TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 357.404 | Formula: C19H23N3O4
H donors: 1 H acceptors: 3 LogP: 1.76 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1noc(c1)COc1cc(C)ccc1C)N1CCC(CC1)C(=O)N
InChi: 1S/C19H23N3O4/c1-12-3-4-13(2)17(9-12)25-11-15-10-16(21-26-15)19(24)22-7-5-14(6-8-22)18(20)23/h3-4,9-10,14H,5-8,11H2,1-2H3,(H2,20,23)
InChiKey: ILKNZNHNTXCVIU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0039	0.0333	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0208	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0064	0.0612	0.0597
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0217	0.0894
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0394	0.1684
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.0597	0.2583
Leishmania major	glucose transporter, lmgt2	0.0065	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0208	0.2266	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0064	0.0612	0.0597
Schistosoma mansoni	protein kinase	0.0064	0.0611	0.2648
Echinococcus granulosus	solute carrier family 22	0.0029	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0611	0.2648
Echinococcus granulosus	lysyl tRNA synthetase	0.0047	0.0414	0.1769
Brugia malayi	hypothetical protein	0.0029	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0217	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Toxoplasma gondii	facilitative glucose transporter GT1	0.0208	0.2266	0.3424
Schistosoma mansoni	glucose transport protein	0.0208	0.2266	1
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0621	0.868
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0064	0.0612	0.0925
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0029	0.0217	0.0894
Plasmodium vivax	sugar transporter, putative	0.0029	0.0217	0.0201
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0621	0.868
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0621	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0621	0.274
Plasmodium falciparum	protein kinase 7	0.0589	0.6617	0.6612
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0208	0.2266	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Echinococcus multilocularis	calcium dependent protein kinase	0.006	0.0566	0.2448
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0208	0.2266	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0064	0.0612	0.0597
Loa Loa (eye worm)	sugar transporter	0.0029	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Brugia malayi	hypothetical protein	0.0029	0.0217	0.0894
Plasmodium falciparum	proline--tRNA ligase	0.0073	0.0715	0.0701
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0394	0.1684
Schistosoma mansoni	sugar transporter	0.0029	0.0217	0.0894
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0715	1
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0012	0.0016	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Giardia lamblia	Sugar-proton symporter	0.0029	0.0217	0.346
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0039	0.0333	0.5587
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.2266	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0064	0.0611	0.2648
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0611	0.2648
Entamoeba histolytica	protein kinase, putative	0.0064	0.0611	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.0597	0.2583
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0063	0.0597	0.2583
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0597	0.2583
Plasmodium vivax	proline--tRNA ligase, putative	0.0073	0.0715	0.0701
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0064	0.0612	0.0597
Leishmania major	protein kinase, putative	0.0064	0.0611	0.855
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0597	0.2583
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0414	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0217	0.0894
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0063	0.0597	0.2634
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0621	0.868
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0208	0.2266	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0012	0.0016	0.0262
Plasmodium vivax	hexose transporter	0.0208	0.2266	0.2253
Plasmodium falciparum	hexose transporter	0.0208	0.2266	0.2253
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0047	0.0414	0.1826
Onchocerca volvulus		0.0029	0.0217	0.5
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0621	0.868
Brugia malayi	lysyl-tRNA synthetase	0.0047	0.0414	0.1769
Echinococcus granulosus	calcium dependent protein kinase	0.006	0.0566	0.2448
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.0217	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0611	0.2648
Brugia malayi	major facilitator superfamily protein	0.0029	0.0217	0.0894
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0394	0.1684
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Onchocerca volvulus		0.0029	0.0217	0.5
Schistosoma mansoni	glucose transport protein	0.0208	0.2266	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0621	0.868
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0414	0.1769
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0217	0.5239
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0621	0.274
Giardia lamblia	Hexose transporter	0.0029	0.0217	0.346
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0012	0.0016	0.0377
Echinococcus granulosus	solute carrier family 22	0.0029	0.0217	0.0894
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0.0134	1
Mycobacterium ulcerans	sugar transporter	0.0029	0.0217	0.5239
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0022	0.0134	0.3243
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0394	0.1684
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trichomonas vaginalis	sugar transport protein, putative	0.0029	0.0217	0.0956
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0621	0.868
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0414	0.1769
Plasmodium vivax	lysine--tRNA ligase, putative	0.0047	0.0414	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trypanosoma cruzi	sugar transporter, putative	0.0029	0.0217	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0621	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Onchocerca volvulus		0.0029	0.0217	0.5
Toxoplasma gondii	sugar transporter ST2	0.0029	0.0217	0.0327
Entamoeba histolytica	hypothetical protein	0.0047	0.0414	0.6679
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0621	0.274
Trichomonas vaginalis	myo-inositol transporter, putative	0.0029	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Echinococcus multilocularis	lysyl tRNA synthetase	0.0047	0.0414	0.1769
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0029	0.0217	0.6499
Schistosoma mansoni	protein kinase	0.0064	0.0611	0.2648
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0621	0.868
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0063	0.0597	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0217	0.0327
Brugia malayi	major facilitator superfamily protein	0.0029	0.0217	0.0894
Onchocerca volvulus		0.0029	0.0217	0.5
Onchocerca volvulus		0.0029	0.0217	0.5
Onchocerca volvulus		0.0029	0.0217	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0611	0.2648
Schistosoma mansoni	hypothetical protein	0.0208	0.2266	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0064	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0217	0.0894
Onchocerca volvulus		0.0029	0.0217	0.5
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0064	0.0612	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0217	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0956
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0063	0.0597	0.9752
Plasmodium falciparum	lysine--tRNA ligase	0.0047	0.0414	0.0399
