TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 382.42 | Formula: C20H25F3N2O2
H donors: 0 H acceptors: 1 LogP: 4.28 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCCC1CCCCN1Cc1nc(oc1C)c1ccc(cc1)C(F)(F)F
InChi: 1S/C20H25F3N2O2/c1-14-18(13-25-11-4-3-5-17(25)10-12-26-2)24-19(27-14)15-6-8-16(9-7-15)20(21,22)23/h6-9,17H,3-5,10-13H2,1-2H3
InChiKey: BVRUKSMTZUIYQH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	GPCR family 2	0.0101	0.092	0.3855
Leishmania major	phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0049	0.0349	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.0265	0.111
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0016	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0066	0.054	0.0526
Schistosoma mansoni	hypothetical protein	0.0101	0.092	0.3855
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0132	0.0554
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0345	0.0329
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.1154	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0016	0.045
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0187	0.5363
Brugia malayi	PHD-finger family protein	0.0034	0.0187	0.0187
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0101	0.092	0.3855
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0016	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0098	0.0083
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.1154	1
Trypanosoma brucei	inositol phosphorylceramide synthase	0.0049	0.0349	1
Onchocerca volvulus		0.0154	0.1502	0.6273
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0101	0.092	0.3855
Echinococcus granulosus	pyruvate kinase	0.0033	0.0173	0.0726
Loa Loa (eye worm)	jmjC domain-containing protein	0.0041	0.0265	0.025
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0451	0.0436
Echinococcus granulosus	peregrin	0.0034	0.0187	0.0784
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0016	0.045
Plasmodium vivax	sphingomyelin synthase 1, putative	0.0049	0.0349	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0098	0.282
Trypanosoma brucei	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0049	0.0349	1
Entamoeba histolytica	hypothetical protein	0.0049	0.0349	1
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 3	0.0049	0.0349	0.0349
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0132	0.0554
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0173	0.0748
Brugia malayi	Sphingomyelin synthase-related 1	0.0049	0.0349	0.0349
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0235	0.2386	0.2386
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0173	0.0726
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0049	0.0349	0.1506
Brugia malayi	Pre-SET motif family protein	0.0201	0.2013	0.2013
Schistosoma mansoni	pyruvate kinase	0.0033	0.0173	0.0726
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0173	0.0158
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0101	0.092	0.092
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0173	0.0748
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.2013	0.2
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0173	0.0158
Echinococcus multilocularis	lysine specific demethylase 5A	0.0041	0.0265	0.111
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.011	0.102	0.8837
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0187	0.0172
Schistosoma mansoni	ap endonuclease	0.0018	0.0016	0.0066
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.011	0.102	0.8632
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0049	0.0349	0.1462
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.00000032356	0.0000092777
Schistosoma mansoni	hypothetical protein	0.0218	0.22	0.9218
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0049	0.0349	0.0349
Echinococcus granulosus	GA binding protein alpha chain	0.0077	0.0663	0.2779
Plasmodium falciparum	glutathione reductase	0.0048	0.0345	0.9878
Echinococcus granulosus	lysine specific demethylase 5A	0.0041	0.0265	0.111
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0049	0.0349	0.1506
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.0049	0.0349	0.0349
Schistosoma mansoni	hypothetical protein	0.0177	0.1753	0.7345
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0235	0.2386	1
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0173	0.0158
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0098	0.282
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0235	0.2386	1
Onchocerca volvulus	Alhambra homolog	0.0034	0.0187	0.0251
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0173	0.0188
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0173	0.4967
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0187	0.0172
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0034	0.0187	0.0784
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0101	0.092	0.3855
Entamoeba histolytica	hypothetical membrane-spanning protein	0.0049	0.0349	1
Leishmania major	trypanothione reductase	0.0048	0.0345	0.9878
Plasmodium falciparum	pyruvate kinase	0.0033	0.0173	0.4967
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0173	0.1501
Brugia malayi	Fli-1 protein	0.0235	0.2385	0.2385
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.011	0.102	0.8837
