Detailed information for compound 763623

Basic information

Technical information
  • TDR Targets ID: 763623
  • Name: (E)-2-cyano-3-[2-(2-fluorophenoxy)-4-oxopyrid o[1,2-a]pyrimidin-3-yl]-N-(4-methoxyphenyl)pr op-2-enamide
  • MW: 456.425 | Formula: C25H17FN4O4
  • H donors: 1 H acceptors: 3 LogP: 3.68 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1c(Oc2ccccc2F)nc2n(c1=O)cccc2)C(=O)Nc1ccc(cc1)OC
  • InChi: 1S/C25H17FN4O4/c1-33-18-11-9-17(10-12-18)28-23(31)16(15-27)14-19-24(34-21-7-3-2-6-20(21)26)29-22-8-4-5-13-30(22)25(19)32/h2-14H,1H3,(H,28,31)/b16-14+
  • InChiKey: XWHNQQGSXBFEIZ-JQIJEIRASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-cyano-3-[2-(2-fluorophenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]-N-(4-methoxyphenyl)prop-2-enamide
  • 2-cyano-3-[2-(2-fluorophenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(4-methoxyphenyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(2-fluorophenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(4-methoxyphenyl)prop-2-enamide
  • 2-cyano-3-[2-(2-fluorophenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(4-methoxyphenyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(2-fluorophenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(4-methoxyphenyl)prop-2-enamide
  • 2-cyano-3-[2-(2-fluorophenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-N-(4-methoxyphenyl)acrylamide
  • (E)-2-cyano-3-[2-(2-fluorophenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-N-(4-methoxyphenyl)acrylamide
  • STOCK4S-37590

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni protein kinase 0.0068 0.0556 0.2506
Echinococcus granulosus calcium dependent protein kinase 0.0064 0.0511 0.2301
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.222 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0661 1
Brugia malayi hypothetical protein 0.0038 0.0228 0.1027
Brugia malayi major facilitator superfamily protein 0.0031 0.0159 0.0717
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0159 0.0717
Onchocerca volvulus 0.0031 0.0159 0.5
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0222 0.222 1
Schistosoma mansoni glucose transport protein 0.0222 0.222 1
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0556 0.2506
Trypanosoma brucei glucose transporter, putative 0.0069 0.0566 0.8484
Trichomonas vaginalis glucose transporter, putative 0.0069 0.0566 0.2431
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0159 0.3867
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trypanosoma brucei glucose transporter, putative 0.0069 0.0566 0.8484
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0222 0.222 1
Toxoplasma gondii protein kinase, putative 0.0628 0.6597 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0566 0.8484
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0566 0.8484
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0159 0.0717
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0159 0.5155
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0068 0.0557 0.0524
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0222 0.222 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0068 0.0557 0.0524
Plasmodium vivax sugar transporter, putative 0.0031 0.0159 0.0125
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0159 0.0717
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.005 0.0357 0.5157
Plasmodium falciparum calcium-dependent protein kinase 3 0.0068 0.0557 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0159 0.0571
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0159 0.0717
Toxoplasma gondii sugar transporter ST1 0.0031 0.0159 0.019
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0068 0.0557 0.0524
Echinococcus multilocularis solute carrier family 22 0.0031 0.0159 0.0717
Leishmania major lysyl-tRNA synthetase, putative 0.005 0.0357 0.5157
Brugia malayi Sugar transporter family protein 0.0222 0.222 1
Entamoeba histolytica hypothetical protein 0.0038 0.0228 0.3712
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Loa Loa (eye worm) sugar transporter 0.0031 0.0159 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0566 0.2431
Loa Loa (eye worm) hypothetical protein 0.0067 0.0541 0.2439
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.005 0.0357 0.3046
Brugia malayi major facilitator superfamily protein 0.0031 0.0159 0.0717
Leishmania major glucose transporter/membrane transporter D2, putative 0.0069 0.0566 0.8484
Schistosoma mansoni hypothetical protein 0.0222 0.222 1
Schistosoma mansoni ap endonuclease 0.002 0.0034 0.0154
Toxoplasma gondii facilitative glucose transporter GT1 0.0222 0.222 0.333
Onchocerca volvulus 0.0031 0.0159 0.5
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Echinococcus granulosus solute carrier family 22 0.0031 0.0159 0.0717
Echinococcus multilocularis calcium dependent protein kinase 0.0064 0.0511 0.2301
Brugia malayi lysyl-tRNA synthetase 0.005 0.0357 0.1609
Schistosoma mansoni ap endonuclease 0.002 0.0034 0.0154
Onchocerca volvulus 0.0031 0.0159 0.5
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0566 0.8484
Plasmodium vivax hexose transporter 0.0222 0.222 0.2193
Giardia lamblia Prolyl-tRNA synthetase 0.0067 0.0541 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0541 0.2439
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0067 0.0541 0.2439
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0067 0.0541 0.2439
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0067 0.0541 0.232
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0068 0.0556 0.2506
Toxoplasma gondii lysine-tRNA ligase 0.005 0.0357 0.0492
Plasmodium falciparum proline--tRNA ligase 0.0078 0.0661 0.0629
Schistosoma mansoni protein kinase 0.0068 0.0556 0.2506
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0228 0.1027
Onchocerca volvulus 0.0031 0.0159 0.5
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0159 0.019
Brugia malayi Sugar transporter family protein 0.0031 0.0159 0.0717
