Detailed information for compound 795107

Basic information

Technical information
  • TDR Targets ID: 795107
  • Name: N-[3,5-dimethyl-1-[(4-methylphenyl)methyl]pyr azol-4-yl]-5-methyl-1,2-oxazole-3-carboxamide
  • MW: 324.377 | Formula: C18H20N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Cn1nc(c(c1C)NC(=O)c1noc(c1)C)C
  • InChi: 1S/C18H20N4O2/c1-11-5-7-15(8-6-11)10-22-14(4)17(13(3)20-22)19-18(23)16-9-12(2)24-21-16/h5-9H,10H2,1-4H3,(H,19,23)
  • InChiKey: WDDYDEYGLFATHH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3,5-dimethyl-1-[(4-methylphenyl)methyl]pyrazol-4-yl]-5-methyl-isoxazole-3-carboxamide
  • N-[3,5-dimethyl-1-[(4-methylphenyl)methyl]-4-pyrazolyl]-5-methyl-3-isoxazolecarboxamide
  • N-[3,5-dimethyl-1-(4-methylbenzyl)pyrazol-4-yl]-5-methyl-isoxazole-3-carboxamide
  • EU-0057263

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0419 0.8335
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0402 0.9708
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trypanosoma cruzi hexose transporter, putative 0.002 0.0171 0.2422
Trypanosoma cruzi hexose transporter 0.0037 0.0419 0.8335
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0402 0.9708
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0206 1
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2485 0.6744
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.012 0.0141
Toxoplasma gondii sugar transporter ST3 0.0017 0.012 0.0038
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.2351 1
Echinococcus granulosus dnaJ subfamily B 0.041 0.5875 0.5874
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0489 0.0814
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0419 0.0977
Brugia malayi major facilitator superfamily protein 0.0017 0.012 0.0327
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0265 0.0344
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0402 0.04
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0401 0.0927
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2351 0.6372
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.3651 1
Schistosoma mansoni cpg binding protein 0.0029 0.0293 0.0193
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.1637 0.1636
Onchocerca volvulus 0.0017 0.012 0.0222
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0402 0.093
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0265 0.0166
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0101 0.01
Plasmodium falciparum protein kinase 6 0.0512 0.7365 1
Schistosoma mansoni protein kinase 0.0037 0.0412 0.0314
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.0273
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.0273
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0402 0.0631
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Leishmania major hypothetical protein, conserved 0.0016 0.0101 0.0776
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0489 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0412 0.1128
Schistosoma mansoni sugar transporter 0.0017 0.012 0.0018
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0489 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0402 0.04
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0101 0.0273
Plasmodium vivax CDK-related protein kinase 6, putative 0.0512 0.7365 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0412 0.1124
Plasmodium vivax hexose transporter 0.0121 0.1637 0.2114
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0121 0.1637 0.1636
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0195 0.2724 0.3611
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0069 0.0189
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.012 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0402 0.093
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0101 0.0776
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0101 0.01
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.012 0.0038
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0489 1
Leishmania major glucose transporter, lmgt2 0.0037 0.0419 0.8335
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0412 0.0653
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0759 0.0664
Schistosoma mansoni alpha-glucosidase 0.0141 0.193 0.1847
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Schistosoma mansoni hypothetical protein 0.0121 0.1637 0.1551
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0412 0.0428
Loa Loa (eye worm) hypothetical protein 0.0036 0.0401 0.1094
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.012 0.2954
Trypanosoma brucei glucosidase, putative 0.0036 0.0402 0.7931
Schistosoma mansoni protein kinase 0.0037 0.0412 0.0314
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0089 0.0238
Onchocerca volvulus 0.0017 0.012 0.0222
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.2263 0.6196
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Echinococcus granulosus solute carrier family 22 0.0017 0.012 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2351 0.6372
Schistosoma mansoni microtubule-associated protein tau 0.0692 1 1
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0378 0.0377
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Onchocerca volvulus 0.0017 0.012 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.3651 1
Onchocerca volvulus 0.0017 0.012 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2351 0.6372
Echinococcus granulosus General substrate transporter 0.0104 0.1389 0.1387
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0217 0.0413
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0125 0.0124
Brugia malayi jmjC domain containing protein 0.0016 0.0101 0.0278
Onchocerca volvulus 0.0017 0.012 0.0222
Leishmania major hypothetical protein, conserved 0.0017 0.012 0.1206
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.012 0.2954
Onchocerca volvulus 0.0017 0.012 0.0222
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0101 0.0776
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.3651 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0412 0.0428
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0419 0.0977
Schistosoma mansoni alpha glucosidase 0.0036 0.0402 0.0304
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0401 0.9681
Trypanosoma cruzi sugar transporter, putative 0.0017 0.012 0.1206
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0265 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.012 0.1206
Echinococcus granulosus phd:f box containing protein 0.0016 0.0101 0.01
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0184
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0402 0.7931
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0058 0.5
Echinococcus multilocularis dnaJ subfamily B 0.041 0.5875 0.5874
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.012 0.0118
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0412 0.1124
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0101 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.012 0.0141
Trypanosoma brucei glucose transporter, putative 0.0037 0.0419 0.8335
