Detailed information for compound 763645

Basic information

Technical information
  • TDR Targets ID: 763645
  • Name: 1-[3-(3-methylbutoxy)phenyl]-2-(5-methyl-1,3, 4-thiadiazol-2-yl)-1H-chromeno[2,3-c]pyrrole- 3,9-dione
  • MW: 461.533 | Formula: C25H23N3O4S
  • H donors: 0 H acceptors: 4 LogP: 4.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CCOc1cccc(c1)C1N(c2nnc(s2)C)C(=O)c2c1c(=O)c1c(o2)cccc1)C
  • InChi: 1S/C25H23N3O4S/c1-14(2)11-12-31-17-8-6-7-16(13-17)21-20-22(29)18-9-4-5-10-19(18)32-23(20)24(30)28(21)25-27-26-15(3)33-25/h4-10,13-14,21H,11-12H2,1-3H3
  • InChiKey: PIBZASOECFWKJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-isopentyloxyphenyl)-2-(5-methyl-1,3,4-thiadiazol-2-yl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 1-(3-isoamoxyphenyl)-2-(5-methyl-1,3,4-thiadiazol-2-yl)-1H-chromeno[2,3-c]pyrrole-3,9-quinone
  • NCGC00101347-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0248 0.0956
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0379 0.1536
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0745 1
Toxoplasma gondii protein kinase, putative 0.0602 0.6628 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0642 0.0925
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0642 0.0925
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Schistosoma mansoni sugar transporter 0.003 0.0248 0.1085
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0445 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0445 0.0399
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0248 0.0327
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0365 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2291 0.2323
Plasmodium vivax sugar transporter, putative 0.003 0.0248 0.0201
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Echinococcus multilocularis solute carrier family 22 0.003 0.0248 0.0208
Plasmodium falciparum mitogen-activated protein kinase 2 0.0344 0.3754 0.3724
Schistosoma mansoni hypothetical protein 0.0183 0.196 0.8554
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0642 0.0597
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0642 0.2699
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2291 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0248 0.5239
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Onchocerca volvulus 0.003 0.0248 0.5
Echinococcus granulosus geminin 0.0183 0.196 0.8524
Entamoeba histolytica hypothetical protein 0.0048 0.0445 0.6679
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0445 0.0625
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0048 0.0262
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0745 1
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0445 0.5783
Trypanosoma brucei glucose transporter, putative 0.0066 0.0651 0.868
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0745 0.0701
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Echinococcus granulosus solute carrier family 22 0.003 0.0248 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0048 0.0377
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0745 0.1081
Schistosoma mansoni protein kinase 0.0065 0.0642 0.2803
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0642 0.0597
Onchocerca volvulus 0.003 0.0248 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0431 0.1707
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Schistosoma mansoni sugar transporter 0.003 0.0248 0.1085
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0642 0.0615
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0651 0.868
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0651 0.868
Plasmodium falciparum protein kinase 7 0.0602 0.6628 0.6612
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0317 0.3994
Schistosoma mansoni hypothetical protein 0.0213 0.2291 1
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0166 0.2978
Toxoplasma gondii sugar transporter ST3 0.003 0.0248 0.0327
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0642 0.855
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0248 0.0956
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0166 0.3243
Trypanosoma cruzi glucose transporter, putative 0.003 0.0248 0.303
Trypanosoma cruzi hexose transporter, putative 0.003 0.0248 0.303
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0248 0.0208
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0248 0.303
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0344 0.3754 0.5643
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0431 0.1881
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Schistosoma mansoni protein kinase 0.0065 0.0642 0.2803
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0642 0.2648
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0642 0.0615
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0166 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0651 0.274
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0248 0.5239
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2291 1
Brugia malayi Sugar transporter family protein 0.003 0.0248 0.0894
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0048 0.0069
Giardia lamblia Sugar-proton symporter 0.003 0.0248 0.346
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0213 0.2291 0.2323
Brugia malayi major facilitator superfamily protein 0.003 0.0248 0.0894
Giardia lamblia Hexose transporter 0.003 0.0248 0.346
Schistosoma mansoni sugar transporter 0.003 0.0248 0.1085
Echinococcus multilocularis General substrate transporter 0.0183 0.1957 0.1977
Plasmodium vivax CDK-related protein kinase 6, putative 0.0904 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0651 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.2291 1
