TDR Targets

Basic information

Technical information

TDR Targets ID: 780740
Name: 2-(3-hydroxyphenyl)-4-nitroisoindole-1,3-dion e
MW: 284.224 | Formula: C14H8N2O5
H donors: 1 H acceptors: 5 LogP: 1.93 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cccc(c1)N1C(=O)c2c(C1=O)cccc2[N+](=O)[O-]
InChi: 1S/C14H8N2O5/c17-9-4-1-3-8(7-9)15-13(18)10-5-2-6-11(16(20)21)12(10)14(15)19/h1-7,17H
InChiKey: VARVCHCPSUXGSP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(3-hydroxyphenyl)-4-nitro-isoindoline-1,3-dione
2-(3-hydroxyphenyl)-4-nitroisoindoline-1,3-dione
2-(3-hydroxyphenyl)-4-nitro-isoindoline-1,3-quinone
2-(3-hydroxyphenyl)-4-nitro-isoindole-1,3-dione
2-(3-Hydroxy-phenyl)-4-nitro-isoindole-1,3-dione
BAS 00086877
Oprea1_377543
ST5298989
Oprea1_292636
ZINC00227047

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0036	0.0428	0.0428
Leishmania major	lysyl-tRNA synthetase, putative	0.0026	0.0286	0.5689
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0435	0.8651
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0041	0.0503	1
Plasmodium falciparum	lysine--tRNA ligase	0.0026	0.0286	0.0399
Chlamydia trachomatis	lysine--tRNA ligase	0.0026	0.0286	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0041	0.0503	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0115	0.0709
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0435	0.269
Onchocerca volvulus		0.0016	0.0145	0.5
Leishmania major	hypothetical protein, conserved	0.0016	0.0145	0.2874
Onchocerca volvulus		0.0016	0.0145	0.5
Trypanosoma cruzi	sugar transporter, putative	0.0016	0.0145	0.2874
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0036	0.0429	0.0597
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0428	0.0428
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0435	0.8651
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0493	0.7179	1
Onchocerca volvulus		0.0016	0.0145	0.5
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0435	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.002	0.0194	0.386
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0435	0.269
Brugia malayi	hypothetical protein	0.0016	0.0145	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0116	0.1618	0.1618
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0435	0.8651
Plasmodium falciparum	protein kinase 6	0.0493	0.7179	1
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0145	0.0145
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Entamoeba histolytica	protein kinase, putative	0.0036	0.0428	1
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0435	0.8651
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0145	0.0145
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0145	0.0894
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0145	0.0145
Toxoplasma gondii	facilitative glucose transporter GT1	0.0116	0.1618	0.3408
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Echinococcus granulosus	solute carrier family 22	0.0016	0.0145	0.0145
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0026	0.0286	0.1769
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0145	0.0894
Echinococcus granulosus	lysyl tRNA synthetase	0.0026	0.0286	0.0286
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0145	0.0145
Schistosoma mansoni	glucose transport protein	0.0116	0.1618	0.1618
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.1618	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Onchocerca volvulus		0.0016	0.0145	0.5
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0145	0.0145
Brugia malayi	Cam kinase protein 1	0.0036	0.0428	0.2648
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0036	0.0428	0.0428
Plasmodium falciparum	protein kinase 7	0.0328	0.4747	0.6612
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0041	0.0503	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0145	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0286	0.1769
Toxoplasma gondii	transporter, major facilitator family protein	0.0016	0.0145	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Trichomonas vaginalis	CAMK family protein kinase	0.0036	0.0428	0.2648
Onchocerca volvulus		0.0016	0.0145	0.5
Trypanosoma brucei	glucose transporter 1E	0.0036	0.0435	0.8651
Toxoplasma gondii	sugar transporter ST1	0.0016	0.0145	0.0305
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0435	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0016	0.0145	0.0201
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0036	0.0428	0.0428
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0026	0.0286	0.5689
Toxoplasma gondii	sugar transporter ST2	0.0016	0.0145	0.0305
Onchocerca volvulus		0.0016	0.0145	0.5
Brugia malayi	hypothetical protein	0.0016	0.0145	0.0894
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.0396	0.0396
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0036	0.0429	0.0597
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0036	0.0429	0.0597
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0036	0.0429	0.0597
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0035	0.0418	0.0418
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0145	0.5052
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0036	0.0428	0.2648
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0016	0.0145	0.6328
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0022	0.0229	1