Onchocerca volvulus 0.0095 0.1254 0.5194
Onchocerca volvulus 0.0017 0.012 0.0222
Loa Loa (eye worm) hypothetical protein 0.0036 0.0401 0.1094
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.012 0.0327
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0489 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Onchocerca volvulus 0.0017 0.012 0.0222
Trypanosoma cruzi hexose transporter, putative 0.0017 0.012 0.1206
Brugia malayi CXXC zinc finger family protein 0.0029 0.0293 0.0802
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.3651 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0419 0.8335
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Brugia malayi Sugar transporter family protein 0.0017 0.012 0.0327
Echinococcus granulosus cpg binding protein 0.003 0.0317 0.0315
Trypanosoma brucei glucose transporter, putative 0.0037 0.0419 0.8335
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0412 0.041
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0412 0.041
Brugia malayi hypothetical protein 0.0017 0.012 0.0327
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2351 0.6372
Echinococcus granulosus solute carrier family 22 0.0017 0.012 0.0118
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0412 0.041
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0265 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0265 0.468
Entamoeba histolytica protein kinase, putative 0.0037 0.0412 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0401 1
Onchocerca volvulus 0.0017 0.012 0.0222
Trichomonas vaginalis glucose transporter, putative 0.0017 0.012 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2351 0.6372
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0419 0.8335
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0402 0.093
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0265 0.0226
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0759 0.0664
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0265 0.0264
Brugia malayi hypothetical protein 0.0017 0.012 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.012 0.0141
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0402 0.093
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.1637 0.1636
Schistosoma mansoni glucose transport protein 0.0121 0.1637 0.1551
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0412 0.0428
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0101 0.0273
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Toxoplasma gondii sugar transporter ST2 0.0017 0.012 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0101 0.0273
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0265 0.0226
Brugia malayi Cam kinase protein 1 0.0037 0.0412 0.1128
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0412 0.0428
Entamoeba histolytica protein kinase, putative 0.0037 0.0412 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0402 0.7931
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0265 0.0166
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0419 0.8335
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0734 0.0733
Loa Loa (eye worm) hypothetical protein 0.0029 0.0302 0.0822
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Schistosoma mansoni sugar transporter 0.0017 0.012 0.0018
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.2263 0.2261
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0412 0.0428
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Schistosoma mansoni glucose transporter 0.0017 0.012 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0759 0.2074
Brugia malayi jmjC domain containing protein 0.0016 0.0101 0.0278
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0258 0.3651 1
Trypanosoma brucei glucose transporter, putative 0.0037 0.0419 0.8335
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0265 0.0264
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0206 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.1637 0.4378
Echinococcus multilocularis microtubule associated protein 2 0.0692 1 1
Plasmodium falciparum protein kinase 7 0.0341 0.486 0.6551
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.1637 0.1636
Schistosoma mansoni glucose transport protein 0.0121 0.1637 0.1551
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0101 0.01
Schistosoma mansoni sugar transporter 0.0017 0.012 0.0018
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0101 0.01
Toxoplasma gondii protein kinase, putative 0.0341 0.486 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0195 0.2724 0.5512
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.1637 0.1636
Brugia malayi jmjC domain containing protein 0.0059 0.0734 0.2012
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0125 0.0124
Schistosoma mansoni alpha-glucosidase 0.0141 0.193 0.1847
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0265 1
Plasmodium vivax sugar transporter, putative 0.0017 0.012 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Brugia malayi hypothetical protein 0.0017 0.012 0.0327
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0489 0.0533
Mycobacterium ulcerans sugar transporter 0.0017 0.012 0.2954
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0401 0.1098
Loa Loa (eye worm) sugar transporter 0.0017 0.012 0.0323
Onchocerca volvulus 0.0017 0.012 0.0222
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0402 0.093
Trypanosoma brucei glucose transporter, putative 0.0037 0.0419 0.8335
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0734 0.0733
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.3651 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0489 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0759 0.0757
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0412 0.041
Trypanosoma cruzi glucose transporter, putative 0.0017 0.012 0.1206
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0402 0.093
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.3651 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0402 0.093
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0734 0.064
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0265 0.468
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0412 0.0314
Trypanosoma brucei glucose transporter 1E 0.0037 0.0419 0.8335
Leishmania major protein kinase, putative 0.0037 0.0412 0.817
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0293 0.0798
Loa Loa (eye worm) hypothetical protein 0.0016 0.0101 0.0273
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Onchocerca volvulus 0.0017 0.012 0.0222
Plasmodium falciparum mitogen-activated protein kinase 2 0.0195 0.2724 0.3611
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.012 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2485 0.6744
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Leishmania major glucose transporter, lmgt3 0.0037 0.0419 0.8335
Loa Loa (eye worm) sugar transporter 0.0121 0.1637 0.4481
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0401 0.0303
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.1637 0.1636
Schistosoma mansoni hypothetical protein 0.041 0.5875 0.5833
