Detailed information for compound 763583

Basic information

Technical information
  • TDR Targets ID: 763583
  • Name: 2-(4-chlorophenyl)sulfonyl-3-[2-(2-fluorophen oxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2- enenitrile
  • MW: 481.883 | Formula: C23H13ClFN3O4S
  • H donors: 0 H acceptors: 4 LogP: 3.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1c(Oc2ccccc2F)nc2n(c1=O)cccc2)S(=O)(=O)c1ccc(cc1)Cl
  • InChi: 1S/C23H13ClFN3O4S/c24-15-8-10-16(11-9-15)33(30,31)17(14-26)13-18-22(32-20-6-2-1-5-19(20)25)27-21-7-3-4-12-28(21)23(18)29/h1-13H/b17-13+
  • InChiKey: WCCFSIRPISUOKB-GHRIWEEISA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-2-(4-chlorophenyl)sulfonyl-3-[2-(2-fluorophenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
  • 2-(4-chlorophenyl)sulfonyl-3-[2-(2-fluorophenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
  • (E)-2-(4-chlorophenyl)sulfonyl-3-[2-(2-fluorophenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
  • 2-(4-chlorophenyl)sulfonyl-3-[2-(2-fluorophenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]prop-2-enenitrile
  • (E)-2-(4-chlorophenyl)sulfonyl-3-[2-(2-fluorophenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]prop-2-enenitrile
  • (E)-2-(4-chlorophenyl)sulfonyl-3-[2-(2-fluorophenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile
  • 2-(4-chlorophenyl)sulfonyl-3-[2-(2-fluorophenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile
  • STOCK4S-60990

