TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 400.357 | Formula: C20H17FN2O6
H donors: 2 H acceptors: 4 LogP: 2.39 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OCC(=O)O)/C=C\1/NC(=O)N(C1=O)Cc1ccccc1F
InChi: 1S/C20H17FN2O6/c1-28-17-9-12(6-7-16(17)29-11-18(24)25)8-15-19(26)23(20(27)22-15)10-13-4-2-3-5-14(13)21/h2-9H,10-11H2,1H3,(H,22,27)(H,24,25)/b15-8+
InChiKey: WJOPMJHHCNTUCI-OVCLIPMQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	antigen, putative	0.0043	0.0275	0.2798
Brugia malayi	calpain family protein 1	0.0113	0.1107	0.3418
Echinococcus granulosus	calpain A	0.0118	0.1167	0.3605
Onchocerca volvulus		0.0055	0.0419	0.4962
Trypanosoma cruzi	cysteine peptidase, putative	0.0055	0.0419	0.1295
Plasmodium vivax	calpain, putative	0.0043	0.0275	0.456
Echinococcus granulosus	cathepsin L cysteine protease	0.0032	0.0154	0.0476
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0154	0.0476
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Loa Loa (eye worm)	hypothetical protein	0.0294	0.3237	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Brugia malayi	Cathepsin L-like precursor	0.0055	0.0419	0.1295
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0103	0.0983	0.3035
Echinococcus multilocularis	cysteine protease	0.0055	0.0419	0.0419
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0275	0.0849
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.0419	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0055	0.0419	0.1295
Echinococcus multilocularis	cathepsin L cysteine protease	0.0055	0.0419	0.0419
Trypanosoma cruzi	kinesin, putative	0.003	0.0123	0.0381
Onchocerca volvulus		0.0055	0.0419	0.4962
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0275	0.2798
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0154	0.0476
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0154	0.0476
Echinococcus multilocularis	cathepsin L cysteine protease	0.0055	0.0419	0.0419
Trypanosoma cruzi	cysteine peptidase, putative	0.0055	0.0419	0.1295
Loa Loa (eye worm)	hypothetical protein	0.01	0.0955	0.295
Echinococcus multilocularis	calpain family protein 1, d	0.0083	0.0754	0.0754
Plasmodium vivax	aspartyl proteinase, putative	0.0049	0.0355	0.7581
Echinococcus multilocularis	cathepsin b	0.0294	0.3237	0.3237
Schistosoma mansoni	calpain-7 (C02 family)	0.0043	0.0275	0.0849
Echinococcus multilocularis	hypothetical protein	0.0043	0.0275	0.0275
Loa Loa (eye worm)	hypothetical protein	0.004	0.0238	0.0736
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0419	0.4266
Schistosoma mansoni	cathepsin D (A01 family)	0.0146	0.1493	0.4611
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0419	0.4266
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0154	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0113	0.1107	0.3418
Brugia malayi	Cathepsin L-like precursor	0.004	0.0238	0.0736
Echinococcus multilocularis	cathepsin L	0.0032	0.0154	0.0154
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0043	0.0275	0.0849
Trypanosoma brucei	calpain-like protein, putative	0.0043	0.0275	0.2798
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0275	0.0849
Loa Loa (eye worm)	ctsf protein	0.0055	0.0419	0.1295
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0055	0.0419	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0275	0.0849
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0049	0.0355	0.0355
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Schistosoma mansoni	cathepsin D (A01 family)	0.0146	0.1493	0.4611
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0049	0.0355	0.1097
Brugia malayi	Cathepsin L-like precursor	0.0055	0.0419	0.1295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0419	0.4266
Echinococcus granulosus	cysteine protease	0.0032	0.0154	0.0476
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0055	0.0419	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0154	0.1567
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0055	0.0419	0.1295
Entamoeba histolytica	calpain large subunit domain III containing protein	0.003	0.0123	0.2945
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Echinococcus granulosus	calpain	0.0043	0.0275	0.0849
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0275	0.2798
Brugia malayi	calpain 5	0.003	0.0123	0.0381
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0055	0.0419	0.1295
Loa Loa (eye worm)	fibroinase	0.0055	0.0419	0.1295
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Echinococcus multilocularis	calpain 7 (C02 family)	0.0043	0.0275	0.0275
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Trypanosoma cruzi	kinesin, putative	0.003	0.0123	0.0381
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Plasmodium falciparum	plasmepsin II	0.0049	0.0355	0.7581
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Entamoeba histolytica	cysteine proteinase 2	0.0032	0.0154	0.3672
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0118	0.1167	0.3605
