Detailed information for compound 740275

Basic information

Technical information
  • TDR Targets ID: 740275
  • Name: 1-[(4-methylpiperidin-1-yl)methyl]naphthalen- 2-ol
  • MW: 255.355 | Formula: C17H21NO
  • H donors: 1 H acceptors: 1 LogP: 3.93 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)Cc1c(O)ccc2c1cccc2
  • InChi: 1S/C17H21NO/c1-13-8-10-18(11-9-13)12-16-15-5-3-2-4-14(15)6-7-17(16)19/h2-7,13,19H,8-12H2,1H3
  • InChiKey: LFRISHBOHIWJNJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4-methyl-1-piperidyl)methyl]naphthalen-2-ol
  • 1-[(4-methyl-1-piperidinyl)methyl]-2-naphthalenol
  • 1-[(4-methyl-1-piperidyl)methyl]-2-naphthol
  • ChemDiv2_001645
  • CBMicro_006156
  • 1-(4-Methyl-piperidin-1-ylmethyl)-naphthalen-2-ol
  • BAS 05331416
  • Oprea1_869454
  • BIM-0006322.P001
  • Oprea1_304833
  • STOCK1S-91098
  • 1-[(4-methylpiperidin-1-ium-1-yl)methyl]naphthalen-2-olate
  • 1-[(4-methyl-1-piperidin-1-iumyl)methyl]-2-naphthalenolate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0437 0.1471
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2969 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0729 0.0913
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.118 1
Echinococcus multilocularis caspase 0.0097 0.0824 0.0824
Schistosoma mansoni hypothetical protein 0.0035 0.0002 0.0002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.012 0.015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.000980205 0 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1789 0.6025
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0327 0.1103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.118 1
Leishmania major GTP-binding protein, putative 0.0044 0.012 0.1016
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0945 0.3184
Loa Loa (eye worm) hypothetical protein 0.0106 0.0945 0.1183
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.072 0.072
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0437 0.0546
Echinococcus granulosus FTZ F1 alpha 0.000980205 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0041 0.0139
Echinococcus granulosus chromobox protein 1 0.0068 0.0437 0.0546
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0097 0.0824 0.0824
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0945 1
Schistosoma mansoni retinoic acid receptor RXR 0.000980205 0 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.0945 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0179 0.1896
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.012 0.1016
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1623 0.1623
Brugia malayi beta-lactamase 0.0106 0.0945 0.3184
Mycobacterium ulcerans lipase LipD 0.0106 0.0945 0.7242
Echinococcus multilocularis importin subunit beta 1 0.006 0.0329 0.0329
Entamoeba histolytica hypothetical protein 0.0048 0.0179 0.1234
Onchocerca volvulus 0.0106 0.0945 0.5173
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0002 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.0945 0.1183
Echinococcus multilocularis sentrin specific protease 7 0.0144 0.1452 0.1452
Brugia malayi Heterochromatin protein 1 0.0068 0.0437 0.1471
Onchocerca volvulus 0.0106 0.0945 0.5173
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.000980205 0 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.000980205 0 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.000980205 0 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1789 0.6025
Loa Loa (eye worm) hypothetical protein 0.006 0.0329 0.0412
Schistosoma mansoni caspase-3 (C14 family) 0.0097 0.0824 0.1031
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0437 0.1471
Echinococcus multilocularis thyroid hormone receptor alpha 0.000980205 0 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.118 0.118
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.118 0.1477
Loa Loa (eye worm) hypothetical protein 0.0106 0.0945 0.1183
Echinococcus multilocularis ecdysone induced protein 78C 0.000980205 0 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.000980205 0 0.5
Schistosoma mansoni thyroid hormone receptor 0.000980205 0 0.5
Plasmodium vivax hypothetical protein, conserved 0.0106 0.0945 1
Onchocerca volvulus Bile acid receptor homolog 0.000980205 0 0.5
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.2969 1
Echinococcus granulosus neuropeptide receptor A26 0.0469 0.5753 0.7199
Mycobacterium leprae Probable lipase LipE 0.0106 0.0945 0.5
Brugia malayi ecdysteroid receptor 0.000980205 0 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.000980205 0 0.5
Schistosoma mansoni nuclear hormone receptor 0.000980205 0 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0327 0.0327
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.118 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.008 0.0219
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.000980205 0 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.0002 0.0011
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.012 0.0404
Echinococcus multilocularis geminin 0.0333 0.3957 0.3957
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.072 0.072
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.012 0.012
Mycobacterium tuberculosis Probable esterase LipL 0.0106 0.0945 0.0753
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0144 0.1452 1
Onchocerca volvulus 0.0091 0.0744 0.4019
Mycobacterium ulcerans beta-lactamase 0.0106 0.0945 0.7242
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0329 0.2787
Schistosoma mansoni chromobox protein 0.0068 0.0437 0.0546
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.1623 0.2031
Schistosoma mansoni caspase-7 (C14 family) 0.0097 0.0824 0.1031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.072 0.0901
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.118 0.1477
Onchocerca volvulus 0.000980205 0 0.5
Mycobacterium tuberculosis Probable lipase LipE 0.0106 0.0945 0.0753
Mycobacterium tuberculosis Probable lipase LipD 0.0106 0.0945 0.0753
