TDR Targets

Basic information

Technical information

TDR Targets ID: 763598
Name: 2-ethoxy-N-(2-oxothiolan-3-yl)acetamide
MW: 203.259 | Formula: C8H13NO3S
H donors: 1 H acceptors: 2 LogP: 0.42 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOCC(=O)NC1CCSC1=O
InChi: 1S/C8H13NO3S/c1-2-12-5-7(10)9-6-3-4-13-8(6)11/h6H,2-5H2,1H3,(H,9,10)
InChiKey: BIBPJQAFGORFNT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-ethoxy-N-(2-oxotetrahydrothiophen-3-yl)acetamide
2-ethoxy-N-(2-oxo-3-tetrahydrothiophenyl)acetamide
2-ethoxy-N-(2-ketotetrahydrothiophen-3-yl)acetamide
2-ethoxy-N-(2-oxothiolan-3-yl)ethanamide
2-Ethoxy-N-(2-oxo-tetrahydro-thiophen-3-yl)-acetamide
MLS000033665
SMR000014083
ChemDiv3_006289
BAS 06979712
STK128656
IDI1_024199

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0371	0.1637
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Brugia malayi	Sugar transporter family protein	0.0031	0.0217	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0067	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0012	0.0016	0.0377
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0031	0.0217	0.6499
Trichomonas vaginalis	glucose transporter, putative	0.0067	0.0621	0.274
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0621	0.868
Onchocerca volvulus		0.0031	0.0217	0.5
Trypanosoma brucei	glucose transporter 2A	0.0067	0.0621	0.868
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.5783
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0031	0.0217	0.6499
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma brucei	sugar transporter, putative	0.0031	0.0217	0.303
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0217	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0067	0.0612	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0333	0.5587
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0371	0.1579
Toxoplasma gondii	lysine-tRNA ligase	0.0049	0.0414	0.0625
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0621	0.274
Onchocerca volvulus		0.0031	0.0217	0.5
Leishmania major	protein kinase, putative	0.0067	0.0611	0.855
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Onchocerca volvulus		0.0031	0.0217	0.5
Onchocerca volvulus		0.0031	0.0217	0.5
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0067	0.0612	0.0925
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0414	1
Echinococcus granulosus	synaptic vesicle 2 protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0067	0.0612	0.0925
Entamoeba histolytica	hypothetical protein	0.0049	0.0414	0.6679
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Toxoplasma gondii	glycyl-tRNA synthetase	0.0012	0.0016	0.0024
Giardia lamblia	Lysyl-tRNA synthetase	0.0049	0.0414	0.6849
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Onchocerca volvulus		0.0031	0.0217	0.5
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0065	0.0597	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Schistosoma mansoni	protein kinase	0.0067	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0333	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0067	0.0612	0.0597
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0031	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0621	0.868
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Trichomonas vaginalis	conserved hypothetical protein	0.0218	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0597	0.2583
Onchocerca volvulus		0.0031	0.0217	0.5
Onchocerca volvulus		0.0031	0.0217	0.5
Toxoplasma gondii	sugar transporter ST2	0.0031	0.0217	0.0327
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0371	0.5185
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0043	0.0348	0.1536
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0217	0.0894
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0065	0.0597	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0065	0.0597	0.2583
Leishmania major	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Brugia malayi	lysyl-tRNA synthetase	0.0049	0.0414	0.1769
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0371	0.1579
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.0371	0.5962
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Toxoplasma gondii	sugar transporter ST1	0.0031	0.0217	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0597	0.2583
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0371	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0414	0.1769
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0621	0.868
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0012	0.0016	0.0377
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0217	0.303
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0041	0.0333	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0031	0.0217	0.0894
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.5783
Schistosoma mansoni	protein kinase	0.0067	0.0611	0.2648
Schistosoma mansoni	glucose transport protein	0.0218	0.2266	1
Leishmania major	glucose transporter, lmgt3	0.0067	0.0621	0.868
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0067	0.0612	0.0597
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0065	0.0597	0.2634
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0371	0.1579
Onchocerca volvulus		0.0031	0.0217	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0621	0.274