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0049	0.0355	0.1097
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.0238	0.5686
Echinococcus granulosus	cathepsin l1	0.0055	0.0419	0.1295
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Onchocerca volvulus		0.0055	0.0419	0.4962
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Echinococcus granulosus	cathepsin b	0.0294	0.3237	1
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.0419	0.1295
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0419	0.4266
Giardia lamblia	Cathepsin B precursor	0.0103	0.0983	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0275	0.2798
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0154	0.0476
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Plasmodium vivax	vivapain-2	0.0055	0.0419	1
Onchocerca volvulus		0.0055	0.0419	0.4962
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0275	0.0849
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0294	0.3237	1
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0275	0.2798
Entamoeba histolytica	cysteine proteinase 1, putative	0.0032	0.0154	0.3672
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Plasmodium vivax	vivapain-2	0.0055	0.0419	1
Onchocerca volvulus		0.0055	0.0419	0.4962
Plasmodium vivax	plasmepsin IV, putative	0.0049	0.0355	0.7581
Loa Loa (eye worm)	calpain family protein 1	0.0113	0.1107	0.3418
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0103	0.0983	0.3035
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0043	0.0275	0.0849
Onchocerca volvulus	Cathepsin L homolog	0.0055	0.0419	0.4962
Loa Loa (eye worm)	calpain 5	0.003	0.0123	0.0381
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Echinococcus granulosus	calpain 7 C02 family	0.0043	0.0275	0.0849
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0294	0.3237	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.004	0.0238	0.0736
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0	0.5
Trypanosoma brucei	calpain-like protein, putative	0.0043	0.0275	0.2798
Brugia malayi	Cathepsin L-like precursor	0.0055	0.0419	0.1295
Brugia malayi	cathepsin B-like cysteine proteinase	0.0294	0.3237	1
Leishmania major	cathepsin L-like protease	0.0055	0.0419	0.4266
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0049	0.0355	0.3613
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0294	0.3237	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0275	0.0849
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0275	0.0849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Brugia malayi	Cathepsin L-like precursor	0.004	0.0238	0.0736
Schistosoma mansoni	calpain-7 (C02 family)	0.0043	0.0275	0.0849
Schistosoma mansoni	cathepsin F (C01 family)	0.004	0.0238	0.0736
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0043	0.0275	0.2798
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0154	0.1567
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0154	0.1567
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0055	0.0419	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0032	0.0154	0.0476
Entamoeba histolytica	cysteine protease, putative	0.0055	0.0419	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0118	0.1167	0.3605
Echinococcus granulosus	cathepsin l1	0.004	0.0238	0.0736
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Trypanosoma brucei	calpain-like protein, putative	0.0043	0.0275	0.2798
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0154	0.3672
Onchocerca volvulus		0.0055	0.0419	0.4962
Onchocerca volvulus	Cathepsin F homolog	0.0055	0.0419	0.4962
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Trypanosoma cruzi	cysteine protease, putative	0.0032	0.0154	0.0476
Trypanosoma brucei	calpain-like protein, putative	0.0043	0.0275	0.2798
Leishmania major	cysteine peptidase A (CPA)	0.0055	0.0419	0.4266
Trypanosoma cruzi	cysteine peptidase, putative	0.0055	0.0419	0.1295
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0055	0.0419	0.0419
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0103	0.0983	1
Echinococcus multilocularis	calpain A	0.0118	0.1167	0.1167
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0419	0.4266
Toxoplasma gondii	cathepsin B	0.0103	0.0983	1
Entamoeba histolytica	cysteine proteinase, putative	0.0055	0.0419	1
Brugia malayi	Cathepsin L-like precursor	0.0055	0.0419	0.1295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Giardia lamblia	Cathepsin B precursor	0.0103	0.0983	1
Brugia malayi	Cathepsin L-like precursor	0.0055	0.0419	0.1295
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0	0.5
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0	0.5
Leishmania major	kinesin, putative	0.003	0.0123	0.1257
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0419	0.4266
Leishmania major	cathepsin L-like protease	0.0055	0.0419	0.4266
Leishmania major	cathepsin L-like protease	0.0055	0.0419	0.4266
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0032	0.0154	0.0476