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0327 0.041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0179 0.0604
Brugia malayi RNA, U transporter 1 0.017 0.1789 0.6026
Loa Loa (eye worm) hypothetical protein 0.009 0.0729 0.0913
Echinococcus granulosus nuclear receptor 2DBD gamma 0.000980205 0 0.5
Brugia malayi chromobox protein homolog 3 0.0038 0.0041 0.0139
Mycobacterium ulcerans esterase/lipase LipP 0.0106 0.0945 0.7242
Schistosoma mansoni hypothetical protein 0.0333 0.3957 0.4951
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.072 0.0901
Toxoplasma gondii hypothetical protein 0.0089951 1 0.5
Plasmodium vivax importin-beta 2, putative 0.006 0.0329 0.2534
Brugia malayi Nuclear hormone receptor family member nhr-14 0.000980205 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.000980205 0 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0106 0.0945 0.1183
Plasmodium falciparum importin beta, putative 0.006 0.0329 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.008 0.0268
Brugia malayi nuclear hormone receptor 0.000980205 0 0.5
Trichomonas vaginalis ran, putative 0.0044 0.012 0.0404
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.118 1
Schistosoma mansoni importin beta-1 0.006 0.0329 0.0412
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0097 0.0824 0.1031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.000980205 0 0.5
Trichomonas vaginalis chromobox protein, putative 0.0041 0.008 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-19 0.000980205 0 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.0002 0.0011
Brugia malayi beta-lactamase family protein 0.0106 0.0945 0.3184
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.012 0.1269
Leishmania major hypothetical protein, conserved 0.0106 0.0945 0.8007
Echinococcus granulosus geminin 0.0333 0.3957 0.4951
Mycobacterium tuberculosis Conserved protein 0.0106 0.0945 0.0753
Brugia malayi Nuclear hormone receptor-like 1 0.000980205 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0945 1
Echinococcus granulosus caspase 0.0097 0.0824 0.1031
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1789 0.6025
Echinococcus granulosus retinoic acid receptor rxr beta a 0.000980205 0 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1789 0.6025
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2969 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0106 0.0945 0.3184
Toxoplasma gondii ABC1 family protein 0.0106 0.0945 0.8007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.072 0.2426
Loa Loa (eye worm) hypothetical protein 0.0089951 1 1
Echinococcus granulosus caspase 3 0.0071 0.048 0.0601
Mycobacterium leprae conserved hypothetical protein 0.0106 0.0945 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0469 0.5753 0.5753
Brugia malayi Nuclear hormone receptor family member nhr-19 0.000980205 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.000980205 0 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2969 1
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0179 0.0604
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.000980205 0 0.5
Schistosoma mansoni hypothetical protein 0.0638 0.7991 1
Echinococcus multilocularis neuropeptide s receptor 0.0469 0.5753 0.5753
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0945 0.3184
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0638 0.7991 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.000980205 0 0.5
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.012 0.1269
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.000980205 0 0.5
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.009 0.0729 0.0913
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0329 0.3481
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0274 0.0343
Echinococcus granulosus beta LACTamase domain containing family member 0.0106 0.0945 0.1183
Mycobacterium tuberculosis Conserved protein 0.0106 0.0945 0.0753
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.1789 1
Schistosoma mansoni ran 0.0044 0.012 0.015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.1623 0.5468
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.191 0.6433
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0106 0.0945 0.0753
Echinococcus multilocularis snurportin 1 0.0638 0.7991 0.7991
Schistosoma mansoni alpha-glucosidase 0.0135 0.1333 0.1668
Schistosoma mansoni alpha-glucosidase 0.0135 0.1333 0.1668
Echinococcus granulosus snurportin 1 0.0638 0.7991 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.1623 0.2031
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0106 0.0945 0.0753
Brugia malayi hypothetical protein 0.0035 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0106 0.0945 0.1183
Loa Loa (eye worm) hypothetical protein 0.0106 0.0945 0.1183
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.000980205 0 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.000980205 0 0.5
Echinococcus multilocularis chromobox protein 1 0.0068 0.0437 0.0437
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1789 0.6025
Schistosoma mansoni hypothetical protein 0.0333 0.3957 0.4951
Echinococcus granulosus nuclear receptor 2DBD gamma 0.000980205 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.000980205 0 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2969 1
Schistosoma mansoni ran 0.0044 0.012 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2969 1
Mycobacterium tuberculosis Conserved protein 0.0106 0.0945 0.0753
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0329 0.3481
Echinococcus multilocularis caspase 3 0.0071 0.048 0.048
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.118 0.1477
Echinococcus multilocularis beta LACTamase domain containing family member 0.0106 0.0945 0.0945
Echinococcus granulosus ecdysone induced protein 78C 0.000980205 0 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.000980205 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.072 0.0901