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0661 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0034 0.0154
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0068 0.0556 0.2506
Entamoeba histolytica protein kinase, putative 0.0068 0.0556 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0222 0.222 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0068 0.0557 0.0796
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0159 0.0571
Echinococcus granulosus solute carrier family 22 0.0031 0.0159 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Echinococcus multilocularis solute carrier family 22 0.0031 0.0159 0.0717
Onchocerca volvulus 0.0031 0.0159 0.5
Trypanosoma brucei glucose transporter, putative 0.0069 0.0566 0.8484
Plasmodium falciparum lysine--tRNA ligase 0.005 0.0357 0.0324
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0566 0.2431
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0068 0.0557 0.0524
Entamoeba histolytica hypothetical protein 0.005 0.0357 0.6187
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0357 1
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0357 0.1609
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0159 0.0571
Trypanosoma brucei glucose transporter 1E 0.0069 0.0566 0.8484
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0159 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0034 0.0154
Giardia lamblia Hexose transporter 0.0031 0.0159 0.2463
Trypanosoma brucei glucose transporter, putative 0.0069 0.0566 0.8484
Onchocerca volvulus 0.0031 0.0159 0.5
Echinococcus granulosus solute carrier family 22 0.0031 0.0159 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Leishmania major glucose transporter, lmgt2 0.0069 0.0566 0.8484
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.005 0.0357 0.5157
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Onchocerca volvulus Putative transporter 0.0031 0.0159 0.5
Brugia malayi hypothetical protein 0.0031 0.0159 0.0717
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0159 0.1994
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Leishmania major protein kinase, putative 0.0068 0.0556 0.8334
Schistosoma mansoni sugar transporter 0.0031 0.0159 0.0717
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0043 0.0291 0.1176
Schistosoma mansoni sugar transporter 0.0031 0.0159 0.0717
Trypanosoma cruzi hexose transporter 0.0069 0.0566 0.8484
Onchocerca volvulus 0.0031 0.0159 0.5
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0566 0.2431
Loa Loa (eye worm) hypothetical protein 0.0052 0.0385 0.1733
Trypanosoma brucei glucose transporter, putative 0.0069 0.0566 0.8484
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0222 0.222 1
Entamoeba histolytica hypothetical protein 0.0038 0.0228 0.3712
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0385 0.1733
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0067 0.0541 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0067 0.0541 0.2439
Onchocerca volvulus 0.0031 0.0159 0.5
Echinococcus granulosus lysyl tRNA synthetase 0.005 0.0357 0.1609
Giardia lamblia Lysyl-tRNA synthetase 0.005 0.0357 0.6369
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0159 0.0571
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0067 0.0541 0.2439
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0042 0.0277 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0159 0.0571
Trypanosoma brucei glucose transporter, putative 0.0069 0.0566 0.8484
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Schistosoma mansoni protein kinase 0.0068 0.0556 0.2506
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0067 0.0541 0.9715
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0159 0.0717
Onchocerca volvulus 0.0031 0.0159 0.5
Echinococcus multilocularis solute carrier family 22 0.0031 0.0159 0.0717
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0207 0.0931
Schistosoma mansoni hypothetical protein 0.0036 0.0207 0.0931
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0159 0.0717
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0067 0.0541 0.2439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0159 0.0717
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0556 0.2506
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0222 0.222 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0068 0.0557 0.0796
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0228 0.1027
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0222 0.222 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0159 0.5155
Plasmodium vivax lysine--tRNA ligase, putative 0.005 0.0357 0.0324
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0159 0.0125
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0357 0.1609
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0159 0.1994
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0222 0.222 1
Onchocerca volvulus 0.0031 0.0159 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Trypanosoma brucei sugar transporter, putative 0.0031 0.0159 0.1994
Echinococcus granulosus General substrate transporter 0.0191 0.1883 0.8481
Onchocerca volvulus 0.0031 0.0159 0.5
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Plasmodium vivax calcium-dependent protein kinase, putative 0.0068 0.0557 0.0524
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0078 0.0661 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0359 0.3697 0.3675
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0556 0.2506
Plasmodium falciparum protein kinase 7 0.0628 0.6597 0.6586
Plasmodium falciparum calcium-dependent protein kinase 2 0.0068 0.0557 0.0524
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0159 0.0571
Schistosoma mansoni hypothetical protein 0.0038 0.0228 0.1027
Echinococcus multilocularis solute carrier family 22 0.0031 0.0159 0.0717
Trypanosoma brucei THT1 - hexose transporter, putative 0.0069 0.0566 0.8484
Trichomonas vaginalis CAMK family protein kinase 0.0068 0.0556 0.2388