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0217 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0342 0.3734 0.5643
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0286 0.3994
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0217 0.6499
Brugia malayi Sugar transporter family protein 0.003 0.0217 0.0894
Toxoplasma gondii sugar transporter ST1 0.003 0.0217 0.0327
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) sugar transporter 0.0212 0.2266 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.2648
Trypanosoma brucei sugar transporter, putative 0.003 0.0217 0.303
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0621 0.274
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0612 0.0925
Loa Loa (eye worm) hypothetical protein 0.0065 0.0611 0.2648
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0621 0.868
Echinococcus granulosus General substrate transporter 0.0182 0.193 0.851
Brugia malayi hypothetical protein 0.003 0.0217 0.0894
Brugia malayi Sugar transporter family protein 0.0212 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0217 0.5239
Plasmodium vivax CDK-related protein kinase 6, putative 0.0899 1 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0715 1
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0217 0.303
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0414 0.5783
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0597 0.2583
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0212 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0414 0.6849
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0217 0.0894
Brugia malayi Sugar transporter family protein 0.003 0.0217 0.0894
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0348 0.1536
Leishmania major glucose transporter, lmgt1 0.0066 0.0621 0.868
Onchocerca volvulus 0.003 0.0217 0.5
Trypanosoma brucei glucose transporter 1E 0.0066 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0016 0.0377
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trypanosoma cruzi hexose transporter 0.0066 0.0621 0.868
Onchocerca volvulus 0.003 0.0217 0.5
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0612 0.0597
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0414 0.5783
Trypanosoma cruzi glucose transporter, putative 0.003 0.0217 0.303
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Onchocerca volvulus 0.003 0.0217 0.5
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0611 0.855
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0414 1
Entamoeba histolytica protein kinase, putative 0.0065 0.0611 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0612 0.0925
Loa Loa (eye worm) hypothetical protein 0.0052 0.0463 0.1987
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0217 0.5239
Trypanosoma cruzi hexose transporter, putative 0.003 0.0217 0.303
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.2648
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0394 0.1681
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0715 0.1081
Trichomonas vaginalis glucose transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0175 0.0709
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0217 0.0894
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0612 0.0597
Onchocerca volvulus Putative transporter 0.003 0.0217 0.5
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0715 1
Toxoplasma gondii sugar transporter ST3 0.003 0.0217 0.0327
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0016 0.0024
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0611 0.2648
Toxoplasma gondii protein kinase, putative 0.0599 0.6617 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0621 0.868
Schistosoma mansoni protein kinase 0.0065 0.0611 0.2648
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0894
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0217 0.303
Schistosoma mansoni glucose transport protein 0.0212 0.2266 1
Schistosoma mansoni glucose transporter 0.003 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0414 0.0625
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0414 0.1769
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2266 1
Onchocerca volvulus 0.003 0.0217 0.5
Echinococcus multilocularis General substrate transporter 0.0182 0.193 0.851
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Onchocerca volvulus 0.003 0.0217 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.2648
Plasmodium falciparum mitogen-activated protein kinase 2 0.0342 0.3734 0.3724
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0611 0.2648
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0715 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0394 0.1681
Trypanosoma brucei glucose transporter 2A 0.0066 0.0621 0.868
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0621 0.868
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0414 0.5783
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0414 0.6932
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0715 1
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0069
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0611 0.2699
Onchocerca volvulus 0.003 0.0217 0.5
Onchocerca volvulus 0.003 0.0217 0.5
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0894
Leishmania major glucose transporter, lmgt3 0.0066 0.0621 0.868
Brugia malayi Cam kinase protein 1 0.0065 0.0611 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0621 0.274
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0217 0.0894
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0342 0.3734 0.3724
Onchocerca volvulus 0.003 0.0217 0.5
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0612 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0394 0.1681
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0612 0.0597
Leishmania major hypothetical protein, conserved 0.003 0.0217 0.303
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0134 0.2978
Onchocerca volvulus 0.003 0.0217 0.5
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0016 0.0468
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2266 1
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0894
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0016 0.0377
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0134 1
Giardia lamblia Hexose transporter 0.003 0.0217 0.346
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0217 0.5239
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0621 0.274
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0621 0.868
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium ulcerans sugar transporter 0.003 0.0217 0.5239
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0134 0.3243
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0394 0.1681
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0394 0.1681
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.2648
Brugia malayi major facilitator superfamily protein 0.003 0.0217 0.0894
Onchocerca volvulus 0.003 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0047 0.0414 0.1769
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0621 0.868
Schistosoma mansoni glucose transport protein 0.0212 0.2266 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0621 0.868
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Entamoeba histolytica hypothetical protein 0.0047 0.0414 0.6679
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0621 0.274
Onchocerca volvulus 0.003 0.0217 0.5
Toxoplasma gondii sugar transporter ST2 0.003 0.0217 0.0327
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0217 0.0956
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0217 0.6499
Schistosoma mansoni protein kinase 0.0065 0.0611 0.2648
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0414 0.1769
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0414 0.0399
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0414 0.1769
Trypanosoma cruzi sugar transporter, putative 0.003 0.0217 0.303
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0621 0.274
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Onchocerca volvulus 0.003 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0612 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0597 0.9752
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0217 0.0894
Brugia malayi major facilitator superfamily protein 0.003 0.0217 0.0894
Onchocerca volvulus 0.003 0.0217 0.5
Onchocerca volvulus 0.003 0.0217 0.5
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0217 0.0327
Onchocerca volvulus 0.003 0.0217 0.5
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0597 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0611 0.2648
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.2648
Schistosoma mansoni hypothetical protein 0.0212 0.2266 1
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0333 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0414 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0597 0.2583
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0217 0.0894
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0597 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0394 0.1681
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0414 0.0399
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0597 0.2583
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0217 0.0201
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0394 0.1681
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0612 0.0597
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2266 1
Schistosoma mansoni protein kinase 0.0065 0.0611 0.2648
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0414 0.1769
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0217 0.0894
Brugia malayi hypothetical protein 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.2648
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0394 0.1681
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0217 0.0894
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0612 0.0597
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0333 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0597 0.2583
Leishmania major glucose transporter, lmgt2 0.0066 0.0621 0.868
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2266 1
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0566 0.2448
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Brugia malayi hypothetical protein 0.003 0.0217 0.0894
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0394 0.1681
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0715 0.0701
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) sugar transporter 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0612 0.0925
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Schistosoma mansoni glucose transport protein 0.0212 0.2266 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0212 0.2266 0.3424
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0621 0.274
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2266 1
Plasmodium falciparum protein kinase 7 0.0599 0.6617 0.6612
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0621 0.274
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0217 0.0894
Plasmodium vivax sugar transporter, putative 0.003 0.0217 0.0201
Loa Loa (eye worm) hypothetical protein 0.0064 0.0597 0.2583
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0597 0.2583
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0597 0.2583
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0612 0.0597
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0715 0.0701
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0414 1
Leishmania major protein kinase, putative 0.0065 0.0611 0.855
Loa Loa (eye worm) hypothetical protein 0.0064 0.0597 0.2583
Giardia lamblia Sugar-proton symporter 0.003 0.0217 0.346
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0333 0.5587
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0016 0.0024
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0715 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.2648
Entamoeba histolytica protein kinase, putative 0.0065 0.0611 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0611 0.2648
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.2266 1
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Onchocerca volvulus 0.003 0.0217 0.5
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0414 0.1826
Plasmodium vivax hexose transporter 0.0212 0.2266 0.2253
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0016 0.0262
Plasmodium falciparum hexose transporter 0.0212 0.2266 0.2253
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0894
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0414 0.1769
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0566 0.2448
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0597 0.2634
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2266 1
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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