Detailed information for compound 794747

Basic information

Technical information
  • TDR Targets ID: 794747
  • Name: ethyl 6-bromo-2-oxochromene-3-carboxylate
  • MW: 297.101 | Formula: C12H9BrO4
  • H donors: 0 H acceptors: 2 LogP: 3.03 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cc2cc(Br)ccc2oc1=O
  • InChi: 1S/C12H9BrO4/c1-2-16-11(14)9-6-7-5-8(13)3-4-10(7)17-12(9)15/h3-6H,2H2,1H3
  • InChiKey: RXGDNKCWEKUYQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 6-bromo-2-oxo-chromene-3-carboxylate
  • 6-bromo-2-oxo-3-chromenecarboxylic acid ethyl ester
  • 6-bromo-2-keto-chromene-3-carboxylic acid ethyl ester
  • 6-Bromo-2-oxo-2H-chromene-3-carboxylic acid ethyl ester
  • BAS 00852496
  • Oprea1_663499
  • IDI1_008710
  • A1265/0057842
  • Oprea1_573298
  • ZINC00062926
  • IFLab1_000491

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glucose transporter 0.0031 0.042 0.0321
Loa Loa (eye worm) TK/INSR protein kinase 0.0127 0.2553 0.5565
Echinococcus multilocularis solute carrier family 22 0.0031 0.042 0.0696
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.0839
Onchocerca volvulus 0.0031 0.042 0.5
Echinococcus multilocularis solute carrier family 22 0.0031 0.042 0.0696
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0589 0.0315
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Schistosoma mansoni tyrosine kinase 0.0127 0.2553 0.5314
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.042 1
Schistosoma mansoni sugar transporter 0.0031 0.042 0.0321
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0484 0.098
Onchocerca volvulus 0.0031 0.042 0.5
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0484 0.0207
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0469 0.0805
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.0469
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0484 0.0469
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0484 0.0207
Echinococcus granulosus solute carrier family 22 0.0031 0.042 0.0321
Trypanosoma brucei sugar transporter, putative 0.0031 0.042 0.144
Onchocerca volvulus 0.0031 0.042 0.5
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0469 0.0434
Echinococcus granulosus epidermal growth factor receptor 0.0058 0.1022 0.1729
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.042 0.144
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Trypanosoma brucei glucose transporter, putative 0.0067 0.1236 1
Onchocerca volvulus 0.0031 0.042 0.5
Onchocerca volvulus 0.0031 0.042 0.5
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.1236 1
Trichomonas vaginalis sugar transporter, putative 0.0067 0.1236 0.2349
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.042 0.5
Leishmania major protein kinase, putative 0.0033 0.0484 0.2105
Schistosoma mansoni sugar transporter 0.0031 0.042 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Loa Loa (eye worm) hypothetical protein 0.0027 0.0333 0.0646
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0283 0.3046
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0218 0.4555 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0484 0.098
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0469 0.0434
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Schistosoma mansoni tyrosine kinase 0.0127 0.2553 0.5314
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.042 0.0321
Onchocerca volvulus 0.0031 0.042 0.5
Plasmodium vivax CDK-related protein kinase 6, putative 0.0464 1 1
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.042 0.0469
Schistosoma mansoni hypothetical protein 0.0218 0.4555 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.042 0.0469
Trypanosoma cruzi hexose transporter 0.0067 0.1236 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0177 0.3649 0.5352
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0469 0.0581
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0589 0.0486
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Trypanosoma cruzi hexose transporter, putative 0.0067 0.1236 1
Onchocerca volvulus Putative transporter 0.0031 0.042 0.5
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0589 0.3208
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Echinococcus multilocularis solute carrier family 22 0.0031 0.042 0.0696
Plasmodium vivax hexose transporter 0.0218 0.4555 0.4397
Brugia malayi hypothetical protein 0.0031 0.042 0.0321
Brugia malayi major facilitator superfamily protein 0.0031 0.042 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Giardia lamblia Hexose transporter 0.0031 0.042 0.7391
Echinococcus granulosus solute carrier family 22 0.0031 0.042 0.0321
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0218 0.4555 1
Echinococcus granulosus solute carrier family 22 0.0031 0.042 0.0321
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0218 0.4555 1
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.042 0.0321
Schistosoma mansoni sugar transporter 0.0031 0.042 0.0321
Schistosoma mansoni tyrosine kinase 0.0057 0.0999 0.1676
Brugia malayi major facilitator superfamily protein 0.0031 0.042 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0058 0.1022 0.1729
Onchocerca volvulus 0.0031 0.042 0.5
Schistosoma mansoni glucose transport protein 0.0218 0.4555 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.1236 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.1236 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0589 0.3208
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Onchocerca volvulus 0.0031 0.042 0.5
Toxoplasma gondii sugar transporter ST3 0.0031 0.042 0.0218
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.042 0.084