Trypanosoma brucei glucose transporter 2A 0.0037 0.0419 0.8335
Brugia malayi jmjC domain containing protein 0.0016 0.0101 0.0278
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0101 0.01
Schistosoma mansoni sugar transporter 0.0017 0.012 0.0018
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0378 0.0377
Onchocerca volvulus 0.0017 0.012 0.0222
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.012 0.0141
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0412 0.041
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0419 0.0977
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0412 0.0428
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.2263 0.2261
Brugia malayi jmjC domain containing protein 0.0061 0.0759 0.2078
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.012 0.0323
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0419 0.0977
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0419 0.0977
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0412 0.0958
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2351 0.6372
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.067 0.1195
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0412 0.041
Brugia malayi jmjC domain containing protein 0.0016 0.0101 0.0278
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0412 0.041
Onchocerca volvulus 0.0017 0.012 0.0222
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.2263 0.6198
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0101 0.01
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0101 0.0776
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0402 0.7931
Onchocerca volvulus 0.0029 0.0293 0.0981
Onchocerca volvulus Putative transporter 0.0017 0.012 0.0222
Leishmania major glucose transporter, lmgt1 0.0037 0.0419 0.8335
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0765 0.0671
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0489 0.0533
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0265 0.3046
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.012 0.0018
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.012 0.0141
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0265 0.0549
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0265 0.5182
Plasmodium falciparum hexose transporter 0.0121 0.1637 0.2114
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0419 0.8335
Onchocerca volvulus 0.0017 0.012 0.0222
Echinococcus granulosus solute carrier family 22 0.0017 0.012 0.0118
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.012 0.0025
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.2263 0.2261
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.012 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.012 0.0141
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0412 0.0653
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.012 0.0327
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0412 0.0653
Brugia malayi major facilitator superfamily protein 0.0017 0.012 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0412 0.0428
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.012 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Schistosoma mansoni cpg binding protein 0.003 0.0317 0.0218
Echinococcus multilocularis solute carrier family 22 0.0017 0.012 0.0118
Echinococcus multilocularis solute carrier family 22 0.0017 0.012 0.0118
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.1637 0.1636
Onchocerca volvulus 0.0017 0.012 0.0222
Echinococcus multilocularis cpg binding protein 0.003 0.0317 0.0315
Echinococcus multilocularis General substrate transporter 0.0104 0.1389 0.1387
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.012 0.0141
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Brugia malayi Sugar transporter family protein 0.0121 0.1637 0.4484
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.2351 0.6372
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.1637 0.1636
Loa Loa (eye worm) hypothetical protein 0.0027 0.0265 0.0723
Toxoplasma gondii facilitative glucose transporter GT1 0.0121 0.1637 0.3227
Trypanosoma brucei glucose transporter, putative 0.0037 0.0419 0.8335
Echinococcus granulosus solute carrier family 22 0.0017 0.012 0.0118
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.012 0.2954
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.012 0.0118
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0402 0.1097
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0401 0.0303
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0412 0.0428
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0402 0.093
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0419 0.8335
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0419 0.0977
Schistosoma mansoni cpg binding protein 0.003 0.0317 0.0218
Trypanosoma brucei glucose transporter, putative 0.0037 0.0419 0.8335
Brugia malayi Sugar transporter family protein 0.0017 0.012 0.0327
Schistosoma mansoni protein kinase 0.0037 0.0412 0.0314
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0401 0.1098
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0412 0.817
Trypanosoma brucei sugar transporter, putative 0.0017 0.012 0.1206
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Echinococcus multilocularis solute carrier family 22 0.0017 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Trypanosoma brucei glucose transporter, putative 0.0037 0.0419 0.8335
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0412 0.0428
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0419 0.8335
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0265 0.0727
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0419 0.0977
Echinococcus multilocularis solute carrier family 22 0.0017 0.012 0.0118
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0734 0.0733
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.012 0.1206
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0402 0.1101
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Toxoplasma gondii sugar transporter ST1 0.0017 0.012 0.0038
Schistosoma mansoni glucose transport protein 0.0121 0.1637 0.1551
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0401 0.0399
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0401 0.0399
Onchocerca volvulus 0.0017 0.012 0.0222
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0258 0.3651 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0412 0.1124
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0412 0.041
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Trypanosoma brucei glucose transporter, putative 0.0037 0.0419 0.8335
Trichomonas vaginalis sugar transporter, putative 0.0017 0.012 0.0141
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0265 0.468
Entamoeba histolytica hypothetical protein 0.0027 0.0265 0.5728
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0401 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0402 0.093
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0323

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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