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Giardia lamblia Sugar-proton symporter 0.0031 0.0159 0.2463
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0566 0.8484
Plasmodium falciparum calcium-dependent protein kinase 1 0.0068 0.0557 0.0524
Trypanosoma brucei glucose transporter, putative 0.0069 0.0566 0.8484
Plasmodium falciparum mitogen-activated protein kinase 2 0.0359 0.3697 0.3675
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0068 0.0556 0.2506
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Entamoeba histolytica hypothetical protein 0.0038 0.0228 0.3712
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Loa Loa (eye worm) hypothetical protein 0.0068 0.0556 0.2506
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0159 0.0571
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0076 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0207 0.0931
Plasmodium falciparum hexose transporter 0.0222 0.222 0.2193
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0117 0.0528
Trypanosoma brucei glucose transporter 2A 0.0069 0.0566 0.8484
Loa Loa (eye worm) hypothetical protein 0.005 0.0357 0.1609
Leishmania major glucose transporter, lmgt3 0.0069 0.0566 0.8484
Trichomonas vaginalis glucose transporter, putative 0.0069 0.0566 0.2431
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.005 0.0357 0.1478
Chlamydia trachomatis lysine--tRNA ligase 0.005 0.0357 1
Brugia malayi Sugar transporter family protein 0.0031 0.0159 0.0717
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0034 0.0154
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0078 0.0661 1
Brugia malayi Cam kinase protein 1 0.0068 0.0556 0.2506
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Echinococcus multilocularis General substrate transporter 0.0191 0.1883 0.8481
Trypanosoma cruzi hexose transporter, putative 0.0069 0.0566 0.8484
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0159 0.1994
Schistosoma mansoni sugar transporter 0.0031 0.0159 0.0717
Loa Loa (eye worm) sugar transporter 0.0222 0.222 1
Echinococcus granulosus solute carrier family 22 0.0031 0.0159 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0159 0.0571
Onchocerca volvulus 0.0031 0.0159 0.5
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0078 0.0661 0.0954
Plasmodium vivax CDK-related protein kinase 6, putative 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Echinococcus multilocularis lysyl tRNA synthetase 0.005 0.0357 0.1609
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0067 0.0541 0.2439
Schistosoma mansoni glucose transport protein 0.0222 0.222 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Schistosoma mansoni glucose transporter 0.0031 0.0159 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0359 0.3697 0.5581
Brugia malayi hypothetical protein 0.0031 0.0159 0.0717
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0229 0.3101
Schistosoma mansoni sugar transporter 0.0031 0.0159 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0159 0.1994
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0159 0.1994
Onchocerca volvulus 0.0031 0.0159 0.5
Schistosoma mansoni glucose transport protein 0.0222 0.222 1
Toxoplasma gondii sugar transporter ST3 0.0031 0.0159 0.019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Plasmodium falciparum calcium-dependent protein kinase 4 0.0068 0.0557 0.0524
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0068 0.0556 0.8334
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.0076 0.1296
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0556 0.2506
Brugia malayi hypothetical protein 0.0031 0.0159 0.0717
Trypanosoma brucei glucose transporter, putative 0.0069 0.0566 0.8484
Loa Loa (eye worm) hypothetical protein 0.0054 0.0407 0.1831
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0068 0.0557 0.0796
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0556 0.2506
Onchocerca volvulus 0.0031 0.0159 0.5
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Entamoeba histolytica protein kinase, putative 0.0068 0.0556 1
Plasmodium vivax proline--tRNA ligase, putative 0.0078 0.0661 0.0629
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0042 0.0277 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0159 1
Onchocerca volvulus 0.0031 0.0159 0.5
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0068 0.0556 0.2506
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0159 0.0717
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0034 0.0154
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0078 0.0661 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0068 0.0556 0.2506
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0159 0.3867
Toxoplasma gondii sugar transporter ST2 0.0031 0.0159 0.019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0385 0.1733
Leishmania major hypothetical protein, conserved 0.0031 0.0159 0.1994
Entamoeba histolytica hypothetical protein 0.0038 0.0228 0.3712
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0566 0.2431
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0159 0.0717
Leishmania major glucose transporter, lmgt1 0.0069 0.0566 0.8484
Onchocerca volvulus 0.0031 0.0159 0.5
Trichomonas vaginalis sugar transporter, putative 0.0069 0.0566 0.2431
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0228 0.1027
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0159 0.3867
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0357 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0556 0.2506
Mycobacterium ulcerans sugar transporter 0.0031 0.0159 0.3867
Loa Loa (eye worm) hypothetical protein 0.0031 0.0159 0.0717
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0159 0.0571
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0385 0.1733
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0068 0.0556 0.2506

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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