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.0839
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0283 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0127 0.2553 0.5495
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0469 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0484 0.032
Loa Loa (eye worm) hypothetical protein 0.0069 0.1275 0.2734
Leishmania major glucose transporter, lmgt1 0.0067 0.1236 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Trichomonas vaginalis glucose transporter, putative 0.0067 0.1236 0.2349
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0127 0.2553 0.5314
Echinococcus multilocularis epidermal growth factor receptor 0.0058 0.1022 0.205
Toxoplasma gondii facilitative glucose transporter GT1 0.0218 0.4555 0.6794
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.0469
Leishmania major hypothetical protein, conserved 0.0031 0.042 0.144
Treponema pallidum prolyl-tRNA synthetase 0.0012 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Trypanosoma cruzi glucose transporter, putative 0.0031 0.042 0.144
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0177 0.3649 0.3464
Loa Loa (eye worm) sugar transporter 0.0218 0.4555 1
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0438 0.0736
Schistosoma mansoni protein kinase 0.0033 0.0484 0.0469
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.042 0.084
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.042 0.0469
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0469 0.0434
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0218 0.4555 1
Echinococcus granulosus solute carrier family 22 0.0031 0.042 0.0321
Onchocerca volvulus 0.0031 0.042 0.5
Schistosoma mansoni tyrosine kinase 0.0057 0.0999 0.1676
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.1236 0.2349
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.042 1
Plasmodium falciparum protein kinase 7 0.0309 0.6571 0.6471
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0589 0.0315
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Loa Loa (eye worm) hypothetical protein 0.0033 0.0469 0.0947
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.042 0.0321
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.042 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0484 0.0207
Onchocerca volvulus 0.0031 0.042 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.0469
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0484 0.098
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0484 0.032
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Mycobacterium ulcerans sugar transporter 0.0031 0.042 1
Trypanosoma cruzi hexose transporter, putative 0.0037 0.056 0.29
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0589 0.3208
Schistosoma mansoni glucose transport protein 0.0218 0.4555 1
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0484 0.0616
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.042 0.0696
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Brugia malayi Sugar transporter family protein 0.0031 0.042 0.0321
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0438 0.0362
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.042 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0484 0.0207
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0283 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.042 0.0469
Loa Loa (eye worm) TK/EGFR protein kinase 0.0058 0.1022 0.2172
Brugia malayi hypothetical protein 0.0031 0.042 0.0321
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Onchocerca volvulus 0.0031 0.042 0.5
Trypanosoma brucei glucose transporter, putative 0.0067 0.1236 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0283 0.0388
Schistosoma mansoni sugar transporter 0.0031 0.042 0.0321
Brugia malayi Protein kinase domain containing protein 0.007 0.1298 0.2375
Schistosoma mansoni protein kinase 0.0033 0.0484 0.0469
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0536
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0484 0.0207
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0484 0.2105
Leishmania major glucose transporter, lmgt3 0.0067 0.1236 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.042 0.0469
Schistosoma mansoni tyrosine kinase 0.0058 0.1022 0.1729
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.1236 1
Brugia malayi Cam kinase protein 1 0.0033 0.0484 0.0469
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.042 0.144
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Plasmodium vivax sugar transporter, putative 0.0031 0.042 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0067 0.1236 0.2349
Plasmodium falciparum mitogen-activated protein kinase 2 0.0177 0.3649 0.3464
Trypanosoma cruzi hexose transporter, putative 0.0031 0.042 0.144
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.1236 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0484 0.0469
Trypanosoma brucei glucose transporter 2A 0.0067 0.1236 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Onchocerca volvulus 0.0031 0.042 0.5
Onchocerca volvulus 0.0031 0.042 0.5
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.042 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0589 0.3208
Toxoplasma gondii sugar transporter ST2 0.0031 0.042 0.0218
Trichomonas vaginalis glucose transporter, putative 0.0031 0.042 0.0469
Schistosoma mansoni protein kinase 0.0033 0.0484 0.0469
Onchocerca volvulus 0.0031 0.042 0.5
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.042 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.1236 0.2349
