Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1721 | 0.1675 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0404 | 0.0351 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.4149 | 1 |
Onchocerca volvulus | 0.0067 | 0.037 | 0.4958 | |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0092 | 0.0745 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0157 | 0.1709 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.4149 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.0408 | 0.0984 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.2816 | 0.2776 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0081 | 0.0061 |
Echinococcus granulosus | geminin | 0.0352 | 0.459 | 0.456 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0112 | 0.1033 | 0.0983 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0092 | 0.0745 | 0.0694 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.0408 | 0.0355 |
Brugia malayi | bZIP transcription factor family protein | 0.0085 | 0.064 | 0.1391 |
Echinococcus granulosus | jun protein | 0.0085 | 0.064 | 0.0589 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0157 | 0.1709 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0352 | 0.459 | 0.456 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0112 | 0.1033 | 0.0983 |
Onchocerca volvulus | Alhambra homolog | 0.0092 | 0.0745 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.4149 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0717 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.0408 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2816 | 0.2776 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0979 | 0.0929 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0128 | 0.128 | 0.1232 |
Brugia malayi | Cytochrome P450 family protein | 0.0049 | 0.0112 | 0.0135 |
Brugia malayi | hypothetical protein | 0.0067 | 0.037 | 0.0748 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0049 | 0.0112 | 0.0057 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0108 | 0.0979 | 0.2196 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0092 | 0.0745 | 0.0694 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.4149 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0112 | 0.1033 | 0.0983 |
Schistosoma mansoni | lipoxygenase | 0.012 | 0.115 | 0.1101 |
Schistosoma mansoni | hypothetical protein | 0.0352 | 0.459 | 0.456 |
Schistosoma mansoni | lipoxygenase | 0.0084 | 0.0617 | 0.0566 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.2816 | 0.2776 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0302 | 0.3852 | 0.3819 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0745 | 0.0694 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.0408 | 0.084 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.012 | 0.115 | 0.1101 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.0408 | 0.0355 |
Echinococcus granulosus | peregrin | 0.0092 | 0.0745 | 0.0694 |
Echinococcus multilocularis | geminin | 0.0352 | 0.459 | 0.456 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0092 | 0.0745 | 0.0694 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0717 | 1 | 1 |
Echinococcus multilocularis | peregrin | 0.0092 | 0.0745 | 0.0694 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.0408 | 0.0355 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0085 | 0.064 | 0.0589 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.0408 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0606 | 0.0554 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.4149 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.0745 | 0.0694 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.0408 | 0.0355 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0112 | 0.1033 | 0.0983 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.0473 | 0.042 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.019 | 0.2199 | 0.2156 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.4149 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.012 | 0.115 | 0.1101 |
Echinococcus granulosus | jumonji domain containing protein | 0.0128 | 0.128 | 0.1232 |
Plasmodium falciparum | phd finger protein, putative | 0.0092 | 0.0745 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0085 | 0.064 | 0.0589 |
Brugia malayi | PHD-finger family protein | 0.0092 | 0.0745 | 0.1641 |
Plasmodium vivax | hypothetical protein, conserved | 0.0092 | 0.0745 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0322 | 0.4149 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.4149 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0717 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0302 | 0.3852 | 0.9026 |
Brugia malayi | hypothetical protein | 0.0232 | 0.2816 | 0.6562 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0473 | 0.042 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0108 | 0.0979 | 0.0929 |
Brugia malayi | Bromodomain containing protein | 0.0092 | 0.0745 | 0.1641 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0112 | 0.1033 | 0.0983 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0081 | 0.0026 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0322 | 0.4149 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0108 | 0.0979 | 0.2196 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0322 | 0.4149 | 0.5 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0157 | 0.1709 | 0.5 |
Schistosoma mansoni | jun-related protein | 0.0069 | 0.0404 | 0.0351 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0302 | 0.3852 | 0.3819 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.0408 | 0.0355 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0322 | 0.4149 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.0408 | 0.0984 |
Schistosoma mansoni | jumonji domain containing protein | 0.024 | 0.2933 | 0.2894 |
Onchocerca volvulus | 0.0047 | 0.0081 | 0.1081 | |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0092 | 0.0745 | 0.0694 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.4149 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0092 | 0.0745 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0081 | 0.0026 |
Echinococcus multilocularis | jun protein | 0.0085 | 0.064 | 0.0589 |
Brugia malayi | hypothetical protein | 0.033 | 0.4262 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.0473 | 0.0993 |
Brugia malayi | jmjC domain containing protein | 0.0112 | 0.1033 | 0.2324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.