Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0054 | 0.0723 | 0.3424 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.4836 | 0.4698 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.007 | 0.111 | 0.0872 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0075 | 0.1228 | 0.581 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.008 | 0.1339 | 0.6337 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0075 | 0.1228 | 0.581 |
Mycobacterium ulcerans | polyketide synthase | 0.0075 | 0.1228 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0113 | 0.2113 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.008 | 0.1339 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0113 | 0.2113 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0061 | 0.0878 | 0.4155 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0061 | 0.0878 | 0.4155 |
Loa Loa (eye worm) | fatty acid synthase | 0.0074 | 0.1204 | 0.0968 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0061 | 0.0878 | 0.4155 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.008 | 0.1339 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.005 | 0.0621 | 0.2941 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0063 | 0.0929 | 0.4398 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.2444 | 0.2242 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0054 | 0.0712 | 0.3708 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0049 | 0.0599 | 0.2574 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.008 | 0.1339 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0075 | 0.1228 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0062 | 0.0901 | 0.4267 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0075 | 0.1228 | 0.581 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.008 | 0.1339 | 0.6337 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.008 | 0.1339 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0073 | 0.1173 | 0.5551 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.008 | 0.1339 | 0.6337 |
Onchocerca volvulus | 0.0131 | 0.2553 | 0.9285 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0075 | 0.1228 | 0.581 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0063 | 0.0929 | 0.4398 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0075 | 0.1228 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0441 | 0.0185 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.007 | 0.111 | 0.5254 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.008 | 0.1339 | 0.6337 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0143 | 0.283 | 0.1935 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0043 | 0.0455 | 0.2155 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0026 | 0.0053 | 0.0251 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0075 | 0.1228 | 0.581 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0113 | 0.2113 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.003 | 0.0162 | 0.0765 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.005 | 0.0621 | 0.2941 |
Mycobacterium ulcerans | polyketide synthase | 0.008 | 0.1339 | 0.6337 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.008 | 0.1339 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0136 | 0.2664 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0075 | 0.1228 | 0.581 |
Mycobacterium ulcerans | thioesterase TesA | 0.0063 | 0.0929 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0075 | 0.1228 | 0.581 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0113 | 0.2113 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0063 | 0.0929 | 0.4398 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0075 | 0.1228 | 0.0132 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0073 | 0.1173 | 0.5551 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.005 | 0.0621 | 0.2941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.