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Trypanosoma cruzi hexose transporter, putative 0.0067 0.1236 1
Onchocerca volvulus 0.0031 0.042 0.5
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Brugia malayi Sugar transporter family protein 0.0218 0.4555 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.1236 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0469 0.0434
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Brugia malayi hypothetical protein 0.0031 0.042 0.0321
Onchocerca volvulus 0.0031 0.042 0.5
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0484 0.0207
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0484 0.0207
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0283 0.6738
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.042 0.0696
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0218 0.4555 1
Echinococcus granulosus General substrate transporter 0.0187 0.3879 0.8416
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Trypanosoma brucei glucose transporter, putative 0.0067 0.1236 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0484 0.0207
Schistosoma mansoni tyrosine kinase 0.0058 0.1022 0.1729
Echinococcus multilocularis General substrate transporter 0.0187 0.3879 0.8478
Loa Loa (eye worm) hypothetical protein 0.0033 0.0469 0.0947
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.0839
Brugia malayi Protein kinase domain containing protein 0.0127 0.2553 0.5314
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.042 0.0218
Loa Loa (eye worm) sugar transporter 0.0031 0.042 0.084
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Trypanosoma cruzi sugar transporter, putative 0.0031 0.042 0.144
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0484 0.032
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0469 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0589 0.3208
Trichomonas vaginalis sugar transporter, putative 0.0067 0.1236 0.2349
Echinococcus granulosus insulin receptor 0.0127 0.2553 0.5314
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0484 0.0839
Entamoeba histolytica protein kinase, putative 0.0033 0.0484 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0484 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0218 0.4555 1
Toxoplasma gondii protein kinase, putative 0.0309 0.6571 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.1236 1
Trypanosoma cruzi hexose transporter, putative 0.0067 0.1236 1
Trypanosoma brucei glucose transporter 1E 0.0067 0.1236 1
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.042 0.0321
Echinococcus multilocularis epidermal growth factor receptor 0.0058 0.1022 0.205
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.1236 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0218 0.4555 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0218 0.4555 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.042 0.0469
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.042 0.0141
Trichomonas vaginalis glucose transporter, putative 0.0067 0.1236 0.2349
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0283 0.6738
Echinococcus multilocularis solute carrier family 22 0.0031 0.042 0.0696
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Echinococcus multilocularis insulin receptor 0.0127 0.2553 0.5495
Toxoplasma gondii sugar transporter ST1 0.0031 0.042 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Leishmania major glucose transporter, lmgt2 0.0067 0.1236 1
Schistosoma mansoni glucose transport protein 0.0218 0.4555 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0469 0.0434
Trypanosoma brucei glucose transporter, putative 0.0067 0.1236 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0469 0.9253
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Plasmodium falciparum hexose transporter 0.0218 0.4555 0.4397
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0484 0.0469
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.042 1
Echinococcus granulosus epidermal growth factor receptor 0.0058 0.1022 0.1729
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.042 0.0469
Schistosoma mansoni tyrosine kinase 0.0057 0.0999 0.1676
Brugia malayi Sugar transporter family protein 0.0031 0.042 0.0321
Giardia lamblia Sugar-proton symporter 0.0031 0.042 0.7391
Loa Loa (eye worm) hypothetical protein 0.0031 0.042 0.084
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0031 0.042 0.0469
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0484 0.0207
Brugia malayi Furin-like cysteine rich region family protein 0.0058 0.1022 0.1729
Schistosoma mansoni tyrosine kinase 0.0058 0.1022 0.1729
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0218 0.4555 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Displacement of [3H]estrone human recombinant 17beta-HSD1 expressed in Escherichia coli BL21 (DE3)-RIL at 6 uM by scintillation counting in presence of NADPH ChEMBL. 21138273
Inhibition (binding) Displacement of [3H]estradiol human recombinant 17beta-HSD2 expressed in Escherichia coli BL21 (DE3)-RIL at 6 uM by scintillation counting in presence of NAD+ ChEMBL. 21138273
Inhibition (binding) Displacement of [3H]estradiol human recombinant 17beta-HSD2 expressed in Escherichia coli BL21 (DE3)-RIL at 0.6 uM by scintillation counting in presence of NAD+ ChEMBL. 21138273
Inhibition (binding) Displacement of [3H]estrone human recombinant 17beta-HSD1 expressed in Escherichia coli BL21 (DE3)-RIL at 0.6 uM by scintillation counting in presence of NADPH ChEMBL. 21138273

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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