Toxoplasma gondii sugar transporter ST2 0.003 0.0248 0.0327
Toxoplasma gondii facilitative glucose transporter GT1 0.0213 0.2291 0.3424
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0248 0.1085
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0248 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0627 0.06
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0445 0.6932
Onchocerca volvulus 0.003 0.0248 0.5
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0651 0.868
Trypanosoma brucei glucose transporter 1E 0.0066 0.0651 0.868
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0365 1
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0651 0.274
Onchocerca volvulus 0.003 0.0248 0.5
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0048 0.0218
Onchocerca volvulus 0.003 0.0248 0.5
Brugia malayi hypothetical protein 0.003 0.0248 0.0894
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0597 0.0569
Onchocerca volvulus 0.003 0.0248 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0431 0.1707
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0627 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0642 0.0597
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0445 0.1769
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0642 0.0597
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0248 0.0894
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0248 0.303
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0248 0.0894
Leishmania major protein kinase, putative 0.0065 0.0642 0.855
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0627 0.2634
Brugia malayi Cam kinase protein 1 0.0065 0.0642 0.2648
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0642 0.2648
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0048 0.0218
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Entamoeba histolytica protein kinase, putative 0.0065 0.0642 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0248 0.0208
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0248 0.0956
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0048 0.0218
Schistosoma mansoni hypothetical protein 0.0183 0.196 0.8554
Echinococcus granulosus solute carrier family 22 0.003 0.0248 0.0894
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0642 0.2648
Onchocerca volvulus 0.003 0.0248 0.5
Echinococcus multilocularis geminin 0.0183 0.196 0.198
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0431 0.1707
Brugia malayi hypothetical protein 0.003 0.0248 0.0894
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0248 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0445 0.1826
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0642 0.0597
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0048 0.0024
Echinococcus granulosus solute carrier family 22 0.003 0.0248 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Trypanosoma brucei glucose transporter, putative 0.0066 0.0651 0.868
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2291 0.2323
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0642 0.0597
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Onchocerca volvulus 0.003 0.0248 0.5
Trypanosoma brucei glucose transporter, putative 0.0066 0.0651 0.868
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0642 0.0615
Brugia malayi major facilitator superfamily protein 0.003 0.0248 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0642 0.2648
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0445 0.1942
Plasmodium vivax hexose transporter 0.0213 0.2291 0.2253
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0431 0.0397
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0745 0.0701
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0431 0.0397
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trypanosoma cruzi sugar transporter, putative 0.003 0.0248 0.303
Mycobacterium ulcerans sugar transporter 0.003 0.0248 0.5239
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Leishmania major glucose transporter, lmgt3 0.0066 0.0651 0.868
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2291 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0627 0.2583
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0651 0.274
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0877 0.9702 1
Loa Loa (eye worm) sugar transporter 0.0213 0.2291 1
Leishmania major glucose transporter, lmgt2 0.0066 0.0651 0.868
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0651 0.868
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0248 0.6499
Toxoplasma gondii sugar transporter ST1 0.003 0.0248 0.0327
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2291 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2291 0.2323
Trypanosoma brucei glucose transporter 2A 0.0066 0.0651 0.868
Trypanosoma brucei glucose transporter, putative 0.0066 0.0651 0.868
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0745 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0642 0.2803
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0642 0.2648
Loa Loa (eye worm) hypothetical protein 0.0052 0.0494 0.1987
Echinococcus granulosus General substrate transporter 0.0183 0.1957 0.851
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0651 0.274
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0642 0.0615
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0627 0.2738
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0642 0.2648
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0642 0.2648
Entamoeba histolytica protein kinase, putative 0.0065 0.0642 1
Schistosoma mansoni glucose transport protein 0.0213 0.2291 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0642 0.0597
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0431 0.1707
