
Trypanosoma cruzi trypanothione reductase, putative 0.0126 0.1238 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0014 0.0019
Onchocerca volvulus 0.003 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.005 0.0271 0.0364
Onchocerca volvulus 0.003 0.0014 0.0034
Schistosoma mansoni twik family of potassium channels-related 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0605 0.7322 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0014 0.0009
Loa Loa (eye worm) TWK-7 protein 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Echinococcus multilocularis twik family of potassium channels 0.003 0.0007 0.0002
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0044 0.0189 0.149
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0189 0.1475
Onchocerca volvulus 0.003 0.0007 0.0008
Schistosoma mansoni calcium-activated potassium channel 0.0576 0.6947 0.9488
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0014 0.0072
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0865 0.086
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0126 0.1238 0.333
Echinococcus granulosus small conductance calcium activated potassium 0.0605 0.7322 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0077 0.0314
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0044 0.0189 0.0491
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0005 0.0007
Loa Loa (eye worm) thioredoxin reductase 0.0126 0.1238 0.1686
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0084 0.0107
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0044 0.0189 0.0533
Plasmodium falciparum thioredoxin reductase 0.0044 0.0189 0.149
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0151 0.0206
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0044 0.0189 0.1475
Echinococcus granulosus TWiK family of potassium channels protein 7 0.003 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0051 0.0283 0.038
Loa Loa (eye worm) uncoordinated protein 58 0.003 0.0007 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0865 0.1165
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0189 0.1475
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0014 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Brugia malayi hypothetical protein 0.003 0.0007 0.0009
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0602 0.0816
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0014 0.0009
Onchocerca volvulus 0.003 0.0007 0.0008
Schistosoma mansoni twik family of potassium channels-related 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Schistosoma mansoni hypothetical protein 0.0605 0.7322 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Echinococcus granulosus potassium channel subfamily K 8 0.003 0.0007 0.001
Trichomonas vaginalis glutathione reductase, putative 0.0044 0.0189 0.0247
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.003 0.0007 0.0009
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.003 0.0007 0.0002
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0298 0.3413 1
Schistosoma mansoni twik family of potassium channels-related 0.003 0.0007 0.0003
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0865 0.6966
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0865 0.3757
Schistosoma mansoni calcium-activated potassium channel 0.003 0.0007 0.0003
Schistosoma mansoni hypothetical protein 0.0174 0.1843 0.2512
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0865 0.1165
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0288 0.3296 0.8894
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0865 0.1165
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0321 0.3705 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0032 0.0041 0.0158
Echinococcus granulosus twik family of potassium channels 0.003 0.0007 0.001
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.003 0.0007 0.0009
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.003 0.0007 0.0009
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.003 0.0007 0.0009
Giardia lamblia Hypothetical protein 0.003 0.0007 0.0003
Schistosoma mansoni twik family of potassium channels-related 0.003 0.0007 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0865 0.1165
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0189 0.1475
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Onchocerca volvulus 0.003 0.0007 0.0008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0044 0.0189 0.5
Plasmodium falciparum glutathione reductase 0.0126 0.1238 1
Schistosoma mansoni calcium-activated potassium channel 0.0605 0.7322 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0609 0.7371 1
Toxoplasma gondii thioredoxin reductase 0.0126 0.1238 1
Schistosoma mansoni kinase 0.0049 0.0259 0.0347
Schistosoma mansoni twik family of potassium channels-related 0.003 0.0007 0.0003
Brugia malayi Thioredoxin reductase 0.0126 0.1238 0.539
Echinococcus multilocularis twik family of potassium channels 0.003 0.0007 0.0002
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0044 0.0189 0.5
Echinococcus multilocularis potassium channel subfamily K 0.003 0.0007 0.0002
Mycobacterium tuberculosis Probable reductase 0.0288 0.3296 0.8894
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0853 0.0849
Echinococcus multilocularis geminin 0.0174 0.1843 0.1839
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.003 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0012
Schistosoma mansoni twik family of potassium channels-related 0.003 0.0007 0.0003
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.003 0.0007 0.0009
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0865 0.1175
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0044 0.0189 0.149
Brugia malayi Pre-SET motif family protein 0.003 0.0014 0.0039
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.003 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0044 0.0189 0.1475
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.003 0.0007 0.0003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0321 0.3705 1
Schistosoma mansoni hypothetical protein 0.0174 0.1843 0.2512
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0084 0.0114
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0243 0.0319
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0151 0.0146
Brugia malayi jmjC domain containing protein 0.0096 0.0853 0.3706
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.7371 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0044 0.0189 0.0184
Toxoplasma gondii ion channel protein 0.003 0.0007 0.0018
Plasmodium falciparum potassium channel 0.003 0.0007 0.0018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0084 0.0107
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0084 0.0078
Loa Loa (eye worm) glutathione reductase 0.0126 0.1238 0.1686
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.003 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.7371 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.7371 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.003 0.0007 0.0009
Trypanosoma brucei trypanothione reductase 0.0126 0.1238 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.7371 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0189 0.1475
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0298 0.3413 0.9209
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0084 0.0107
Trichomonas vaginalis set domain proteins, putative 0.0238 0.2661 0.3604
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0189 0.1475
Echinococcus granulosus potassium channel subfamily K 8 0.003 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.003 0.0007 0.0009
Echinococcus granulosus Two pore potassium channel protein sup 9 0.003 0.0007 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0865 0.1165
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0077 0.0098
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0044 0.0189 0.0803
Echinococcus granulosus twik family of potassium channels 0.003 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0189 0.1475
Mycobacterium tuberculosis Probable oxidoreductase 0.0321 0.3705 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.003 0.0007 0.0009
Echinococcus granulosus potassium channel subfamily K 0.003 0.0007 0.001
Brugia malayi jmjC domain containing protein 0.0036 0.0084 0.0343
Giardia lamblia Kinase, PLK 0.0097 0.0865 0.1167
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.003 0.0007 0.0009
Plasmodium vivax potassium channel, putative 0.003 0.0007 0.0018
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0032 0.0041 0.0158
Echinococcus multilocularis calcium activated potassium channel variant 0.003 0.0007 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0044 0.0189 0.1475
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0298 0.3413 0.285
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0865 0.1181
Loa Loa (eye worm) TWK-28 protein 0.003 0.0007 0.0003
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0321 0.3705 1
Plasmodium vivax SET domain protein, putative 0.003 0.0014 0.0072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0189 0.1475
Trichomonas vaginalis mercuric reductase, putative 0.0044 0.0189 0.0247
Brugia malayi hypothetical protein 0.003 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0003
Echinococcus granulosus thioredoxin glutathione reductase 0.0127 0.1252 0.171
Giardia lamblia Fructose-bisphosphate aldolase 0.0609 0.7371 1
Onchocerca volvulus 0.003 0.0007 0.0008
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.003 0.0007 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0243 0.0319
Schistosoma mansoni hypothetical protein 0.0035 0.0077 0.0098
Echinococcus granulosus geminin 0.0174 0.1843 0.2517
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0288 0.3296 0.8894

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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