TDR Targets

Basic information

Technical information

TDR Targets ID: 754500
Name: 5-[(3-methoxyphenyl)methylidene]-2-(2-methylp henyl)-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-o ne
MW: 353.438 | Formula: C19H19N3O2S
H donors: 0 H acceptors: 3 LogP: 4.66 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C=C1SC2N(C1=O)NC(N2)c1ccccc1C
InChi: 1S/C19H15N3O2S/c1-12-6-3-4-9-15(12)17-20-19-22(21-17)18(23)16(25-19)11-13-7-5-8-14(10-13)24-2/h3-11H,1-2H3/b16-11-
InChiKey: QSHYKGMZYYKRFK-WJDWOHSUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z)-5-[(3-methoxyphenyl)methylidene]-2-(2-methylphenyl)-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
5-[(3-methoxyphenyl)methylene]-2-(2-methylphenyl)thiazolo[2,3-e][1,2,4]triazol-6-one
(5Z)-5-[(3-methoxyphenyl)methylene]-2-(2-methylphenyl)thiazolo[2,3-e][1,2,4]triazol-6-one
5-[(3-methoxyphenyl)methylene]-2-(2-methylphenyl)-6-thiazolo[2,3-e][1,2,4]triazolone
(5Z)-5-[(3-methoxyphenyl)methylene]-2-(2-methylphenyl)-6-thiazolo[2,3-e][1,2,4]triazolone
5-(3-methoxybenzylidene)-2-(2-methylphenyl)thiazolo[2,3-e][1,2,4]triazol-6-one
(5Z)-5-(3-methoxybenzylidene)-2-(2-methylphenyl)thiazolo[2,3-e][1,2,4]triazol-6-one
ZINC00532211
STOCK4S-24787