Echinococcus multilocularis	General substrate transporter	0.01	0.1377	0.1377
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Onchocerca volvulus		0.0016	0.0145	0.5
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0435	0.8651
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0145	0.0145
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0036	0.0429	0.0903
Plasmodium vivax	sugar transporter, putative	0.0016	0.0145	0.0201
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0016	0.0145	0.6328
Loa Loa (eye worm)	sugar transporter	0.0116	0.1618	1
Brugia malayi	Sugar transporter family protein	0.0016	0.0145	0.0894
Toxoplasma gondii	protein kinase, putative	0.0328	0.4747	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Brugia malayi	hypothetical protein	0.0016	0.0145	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Echinococcus granulosus	solute carrier family 22	0.0016	0.0145	0.0145
Onchocerca volvulus	Putative transporter	0.0016	0.0145	0.5
Onchocerca volvulus		0.0016	0.0145	0.5
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0116	0.1618	0.1618
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0145	0.5052
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Leishmania major	glucose transporter, lmgt1	0.0036	0.0435	0.8651
Onchocerca volvulus		0.0016	0.0145	0.5
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0435	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0145	0.0894
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0036	0.0435	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0428	0.2648
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0435	0.8651
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0116	0.1618	0.1618
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0145	0.0145
Schistosoma mansoni	glucose transport protein	0.0116	0.1618	0.1618
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Trichomonas vaginalis	myo-inositol transporter, putative	0.0016	0.0145	0.0894
Schistosoma mansoni	microtubule-associated protein tau	0.0685	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0145	0.0894
Echinococcus granulosus	General substrate transporter	0.01	0.1377	0.1377
Trypanosoma cruzi	hexose transporter, putative	0.0016	0.0145	0.2874
Toxoplasma gondii	lysine-tRNA ligase	0.0026	0.0286	0.0603
Giardia lamblia	Prolyl-tRNA synthetase	0.0035	0.0418	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.1618	0.1618
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Chlamydia trachomatis	proline--tRNA ligase	0.0012	0.0085	0.2978
Toxoplasma gondii	sugar transporter ST3	0.0016	0.0145	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0035	0.0418	0.0418
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0036	0.0429	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0418	0.2583
Plasmodium falciparum	proline--tRNA ligase	0.0041	0.0503	0.0701
Schistosoma mansoni	protein kinase	0.0036	0.0428	0.0428
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0035	0.0418	0.0418
Leishmania major	glucose transporter, lmgt3	0.0036	0.0435	0.8651
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0026	0.0286	0.5689
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0145	0.0145
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0145	0.0894
Plasmodium vivax	proline--tRNA ligase, putative	0.0041	0.0503	0.0701
Leishmania major	myo-inositol/proton symporter (MIT)	0.0016	0.0145	0.2874
Trypanosoma cruzi	hexose transporter	0.0036	0.0435	0.8651
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0036	0.0428	0.8517
Brugia malayi	Sugar transporter family protein	0.0116	0.1618	1
Schistosoma mansoni	serine/threonine protein kinase	0.0036	0.0428	0.0428
Echinococcus multilocularis	lysyl tRNA synthetase	0.0026	0.0286	0.0286
Onchocerca volvulus		0.0016	0.0145	0.5
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0036	0.0429	0.0597
Plasmodium vivax	hexose transporter	0.0116	0.1618	0.2253
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.1618	0.1618
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Mycobacterium ulcerans	sugar transporter	0.0016	0.0145	0.5052
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0012	0.0085	0.2978
Giardia lamblia	Lysyl-tRNA synthetase	0.0026	0.0286	0.6849
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0035	0.0418	0.9752
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Loa Loa (eye worm)	sugar transporter	0.0016	0.0145	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0035	0.0418	0.2583
Schistosoma mansoni	protein kinase	0.0036	0.0428	0.0428
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0188	0.2674	0.3724
Schistosoma mansoni	hypothetical protein	0.0116	0.1618	0.1618
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0036	0.0429	0.0597
Schistosoma mansoni	protein kinase	0.0036	0.0428	0.0428
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0286	1
Trichomonas vaginalis	sugar transport protein, putative	0.0016	0.0145	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Trypanosoma brucei	sugar transporter, putative	0.0016	0.0145	0.2874
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0016	0.0145	0.2874
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0435	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Schistosoma mansoni	sugar transporter	0.0016	0.0145	0.0145
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0036	0.0428	0.0428
