Detailed information for compound 762128

Basic information

Technical information
  • TDR Targets ID: 762128
  • Name: 1-[(5-bromo-2-methoxyphenyl)methyl]-4-[(2-met hoxyphenyl)methyl]piperazine
  • MW: 405.329 | Formula: C20H25BrN2O2
  • H donors: 0 H acceptors: 0 LogP: 3.7 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CN1CCN(CC1)Cc1cc(Br)ccc1OC
  • InChi: 1S/C20H25BrN2O2/c1-24-19-6-4-3-5-16(19)14-22-9-11-23(12-10-22)15-17-13-18(21)7-8-20(17)25-2/h3-8,13H,9-12,14-15H2,1-2H3
  • InChiKey: FIXSENWVSWXVNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(5-bromo-2-methoxy-phenyl)methyl]-4-[(2-methoxyphenyl)methyl]piperazine
  • 1-(5-bromo-2-methoxy-benzyl)-4-(2-methoxybenzyl)piperazine
  • Oprea1_376553
  • STK137956

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-NAC-like protein 0.0035 0.0471 0.0524
Treponema pallidum NADH oxidase 0.003 0.037 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0355 0.0355
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.2769 0.2769
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0192 0.0068
Brugia malayi follicle stimulating hormone receptor 0.0456 0.8932 1
Loa Loa (eye worm) glutathione reductase 0.0085 0.1489 0.1664
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0684 0.0684
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.037 0.0248
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0619 0.0462
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.037 0.0898
Loa Loa (eye worm) hypothetical protein 0.0099 0.1755 0.1963
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0192 0.0212
Schistosoma mansoni cpg binding protein 0.0034 0.0453 0.0332
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0194 0.3682 0.887
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0906 0.0791
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.1499 0.1499
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0355 0.0234
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0192 0.0068
Entamoeba histolytica hypothetical protein 0.0143 0.2656 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0192 0.0068
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.037 0.2461
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0192 0.0192
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0657 0.3309
Loa Loa (eye worm) hypothetical protein 0.0031 0.0403 0.0448
Schistosoma mansoni transcription factor btf3 0.0035 0.0471 0.035
Mycobacterium tuberculosis Probable reductase 0.0194 0.3682 0.887
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.577 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.2613 0.4154
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0192 0.0212
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.037 0.2461
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.577 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0657 0.0657
Schistosoma mansoni hypothetical protein 0.0509 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0194 0.3682 0.887
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.037 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0192 0.0212
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0657 0.3232
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0192 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0192 0.0212
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0161 0.0178
Brugia malayi Inositol-1 0.0073 0.1237 0.1382
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0684 0.0684
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0906 0.2418
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.1237 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.2933 0.6931
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1237 0.1773
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.037 0.113
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0471 0.3139
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0085 0.1489 0.3186
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0355 0.0779
Schistosoma mansoni cpg binding protein 0.0034 0.0453 0.0332
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.037 0.037
Echinococcus multilocularis cpg binding protein 0.0034 0.0453 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0192 0.0212
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.037 0.02
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.1499 0.1499
Schistosoma mansoni hypothetical protein 0.0453 0.8881 0.8867
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0971 0.1085
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.037 0.0898
Echinococcus granulosus transcription factor btf3 0.0035 0.0471 0.0471
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0684 0.0764
Echinococcus multilocularis geminin 0.0509 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0194 0.3682 0.887
Entamoeba histolytica hypothetical protein 0.0143 0.2656 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0471 0.116
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1671 0.1671
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0582 0.0582
Schistosoma mansoni cpg binding protein 0.0032 0.0416 0.0295
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1237 0.1605
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0192 0.0192
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0192 0.0212
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0192 0.0192
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0192 0.0192
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0584 0.39
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0212
Schistosoma mansoni transcription factor LCR-F1 0.0143 0.2656 0.2563
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.577 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.2897 0.3241
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0192 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0355 0.0395
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.1237 0.3655
Brugia malayi ecdysteroid receptor 0.0021 0.0192 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0192 0.0212
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1129 0.1262
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0684 0.0764
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.1237 0.1237
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0804 0.0803
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.037 0.02
