TDR Targets

Basic information

Technical information

TDR Targets ID: 784641
Name: 2-[(3-methylphenyl)amino]-N-[(3,4,5-trimethox yphenyl)methylideneamino]acetamide
MW: 357.404 | Formula: C19H23N3O4
H donors: 2 H acceptors: 1 LogP: 3.16 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(C=NNC(=O)CNc2cccc(c2)C)cc(c1OC)OC
InChi: 1S/C19H23N3O4/c1-13-6-5-7-15(8-13)20-12-18(23)22-21-11-14-9-16(24-2)19(26-4)17(10-14)25-3/h5-11,20H,12H2,1-4H3,(H,22,23)/b21-11+
InChiKey: PFULLCPDNZNVFW-SRZZPIQSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(3-methylphenyl)amino]-N-[(3,4,5-trimethoxyphenyl)methyleneamino]acetamide
2-[(3-methylphenyl)amino]-N-[(3,4,5-trimethoxybenzylidene)amino]acetamide
2-[(3-methylphenyl)amino]-N-[(3,4,5-trimethoxyphenyl)methylideneamino]ethanamide
A0664/0030909

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0033	0.0265	0.1193
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0562	0.7015	1
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3157	0.2283
Leishmania major	pteridine reductase 1	0.0042	0.0373	0.1806
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0463	0.1417
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.1336	0.4232
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0169	0.0534
Leishmania major	oxidoreductase-like protein	0.0042	0.0373	0.1806
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0042	0.0373	0.0074
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0042	0.0373	0.0074
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0598	0.2923
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3157	0.2283
Schistosoma mansoni	hypothetical protein	0.0166	0.1961	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0598	0.0411
Onchocerca volvulus		0.0042	0.0373	0.1075
Echinococcus multilocularis	tumor protein p63	0.034	0.418	0.418
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0035	0.0084
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.1426	0.7224
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0035	0.0054
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0562	0.7015	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0463	0.1466
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.2132	0.0235
Onchocerca volvulus	Glucosylceramidase homolog	0.0171	0.2015	1
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.1426	0.7224
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.1336	0.4232
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0038	0.0323	0.1496
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0124	0.1426	0.4518
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0265	0.0839
Trypanosoma brucei	oxidoreductase-like protein	0.0042	0.0373	1
Onchocerca volvulus		0.005	0.0473	0.1618
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0035	0.0035
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0265	0.0786
Echinococcus granulosus	tar DNA binding protein	0.0124	0.1426	0.3412
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0038	0.0323	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0598	0.0411
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0463	0.1466
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0038	0.0323	0.0972
Brugia malayi	intermediate filament protein	0.0026	0.0175	0.05
Loa Loa (eye worm)	TAR-binding protein	0.0124	0.1426	0.4518
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0018	0.0057
Mycobacterium tuberculosis	Probable oxidoreductase	0.0042	0.0373	0.0074
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0038	0.0323	0.0323
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0175	0.0554
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3157	0.2283
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0175	0.0554
Schistosoma mansoni	hypothetical protein	0.0166	0.1961	1
Echinococcus multilocularis	lamin dm0	0.0026	0.0175	0.0175
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.026	0.3157	1
Echinococcus granulosus	lamin dm0	0.0026	0.0175	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0035	0.0111
Loa Loa (eye worm)	oxidoreductase	0.0038	0.0323	0.1023
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.1426	0.7224
Mycobacterium ulcerans	short chain dehydrogenase	0.0042	0.0373	0.0074
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0042	0.0373	1
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0562	0.7015	1
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0562	0.7015	1
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0473	0.2273
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0562	0.7015	1
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0038	0.0323	0.1023
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0598	0.2923
Echinococcus granulosus	GPCR family 2	0.0016	0.0035	0.0084
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.026	0.3157	1
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0562	0.7015	1
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.1426	0.7224
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3157	0.2283
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0035	0.0054
Schistosoma mansoni	lamin	0.0026	0.0175	0.0727
Brugia malayi	TAR-binding protein	0.0124	0.1426	0.4487
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0562	0.7015	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0598	0.0598
Echinococcus multilocularis	lamin	0.0026	0.0175	0.0175
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0035	0.0035
Loa Loa (eye worm)	RNA binding protein	0.0124	0.1426	0.4518
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0042	0.0373	0.0074
Echinococcus multilocularis	tar DNA binding protein	0.0124	0.1426	0.1426
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0175	0.0727
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0042	0.0373	0.0074
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0463	0.1417
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0598	0.0411
Onchocerca volvulus		0.0038	0.0323	0.0805
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0035	0.0111
Trichomonas vaginalis	hypothetical protein	0.0562	0.7015	1
Echinococcus granulosus	lamin	0.0026	0.0175	0.0418
Echinococcus multilocularis	geminin	0.0166	0.1961	0.1961
Brugia malayi	RNA recognition motif domain containing protein	0.0124	0.1426	0.4487
Brugia malayi	MH2 domain containing protein	0.0117	0.1336	0.4199
Schistosoma mansoni	lamin	0.0026	0.0175	0.0727
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0038	0.0323	0.0972
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.2132	0.0235
Schistosoma mansoni	dihydropteridine reductase	0.0038	0.0323	0.1496
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0598	0.0411
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.1426	0.7224
Echinococcus granulosus	tumor protein p63	0.034	0.418	1
Echinococcus multilocularis	musashi	0.0026	0.0175	0.0175
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3157	0.2283
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0038	0.0323	0.0773
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0035	0.0084
Echinococcus granulosus	geminin	0.0166	0.1961	0.469
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0175	0.05
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0562	0.7015	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0598	0.0411
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.3157	0.2283
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	0.0554
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0598	1
Echinococcus granulosus	intermediate filament protein	0.0026	0.0175	0.0418
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0035	0.0035
Brugia malayi	RNA binding protein	0.0124	0.1426	0.4487
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0323	0.1023
Loa Loa (eye worm)	hypothetical protein	0.005	0.0473	0.1497
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0038	0.0323	0.1023
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0598	0.143

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 784641