Detailed information for compound 738013

Basic information

Technical information
  • TDR Targets ID: 738013
  • Name: 2-[[5-(4-chlorophenyl)-1H-1,2,4-triazol-3-yl] sulfanyl]-N-(3-cyano-4,5,6,7-tetrahydro-1-ben zothiophen-2-yl)acetamide
  • MW: 429.946 | Formula: C19H16ClN5OS2
  • H donors: 2 H acceptors: 4 LogP: 4.85 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(NC(=O)CSc2[nH]nc(n2)c2ccc(cc2)Cl)sc2c1CCCC2
  • InChi: 1S/C19H16ClN5OS2/c20-12-7-5-11(6-8-12)17-23-19(25-24-17)27-10-16(26)22-18-14(9-21)13-3-1-2-4-15(13)28-18/h5-8H,1-4,10H2,(H,22,26)(H,23,24,25)
  • InChiKey: ZCXNLIWZPVRBQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-(4-chlorophenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-(3-cyano-4,5,6,7-tetrahydrobenzothiophen-2-yl)acetamide
  • 2-[[5-(4-chlorophenyl)-1H-1,2,4-triazol-3-yl]thio]-N-(3-cyano-4,5,6,7-tetrahydrobenzothiophen-2-yl)acetamide
  • 2-[[5-(4-chlorophenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)ethanamide
  • CBKinase1_019756
  • CBKinase1_007356

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0062 0.0217 0.0528
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0025 0.0016 0.0043
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0442 0.2266 0.5905
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0025 0.0016 0.0468
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0062 0.0217 1
Onchocerca volvulus 0.0062 0.0217 1
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0025 0.0016 0.0262
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0062 0.0121
Schistosoma mansoni protein kinase 0.0135 0.0611 0.1564
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0135 0.0611 0.855
Treponema pallidum prolyl-tRNA synthetase 0.0047 0.0134 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0135 0.0611 0.268
Leishmania major hypothetical protein, conserved 0.0062 0.0217 0.303
Leishmania major glucose transporter/membrane transporter D2, putative 0.0137 0.0621 0.868
Echinococcus granulosus solute carrier family 22 0.0062 0.0217 0.0528
Echinococcus granulosus microtubule associated protein 2 0.073 0.3826 1
Trypanosoma cruzi hexose transporter, putative 0.0075 0.0286 0.3994
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0217 0.0933
Toxoplasma gondii sugar transporter ST3 0.0062 0.0217 0.0327
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0143
Leishmania major threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0218
Trypanosoma brucei sugar transporter, putative 0.0062 0.0217 0.303
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0217 0.0956
Onchocerca volvulus 0.0062 0.0217 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0132 0.0597 0.9756
Plasmodium vivax lysine--tRNA ligase, putative 0.0099 0.0414 0.0399
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0442 0.2266 0.5905
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0217 0.0933
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Brugia malayi Sugar transporter family protein 0.0062 0.0217 0.0933
Onchocerca volvulus Putative transporter 0.0062 0.0217 1
Onchocerca volvulus 0.0062 0.0217 1
Trypanosoma brucei glucose transporter, putative 0.0137 0.0621 0.868
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0442 0.2266 0.5905
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.1314
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0062 0.0217 0.303
Brugia malayi major facilitator superfamily protein 0.0062 0.0217 0.0933
Schistosoma mansoni glucose transport protein 0.0442 0.2266 0.5905
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Echinococcus granulosus General substrate transporter 0.0379 0.193 0.5025
Schistosoma mansoni sugar transporter 0.0062 0.0217 0.0528
Onchocerca volvulus 0.0062 0.0217 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.1874 1 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0099 0.0414 0.6932
Plasmodium falciparum calcium-dependent protein kinase 2 0.0135 0.0612 0.0597
Schistosoma mansoni sugar transporter 0.0062 0.0217 0.0528
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0062 0.0121
Plasmodium falciparum calcium-dependent protein kinase 4 0.0135 0.0612 0.0597
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0132 0.0597 0.2615
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0025 0.0016 0.0043
Mycobacterium ulcerans integral membrane transport protein 0.0062 0.0217 0.5239
Echinococcus multilocularis calcium dependent protein kinase 0.0127 0.0566 0.1445
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0062 0.0217 0.6499
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0086 0.0348 0.1536
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0137 0.0621 0.868
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0062 0.0121
Trypanosoma brucei THT1 - hexose transporter, putative 0.0137 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0072 0.0271 0.1173
Mycobacterium ulcerans sugar transporter 0.0062 0.0217 0.5239
Leishmania major glucose transporter, lmgt2 0.0137 0.0621 0.868
Schistosoma mansoni hypothetical protein 0.0038 0.0085 0.0183
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.0217 0.0933
Echinococcus multilocularis General substrate transporter 0.0379 0.193 0.5025
Schistosoma mansoni lysyl-tRNA synthetase 0.0099 0.0414 0.1045