Brugia malayi	lysyl-tRNA synthetase	0.0026	0.0286	0.1769
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.1618	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0428	0.0428
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0435	0.8651
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0116	0.1618	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0418	0.2583
Trichomonas vaginalis	glucose transporter, putative	0.0036	0.0435	0.269
Trichomonas vaginalis	glucose transporter, putative	0.0016	0.0145	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0041	0.0503	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0145	0.0145
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Schistosoma mansoni	sugar transporter	0.0016	0.0145	0.0145
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0041	0.0503	0.106
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Plasmodium falciparum	hexose transporter	0.0116	0.1618	0.2253
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0188	0.2674	0.5632
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0428	0.0428
Entamoeba histolytica	protein kinase, putative	0.0036	0.0428	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0036	0.0429	0.0597
Trypanosoma brucei	glucose transporter 2A	0.0036	0.0435	0.8651
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0036	0.0429	0.0903
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0188	0.2674	0.3724
Echinococcus multilocularis	microtubule associated protein 2	0.0685	1	1
Echinococcus granulosus	solute carrier family 22	0.0016	0.0145	0.0145
Echinococcus granulosus	solute carrier family 22	0.0016	0.0145	0.0145
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0435	0.269
Onchocerca volvulus		0.0016	0.0145	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0145	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0036	0.0435	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0035	0.0418	0.2583
Schistosoma mansoni	sugar transporter	0.0016	0.0145	0.0145
Brugia malayi	major facilitator superfamily protein	0.0016	0.0145	0.0894
Giardia lamblia	Sugar-proton symporter	0.0016	0.0145	0.346
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Brugia malayi	major facilitator superfamily protein	0.0016	0.0145	0.0894
Onchocerca volvulus		0.0016	0.0145	0.5
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0035	0.0418	1
Leishmania major	glucose transporter, lmgt2	0.0036	0.0435	0.8651
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0116	0.1618	0.1618
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0036	0.0435	0.8651
Onchocerca volvulus		0.0016	0.0145	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.0396	0.0396
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0035	0.0418	0.0418
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0145	0.5052
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0036	0.0428	0.2648
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0026	0.0286	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0239	0.1477
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0145	0.0894
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0035	0.0418	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0229	0.5469
Trypanosoma cruzi	glucose transporter, putative	0.0016	0.0145	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0435	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0145	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0036	0.0435	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0145	0.0894
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0286	0.0286
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0145	0.0894
Leishmania major	protein kinase, putative	0.0036	0.0428	0.8517
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0229	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Onchocerca volvulus		0.0016	0.0145	0.5
Onchocerca volvulus		0.0016	0.0145	0.5
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0145	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0036	0.0429	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0321	0.1987
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0435	0.269
Onchocerca volvulus		0.0016	0.0145	0.5
Schistosoma mansoni	glucose transport protein	0.0116	0.1618	0.1618
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0036	0.0428	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Giardia lamblia	Hexose transporter	0.0016	0.0145	0.346
Schistosoma mansoni	glucose transporter	0.0016	0.0145	0.0145
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0036	0.0429	0.0597
Entamoeba histolytica	hypothetical protein	0.0026	0.0286	0.6679
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0036	0.0428	0.0428
Schistosoma mansoni	sugar transporter	0.0016	0.0145	0.0145
Trypanosoma brucei	glucose transporter, putative	0.0036	0.0435	0.8651
Plasmodium vivax	lysine--tRNA ligase, putative	0.0026	0.0286	0.0399
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0026	0.0286	0.6849
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.0085	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0026	0.0286	0.0286
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0041	0.0503	1
Brugia malayi	Sugar transporter family protein	0.0016	0.0145	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0145	0.0894

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 780740