Entamoeba histolytica	protein kinase, putative	0.003	0.0123	0.2945
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0154	0.1567
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0154	0.3672
Echinococcus granulosus	calpain 5	0.0043	0.0275	0.0849
Giardia lamblia	Cathepsin B precursor	0.0103	0.0983	1
Leishmania major	cathepsin L-like protease	0.0055	0.0419	0.4266
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0419	0.1295
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0103	0.0983	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0603	0.1862
Echinococcus multilocularis	cysteine protease	0.0055	0.0419	0.0419
Brugia malayi	cathepsin L-like precursor	0.004	0.0238	0.0736
Onchocerca volvulus		0.007	0.0603	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Schistosoma mansoni	cathepsin F (C01 family)	0.0055	0.0419	0.1295
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Leishmania major	cathepsin L-like protease	0.0055	0.0419	0.4266
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0055	0.0419	0.4266
Trypanosoma cruzi	cysteine peptidase, putative	0.0055	0.0419	0.1295
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0275	0.0849
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0419	0.4266
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0055	0.0419	0.0419
Brugia malayi	Cathepsin L-like precursor	0.0055	0.0419	0.1295
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Plasmodium falciparum	plasmepsin VI	0.0049	0.0355	0.7581
Schistosoma mansoni	calpain (C02 family)	0.0043	0.0275	0.0849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0238	0.2426
Schistosoma mansoni	calpain C (C02 family)	0.0043	0.0275	0.0849
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0118	0.1167	0.3605
Leishmania major	cathepsin L-like protease	0.0055	0.0419	0.4266
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0419	0.4266
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0055	0.0419	0.1295
Schistosoma mansoni	cathepsin F (C01 family)	0.0055	0.0419	0.1295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0238	0.2426
Loa Loa (eye worm)	hypothetical protein	0.004	0.0238	0.0736
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Loa Loa (eye worm)	calpain	0.0043	0.0275	0.0849
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0103	0.0983	1
Echinococcus multilocularis	calpain 5	0.0043	0.0275	0.0275
Loa Loa (eye worm)	calpain family protein 1	0.0083	0.0754	0.233
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0154	0.0476
Echinococcus granulosus	calpain A	0.0043	0.0275	0.0849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0055	0.0419	0.4266
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0055	0.0419	0.4266
Onchocerca volvulus	Cathepsin L homolog	0.0055	0.0419	0.4962
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0154	0.3672
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Trypanosoma cruzi	cysteine proteinase, putative	0.0032	0.0154	0.0476
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0154	0.3672
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0419	0.4266
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0049	0.0355	0.1097
Loa Loa (eye worm)	cysteine protease	0.0055	0.0419	0.1295
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0294	0.3237	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.004	0.0238	0.0736
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0113	0.1107	0.3418
Echinococcus multilocularis	cathepsin b	0.0294	0.3237	0.3237
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0154	0.3672
Trypanosoma brucei	kinesin, putative	0.003	0.0123	0.1257
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0118	0.1167	0.1167
Brugia malayi	calpain 7	0.0043	0.0275	0.0849
Echinococcus granulosus	cathepsin L	0.0032	0.0154	0.0476
Leishmania major	cathepsin L-like protease	0.0055	0.0419	0.4266
Echinococcus multilocularis	calpain	0.0043	0.0275	0.0275
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0419	0.4266
Onchocerca volvulus		0.0055	0.0419	0.4962
Plasmodium falciparum	plasmepsin IV	0.0049	0.0355	0.7581
Loa Loa (eye worm)	cathepsin B	0.0103	0.0983	0.3035
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0754	0.233
Toxoplasma gondii	cathepsin CPL	0.0055	0.0419	0.1022
Loa Loa (eye worm)	hypothetical protein	0.004	0.0238	0.0736
Trypanosoma cruzi	cruzipain precursor, putative	0.0055	0.0419	0.1295
Brugia malayi	calpain family protein 1	0.0113	0.1107	0.3418
Leishmania major	cathepsin L-like protease	0.0055	0.0419	0.4266
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0043	0.0275	0.0849
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0043	0.0275	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0355	0.1097
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0294	0.3237	1
Plasmodium falciparum	plasmepsin I	0.0049	0.0355	0.7581
Echinococcus granulosus	cathepsin b	0.0294	0.3237	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 777073