Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.4716 | 0.1027 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.024 | 0.7168 | 0.7168 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.024 | 0.7168 | 0.6974 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.316 | 0.316 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2996 | 0.2996 |
Echinococcus granulosus | beta galactosidase | 0.0137 | 0.2996 | 0.2517 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0209 | 0.5925 | 0.5646 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.031 | 1 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.024 | 0.7168 | 0.6974 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2996 | 0.2996 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0209 | 0.5925 | 0.5646 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.026 | 0.7974 | 0.7974 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.026 | 0.7974 | 0.2846 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.4716 | 0.1027 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.024 | 0.7168 | 0.4993 |
Schistosoma mansoni | alpha-glucosidase | 0.031 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.031 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Onchocerca volvulus | 0.031 | 1 | 1 | |
Schistosoma mansoni | beta-galactosidase | 0.0137 | 0.2996 | 0.2517 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.031 | 1 | 1 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0079 | 0.0641 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.024 | 0.7168 | 0.6974 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0209 | 0.5925 | 0.5646 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0209 | 0.5925 | 0.5646 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.0079 | 0.0641 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.031 | 1 | 1 |
Echinococcus multilocularis | beta galactosidase | 0.0137 | 0.2996 | 0.2517 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0209 | 0.5925 | 0.5646 |
Schistosoma mansoni | alpha-glucosidase | 0.031 | 1 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0109 | 0.1837 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.024 | 0.7168 | 0.6974 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0079 | 0.0641 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.026 | 0.7974 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0209 | 0.5925 | 0.5646 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C10 (functional) | = 58.7 uM | Concentration required to reduce plating efficiency to 10 percent of controls, under aerobic conditions in mouse SCCVII tumor cells. | ChEMBL. | 12502371 |
C10 (functional) | = 67.7 uM | Concentration required to reduce plating efficiency to 10 percent of controls, under hypoxic conditions in mouse SCCVII tumor cells. | ChEMBL. | 12502371 |
HCR (functional) | = 0.87 | Intraexperimental difference between the hypoxic and aerobic cytotoxicity | ChEMBL. | 12502371 |
RHT (functional) | = 0.15 | Intraexperimental ratio of hypoxic TPZ C10 to hypoxic BTO C10 in mouse SCCVII tumor cells. | ChEMBL. | 12502371 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.