Echinococcus multilocularis solute carrier family 22 0.003 0.0248 0.0208
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0248 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0745 1
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0248 0.0894
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0048 0.0377
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0248 0.5239
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0248 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0248 0.0956
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0627 0.2583
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0445 1
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0445 1
Onchocerca volvulus 0.003 0.0248 0.5
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0651 0.274
Plasmodium falciparum hexose transporter 0.0213 0.2291 0.2253
Schistosoma mansoni glucose transport protein 0.0213 0.2291 1
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0048 0.0468
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trypanosoma brucei glucose transporter, putative 0.0066 0.0651 0.868
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0344 0.3754 0.3724
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0627 0.2583
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0048 0.0218
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0248 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Leishmania major glucose transporter, lmgt1 0.0066 0.0651 0.868
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0445 0.5783
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Onchocerca volvulus 0.003 0.0248 0.5
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0048 0.0218
Schistosoma mansoni sugar transporter 0.003 0.0248 0.1085
Onchocerca volvulus 0.003 0.0248 0.5
Brugia malayi hypothetical protein 0.003 0.0248 0.0894
Trypanosoma cruzi hexose transporter 0.0066 0.0651 0.868
Trypanosoma brucei glucose transporter, putative 0.0066 0.0651 0.868
Echinococcus multilocularis solute carrier family 22 0.003 0.0248 0.0208
Trypanosoma brucei glucose transporter, putative 0.0066 0.0651 0.868
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0597 0.2448
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0651 0.274
Brugia malayi Sugar transporter family protein 0.0213 0.2291 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Trypanosoma brucei sugar transporter, putative 0.003 0.0248 0.303
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0248 0.0201
Loa Loa (eye worm) hypothetical protein 0.0065 0.0642 0.2648
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0445 0.5783
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Schistosoma mansoni glucose transporter 0.003 0.0248 0.1085
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0651 0.868
Onchocerca volvulus Putative transporter 0.003 0.0248 0.5
Schistosoma mansoni protein kinase 0.0065 0.0642 0.2803
Loa Loa (eye worm) hypothetical protein 0.0048 0.0445 0.1769
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0248 0.0894
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0207 0.0709
Trichomonas vaginalis glucose transporter, putative 0.003 0.0248 0.0956
Loa Loa (eye worm) sugar transporter 0.003 0.0248 0.0894
Onchocerca volvulus 0.003 0.0248 0.5
Trypanosoma brucei glucose transporter, putative 0.0066 0.0651 0.868
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0445 0.6849
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0248 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0745 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0445 0.1769
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0048 0.021
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0445 0.0399
Loa Loa (eye worm) hypothetical protein 0.0064 0.0627 0.2583
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Echinococcus granulosus solute carrier family 22 0.003 0.0248 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Onchocerca volvulus 0.003 0.0248 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0651 0.274
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0651 0.868
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0248 0.0956
Onchocerca volvulus 0.003 0.0248 0.5
Onchocerca volvulus 0.003 0.0248 0.5
Brugia malayi Sugar transporter family protein 0.003 0.0248 0.0894
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0642 0.0597
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0642 0.0597
Schistosoma mansoni glucose transport protein 0.0213 0.2291 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0248 0.0894
Onchocerca volvulus 0.003 0.0248 0.5
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0365 0.5587
Leishmania major hypothetical protein, conserved 0.003 0.0248 0.303
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0627 0.9752
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0627 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0048 0.0024
Echinococcus multilocularis solute carrier family 22 0.003 0.0248 0.0208
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0642 0.0925
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0627 0.2583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0431 0.1881
Trichomonas vaginalis sugar transporter, putative 0.003 0.0248 0.0956
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0248 0.6499
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0627 0.2738
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0431 0.1881
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0445 0.1942
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0445 0.0411

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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