Schistosoma mansoni protein kinase 0.0135 0.0611 0.1564
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Brugia malayi hypothetical protein 0.0062 0.0217 0.0933
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Toxoplasma gondii sugar transporter ST1 0.0062 0.0217 0.0327
Brugia malayi Sugar transporter family protein 0.0442 0.2266 1
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.1314
Brugia malayi Cam kinase protein 1 0.0135 0.0611 0.268
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0132 0.0597 0.1525
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0135 0.0611 0.268
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0135 0.0612 0.0925
Echinococcus multilocularis solute carrier family 22 0.0062 0.0217 0.0528
Echinococcus multilocularis GPCR, family 2 0.0033 0.0062 0.0121
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0135 0.0612 0.0925
Toxoplasma gondii sugar transporter ST2 0.0062 0.0217 0.0327
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0135 0.0612 0.0597
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0006 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0217 0.0956
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0062 0.0217 0.5239
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0218
Toxoplasma gondii protein kinase, putative 0.1247 0.6617 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0006 0.0083
Loa Loa (eye worm) hypothetical protein 0.0135 0.0611 0.268
Echinococcus granulosus solute carrier family 22 0.0062 0.0217 0.0528
Schistosoma mansoni hypothetical protein 0.0072 0.0271 0.067
Echinococcus multilocularis solute carrier family 22 0.0062 0.0217 0.0528
Plasmodium falciparum proline--tRNA ligase 0.0154 0.0715 0.0701
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0442 0.2266 0.5905
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0025 0.0016 0.0024
Trichomonas vaginalis sugar transport protein, putative 0.0062 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Plasmodium vivax hexose transporter 0.0442 0.2266 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Echinococcus granulosus GPCR family 2 0.0033 0.0062 0.0121
Entamoeba histolytica protein kinase, putative 0.0135 0.0611 1
Echinococcus multilocularis tumor protein p63 0.0328 0.1655 0.4302
Echinococcus multilocularis microtubule associated protein 2 0.073 0.3826 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0135 0.0611 0.1564
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0062 0.0247
Schistosoma mansoni sugar transporter 0.0062 0.0217 0.0528
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0271 0.1173
Onchocerca volvulus 0.0062 0.0217 1
Schistosoma mansoni glucose transport protein 0.0442 0.2266 0.5905
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0121
Entamoeba histolytica hypothetical protein 0.0099 0.0414 0.6732
Onchocerca volvulus 0.0062 0.0217 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0099 0.0414 0.1045
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0154 0.0715 1
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.1314
Leishmania major protein kinase, putative 0.0135 0.0611 0.855
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0062 0.0217 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0062 0.0247
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0099 0.0414 0.1826
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0154 0.0715 1
Plasmodium vivax proline--tRNA ligase, putative 0.0154 0.0715 0.0701
Trypanosoma cruzi hexose transporter, putative 0.0137 0.0621 0.868
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0006 0.0099
Schistosoma mansoni lysyl-tRNA synthetase 0.0099 0.0414 0.1045
Giardia lamblia Lysyl-tRNA synthetase 0.0099 0.0414 0.6849
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0062 0.0217 0.0528
Schistosoma mansoni protein kinase 0.0135 0.0611 0.1564
Chlamydia trachomatis proline--tRNA ligase 0.0047 0.0134 0.2978
Mycobacterium ulcerans hypothetical protein 0.0023 0.0006 0.0143
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0054 0.0175 0.0749
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0048 0.0141 0.0598
Loa Loa (eye worm) sugar transporter 0.0442 0.2266 1
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0621 0.274
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0611 0.1564
Trypanosoma brucei glucose transporter, putative 0.0137 0.0621 0.868
Loa Loa (eye worm) sugar transporter 0.0062 0.0217 0.0933
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0143
Schistosoma mansoni microtubule-associated protein tau 0.073 0.3826 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0135 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Brugia malayi lysyl-tRNA synthetase 0.0099 0.0414 0.1804
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0006 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0217 0.0956
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0099 0.0414 1
Onchocerca volvulus 0.0062 0.0217 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0062 0.0217 0.0528
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0135 0.0611 0.268
Onchocerca volvulus 0.0062 0.0217 1
Echinococcus multilocularis solute carrier family 22 0.0062 0.0217 0.0528
