Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1474 | 0.2529 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0811 | 0.1433 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0628 | 0.0518 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.2082 | 0.8191 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0085 | 0.2521 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0045 | 0.0899 | 0.0096 |
Trypanosoma cruzi | GMP reductase | 0.0085 | 0.2521 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0811 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0625 | 0.2189 |
Brugia malayi | GMP reductase | 0.0035 | 0.0525 | 0.1775 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0811 | 0.1391 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0811 | 0.0464 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0811 | 0.1433 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0085 | 0.2521 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.0811 | 0.0464 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0531 | 0.0911 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.008 | 0.2318 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0085 | 0.2521 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0811 | 0.0464 |
Leishmania major | guanosine monophosphate reductase | 0.0085 | 0.2521 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0811 | 0.1391 |
Onchocerca volvulus | 0.0042 | 0.0811 | 1 | |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0811 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0085 | 0.2521 | 1 |
Trypanosoma brucei | GMP reductase | 0.0085 | 0.2521 | 1 |
Onchocerca volvulus | 0.0042 | 0.0811 | 1 | |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0045 | 0.0899 | 0.0954 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0085 | 0.2521 | 0.1861 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0811 | 0.2954 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0811 | 0.1433 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0531 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0722 | 0.0989 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1474 | 0.2529 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0085 | 0.2521 | 0.4324 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0811 | 0.1433 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0811 | 0.2954 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0798 | 0.1368 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.0811 | 0.0464 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0811 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0085 | 0.2521 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0085 | 0.2521 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0811 | 0.1433 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0811 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.583 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0811 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 0.583 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0085 | 0.2521 | 0.4324 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.008 | 0.2318 | 0.8869 |
Echinococcus granulosus | geminin | 0.0167 | 0.583 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0085 | 0.2521 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.583 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0085 | 0.2521 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0811 | 0.1391 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.008 | 0.2318 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.0811 | 0.0464 |
Onchocerca volvulus | 0.0042 | 0.0811 | 1 | |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0085 | 0.2521 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0085 | 0.2521 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0811 | 0.0464 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0811 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0035 | 0.0525 | 0.1775 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.0811 | 0.0464 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0811 | 0.1433 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0085 | 0.2521 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0035 | 0.0525 | 0.1775 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0811 | 0.1433 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0811 | 0.1391 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0085 | 0.2521 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0811 | 0.2954 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.1617 | 0.2773 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0811 | 0.2954 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1912 | 0.695 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0811 | 0.1433 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0085 | 0.2521 | 0.4324 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 0.05 uM | Anti viral activity of the compound against VZV(Ito strain) in WI-38 cell monolayers. | ChEMBL. | 1316966 |
ID50 (functional) | = 0.05 uM | Anti viral activity of the compound against VZV(Ito strain) in WI-38 cell monolayers. | ChEMBL. | 1316966 |
ID50 (functional) | = 0.4 uM | Anti viral activity of the compound against VZV(Ellen strain) in WI-38 cell monolayers. | ChEMBL. | 1316966 |
ID50 (functional) | = 0.4 uM | Anti viral activity of the compound against VZV(Ellen strain) in WI-38 cell monolayers. | ChEMBL. | 1316966 |
ID50 (functional) | = 1.1 uM | Anti viral activity of the compound against VZV(9021 strain) in WI-38 cell monolayers. | ChEMBL. | 1316966 |
ID50 (functional) | = 1.1 uM | Anti viral activity of the compound against VZV(9021 strain) in WI-38 cell monolayers. | ChEMBL. | 1316966 |
ID50 (functional) | = 3.5 uM | Anti viral activity of the compound against HSV-1(Schooler) in WI-38 cell monolayers | ChEMBL. | 1316966 |
ID50 (functional) | = 3.5 uM | Anti viral activity of the compound against HSV-1(Schooler) in WI-38 cell monolayers | ChEMBL. | 1316966 |
ID50 (functional) | > 220 uM | Anti viral activity of the compound against VZV(Kanno-Kohmura(TK-) strain) in WI-38 cell monolayers. | ChEMBL. | 1316966 |
ID50 (functional) | > 220 uM | Anti viral activity of the compound against VZV(Kanno-Kohmura(TK-) strain) in WI-38 cell monolayers. | ChEMBL. | 1316966 |
ID50 (functional) | > 280 uM | Anti viral activity of the compound against HSV-2(186) in WI-38 cell monolayers | ChEMBL. | 1316966 |
ID50 (functional) | > 280 uM | Anti viral activity of the compound against HSV-2(186) in WI-38 cell monolayers | ChEMBL. | 1316966 |
ID50 (functional) | = 350 uM | Anti viral activity of the compound against HCMV(AD169) in WI-38 cell monolayers | ChEMBL. | 1316966 |
ID50 (functional) | = 350 uM | Anti viral activity of the compound against HCMV(AD169) in WI-38 cell monolayers | ChEMBL. | 1316966 |
ID50 (functional) | > 400 uM | Growth inhibitory activity of the compound against WI-38 cells | ChEMBL. | 1316966 |
ID50 (functional) | > 400 uM | Growth inhibitory activity of the compound against WI-38 cells | ChEMBL. | 1316966 |
Kinase activity (binding) | = 333 pM min-1*ml-1 | Kinase activity of the compound against purified VZV Thymidine kinase(conversion of the nucleoside analogue to its monophosphate by VZV -TK ) | ChEMBL. | 1316966 |
Kinase activity (binding) | = 333 pM min-1*ml-1 | Kinase activity of the compound against purified VZV Thymidine kinase(conversion of the nucleoside analogue to its monophosphate by VZV -TK ) | ChEMBL. | 1316966 |
Therapeutic index (functional) | > 2 | Therapeutic index of compound maesured as ratio of ID50 for WI-38 cell growth inhibition / ID50 anti-VZV(strain Ellen) | ChEMBL. | 1316966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.