Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Onchocerca volvulus | Alpha 1,3 fucosyltransferase homolog | 0.0044 | 0.2265 | 0.5 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0044 | 0.2265 | 1 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0044 | 0.2265 | 1 |
Brugia malayi | alpha1,3-fucosyltransferase homologue | 0.0104 | 1 | 0.5 |
Echinococcus multilocularis | alpha(13)fucosyltransferase | 0.0044 | 0.2265 | 1 |
Echinococcus multilocularis | alpha(13)fucosyltransferase | 0.0044 | 0.2265 | 1 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0044 | 0.2265 | 1 |
Echinococcus granulosus | alpha13fucosyltransferase | 0.0044 | 0.2265 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0104 | 1 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0104 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2265 | 0.2265 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0044 | 0.2265 | 1 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0044 | 0.2265 | 1 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0044 | 0.2265 | 1 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0044 | 0.2265 | 1 |
Echinococcus multilocularis | glycoprotein 3 alpha L fucosyltransferase | 0.0044 | 0.2265 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0104 | 1 | 1 |
Echinococcus granulosus | glycoprotein 3 alpha L fucosyltransferase | 0.0044 | 0.2265 | 1 |
Loa Loa (eye worm) | fucosyl transferase | 0.0104 | 1 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0104 | 1 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0104 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.2 nM | Binding affinity for diazepam sensitive (DS) isoform of the benzodiazepine (Bz) binding site on GABAA receptors | ChEMBL. | 8390574 |
Ki (binding) | = 2.2 nM | Binding affinity for diazepam sensitive (DS) isoform of the benzodiazepine (Bz) binding site on GABAA receptors | ChEMBL. | 8390574 |
Ki (binding) | = 2810 nM | Binding affinity for diazepam insensitive (DI) isoform of the benzodiazepine (Bz) binding site on GABAA receptors | ChEMBL. | 8390574 |
Ki (binding) | = 2810 nM | Binding affinity for diazepam insensitive (DI) isoform of the benzodiazepine (Bz) binding site on GABAA receptors | ChEMBL. | 8390574 |
Ratio (binding) | = 1277 | Ratio of binding affinity against DI Bz receptor to that of DS Bz receptor | ChEMBL. | 8390574 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.