TDR Targets

Basic information

Technical information

TDR Targets ID: 769657
Name: 2-[(4-methoxyphenyl)sulfonyl-(4-methylphenyl) amino]-N-(3-methylphenyl)acetamide
MW: 424.513 | Formula: C23H24N2O4S
H donors: 1 H acceptors: 3 LogP: 4.23 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)C)CC(=O)Nc1cccc(c1)C
InChi: 1S/C23H24N2O4S/c1-17-7-9-20(10-8-17)25(16-23(26)24-19-6-4-5-18(2)15-19)30(27,28)22-13-11-21(29-3)12-14-22/h4-15H,16H2,1-3H3,(H,24,26)
InChiKey: BGCHMQAVCPOVDG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(4-methoxyphenyl)sulfonyl-(4-methylphenyl)amino]-N-(3-methylphenyl)ethanamide
EU-0012295

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	MH2 domain containing protein	0.0117	0.4696	1
Brugia malayi	beta-lactamase family protein	0.0037	0.1199	0.2553
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0011	0.0055	0.0102
Brugia malayi	chromobox protein homolog 3	0.0011	0.0055	0.0118
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0011	0.0055	0.0462
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0011	0.0055	0.5
Schistosoma mansoni	chromobox protein	0.0011	0.0055	0.0102
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.1199	0.2216
Schistosoma mansoni	lamin	0.0028	0.0789	0.1458
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.1199	1
Schistosoma mansoni	lamin	0.0028	0.0789	0.1458
Echinococcus multilocularis	chromobox protein 1	0.0011	0.0055	0.0102
Brugia malayi	Valyl-tRNA synthetase	0.0011	0.0055	0.0118
Onchocerca volvulus		0.0037	0.1199	1
Entamoeba histolytica	hypothetical protein	0.0011	0.0055	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.1199	0.2216
Echinococcus granulosus	chromobox protein 2	0.0011	0.0055	0.0111
Brugia malayi	Heterochromatin protein 1	0.0011	0.0055	0.0118
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.1199	0.5
Onchocerca volvulus		0.0011	0.0055	0.0462
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0055	0.5
Onchocerca volvulus		0.0028	0.0789	0.6581
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1199	0.2553
Echinococcus multilocularis	lamin	0.0028	0.0789	0.1458
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.4696	1
Entamoeba histolytica	hypothetical protein	0.0011	0.0055	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.1199	0.5
Echinococcus granulosus	intermediate filament protein	0.0028	0.0789	0.1586
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0055	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0055	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0055	0.0118
Loa Loa (eye worm)	heterochromatin protein 1	0.0011	0.0055	0.0118
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.1199	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0133	0.541	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.1199	1
Onchocerca volvulus		0.0037	0.1199	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1199	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0055	0.0118
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0789	0.168
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0156	0.0288
Loa Loa (eye worm)	CHromoDomain protein family member	0.0011	0.0055	0.0118
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0055	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0156	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0789	0.168
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.1199	0.2216
Brugia malayi	beta-lactamase	0.0037	0.1199	0.2553
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0011	0.0055	0.0102
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.1199	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1199	0.2553
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0055	0.0102
Brugia malayi	M-phase phosphoprotein, mpp8	0.0011	0.0055	0.0118
Leishmania major	hypothetical protein, conserved	0.0037	0.1199	0.5
Plasmodium falciparum	heterochromatin protein 1	0.0011	0.0055	0.5
Onchocerca volvulus		0.0028	0.0789	0.6581
Echinococcus multilocularis	Chromo domain	0.0011	0.0055	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1199	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0134	0.0285
Brugia malayi	CHD4 protein	0.0011	0.0055	0.0118
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0011	0.0055	0.0462
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0789	0.1458
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0011	0.0055	0.5
Echinococcus granulosus	chromobox protein 1	0.0011	0.0055	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0055	0.0118
Schistosoma mansoni	thyroid hormone receptor	0.0133	0.541	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0221	0.0471
Schistosoma mansoni	chromobox protein	0.0011	0.0055	0.0102
Echinococcus granulosus	Chromo domain	0.0011	0.0055	0.0111
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.4976	0.9197
Brugia malayi	intermediate filament protein	0.0028	0.0789	0.168
Echinococcus granulosus	lamin	0.0028	0.0789	0.1586
Schistosoma mansoni	chromobox protein	0.0011	0.0055	0.0102
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.1199	0.2553
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0011	0.0055	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0055	0.0118
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.1199	1
Echinococcus multilocularis	chromobox protein 2	0.0011	0.0055	0.0102
Mycobacterium leprae	Probable lipase LipE	0.0037	0.1199	0.5
Echinococcus granulosus	Chromobox protein 3	0.0011	0.0055	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0055	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1199	0.2553
Schistosoma mansoni	hypothetical protein	0.0123	0.4976	0.9197
Loa Loa (eye worm)	beta-lactamase	0.0037	0.1199	0.2553
Echinococcus granulosus	lamin dm0	0.0028	0.0789	0.1586
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0011	0.0055	0.0111
Echinococcus multilocularis	lamin dm0	0.0028	0.0789	0.1458
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0789	0.168
Entamoeba histolytica	hypothetical protein	0.0011	0.0055	0.5
Brugia malayi	hypothetical protein	0.0011	0.0055	0.0118
Echinococcus multilocularis	Chromobox protein 3	0.0011	0.0055	0.0102
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0011	0.0055	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0055	0.0118
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0011	0.0055	0.0102
Echinococcus granulosus	chromobox protein 1	0.0011	0.0055	0.0111
Echinococcus multilocularis	chromobox protein 1	0.0011	0.0055	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0055	0.0118
Echinococcus multilocularis	musashi	0.0028	0.0789	0.1458
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.1199	1
Brugia malayi	Associated with TFs and helicases family protein	0.0011	0.0055	0.0118
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.1199	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1199	0.2553
Schistosoma mansoni	thyroid hormone receptor	0.0133	0.541	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.4976	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.1199	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0767	0.1632
Onchocerca volvulus		0.0037	0.1199	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0134	0.0285
Schistosoma mansoni	chromobox protein	0.0011	0.0055	0.0102
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0156	0.0314
Brugia malayi	Protein cec-1.	0.0011	0.0055	0.0118
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.1199	0.5
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0221	0.0471
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0011	0.0055	0.0102
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.1199	0.2409
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.4696	1
Onchocerca volvulus		0.0011	0.0055	0.0462
Trichomonas vaginalis	esterase, putative	0.0037	0.1199	1
Onchocerca volvulus		0.0011	0.0055	0.0462
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0011	0.0055	0.0111
Brugia malayi	beta-lactamase family protein	0.0037	0.1199	0.2553
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0789	0.168
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.1266	1
Loa Loa (eye worm)	helicase	0.0011	0.0055	0.0118
Brugia malayi	SET domain containing protein	0.0011	0.0055	0.0118
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0011	0.0055	0.5
Toxoplasma gondii	ABC1 family protein	0.0037	0.1199	1
Schistosoma mansoni	hypothetical protein	0.0011	0.0055	0.0102

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 769657