Trichomonas vaginalis glucose transporter, putative 0.0137 0.0621 0.274
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0218
Echinococcus granulosus calcium dependent protein kinase 0.0127 0.0566 0.1445
Trypanosoma brucei THT1 - hexose transporter, putative 0.0137 0.0621 0.868
Trypanosoma brucei glucose transporter, putative 0.0137 0.0621 0.868
Plasmodium falciparum hexose transporter 0.0442 0.2266 0.2253
Trichomonas vaginalis glucose transporter, putative 0.0062 0.0217 0.0956
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0121
Onchocerca volvulus 0.0062 0.0217 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0085 0.0183
Trichomonas vaginalis sugar transporter, putative 0.0137 0.0621 0.274
Trypanosoma cruzi hexose transporter, putative 0.0062 0.0217 0.303
Onchocerca volvulus 0.0062 0.0217 1
Trichomonas vaginalis glucose transporter, putative 0.0137 0.0621 0.274
Giardia lamblia Sugar-proton symporter 0.0062 0.0217 0.346
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Giardia lamblia Hexose transporter 0.0062 0.0217 0.346
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0099 0.0414 0.5783
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Loa Loa (eye worm) major facilitator superfamily transporter 0.0062 0.0217 0.0933
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0062 0.0247
Echinococcus granulosus lysyl tRNA synthetase 0.0099 0.0414 0.1045
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0006 0.0143
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0043
Leishmania major lysyl-tRNA synthetase, putative 0.0099 0.0414 0.5783
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0154 0.0715 1
Schistosoma mansoni glucose transporter 0.0062 0.0217 0.0528
Brugia malayi hypothetical protein 0.0062 0.0217 0.0933
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0141 0.0329
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0006 0.0177
Echinococcus granulosus solute carrier family 22 0.0062 0.0217 0.0528
Trichomonas vaginalis sugar transporter, putative 0.0137 0.0621 0.274
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0451 0.1971
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Echinococcus multilocularis synaptic vesicle 2 protein 0.0062 0.0217 0.0528
Trypanosoma brucei glucose transporter 2A 0.0137 0.0621 0.868
Entamoeba histolytica protein kinase, putative 0.0135 0.0611 1
Onchocerca volvulus 0.0062 0.0217 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0451 0.1971
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Onchocerca volvulus 0.0062 0.0217 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0062 0.0217 0.0528
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0121
Loa Loa (eye worm) hypothetical protein 0.0132 0.0597 0.2615
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0121
Leishmania major myo-inositol/proton symporter (MIT) 0.0062 0.0217 0.303
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0135 0.0611 0.1564
Schistosoma mansoni hypothetical protein 0.0442 0.2266 0.5905
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0135 0.0611 0.1564
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0137 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Leishmania major glucose transporter, lmgt1 0.0137 0.0621 0.868
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0006 0.0143
Brugia malayi glycyl-tRNA synthetase 0.0025 0.0016 0.0043
Onchocerca volvulus 0.0062 0.0217 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0132 0.0597 0.1525
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Plasmodium vivax sugar transporter, putative 0.0062 0.0217 0.0201
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Chlamydia trachomatis lysine--tRNA ligase 0.0099 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0414 0.1804
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0025 0.0016 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0132 0.0597 0.1525
Schistosoma mansoni sugar transporter 0.0062 0.0217 0.0528
Plasmodium falciparum lysine--tRNA ligase 0.0099 0.0414 0.0399
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0025 0.0016 0.016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0062 0.0247
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0132 0.0597 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0084 0.0333 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0085 0.0183
Giardia lamblia Prolyl-tRNA synthetase 0.0132 0.0597 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0135 0.0611 0.1564
Echinococcus multilocularis solute carrier family 22 0.0062 0.0217 0.0528
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0099 0.0414 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0135 0.0612 0.0925
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0062 0.0217 0.6499
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0442 0.2266 0.5905
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0084 0.0333 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Trichomonas vaginalis myo-inositol transporter, putative 0.0062 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0137 0.0621 0.274
Plasmodium falciparum calcium-dependent protein kinase 1 0.0135 0.0612 0.0597
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0006 0.0177
Leishmania major glucose transporter, lmgt3 0.0137 0.0621 0.868
