TDR Targets

Basic information

Technical information

TDR Targets ID: 764965
Name: N-(4-bromophenyl)-2-[2-[(4-methoxyphenyl)amin o]-4-oxo-1,3-thiazol-5-yl]acetamide
MW: 434.307 | Formula: C18H16BrN3O3S
H donors: 2 H acceptors: 2 LogP: 3.21 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)NC1=NC(=O)C(S1)CC(=O)Nc1ccc(cc1)Br
InChi: 1S/C18H16BrN3O3S/c1-25-14-8-6-13(7-9-14)21-18-22-17(24)15(26-18)10-16(23)20-12-4-2-11(19)3-5-12/h2-9,15H,10H2,1H3,(H,20,23)(H,21,22,24)
InChiKey: VHIROAOVXFYNOP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-bromophenyl)-2-[2-[(4-methoxyphenyl)amino]-4-oxo-thiazol-5-yl]acetamide
N-(4-bromophenyl)-2-[2-[(4-methoxyphenyl)amino]-4-oxo-5-thiazolyl]acetamide
N-(4-bromophenyl)-2-[4-keto-2-[(4-methoxyphenyl)amino]thiazol-5-yl]acetamide
N-(4-bromophenyl)-2-[2-[(4-methoxyphenyl)amino]-4-oxo-1,3-thiazol-5-yl]ethanamide
EU-0014855
ST5055299