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0394	0.1684
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0394	0.1684
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0029	0.0217	0.0201
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0063	0.0597	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0039	0.0333	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0414	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.0217	0.0894
Giardia lamblia	Prolyl-tRNA synthetase	0.0063	0.0597	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0063	0.0597	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0217	0.0894
Schistosoma mansoni	protein kinase	0.0064	0.0611	0.2648
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0064	0.0611	0.2648
Toxoplasma gondii	protein kinase, putative	0.0589	0.6617	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0065	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Echinococcus multilocularis	General substrate transporter	0.0179	0.193	0.851
Onchocerca volvulus		0.0029	0.0217	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0208	0.2266	1
Onchocerca volvulus		0.0029	0.0217	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0611	0.2648
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0611	0.2648
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0337	0.3734	0.3724
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0715	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Schistosoma mansoni	glucose transporter	0.0029	0.0217	0.0894
Schistosoma mansoni	glucose transport protein	0.0208	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Leishmania major	myo-inositol/proton symporter (MIT)	0.0029	0.0217	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0414	0.1769
Toxoplasma gondii	lysine-tRNA ligase	0.0047	0.0414	0.0625
Schistosoma mansoni	sugar transporter	0.0029	0.0217	0.0894
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0611	0.2699
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0069
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0715	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Onchocerca volvulus		0.0029	0.0217	0.5
Echinococcus granulosus	solute carrier family 22	0.0029	0.0217	0.0894
Onchocerca volvulus		0.0029	0.0217	0.5
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0621	0.868
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0621	0.868
Trypanosoma brucei	glucose transporter 2A	0.0065	0.0621	0.868
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0394	0.1684
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0047	0.0414	0.6932
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0047	0.0414	0.5783
Chlamydia trachomatis	proline--tRNA ligase	0.0022	0.0134	0.2978
Leishmania major	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0064	0.0612	0.0597
Leishmania major	hypothetical protein, conserved	0.0029	0.0217	0.303
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0208	0.2266	1
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0012	0.0016	0.0468
Onchocerca volvulus		0.0029	0.0217	0.5
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0337	0.3734	0.3724
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.0217	0.0894
Leishmania major	glucose transporter, lmgt3	0.0065	0.0621	0.868
Brugia malayi	Cam kinase protein 1	0.0064	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0621	0.274
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0956
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0394	0.1684
Onchocerca volvulus		0.0029	0.0217	0.5
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0064	0.0612	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Loa Loa (eye worm)	sugar transporter	0.0208	0.2266	1
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0217	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0621	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0611	0.2648
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0012	0.0016	0.0218
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0064	0.0612	0.0925
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0611	0.2648
Trypanosoma brucei	sugar transporter, putative	0.0029	0.0217	0.303
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0286	0.3994
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0217	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0337	0.3734	0.5643
Toxoplasma gondii	sugar transporter ST1	0.0029	0.0217	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0029	0.0217	0.6499
Brugia malayi	Sugar transporter family protein	0.0029	0.0217	0.0894
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0047	0.0414	0.5783
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0063	0.0597	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Echinococcus granulosus	solute carrier family 22	0.0029	0.0217	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0208	0.2266	1
Echinococcus granulosus	General substrate transporter	0.0179	0.193	0.851
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0621	0.868
Schistosoma mansoni	sugar transporter	0.0029	0.0217	0.0894
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0884	1	1
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0217	0.5239
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0029	0.0217	0.303
Schistosoma mansoni	sugar transporter	0.0029	0.0217	0.0894
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0715	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0217	0.0956
Brugia malayi	Sugar transporter family protein	0.0208	0.2266	1
Brugia malayi	hypothetical protein	0.0029	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Onchocerca volvulus		0.0029	0.0217	0.5
Trypanosoma cruzi	glucose transporter, putative	0.0029	0.0217	0.303
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0064	0.0612	0.0597
Leishmania major	lysyl-tRNA synthetase, putative	0.0047	0.0414	0.5783
Chlamydia trachomatis	lysine--tRNA ligase	0.0047	0.0414	1
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0064	0.0611	0.855
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0041	0.0348	0.1536
Brugia malayi	Sugar transporter family protein	0.0029	0.0217	0.0894
Giardia lamblia	Lysyl-tRNA synthetase	0.0047	0.0414	0.6849
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0012	0.0016	0.0377
Trypanosoma cruzi	hexose transporter	0.0065	0.0621	0.868
Onchocerca volvulus		0.0029	0.0217	0.5
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Leishmania major	glucose transporter, lmgt1	0.0065	0.0621	0.868
Trypanosoma brucei	glucose transporter 1E	0.0065	0.0621	0.868
Onchocerca volvulus		0.0029	0.0217	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0394	0.1684
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0073	0.0715	0.1081
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0064	0.0612	0.0597
Onchocerca volvulus	Putative transporter	0.0029	0.0217	0.5
Toxoplasma gondii	glycyl-tRNA synthetase	0.0012	0.0016	0.0024
Toxoplasma gondii	sugar transporter ST3	0.0029	0.0217	0.0327
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0715	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0026	0.0175	0.0709
Trichomonas vaginalis	glucose transporter, putative	0.0029	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0217	0.0894
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0064	0.0611	0.2648
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0217	0.0894
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0217	0.5239
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0064	0.0612	0.0925
Entamoeba histolytica	protein kinase, putative	0.0064	0.0611	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0463	0.1987
Trypanosoma cruzi	hexose transporter, putative	0.0029	0.0217	0.303
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0611	0.2648

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763762