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0135 0.0612 0.0597
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0442 0.2266 0.5905
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Brugia malayi major facilitator superfamily protein 0.0062 0.0217 0.0933
Brugia malayi Major Facilitator Superfamily protein 0.0062 0.0217 0.0933
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0451 0.1971
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0135 0.0611 0.1564
Brugia malayi hypothetical protein 0.0038 0.0085 0.0352
Onchocerca volvulus 0.0062 0.0217 1
Toxoplasma gondii transporter, major facilitator family protein 0.0062 0.0217 0.0327
Trypanosoma brucei glucose transporter, putative 0.0137 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.0621 0.274
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0218
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0442 0.2266 0.5905
Plasmodium falciparum mitogen-activated protein kinase 2 0.0713 0.3734 0.3724
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0025 0.0016 0.0043
Onchocerca volvulus 0.0062 0.0217 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0154 0.0715 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0006 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0713 0.3734 0.3724
Plasmodium falciparum protein kinase 7 0.1247 0.6617 0.6612
Trypanosoma brucei THT1 - hexose transporter, putative 0.0137 0.0621 0.868
Trypanosoma brucei glucose transporter, putative 0.0137 0.0621 0.868
Trypanosoma brucei glucose transporter 1E 0.0137 0.0621 0.868
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0006 0.0143
Onchocerca volvulus 0.0062 0.0217 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0006 0.0143
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Trypanosoma cruzi hexose transporter, putative 0.0137 0.0621 0.868
Schistosoma mansoni glucose transport protein 0.0442 0.2266 0.5905
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0132 0.0597 0.1525
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Toxoplasma gondii lysine-tRNA ligase 0.0099 0.0414 0.0625
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0154 0.0715 1
Echinococcus granulosus solute carrier family 22 0.0062 0.0217 0.0528
Onchocerca volvulus 0.0048 0.0141 0.6411
Toxoplasma gondii glycyl-tRNA synthetase 0.0025 0.0016 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0084 0.0333 0.5587
Trypanosoma cruzi glucose transporter, putative 0.0062 0.0217 0.303
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0085 0.0183
Trypanosoma cruzi sugar transporter, putative 0.0062 0.0217 0.303
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0154 0.0715 0.1081
Trichomonas vaginalis CAMK family protein kinase 0.0135 0.0611 0.2699
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0135 0.0611 0.1564
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0025 0.0016 0.0377
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0135 0.0612 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0442 0.2266 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0135 0.0612 0.0597
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0132 0.0597 0.2634
Plasmodium falciparum calcium-dependent protein kinase 3 0.0135 0.0612 0.0597
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0025 0.0016 0.0377
Loa Loa (eye worm) hypothetical protein 0.0108 0.0463 0.2021
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0135 0.0611 0.1564
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0135 0.0611 0.1564
Trypanosoma cruzi hexose transporter, putative 0.0137 0.0621 0.868
Echinococcus granulosus tumor protein p63 0.0328 0.1655 0.4302
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0047 0.0134 0.3243
Brugia malayi hypothetical protein 0.0062 0.0217 0.0933
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0062 0.0217 0.5239
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0217 0.0956
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0713 0.3734 0.5643
Trypanosoma brucei glucose transporter, putative 0.0137 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0132 0.0597 0.2615
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0069
Trypanosoma cruzi hexose transporter 0.0137 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0106 0.0451 0.1971
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0025 0.0016 0.016
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0442 0.2266 0.5905
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0025 0.0016 0.0218
Entamoeba histolytica hypothetical protein 0.0038 0.0085 0.1314
Toxoplasma gondii facilitative glucose transporter GT1 0.0442 0.2266 0.3424
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0062 0.0121
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0217 0.0956
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0006 0.0099
Loa Loa (eye worm) hypothetical protein 0.0062 0.0217 0.0933
Brugia malayi Sugar transporter family protein 0.0062 0.0217 0.0933
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0132 0.0597 0.2615
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0099 0.0414 0.5783

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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