TDR Targets

Basic information

Technical information

TDR Targets ID: 765025
Name: (5E)-5-[(4-ethoxy-3-methoxyphenyl)methylidene ]-2-(4-prop-2-enoxyphenyl)-[1,3]thiazolo[2,3- e][1,2,4]triazol-6-one
MW: 439.527 | Formula: C23H25N3O4S
H donors: 0 H acceptors: 3 LogP: 5.25 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: C=CCOc1ccc(cc1)C1NC2N(N1)C(=O)/C(=C\c1ccc(c(c1)OC)OCC)/S2
InChi: 1S/C23H21N3O4S/c1-4-12-30-17-9-7-16(8-10-17)21-24-23-26(25-21)22(27)20(31-23)14-15-6-11-18(29-5-2)19(13-15)28-3/h4,6-11,13-14H,1,5,12H2,2-3H3/b20-14+
InChiKey: SWTYYBUBFBRNHV-XSFVSMFZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5E)-2-(4-allyloxyphenyl)-5-[(4-ethoxy-3-methoxy-phenyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
(5E)-2-(4-allyloxyphenyl)-5-[(4-ethoxy-3-methoxyphenyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
(5E)-2-(4-allyloxyphenyl)-5-(4-ethoxy-3-methoxy-benzylidene)thiazolo[2,3-e][1,2,4]triazol-6-one
(5E)-5-[(4-ethoxy-3-methoxy-phenyl)methylidene]-2-(4-prop-2-enoxyphenyl)-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cellular tumor antigen P53	0.0103	0.1156	0.2417
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0348	0.0327
Brugia malayi	RNA binding protein	0.0343	0.4714	1
Echinococcus multilocularis	lamin dm0	0.0087	0.093	0.0911
Brugia malayi	Intermediate filament tail domain containing protein	0.0087	0.093	0.1974
Loa Loa (eye worm)	MH2 domain-containing protein	0.0255	0.3409	0.7232
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0718	0.1485
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0195	0.0612
Onchocerca volvulus		0.0038	0.0195	0.1689
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0195	0.0174
Entamoeba histolytica	hypothetical protein	0.0073	0.0718	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0058	0.0492	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0343	0.4714	1
Echinococcus granulosus	intermediate filament protein	0.0087	0.093	0.0911
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0195	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0348	0.0738
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0348	0.0738
Brugia malayi	hypothetical protein	0.0058	0.0492	0.1043
Echinococcus multilocularis	musashi	0.0087	0.093	0.0911
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.3191	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0058	0.0492	1
Mycobacterium ulcerans	lipase LipD	0.0038	0.0195	1
Schistosoma mansoni	tar DNA-binding protein	0.0343	0.4714	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0042	0.0262	0.0241
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0195	1
Schistosoma mansoni	lamin	0.0087	0.093	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0195	0.0414
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0348	0.0327
Schistosoma mansoni	tar DNA-binding protein	0.0343	0.4714	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0348	0.0327
Brugia malayi	MH2 domain containing protein	0.0255	0.3409	0.7232
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0195	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1171	0.2483
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0152	0.188	0.3987
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0239	0.0506
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0195	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0348	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0239	0.0506
Loa Loa (eye worm)	transcription factor SMAD2	0.0255	0.3409	0.7232
Entamoeba histolytica	hypothetical protein	0.0073	0.0718	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0087	0.093	0.1974
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0195	0.0174
Entamoeba histolytica	hypothetical protein	0.0073	0.0718	1
Onchocerca volvulus		0.0038	0.0195	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0195	0.0414
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0195	0.0414
Brugia malayi	latrophilin 2 splice variant baaae	0.0104	0.1171	0.2483
Brugia malayi	RNA recognition motif domain containing protein	0.0343	0.4714	1
Schistosoma mansoni	hypothetical protein	0.0104	0.1171	0.2449
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0195	0.0414
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0152	0.188	0.3987
Schistosoma mansoni	tar DNA-binding protein	0.0343	0.4714	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0195	0.0414
Trypanosoma cruzi	PAB1-binding protein , putative	0.0058	0.0492	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0718	0.0698