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0049	0.0349	0.1506
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0173	0.0173
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0173	0.4967
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0173	0.4967
Giardia lamblia	PHD finger protein 15	0.0034	0.0187	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0016	0.0066
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0235	0.2386	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0132	0.0554
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0121	0.0505
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.00000032356	0.0000092777
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0173	0.4967
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0098	0.282
Trichomonas vaginalis	sphingomyelin synthetase, putative	0.0049	0.0349	0.1506
Brugia malayi	glutathione reductase	0.0048	0.0345	0.0345
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0319	0.3302	0.3302
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0016	0.045
Schistosoma mansoni	hypothetical protein	0.0101	0.092	0.3855
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0345	0.9878
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0132	0.3791
Entamoeba histolytica	hypothetical protein	0.0049	0.0349	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0016	1
Plasmodium falciparum	sphingomyelin synthase 1, putative	0.0049	0.0349	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0173	0.0188
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0016	0.0068
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.011	0.102	0.8837
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0235	0.2386	1
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0345	0.9878
Brugia malayi	hypothetical protein	0.0154	0.1502	0.1502
Toxoplasma gondii	hypothetical protein	0.0049	0.0349	1
Leishmania major	hypothetical protein, conserved	0.0026	0.0098	0.282
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0187	0.5363
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0132	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0132	0.0117
Entamoeba histolytica	hypothetical protein	0.0049	0.0349	1
Schistosoma mansoni	gabp alpha	0.0077	0.0663	0.2779
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0098	0.282
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0049	0.0349	0.1462
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0173	0.0173
Trypanosoma brucei	ceramide phosphorylethanolamine synthase	0.0049	0.0349	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0098	0.282
Onchocerca volvulus		0.0229	0.2316	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0349	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0218	0.22	0.2187
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0132	0.0554
Plasmodium falciparum	thioredoxin reductase	0.0017	0.00000032356	0.0000092777
Echinococcus granulosus	pyruvate kinase	0.0033	0.0173	0.0726
Echinococcus multilocularis	peregrin	0.0034	0.0187	0.0784
Echinococcus granulosus	PHD finger protein rhinoceros	0.0034	0.0187	0.0784
Entamoeba histolytica	hypothetical protein	0.0049	0.0349	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0173	0.0158
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0345	0.2985
Plasmodium falciparum	phd finger protein, putative	0.0034	0.0187	0.5363
Plasmodium vivax	SET domain protein, putative	0.0029	0.0132	0.3791
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0111	0.1028	0.4309
Leishmania major	pyruvate kinase	0.0033	0.0173	0.4967
Echinococcus multilocularis	GA binding protein alpha chain	0.0077	0.0663	0.2779
Schistosoma mansoni	spingomyelin synthetase-related	0.0049	0.0349	0.1462
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.00000032356	0.0000092777
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0016	0.0136
Trichomonas vaginalis	hypothetical protein	0.0049	0.0349	0.1506
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0173	0.0726
Brugia malayi	jmjC domain containing protein	0.0111	0.1028	0.1028
Mycobacterium tuberculosis	Probable dehydrogenase	0.011	0.102	0.8837
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.1154	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0349	0.0334
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.00000032356	0.0000092777
Toxoplasma gondii	exonuclease III APE	0.0018	0.0016	0.045
Schistosoma mansoni	hypothetical protein	0.0177	0.1753	0.7345
Loa Loa (eye worm)	fli-1 protein	0.0235	0.2385	0.2373
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.00000032356	0.000001356
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0016	0.0839
Plasmodium falciparum	sphingomyelin synthase 2, putative	0.0049	0.0349	1
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0173	0.4967
Mycobacterium tuberculosis	Probable reductase	0.011	0.102	0.8837
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0016	0.045
Loa Loa (eye worm)	hypothetical protein	0.0319	0.3302	0.3292
Plasmodium falciparum	sphingomyelin synthase 1, putative	0.0049	0.0349	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0016	0.045
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0349	0.1506