Toxoplasma gondii	transporter, major facilitator family protein	0.0031	0.0217	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0371	0.1579
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0031	0.0217	0.5239
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0715	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0371	0.1637
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Plasmodium vivax	sugar transporter, putative	0.0031	0.0217	0.0201
Schistosoma mansoni	protein kinase	0.0067	0.0611	0.2648
Schistosoma mansoni	glucose transport protein	0.0218	0.2266	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0062	0.0566	0.2448
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0031	0.0217	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0894
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0067	0.0612	0.0597
Plasmodium falciparum	protein kinase 7	0.0615	0.6617	0.6612
Toxoplasma gondii	facilitative glucose transporter GT1	0.0218	0.2266	0.3424
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0621	0.274
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Trichomonas vaginalis	glucose transporter, putative	0.0067	0.0621	0.274
Entamoeba histolytica	protein kinase, putative	0.0067	0.0611	1
Onchocerca volvulus		0.0031	0.0217	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0067	0.0612	0.0597
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0597	0.2583
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0621	0.868
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.1826
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0715	1
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0611	0.2648
Giardia lamblia	Prolyl-tRNA synthetase	0.0065	0.0597	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0597	0.2583
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0065	0.0597	0.2583
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0067	0.0612	0.0597
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0067	0.0621	0.274
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0715	1
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0894
Chlamydia trachomatis	proline--tRNA ligase	0.0023	0.0134	0.2978
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0371	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0894
Echinococcus granulosus	calcium dependent protein kinase	0.0062	0.0566	0.2448
Echinococcus multilocularis	lysyl tRNA synthetase	0.0049	0.0414	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0218	0.2266	1
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0134	1
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Plasmodium falciparum	lysine--tRNA ligase	0.0049	0.0414	0.0399
Brugia malayi	hypothetical protein	0.0031	0.0217	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0621	0.868
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0067	0.0612	0.0597
Schistosoma mansoni	glucose transport protein	0.0218	0.2266	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0065	0.0597	0.9752
Trichomonas vaginalis	sugar transport protein, putative	0.0031	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0031	0.0217	0.0894
Trypanosoma cruzi	sugar transporter, putative	0.0031	0.0217	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0371	0.5185
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0352	0.3734	0.3724
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0067	0.0612	0.0597
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0067	0.0611	0.2648
Trichomonas vaginalis	myo-inositol transporter, putative	0.0031	0.0217	0.0956
Giardia lamblia	Hexose transporter	0.0031	0.0217	0.346
Trypanosoma brucei	glucose transporter 1E	0.0067	0.0621	0.868
Mycobacterium ulcerans	integral membrane transport protein	0.0031	0.0217	0.5239
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0067	0.0621	0.868
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Plasmodium vivax	hexose transporter	0.0218	0.2266	0.2253
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0076	0.0715	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0031	0.0217	0.0894
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0923	1	1
Brugia malayi	major facilitator superfamily protein	0.0031	0.0217	0.0894
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0012	0.0016	0.0468
Echinococcus granulosus	solute carrier family 22	0.0031	0.0217	0.0894
Loa Loa (eye worm)	sugar transporter	0.0218	0.2266	1
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0621	0.868
Echinococcus granulosus	General substrate transporter	0.0187	0.193	0.851
Leishmania major	hypothetical protein, conserved	0.0031	0.0217	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Schistosoma mansoni	glucose transporter	0.0031	0.0217	0.0894
Brugia malayi	hypothetical protein	0.0031	0.0217	0.0894
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0031	0.0217	0.303
Giardia lamblia	Sugar-proton symporter	0.0031	0.0217	0.346
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0218	0.2266	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0049	0.0414	0.5783
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0065	0.0597	0.2583
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.0371	0.5185
Onchocerca volvulus		0.0031	0.0217	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0067	0.0611	0.2699
Onchocerca volvulus		0.0031	0.0217	0.5
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0069
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0621	0.868