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	ataxin-2 like protein, putative	0.0128	0.0962	1
Brugia malayi	hypothetical protein	0.0128	0.0962	0.2797
Schistosoma mansoni	tar DNA-binding protein	0.039	0.344	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0083	0.0241
Onchocerca volvulus		0.0159	0.1254	1
Schistosoma mansoni	tar DNA-binding protein	0.039	0.344	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0075	0.0466	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0111	0.08	0.2327
Brugia malayi	MH2 domain containing protein	0.0257	0.2183	0.6347
Brugia malayi	Intermediate filament tail domain containing protein	0.0111	0.08	0.2327
Brugia malayi	TAR-binding protein	0.039	0.344	1
Echinococcus granulosus	lamin dm0	0.0111	0.08	0.0723
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0466	0.5
Echinococcus multilocularis	lamin dm0	0.0111	0.08	0.0723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0111	0.08	0.2327
Mycobacterium ulcerans	beta-lactamase	0.0075	0.0466	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0466	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.024	0.0697
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0053	0.0259	0.0178
Echinococcus granulosus	beta LACTamase domain containing family member	0.0075	0.0466	0.0386
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.0793	0.2306
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0962	0.2797
Schistosoma mansoni	cellular tumor antigen P53	0.0159	0.1254	0.3488
Mycobacterium tuberculosis	Probable lipase LipD	0.0075	0.0466	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1254	0.3645
Onchocerca volvulus		0.0075	0.0466	0.3713
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0466	0.1353
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0466	0.1353
Loa Loa (eye worm)	beta-lactamase	0.0075	0.0466	0.1353
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0466	0.1083
Entamoeba histolytica	hypothetical protein	0.0113	0.0826	1
Brugia malayi	hypothetical protein	0.0113	0.0826	0.2401
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0075	0.0466	1
Echinococcus granulosus	tar DNA binding protein	0.039	0.344	0.3385
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0466	0.114
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0465	0.135
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0075	0.0466	0.1353
Loa Loa (eye worm)	hypothetical protein	0.011	0.0793	0.2306
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.039	0.344	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0083	0.0241
Echinococcus multilocularis	tumor protein p63	0.1084	1	1
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0083	0.0241
Brugia malayi	RNA binding protein	0.039	0.344	1
Schistosoma mansoni	lamin	0.0111	0.08	0.2137
Mycobacterium leprae	Probable lipase LipE	0.0075	0.0466	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0083	0.0241
Brugia malayi	hypothetical protein	0.0083	0.0534	0.1552
Mycobacterium leprae	conserved hypothetical protein	0.0075	0.0466	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0075	0.0466	0.1083
Onchocerca volvulus		0.0075	0.0466	0.3713
Schistosoma mansoni	hypothetical protein	0.0113	0.0826	0.2213
Schistosoma mansoni	intermediate filament proteins	0.0111	0.08	0.2137
Trypanosoma cruzi	PAB1-binding protein , putative	0.0128	0.0962	1
Echinococcus granulosus	lamin	0.0111	0.08	0.0723
Mycobacterium tuberculosis	Probable hydrolase	0.0075	0.0466	0.1083
Schistosoma mansoni	tar DNA-binding protein	0.039	0.344	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0075	0.0466	0.1353
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0075	0.0466	0.0386
Leishmania major	hypothetical protein, conserved	0.0075	0.0466	0.4839
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0466	0.1083
Onchocerca volvulus		0.0111	0.08	0.6383
Brugia malayi	beta-lactamase family protein	0.0075	0.0466	0.1353
Schistosoma mansoni	hypothetical protein	0.0057	0.0296	0.0634
Echinococcus multilocularis	tar DNA binding protein	0.039	0.344	0.3385
Plasmodium falciparum	ataxin-2 like protein, putative	0.0128	0.0962	0.5
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0057	0.0296	0.0215
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0466	0.1083
Echinococcus granulosus	intermediate filament protein	0.0111	0.08	0.0723
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0466	0.114
Mycobacterium ulcerans	lipase LipD	0.0075	0.0466	1
Onchocerca volvulus		0.0111	0.08	0.6383
Entamoeba histolytica	hypothetical protein	0.0113	0.0826	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0057	0.0296	0.0215
Entamoeba histolytica	hypothetical protein	0.0113	0.0826	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0128	0.0962	1
Onchocerca volvulus		0.0075	0.0466	0.3713
Schistosoma mansoni	tar DNA-binding protein	0.039	0.344	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0481	0.4299	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.0793	0.2306
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0113	0.0826	0.0749
Loa Loa (eye worm)	TAR-binding protein	0.039	0.344	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0113	0.0826	0.0749
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0466	0.5
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0466	0.1353
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0259	0.0753
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0466	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.024	0.0697
Brugia malayi	cytoplasmic intermediate filament protein	0.0059	0.0315	0.0915
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0059	0.0315	0.0915
Schistosoma mansoni	hypothetical protein	0.0075	0.0465	0.1137
Entamoeba histolytica	hypothetical protein	0.0113	0.0826	1
Loa Loa (eye worm)	intermediate filament protein	0.0111	0.08	0.2327
Loa Loa (eye worm)	transcription factor SMAD2	0.0257	0.2183	0.6347
Brugia malayi	intermediate filament protein	0.0111	0.08	0.2327
Echinococcus multilocularis	lamin	0.0111	0.08	0.0723
Schistosoma mansoni	lamin	0.0111	0.08	0.2137
Trichomonas vaginalis	esterase, putative	0.0075	0.0466	0.5
Toxoplasma gondii	LsmAD domain-containing protein	0.0128	0.0962	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.0465	0.135
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0053	0.0259	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0466	0.1353
Schistosoma mansoni	transcription factor LCR-F1	0.0113	0.0826	0.2213
Loa Loa (eye worm)	RNA binding protein	0.039	0.344	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0075	0.0466	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0466	0.1353
Plasmodium falciparum	ataxin-2 like protein, putative	0.0128	0.0962	0.5
Mycobacterium tuberculosis	Probable lipase LipE	0.0075	0.0466	0.1083
Loa Loa (eye worm)	MH2 domain-containing protein	0.0257	0.2183	0.6347
Brugia malayi	beta-lactamase family protein	0.0075	0.0466	0.1353
Leishmania major	hypothetical protein, conserved	0.0128	0.0962	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.0793	0.2306
Mycobacterium ulcerans	hypothetical protein	0.0075	0.0466	1
Schistosoma mansoni	tar DNA-binding protein	0.039	0.344	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0075	0.0466	0.1083
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0781	0.2271
Echinococcus multilocularis	musashi	0.0111	0.08	0.0723
Trypanosoma cruzi	PAB1-binding protein , putative	0.0128	0.0962	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0466	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.039	0.344	1
Brugia malayi	beta-lactamase	0.0075	0.0466	0.1353
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0466	0.1353
Mycobacterium ulcerans	esterase/lipase LipP	0.0075	0.0466	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 764965