Detailed information for compound 793438

Basic information

Technical information
  • TDR Targets ID: 793438
  • Name: N-cyclohexyl-2-(4-fluorophenyl)imidazo[3,2-a] pyrazin-3-amine
  • MW: 310.369 | Formula: C18H19FN4
  • H donors: 1 H acceptors: 2 LogP: 4.58 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1nc2n(c1NC1CCCCC1)ccnc2
  • InChi: 1S/C18H19FN4/c19-14-8-6-13(7-9-14)17-18(21-15-4-2-1-3-5-15)23-11-10-20-12-16(23)22-17/h6-12,15,21H,1-5H2
  • InChiKey: CECLWINCPAKRSB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-cyclohexyl-2-(4-fluorophenyl)-3-imidazo[3,2-a]pyrazinamine
  • cyclohexyl-[2-(4-fluorophenyl)imidazo[3,2-a]pyrazin-3-yl]amine
  • ZINC03896477
  • STK228065

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Echinococcus granulosus p2X purinoceptor 4 0.0294 0.8566 0.8552
Loa Loa (eye worm) hypothetical protein 0.015 0.3971 0.6657
Loa Loa (eye worm) hypothetical protein 0.005 0.0744 0.1248
Brugia malayi Bromodomain containing protein 0.003 0.0111 0.0185
Brugia malayi Pre-SET motif family protein 0.0212 0.5964 1
Brugia malayi carbohydrate phosphorylase 0.0122 0.3067 0.5143
Schistosoma mansoni glycogen phosphorylase 0.0122 0.3067 0.3497
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.2183 0.2106
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.3827 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0335 0.0561
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1204 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1204 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0335 0.0265
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0111 0.0185
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0484 0.039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0133 0.0027
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0111 0.3305
Trichomonas vaginalis glycogen phosphorylase, putative 0.0122 0.3067 0.326
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0311 0.0237
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.068 0.0588
Chlamydia trachomatis glycogen phosphorylase 0.0122 0.3067 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.2448 0.4104
Brugia malayi jmjC domain containing protein 0.0036 0.0311 0.0522
Schistosoma mansoni P2X receptor subunit 0.0294 0.8566 1
Onchocerca volvulus 0.0037 0.0335 0.033
Echinococcus multilocularis p2X purinoceptor 4 0.0294 0.8566 0.855
Schistosoma mansoni P2X receptor subunit 0.0294 0.8566 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.068 0.0576
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0133 0.0027
Echinococcus multilocularis tumor protein p63 0.0338 1 1
Echinococcus granulosus geminin 0.0169 0.4567 0.4513
Onchocerca volvulus 0.0242 0.6905 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.2183 0.366
Schistosoma mansoni hypothetical protein 0.0169 0.4567 0.527
Echinococcus granulosus GPCR family 2 0.0048 0.068 0.0588
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.2183 0.2106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.8717 1
Trichomonas vaginalis set domain proteins, putative 0.0242 0.6905 0.7838
Brugia malayi Latrophilin receptor protein 2 0.0048 0.068 0.114
Loa Loa (eye worm) beta-lactamase 0.0037 0.0335 0.0561
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0335 0.2779
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0335 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2183 0.2451
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1204 1
Leishmania major cathepsin L-like protease 0.0064 0.1204 1
Echinococcus granulosus Glycosyl transferase family 35 0.0122 0.3067 0.2999
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.2183 0.366
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0335 0.0239
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.068 0.114
Entamoeba histolytica glycogen phosphorylase, putative 0.0122 0.3067 0.2821
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.8717 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.8717 1
Schistosoma mansoni hypothetical protein 0.0169 0.4567 0.527
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.3971 0.6657
Echinococcus multilocularis GPCR, family 2 0.0048 0.068 0.0576
Loa Loa (eye worm) hypothetical protein 0.0048 0.068 0.114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.8717 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0792 0.1328
Loa Loa (eye worm) hypothetical protein 0.0037 0.0335 0.0561
Schistosoma mansoni glycogen phosphorylase 0.0053 0.0848 0.0872
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.2183 0.2095
Brugia malayi beta-lactamase family protein 0.0037 0.0335 0.0561
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.6681 1
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.1204 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.0122 0.3067 0.326
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0311 0.0522
Schistosoma mansoni hypothetical protein 0.0048 0.068 0.0673
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0133 0.0027
Brugia malayi jmjC domain containing protein 0.0097 0.228 0.3823
Onchocerca volvulus 0.003 0.0133 0.0034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.3971 0.6657
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0335 0.0561
Onchocerca volvulus 0.0037 0.0335 0.033
Leishmania major hypothetical protein, conserved 0.0037 0.0335 0.2779
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.3827 0.5503
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0133 0.0023
