Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0056 | 0.1709 | 0.196 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.1643 | 0.2121 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.077 | 0.0862 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1027 | 0.1178 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0174 | 0.0003 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0124 | 0.4465 | 0.8837 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.077 | 0.0862 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.077 | 0.4065 |
Echinococcus granulosus | geminin | 0.019 | 0.7105 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0056 | 0.1709 | 0.1798 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0172 | 0.000000065234 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.1762 | 0.2021 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.1643 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0174 | 0.0003 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0721 | 0.0792 |
Brugia malayi | Animal haem peroxidase family protein | 0.0056 | 0.1709 | 0.196 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0056 | 0.1709 | 0.1798 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Brugia malayi | Blistered cuticle protein 3 | 0.0056 | 0.1709 | 0.196 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0019 | 0.0203 | 0.0232 |
Schistosoma mansoni | peroxidasin | 0.0056 | 0.1709 | 0.2216 |
Mycobacterium tuberculosis | Probable reductase | 0.0124 | 0.4465 | 0.8837 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0174 | 0.0003 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0203 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.008 | 0.2686 | 0.3626 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.1643 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0056 | 0.1709 | 0.1798 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0018 | 0.0172 | 0.000000080418 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Onchocerca volvulus | Peroxidase homolog | 0.0056 | 0.1709 | 0.1563 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.077 | 0.0862 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0019 | 0.0203 | 0.5 |
Brugia malayi | Cadherin domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0174 | 0.02 |
Brugia malayi | Animal haem peroxidase family protein | 0.0056 | 0.1709 | 0.196 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2686 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0019 | 0.0203 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.077 | 0.0699 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0138 | 0.5026 | 1 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2686 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.077 | 0.0862 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0174 | 0.0003 |
Brugia malayi | glutathione reductase | 0.0055 | 0.1643 | 0.1884 |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.1643 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0138 | 0.5026 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1027 | 0.1 |
Onchocerca volvulus | 0.0056 | 0.1709 | 0.1563 | |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0203 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.1643 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0138 | 0.5026 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0174 | 0.02 |
Onchocerca volvulus | 0.0033 | 0.077 | 0.0608 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0056 | 0.1709 | 0.1798 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0019 | 0.0203 | 0.0044 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0138 | 0.5026 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0018 | 0.0172 | 0.000000080418 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.077 | 0.0862 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0019 | 0.0203 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0174 | 0.0003 |
Brugia malayi | Delta serrate ligand family protein | 0.0018 | 0.0172 | 0.0198 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0174 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0019 | 0.0203 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.1643 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0056 | 0.1709 | 0.1798 |
Loa Loa (eye worm) | glutathione reductase | 0.0055 | 0.1643 | 0.172 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.2686 | 0.3626 |
Brugia malayi | notch-like transmembrane receptor | 0.0018 | 0.0172 | 0.0198 |
Brugia malayi | EGF-like domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.1643 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0124 | 0.4465 | 0.8837 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.1643 | 0.2121 |
Schistosoma mansoni | peroxidasin | 0.0056 | 0.1709 | 0.2216 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0174 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0174 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.7105 | 1 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2686 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0124 | 0.4465 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.008 | 0.2686 | 0.3626 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1027 | 0.1233 |
Treponema pallidum | NADH oxidase | 0.0019 | 0.0203 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0174 | 0.0003 |
Echinococcus multilocularis | geminin | 0.019 | 0.7105 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.023 | 0.8718 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0056 | 0.1709 | 0.1563 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.7852 | 0.8986 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0019 | 0.0203 | 0.0044 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0018 | 0.0172 | 0.0198 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0019 | 0.0203 | 0.0206 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0018 | 0.0172 | 0.000000056724 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.7105 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.077 | 0.0862 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0124 | 0.4465 | 0.8837 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.1762 | 0.186 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0208 | 0.7852 | 0.7814 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.1643 | 0.1884 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.077 | 0.0862 |
Onchocerca volvulus | 0.0056 | 0.1709 | 0.1563 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0056 | 0.1709 | 0.1563 |
Brugia malayi | hypothetical protein | 0.008 | 0.2686 | 0.3081 |
Leishmania major | trypanothione reductase | 0.0055 | 0.1643 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.023 | 0.8718 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1762 | 0.186 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0055 | 0.1643 | 0.2985 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.008 | 0.2686 | 0.3626 |
Echinococcus granulosus | peroxidasin | 0.0056 | 0.1709 | 0.2216 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0019 | 0.0203 | 0.5 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0019 | 0.0203 | 0.0044 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2686 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.1643 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.077 | 0.0883 |
Echinococcus multilocularis | peroxidasin | 0.0056 | 0.1709 | 0.2216 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0055 | 0.1643 | 0.172 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0018 | 0.0172 | 0.000000056724 |
Brugia malayi | Muscle positioning protein 4 | 0.0018 | 0.0172 | 0.0198 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.077 | 0.394 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0019 | 0.0203 | 0.0206 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.1762 | 0.2021 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0174 | 0.0003 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0018 | 0.0172 | 0.0198 |
Brugia malayi | N-terminal motif family protein | 0.0208 | 0.7852 | 0.9006 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Brugia malayi | Cadherin domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Brugia malayi | Animal haem peroxidase family protein | 0.0056 | 0.1709 | 0.196 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0056 | 0.1709 | 0.1563 |
Onchocerca volvulus | 0.0056 | 0.1709 | 0.1563 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0056 | 0.1709 | 0.1563 |
Brugia malayi | Animal haem peroxidase family protein | 0.0056 | 0.1709 | 0.196 |
Onchocerca volvulus | Peroxidasin homolog | 0.0056 | 0.1709 | 0.1563 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.432 | 0.4853 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0124 | 0.4465 | 0.8837 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0174 | 0.0003 |
Brugia malayi | hypothetical protein | 0.0056 | 0.1709 | 0.196 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0174 | 0.0002 |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Brugia malayi | Peroxidasin | 0.0056 | 0.1709 | 0.196 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1709 | 0.1798 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.432 | 0.4853 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0018 | 0.0172 | 0.0198 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.432 | 0.4955 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.