Brugia malayi	beta-lactamase family protein	0.0038	0.0195	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0492	0.1043
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0195	0.0612
Schistosoma mansoni	hypothetical protein	0.0073	0.0718	0.1485
Schistosoma mansoni	intermediate filament proteins	0.0087	0.093	0.1937
Echinococcus multilocularis	tar DNA binding protein	0.0343	0.4714	0.4703
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0195	0.5
Entamoeba histolytica	hypothetical protein	0.0073	0.0718	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0042	0.0262	0.0241
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0348	0.0738
Echinococcus multilocularis	tumor protein p63	0.0701	1	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0195	1
Brugia malayi	TAR-binding protein	0.0343	0.4714	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0195	0.0612
Brugia malayi	hypothetical protein	0.0073	0.0718	0.1524
Loa Loa (eye worm)	hypothetical protein	0.0087	0.093	0.1974
Loa Loa (eye worm)	hypothetical protein	0.0152	0.188	0.3987
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0195	0.5
Brugia malayi	beta-lactamase family protein	0.0038	0.0195	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0195	0.0414
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0718	0.0698
Leishmania major	hypothetical protein, conserved	0.0038	0.0195	0.3969
Trichomonas vaginalis	esterase, putative	0.0038	0.0195	0.5
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0195	1
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0195	0.0414
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0195	0.037
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0195	0.5
Onchocerca volvulus		0.0087	0.093	0.8051
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1156	0.2452
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0348	0.0327
Echinococcus granulosus	tar DNA binding protein	0.0343	0.4714	0.4703
Loa Loa (eye worm)	RNA binding protein	0.0343	0.4714	1
Loa Loa (eye worm)	intermediate filament protein	0.0087	0.093	0.1974
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0348	0.0327
Onchocerca volvulus		0.0103	0.1156	1
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0195	1
Loa Loa (eye worm)	TAR-binding protein	0.0343	0.4714	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0047	0.0331	0.0702
Echinococcus granulosus	lamin dm0	0.0087	0.093	0.0911
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0195	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0195	0.0414
Echinococcus multilocularis	lamin	0.0087	0.093	0.0911
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0195	0.0612
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0195	0.0612
Plasmodium vivax	ataxin-2 like protein, putative	0.0058	0.0492	1
Brugia malayi	beta-lactamase	0.0038	0.0195	0.0414
Trypanosoma brucei	PAB1-binding protein , putative	0.0058	0.0492	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0152	0.188	0.3987
Onchocerca volvulus		0.0038	0.0195	0.1689
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0195	1
Echinococcus granulosus	lamin	0.0087	0.093	0.0911
Schistosoma mansoni	tar DNA-binding protein	0.0343	0.4714	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0348	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0907	0.1924
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0195	0.037
Brugia malayi	hypothetical protein	0.0037	0.019	0.0402
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0195	0.5
Onchocerca volvulus		0.0087	0.093	0.8051
Schistosoma mansoni	lamin	0.0087	0.093	0.1937
Echinococcus granulosus	GPCR family 2	0.0048	0.0348	0.0327
Brugia malayi	intermediate filament protein	0.0087	0.093	0.1974
Brugia malayi	cytoplasmic intermediate filament protein	0.0047	0.0331	0.0702
Schistosoma mansoni	tar DNA-binding protein	0.0343	0.4714	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0348	0.0738
Schistosoma mansoni	hypothetical protein	0.0048	0.0348	0.0696
Plasmodium falciparum	ataxin-2 like protein, putative	0.0058	0.0492	0.5
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0195	0.0612
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0195	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0195	0.0414
Trypanosoma cruzi	PAB1-binding protein , putative	0.0058	0.0492	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0348	0.0696
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0195	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0262	0.0557
Leishmania major	hypothetical protein, conserved	0.0058	0.0492	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 765025