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0251	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0218	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0125	0.3033	1
Onchocerca volvulus		0.0035	0.0719	0.0721
Schistosoma mansoni	hypothetical protein	0.0015	0.0218	0.0215
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0719	0.0126
Brugia malayi	hypothetical protein	0.0037	0.0767	0.2529
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0719	0.0851
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.5537	0.9575
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.1065	0.3512
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0719	0.2371
Schistosoma mansoni	pyruvate kinase	0.0032	0.0655	0.0653
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0719	0.0126
Brugia malayi	hypothetical protein	0.0125	0.3033	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0218	0.0215
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1341	0.1338
Echinococcus granulosus	pyruvate kinase	0.0032	0.0655	0.0653
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0719	0.0126
Echinococcus granulosus	pyruvate kinase	0.0017	0.0251	0.0249
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0088	0.2087	1
Echinococcus granulosus	pyruvate kinase	0.0032	0.0655	0.0653
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0673	0.2218
Brugia malayi	beta-lactamase family protein	0.0035	0.0719	0.2371
Echinococcus multilocularis	cpg binding protein	0.0029	0.058	0.0578
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0655	0.0463
Treponema pallidum	polypeptide deformylase (def)	0.0231	0.5754	0.5
Schistosoma mansoni	hypothetical protein	0.0015	0.0218	0.0215
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0218	0.0215
Plasmodium vivax	pyruvate kinase, putative	0.0032	0.0655	0.0734
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.001	0.0076	0.0251
Schistosoma mansoni	pyruvate kinase	0.0032	0.0655	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0673	0.2218
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.054	0.1779
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0218	0.0717
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0655	0.0463
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0719	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0404	0.1332
Plasmodium falciparum	pyruvate kinase	0.0032	0.0655	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1065	0.3512
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0719	0.0449
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0719	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0673	0.067
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0251	0.0249
Entamoeba histolytica	hypothetical protein	0.0037	0.0767	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.3033	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0767	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0719	0.0126
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0719	0.0717
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0404	0.1332
Brugia malayi	CXXC zinc finger family protein	0.0028	0.054	0.1779
Echinococcus granulosus	geminin	0.0331	0.8316	0.8315
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0218	0.0215
Plasmodium vivax	peptide deformylase, putative	0.0231	0.5754	1
Onchocerca volvulus		0.0035	0.0719	0.0721
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0046	0.0044
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0231	0.5754	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0719	0.0449
Brugia malayi	beta-lactamase family protein	0.0035	0.0719	0.2371
Schistosoma mansoni	hypothetical protein	0.0015	0.0218	0.0215
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0032	0.0655	0.2159
Trichomonas vaginalis	esterase, putative	0.0035	0.0719	1
Echinococcus granulosus	cpg binding protein	0.0029	0.058	0.0578
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0719	0.0126
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0719	0.2371
Leishmania major	polypeptide deformylase-like protein, putative	0.0088	0.2087	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0719	0.2371
Schistosoma mansoni	hypothetical protein	0.0037	0.0767	0.0765
Echinococcus granulosus	pyruvate kinase	0.0017	0.0251	0.0249
Echinococcus multilocularis	pyruvate kinase	0.0026	0.048	0.0478
Onchocerca volvulus	Huntingtin homolog	0.0125	0.3033	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0719	0.2371
Echinococcus granulosus	pyruvate kinase	0.0017	0.0251	0.0249
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0719	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0218	0.0215
Trypanosoma brucei	Peptide deformylase 2	0.0088	0.2087	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0719	0.0717
Schistosoma mansoni	cpg binding protein	0.0029	0.058	0.0578
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0719	0.0126
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0719	0.0717
Echinococcus multilocularis	dnaJ subfamily B	0.0397	1	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0719	0.0126
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0719	0.0126
Entamoeba histolytica	hypothetical protein	0.0037	0.0767	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0719	0.2371
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0719	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0719	1
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0231	0.5754	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0218	0.0717
Toxoplasma gondii	pyruvate kinase PyK1	0.0032	0.0655	0.0734
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0719	0.0717
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.1179	0.1686
Leishmania major	hypothetical protein, conserved	0.0035	0.0719	0.0449
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0719	0.2371
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0088	0.2087	1
Schistosoma mansoni	cpg binding protein	0.0029	0.058	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0719	0.2371
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0719	0.0126
Toxoplasma gondii	hypothetical protein	0.0231	0.5754	1
Giardia lamblia	Pyruvate kinase	0.0032	0.0655	1
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0719	0.0449
Schistosoma mansoni	cpg binding protein	0.0028	0.054	0.0537
Echinococcus multilocularis	pyruvate kinase	0.0032	0.0655	0.0653
Trypanosoma brucei	Polypeptide deformylase 1	0.0088	0.2087	1
Echinococcus granulosus	GPCR family 2	0.0015	0.0218	0.0215
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0251	0.0249
Chlamydia trachomatis	peptide deformylase	0.0231	0.5754	1
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0088	0.2087	1
Onchocerca volvulus	Huntingtin homolog	0.0125	0.3033	1
Echinococcus multilocularis	pyruvate kinase	0.0032	0.0655	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0719	0.2371
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0655	0.2159
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0767	0.0765
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0767	0.0765
Schistosoma mansoni	hypothetical protein	0.0331	0.8316	0.8315
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0218	0.0717
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.1065	0.3512
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0046	0.0044
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0719	0.0126
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0719	0.0126
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0719	0.0126
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0231	0.5754	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.1065	0.3512
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0088	0.2087	1
Schistosoma mansoni	hypothetical protein	0.0397	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0719	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0719	0.0126
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0719	0.0126
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0719	0.0126
Schistosoma mansoni	hypothetical protein	0.0015	0.0218	0.0215
Toxoplasma gondii	ABC1 family protein	0.0035	0.0719	0.0851
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0767	0.0765
Entamoeba histolytica	hypothetical protein	0.0037	0.0767	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0655	0.2159
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0032	0.0655	0.2159
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0043	0.0143
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0046	0.0152
Mycobacterium ulcerans	lipase LipD	0.0035	0.0719	0.0126
Brugia malayi	beta-lactamase	0.0035	0.0719	0.2371
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0655	0.0463
Plasmodium falciparum	peptide deformylase	0.0231	0.5754	1
Schistosoma mansoni	pyruvate kinase	0.0017	0.0251	0.0249
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0655	0.2159
Mycobacterium ulcerans	peptide deformylase	0.0231	0.5754	1
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0719	0.2371
Echinococcus multilocularis	geminin	0.0331	0.8316	0.8315
Schistosoma mansoni	hypothetical protein	0.0331	0.8316	0.8315
Onchocerca volvulus		0.0035	0.0719	0.0721
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0218	0.0215
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0655	0.2159

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 754500