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0213 0.0235
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1755 0.1963
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0031 0.0403 0.0282
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.026 0.1717
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0906 0.0906
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0192 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0192 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0192 0.0212
Plasmodium falciparum thioredoxin reductase 0.003 0.037 0.2461
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0471 0.0383
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0513 0.0513
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.1237 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0471 0.116
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0657 0.3232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0192 0.0212
Schistosoma mansoni inositol monophosphatase 0.0073 0.1237 0.1126
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.037 0.0286
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0192 0.0192
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0403 0.0403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0192 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0192 0.0212
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0213 0.0235
Leishmania major basic transcription factor 3a, putative 0.0035 0.0471 0.0383
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0192 0.0212
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.577 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0192 0.0192
Entamoeba histolytica hypothetical protein 0.0035 0.0471 0.088
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0619 0.0462
Leishmania major trypanothione reductase 0.0085 0.1489 0.2231
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0403 0.0448
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0471 0.0524
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0906 0.1173
Brugia malayi hypothetical protein 0.0143 0.2656 0.2971
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0657 0.3309
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0355 0.0395
Brugia malayi glutathione reductase 0.0085 0.1489 0.1664
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0355 0.0355
Brugia malayi Thioredoxin reductase 0.0085 0.1489 0.1664
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.1084 0.2136
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.1493 0.1493
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.1237 0.1237
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.037 0.02
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0906 0.0906
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0684 0.0567
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0192 0.0192
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.2769 0.3099
Brugia malayi Bromodomain containing protein 0.0032 0.0429 0.0477
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0143 0.2656 0.2656
Trypanosoma cruzi trypanothione reductase, putative 0.0085 0.1489 0.2072
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0471 0.1716
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0619 0.0653
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0192 0.0068
Schistosoma mansoni hypothetical protein 0.0143 0.2656 0.2563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0684 0.0567
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.037 0.037
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0477 0.0477
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0192 0.0212
Schistosoma mansoni inositol monophosphatase 0.0073 0.1237 0.1126
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.2613 0.4271
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0403 0.0403
Echinococcus multilocularis peregrin 0.0032 0.0429 0.0429
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0403 0.0403
Trypanosoma brucei trypanothione reductase 0.0085 0.1489 0.2231
Onchocerca volvulus 0.0155 0.2897 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0456 0.8932 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0192 0.0068
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0906 0.1012
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1237 0.1773
Loa Loa (eye worm) acetyltransferase 0.0149 0.2769 0.3099
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.037 0.0412
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0403 0.0403
Echinococcus multilocularis GPCR, family 2 0.0031 0.0403 0.0403
Echinococcus granulosus peregrin 0.0032 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0212
Plasmodium vivax thioredoxin reductase, putative 0.0085 0.1489 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0906 0.1676
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0192 0.0192
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.1493 0.1493
Plasmodium falciparum glutathione reductase 0.003 0.037 0.2461
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0192 0.0068
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0192 0.0212
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0192 0.0192
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0192 0.0212
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0513 0.0572
Echinococcus granulosus cpg binding protein 0.0034 0.0453 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0192 0.0212
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.037 0.2461
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.037 0.02
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.037 0.02
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.1493 0.167
Onchocerca volvulus 0.0085 0.1493 0.4812
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.1084 0.2136
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0194 0.3682 0.887
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0192 0.0212
Onchocerca volvulus 0.0032 0.0416 0.0829
Mycobacterium ulcerans hypothetical protein 0.0157 0.2933 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1755 0.1963
Toxoplasma gondii thioredoxin reductase 0.0085 0.1489 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0619 0.0462
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1671 0.1671
Entamoeba histolytica hypothetical protein 0.0143 0.2656 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1755 0.1963