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.012 0.015
Loa Loa (eye worm) hypothetical protein 0.0089951 1 1
Brugia malayi nuclear receptor NHR-88 0.000980205 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0041 0.0052
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0179 0.0604
Leishmania major importin beta-1 subunit, putative 0.0048 0.0179 0.1518
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.118 1
Echinococcus multilocularis FTZ F1 alpha 0.000980205 0 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.191 0.6433
Onchocerca volvulus 0.0106 0.0945 0.5173
Brugia malayi steroid hormone receptor 0.000980205 0 0.5
Schistosoma mansoni thyroid hormone receptor 0.000980205 0 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.0002 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.000980205 0 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.072 0.0901
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.0945 0.3184
Brugia malayi Nuclear hormone receptor family member nhr-41 0.000980205 0 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.0945 0.1183
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.0945 0.3184
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.118 0.104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.072 0.0901
Echinococcus multilocularis chromobox protein 1 0.0068 0.0437 0.0437
Echinococcus granulosus neuropeptide s receptor 0.0469 0.5753 0.7199
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.000980205 0 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.000980205 0 0.5
Brugia malayi Importin beta-1 subunit 0.006 0.0329 0.1108
Echinococcus granulosus chromobox protein 1 0.0068 0.0437 0.0546
Entamoeba histolytica Ran family GTPase 0.0044 0.012 0.0826
Loa Loa (eye worm) hypothetical protein 0.0106 0.0945 0.1183
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0679 0.8533 1
Echinococcus granulosus importin subunit beta 1 0.006 0.0329 0.0412
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.0945 0.3184
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.000980205 0 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1623 0.1623
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.2585 0.3235
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0144 0.1452 0.1817
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.2969 0.3715
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.000980205 0 0.5
Schistosoma mansoni chromobox protein 0.0068 0.0437 0.0546
Schistosoma mansoni RAR-like nuclear receptor 0.000980205 0 0.5
Trichomonas vaginalis esterase, putative 0.0106 0.0945 0.3184
Loa Loa (eye worm) beta-lactamase 0.0106 0.0945 0.1183
Echinococcus multilocularis expressed conserved protein 0.0132 0.1285 0.1285
Brugia malayi follicle stimulating hormone receptor 0.023 0.2585 0.8708
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0327 0.041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.000980205 0 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.2969 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.012 0.5
Echinococcus granulosus expressed conserved protein 0.0132 0.1285 0.1608
Echinococcus granulosus sentrin specific protease 7 0.0144 0.1452 0.1817
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0106 0.0945 0.7242
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0041 0.0139
Entamoeba histolytica hypothetical protein 0.0035 0.0002 0.0011
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0106 0.0945 0.0753
Toxoplasma gondii hypothetical protein 0.009 0.0729 0.6179
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.000980205 0 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.000980205 0 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1789 0.6025
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.012 0.1269
Loa Loa (eye worm) hypothetical protein 0.009 0.0729 0.0913
Mycobacterium ulcerans hypothetical protein 0.0106 0.0945 0.7242
Brugia malayi beta-lactamase family protein 0.0106 0.0945 0.3184
Loa Loa (eye worm) hypothetical protein 0.0089951 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.1789 0.6025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.000980205 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0106 0.0945 0.1183
Schistosoma mansoni coup transcription factor 0.000980205 0 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0106 0.0945 0.0753
Brugia malayi Steroid receptor seven-up type 2 0.000980205 0 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0327 0.2773
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0089951 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.072 0.0901
Brugia malayi Nuclear hormone receptor family member nhr-49 0.000980205 0 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.000980205 0 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.000980205 0 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 0.3684 uM ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 0.37 uM Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) = 0.49 uM Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) 0.4921 uM ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 1.31 uM Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) = 2.42 uM Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
Percent growth inhibition (functional) = 90.5 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye Saint Jude. 20485428
Percent growth inhibition (functional) = 93.9 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye Saint Jude. 20485428
Percent growth inhibition (functional) = 101.6 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye Saint Jude. 20485428
Percent growth inhibition (functional) = 102 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye Saint Jude. 20485428

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 20485428

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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