Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | 0.0027 | 0.0518 | 0.0518 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.2508 | 0.2099 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0027 | 0.0518 | 0.0518 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2058 | 0.2058 |
Brugia malayi | bZIP transcription factor family protein | 0.0092 | 0.3304 | 0.3304 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3195 | 0.3195 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0564 | 0.0048 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2058 | 0.2382 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.1522 | 0.1552 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0027 | 0.0518 | 0.0518 |
Schistosoma mansoni | lamin | 0.0028 | 0.0564 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0518 | 0.0518 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0564 | 0.0071 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0135 | 0.516 | 0.7182 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0247 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.0518 | 0.0518 |
Schistosoma mansoni | lamin | 0.0028 | 0.0564 | 0.0071 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0092 | 0.3304 | 0.2937 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2084 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.2084 | 0.1651 |
Schistosoma mansoni | jun-related protein | 0.0074 | 0.2563 | 0.3163 |
Echinococcus granulosus | geminin | 0.0177 | 0.6981 | 0.6816 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.2084 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0027 | 0.0518 | 0.0518 |
Brugia malayi | steroid hormone receptor | 0.0027 | 0.0518 | 0.0518 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.2508 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.2508 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0564 | 0.0564 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.2084 | 0.2423 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0518 | 0.0518 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0564 | 0.0048 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2058 | 0.2058 |
Brugia malayi | hypothetical protein | 0.0072 | 0.2454 | 0.2454 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0027 | 0.0518 | 0.0518 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2058 | 0.2058 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0027 | 0.0518 | 0.0518 |
Echinococcus multilocularis | jun protein | 0.0092 | 0.3304 | 0.2937 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.2563 | 0.3163 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0518 | 0.0518 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0027 | 0.0518 | 0.0518 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.2084 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.2508 | 0.3079 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.2508 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.1522 | 0.1552 |
Echinococcus multilocularis | geminin | 0.0177 | 0.6981 | 0.6816 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0518 | 0.0518 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.2508 | 0.2099 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0092 | 0.3304 | 0.2937 |
Onchocerca volvulus | 0.0072 | 0.2454 | 1 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 1 | 1 |
Echinococcus granulosus | jun protein | 0.0092 | 0.3304 | 0.2937 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.6981 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.2084 | 0.2423 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0027 | 0.0518 | 0.0518 |
Brugia malayi | nuclear receptor NHR-88 | 0.0027 | 0.0518 | 0.0518 |
Echinococcus granulosus | lamin | 0.0028 | 0.0564 | 0.0048 |
Onchocerca volvulus | 0.005 | 0.1522 | 0.5183 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.2084 | 0.1651 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2058 | 0.2058 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0518 | 0.0518 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2058 | 0.1624 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0518 | 0.0518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2058 | 0.2382 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0247 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0027 | 0.0518 | 0.0518 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.0518 | 0.0518 |
Brugia malayi | hypothetical protein | 0.0073 | 0.2508 | 0.2508 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.1522 | 0.1522 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2058 | 0.2058 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0564 | 0.0564 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.0518 | 0.0518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2058 | 0.2382 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0027 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2058 | 0.2058 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0027 | 0.0518 | 0.0518 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.2508 | 0.3079 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0027 | 0.0518 | 0.0518 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0564 | 0.0048 |
Brugia malayi | nuclear hormone receptor | 0.0027 | 0.0518 | 0.0518 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0135 | 0.516 | 0.4896 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0027 | 0.0518 | 0.0518 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.2084 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2058 | 0.2382 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0542 | 0.0542 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0564 | 0.0048 |
Onchocerca volvulus | 0.0028 | 0.0564 | 0.0236 | |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0027 | 0.0518 | 0.0518 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0027 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0027 | 0.0518 | 0.0518 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0027 | 0.0518 | 0.0518 |
Onchocerca volvulus | 0.0028 | 0.0564 | 0.0236 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0564 | 0.0564 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2084 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0027 | 0.0518 | 0.0518 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0564 | 0.0048 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.2508 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2084 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.6981 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2058 | 0.2382 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.012 | 0.4543 | 0.4244 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0027 | 0.0518 | 0.0518 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2058 | 0.1624 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.