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0216 0.4117 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0684 0.0684
Brugia malayi CXXC zinc finger family protein 0.0032 0.0416 0.0463
Schistosoma mansoni coup transcription factor 0.0021 0.0192 0.0068
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0584 0.1352
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0194 0.3682 0.887
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0212
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0513 0.0394
Loa Loa (eye worm) hypothetical protein 0.0067 0.1129 0.1262
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.083 0.0927
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1282 0.1172
Plasmodium falciparum thioredoxin reductase 0.0085 0.1489 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0192 0.0212
Echinococcus granulosus dnaJ subfamily B 0.0453 0.8881 0.8881
Mycobacterium tuberculosis Probable oxidoreductase 0.0216 0.4117 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0355 0.2362
Schistosoma mansoni hypothetical protein 0.0031 0.0403 0.0282
Echinococcus multilocularis transcription factor btf3 0.0035 0.0471 0.0471
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0471 0.0186
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0192 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0192 0.0212
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0403 0.0448
Plasmodium falciparum glutathione reductase 0.0085 0.1489 1
Toxoplasma gondii hypothetical protein 0.0048 0.0743 0.3936
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.037 0.0413
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0216 0.4117 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0403 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0192 0.0212
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.037 0.0413
Brugia malayi jmjC domain containing protein 0.0094 0.1671 0.1869
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0212
Loa Loa (eye worm) hypothetical protein 0.0085 0.1493 0.167
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.1061 0.6522
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0029 0.0355 0.0234
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0416 0.0463
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0509 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.1237 0.7951
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0143 0.2656 0.2656
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0513 0.0394
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0355 0.2362
Entamoeba histolytica hypothetical protein 0.0143 0.2656 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0769 0.0858
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0471 0.3139
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0657 0.4394
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0192 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0212
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0471 0.0186
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0684 0.0684
Schistosoma mansoni hypothetical protein 0.0031 0.0403 0.0282
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.026 0.1717
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0192 0.0068
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.037 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0355 0.0779
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0212
Echinococcus granulosus GPCR family 2 0.0031 0.0403 0.0403
Loa Loa (eye worm) inositol-1 0.0073 0.1237 0.1382
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.2769 0.2678
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.037 0.113
Echinococcus multilocularis dnaJ subfamily B 0.0453 0.8881 0.8881
Brugia malayi hypothetical protein 0.0155 0.2897 0.3241
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1237 0.1605
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0192 0.0192
Brugia malayi PHD-finger family protein 0.0029 0.0355 0.0395
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0192 0.0192
Brugia malayi nuclear hormone receptor 0.0021 0.0192 0.0212
Brugia malayi nuclear receptor NHR-88 0.0021 0.0192 0.0212
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0192 0.0192
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0192 0.0212
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.037 0.02
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0471 0.088
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.2613 0.4271
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.037 0.0645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0192 0.0212
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.037 0.2461
Loa Loa (eye worm) thioredoxin reductase 0.0085 0.1489 0.1664
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0471 0.116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0212
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.2685 0.2685
Brugia malayi jmjC domain containing protein 0.0037 0.0513 0.0572
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0906 0.2418
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0194 0.3682 0.887
Onchocerca volvulus Alhambra homolog 0.0029 0.0355 0.0604
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1133 0.1021
Plasmodium vivax glutathione reductase, putative 0.0085 0.1489 1
Schistosoma mansoni hypothetical protein 0.0067 0.1129 0.1017
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0584 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0684 0.0567
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.1237 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.1237 0.4078
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0216 0.4117 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.037 0.02
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.1493 0.1386
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.1237 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0192 0.0068
Schistosoma mansoni hypothetical protein 0.0031 0.0403 0.0282
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.037 0.02
Echinococcus granulosus jumonji domain containing protein 0.004 0.0582 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0192 0.0212
Brugia malayi steroid hormone receptor 0.0021 0.0192 0.0212

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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