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0132	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0349	0.0334
Brugia malayi	latrophilin 2 splice variant baaae	0.0218	0.22	0.22
Brugia malayi	hypothetical protein	0.0026	0.0098	0.0098
Brugia malayi	jmjC domain containing protein	0.0041	0.0265	0.0265
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0187	0.5363
Brugia malayi	Bromodomain containing protein	0.0034	0.0187	0.0187
Echinococcus multilocularis	jumonji domain containing protein	0.0047	0.0332	0.1391
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0345	0.9878
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0345	0.1444
Loa Loa (eye worm)	hypothetical protein	0.0933	1	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0034	0.0187	0.0784
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0173	0.4967
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0066	0.005
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.2316	1
Entamoeba histolytica	hypothetical protein	0.0049	0.0349	1
Trypanosoma brucei	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0049	0.0349	1
Trypanosoma cruzi	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0049	0.0349	1
Trypanosoma brucei	trypanothione reductase	0.0048	0.0345	0.9878
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0049	0.0349	0.0349
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0066	0.1497
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0098	0.282
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0345	0.9878
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.1154	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0173	0.0188
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0345	0.0329
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0098	0.282
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1502	0.1489
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0016	0.045
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0345	0.1444
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0098	0.0412
Brugia malayi	Ets-domain containing protein	0.0077	0.0663	0.0663
Echinococcus granulosus	jumonji domain containing protein	0.0047	0.0332	0.1391
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0132	0.0554
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0101	0.092	0.0906
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0345	0.9878
Echinococcus multilocularis	geminin	0.0177	0.1753	0.7345
Plasmodium vivax	sphingomyelin synthase 2, putative	0.0049	0.0349	1
Brugia malayi	Latrophilin receptor protein 2	0.0101	0.092	0.092
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0016	1
Leishmania major	pyruvate kinase	0.0033	0.0173	0.4967
Schistosoma mansoni	hypothetical protein	0.0034	0.0187	0.0784
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.00000032356	0.0000092777
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0235	0.2386	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0319	0.3302	0.3302
Trypanosoma cruzi	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0049	0.0349	1
Schistosoma mansoni	hypothetical protein	0.0101	0.092	0.3855
Loa Loa (eye worm)	jmjC domain-containing protein	0.007	0.0581	0.0566
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0101	0.092	0.3855
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.00000032356	0.000001356
Schistosoma mansoni	hypothetical protein	0.0101	0.092	0.3855
Loa Loa (eye worm)	hypothetical protein	0.0101	0.092	0.0906
Plasmodium falciparum	glutathione reductase	0.0017	0.00000032356	0.0000092777
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.00000032356	0.000001356
Brugia malayi	Pre-SET motif family protein	0.0029	0.0132	0.0132
Schistosoma mansoni	ets-related	0.0235	0.2385	0.9995
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0349	0.0334
Schistosoma mansoni	jumonji domain containing protein	0.0088	0.0779	0.3266
Echinococcus multilocularis	GPCR, family 2	0.0101	0.092	0.3855
Chlamydia trachomatis	pyruvate kinase	0.0033	0.0173	1
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0016	0.0068
Schistosoma mansoni	ap endonuclease	0.0018	0.0016	0.0066
Echinococcus granulosus	geminin	0.0177	0.1753	0.7345
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.00000032356	0.0000092777
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0349	0.0334
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0111	0.1028	0.4309
Schistosoma mansoni	pyruvate kinase	0.0033	0.0173	0.0726
Giardia lamblia	Pyruvate kinase	0.0033	0.0173	0.9262
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.011	0.102	0.8837
Mycobacterium ulcerans	pyruvate kinase	0.0033	0.0173	1
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0077	0.0663	0.0648
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0235	0.2386	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0235	0.2386	0.2374
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.0265	0.111
Brugia malayi	Thioredoxin reductase	0.0048	0.0345	0.0345
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0235	0.2386	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0319	0.3302	0.3292
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0066	0.005
Brugia malayi	Ets-domain containing protein	0.0077	0.0663	0.0663

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 755359