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0371	0.1579
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Onchocerca volvulus		0.0031	0.0217	0.5
Echinococcus granulosus	lysyl tRNA synthetase	0.0049	0.0414	0.1769
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0049	0.0414	0.6932
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0067	0.0611	0.2648
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Onchocerca volvulus		0.0031	0.0217	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0414	0.1769
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Onchocerca volvulus		0.0031	0.0217	0.5
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0611	0.2648
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0012	0.0016	0.0262
Brugia malayi	Sugar transporter family protein	0.0031	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0463	0.1987
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0621	0.868
Trypanosoma cruzi	hexose transporter	0.0067	0.0621	0.868
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0023	0.0134	0.3243
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0031	0.0217	0.0894
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0076	0.0715	0.1081
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Onchocerca volvulus		0.0031	0.0217	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0067	0.0612	0.0597
Mycobacterium ulcerans	sugar transporter	0.0031	0.0217	0.5239
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Plasmodium falciparum	proline--tRNA ligase	0.0076	0.0715	0.0701
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.0371	0.6113
Entamoeba histolytica	protein kinase, putative	0.0067	0.0611	1
Schistosoma mansoni	sugar transporter	0.0031	0.0217	0.0894
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0371	0.1579
Onchocerca volvulus		0.0031	0.0217	0.5
Toxoplasma gondii	protein kinase, putative	0.0615	0.6617	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Brugia malayi	hypothetical protein	0.0031	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0621	0.868
Schistosoma mansoni	lysyl-tRNA synthetase	0.0049	0.0414	0.1769
Brugia malayi	major facilitator superfamily protein	0.0031	0.0217	0.0894
Leishmania major	myo-inositol/proton symporter (MIT)	0.0031	0.0217	0.303
Chlamydia trachomatis	lysine--tRNA ligase	0.0049	0.0414	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0371	0.5185
Brugia malayi	Sugar transporter family protein	0.0218	0.2266	1
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0217	0.0956
Plasmodium vivax	proline--tRNA ligase, putative	0.0076	0.0715	0.0701
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0352	0.3734	0.5643
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Leishmania major	glucose transporter, lmgt2	0.0067	0.0621	0.868
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0067	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Onchocerca volvulus	Putative transporter	0.0031	0.0217	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0286	0.3994
Echinococcus multilocularis	General substrate transporter	0.0187	0.193	0.851
Schistosoma mansoni	hypothetical protein	0.0218	0.2266	1
Trypanosoma cruzi	glucose transporter, putative	0.0031	0.0217	0.303
Plasmodium vivax	lysine--tRNA ligase, putative	0.0049	0.0414	0.0399
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0049	0.0414	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0067	0.0621	0.868
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0067	0.0612	0.0925
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0012	0.0016	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0621	0.274
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0371	0.1579
Echinococcus multilocularis	solute carrier family 22	0.0031	0.0217	0.0894
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0031	0.0217	0.5239
Loa Loa (eye worm)	sugar transporter	0.0031	0.0217	0.0894
Brugia malayi	Cam kinase protein 1	0.0067	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0027	0.0175	0.0709
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0076	0.0715	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0371	0.1637
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0217	0.0894
Leishmania major	glucose transporter, lmgt1	0.0067	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0217	0.0894
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0352	0.3734	0.3724
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0031	0.0217	0.0201
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0067	0.0611	0.855
Trypanosoma brucei	glucose transporter, putative	0.0067	0.0621	0.868
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0067	0.0611	0.2648
Plasmodium falciparum	hexose transporter	0.0218	0.2266	0.2253
Brugia malayi	Major Facilitator Superfamily protein	0.0031	0.0217	0.0894
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0371	0.1579
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Toxoplasma gondii	sugar transporter ST3	0.0031	0.0217	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0217	0.0956
Trypanosoma cruzi	hexose transporter, putative	0.0067	0.0621	0.868

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.2944 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	112.2018 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1391853
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 763598