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0133 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Echinococcus multilocularis Glycosyl transferase, family 35 0.0122 0.3067 0.299
Brugia malayi beta-lactamase 0.0037 0.0335 0.0561
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0766 0.6362
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0133 0.3987
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0335 0.2779
Brugia malayi beta-lactamase family protein 0.0037 0.0335 0.0561
Giardia lamblia Fructose-bisphosphate aldolase 0.0298 0.8717 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0111 0.0185
Loa Loa (eye worm) hypothetical protein 0.0037 0.0335 0.0561
Echinococcus multilocularis geminin 0.0169 0.4567 0.4506
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.8717 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0335 1
Echinococcus granulosus p2X purinoceptor 4 0.0294 0.8566 0.8552
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.8717 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.228 0.2204
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0311 0.0237
Loa Loa (eye worm) hypothetical protein 0.003 0.0133 0.0224
Loa Loa (eye worm) hypothetical protein 0.0037 0.0335 0.0561
Loa Loa (eye worm) hypothetical protein 0.0037 0.0335 0.0561
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0053 0.0848 0.1469
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.228 0.2194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0133 0.0027
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0053 0.0848 0.0808
Echinococcus multilocularis p2X purinoceptor 4 0.0294 0.8566 0.855
Echinococcus granulosus glycogen phosphorylase 0.0122 0.3067 0.2999
Schistosoma mansoni glycogen phosphorylase 0.0122 0.3067 0.3497
Treponema pallidum fructose-bisphosphate aldolase 0.0298 0.8717 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.8717 1
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0744 0.0749
Echinococcus multilocularis glycogen phosphorylase 0.0122 0.3067 0.299
Brugia malayi PHD-finger family protein 0.003 0.0111 0.0185
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0111 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.8717 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0133 0.0036
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0311 0.0203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.2183 0.2095
Plasmodium vivax SET domain protein, putative 0.003 0.0133 0.3987
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0335 0.2779
Giardia lamblia Glycogen phosphorylase 0.0122 0.3067 0.3435
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.068 0.0576
Schistosoma mansoni hypothetical protein 0.0048 0.068 0.0673
Echinococcus multilocularis glycogen phosphorylase 0.0122 0.3067 0.299
Entamoeba histolytica glycogen phosphorylase, putative 0.0122 0.3067 0.2821
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.068 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0335 0.0561
Onchocerca volvulus 0.005 0.0744 0.0932
Leishmania major cathepsin L-like protease 0.0064 0.1204 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.8717 1
Echinococcus granulosus peregrin 0.003 0.0111 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2183 0.2451
Leishmania major cathepsin L-like protease 0.0064 0.1204 1
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0484 0.0378
Echinococcus granulosus glycogen phosphorylase 0.0122 0.3067 0.2999
Loa Loa (eye worm) glycogen phosphorylase 0.0122 0.3067 0.5143
Schistosoma mansoni P2X receptor subunit 0.0294 0.8566 1
Schistosoma mansoni hypothetical protein 0.0048 0.068 0.0673
Echinococcus multilocularis p2X purinoceptor 4 0.0294 0.8566 0.855
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.068 0.114
Onchocerca volvulus Glycogen phosphorylase homolog 0.0122 0.3067 0.4352
Plasmodium falciparum phd finger protein, putative 0.003 0.0111 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.1027 0.8525
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0335 0.0265
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.3971 0.6657
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.8717 1
Plasmodium vivax hypothetical protein, conserved 0.003 0.0111 0.3305
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1126 0.1888
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.2448 0.4104
Loa Loa (eye worm) hypothetical protein 0.0037 0.0335 0.0561
Schistosoma mansoni hypothetical protein 0.0103 0.2448 0.2764
Brugia malayi Pre-SET motif family protein 0.003 0.0133 0.0224
Onchocerca volvulus 0.0037 0.0335 0.033
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0111 0.3305
Echinococcus granulosus p2X purinoceptor 4 0.0294 0.8566 0.8552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Schistosoma mansoni hypothetical protein 0.0048 0.068 0.0673
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0335 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1204 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.5964 1
Schistosoma mansoni jumonji domain containing protein 0.0077 0.1638 0.1807
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0311 0.0216
Schistosoma mansoni P2X receptor subunit 0.0294 0.8566 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.3827 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2183 0.2451

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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