Detailed information for compound 796908

Basic information

Technical information
  • TDR Targets ID: 796908
  • Name: N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-(4-met hylsulfanylphenyl)imidazo[3,2-a]pyridin-3-ami ne
  • MW: 389.47 | Formula: C22H19N3O2S
  • H donors: 1 H acceptors: 1 LogP: 5.53 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)c1nc2n(c1Nc1ccc3c(c1)OCCO3)cccc2
  • InChi: 1S/C22H19N3O2S/c1-28-17-8-5-15(6-9-17)21-22(25-11-3-2-4-20(25)24-21)23-16-7-10-18-19(14-16)27-13-12-26-18/h2-11,14,23H,12-13H2,1H3
  • InChiKey: SIKIVIYEPDDJHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-[4-(methylthio)phenyl]-3-imidazo[3,2-a]pyridinamine
  • 2,3-dihydro-1,4-benzodioxin-7-yl-[2-[4-(methylthio)phenyl]imidazo[3,2-a]pyridin-3-yl]amine
  • STK228178
  • ZINC04733596
  • EU-0058211

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum NADH oxidase 0.0018 0.0045 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0685 0.0995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0299 0.0433
Loa Loa (eye worm) TAR-binding protein 0.0196 0.5389 0.8093
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.8574 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.6462 0.9703
Onchocerca volvulus 0.0042 0.0782 0.0708
Schistosoma mansoni hypothetical protein 0.0049 0.0982 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0758 0.1102
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0002 0.0003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0982 0.0982
Loa Loa (eye worm) hypothetical protein 0.0027 0.0331 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0971 0.1412
Brugia malayi RNA binding protein 0.0196 0.5389 0.8093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0971 0.1412
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0203 0.0234
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.044 0.044
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0045 0.005
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0045 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0301 0.0435
Onchocerca volvulus 0.0031 0.0432 0.0173
Loa Loa (eye worm) hypothetical protein 0.0031 0.0432 0.0648
Plasmodium falciparum thioredoxin reductase 0.0051 0.1048 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.3801 0.4432
Schistosoma mansoni tar DNA-binding protein 0.0196 0.5389 1
Echinococcus multilocularis lamin 0.0027 0.0318 0.0318
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0787 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0598 0.0868
Echinococcus multilocularis tumor protein p63 0.035 1 1
Trichomonas vaginalis chromobox protein, putative 0.007 0.1603 0.2333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0971 0.1412
Onchocerca volvulus 0.0245 0.6865 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.1048 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0385 0.0557
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0685 0.056
Schistosoma mansoni hypothetical protein 0.0106 0.2687 0.4986
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0598 0.0868
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0003 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.4156 0.6241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0673 0.0978
Plasmodium falciparum thioredoxin reductase 0.0018 0.0045 0.0396
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.8574 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Echinococcus granulosus chromobox protein 1 0.007 0.1603 0.1603
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.4286 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0045 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.058 0.058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0045 0.005
Plasmodium vivax SET domain protein, putative 0.0031 0.044 0.4177
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.3013 0.7029
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0674 0.0784
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0045 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0299 0.0433
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0787 0.0916
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.2687 0.4035
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0971 0.1131
Loa Loa (eye worm) RNA binding protein 0.0196 0.5389 0.8093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.4156 0.6241
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0045 0.0097
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.044 0.0816
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0774 0.1124
Schistosoma mansoni lamin 0.0027 0.0318 0.0591
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0045 0.005
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0045 0.0396
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.6659 1
Echinococcus multilocularis tar DNA binding protein 0.0196 0.5389 0.5389
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.3404 0.7941
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0045 0.005
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.1048 0.2438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0598 0.0868
Brugia malayi chromobox protein homolog 3 0.0039 0.0685 0.1028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0045 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.044 0.0816
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0045 0.0083
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.6659 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0971 0.1131
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0598 0.5692
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0331 0.3138
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0782 0.145
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0045 0.5
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.3801 0.4432
Echinococcus granulosus chromobox protein 1 0.007 0.1603 0.1603
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0982 0.1475
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0045 0.005
Brugia malayi Heterochromatin protein 1 0.007 0.1603 0.2408
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0045 0.0396
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0971 0.1131
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0971 0.1459
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.1048 0.122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0301 0.0435
Toxoplasma gondii thioredoxin reductase 0.0051 0.1048 1
Plasmodium falciparum glutathione reductase 0.0051 0.1048 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.044 0.044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.3404 0.7941
Echinococcus multilocularis geminin 0.0171 0.4635 0.4635
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0318 0.0478
Loa Loa (eye worm) hypothetical protein 0.0155 0.4156 0.6241
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0971 0.1131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.046 0.0667
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0674 0.0784
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0045 0.005
Schistosoma mansoni hypothetical protein 0.0171 0.4635 0.86
Brugia malayi follicle stimulating hormone receptor 0.0232 0.6462 0.9703
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0971 0.1803
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0045 0.0396
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0982 0.0982
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0787 0.0916
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0982 0.1475
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0971 0.0971
Mycobacterium tuberculosis Probable reductase 0.0117 0.3013 0.7029
Brugia malayi hypothetical protein 0.0018 0.0041 0.0062
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0045 0.005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0318 0.0478
Toxoplasma gondii hypothetical protein 0.0049 0.0975 0.9301
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0045 0.5
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0045 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0385 0.0557
Leishmania major hypothetical protein, conserved 0.0027 0.0331 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0491 0.0713
Brugia malayi hypothetical protein 0.0036 0.058 0.0871
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0774 0.1124
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.1048 0.1573
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0598 0.0868
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.1048 0.1048
Echinococcus granulosus lamin dm0 0.0027 0.0318 0.0318
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0045 0.0062
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0119 0.0136
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.3013 0.7029
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1603 0.2408
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0685 0.0995
Schistosoma mansoni tar DNA-binding protein 0.0196 0.5389 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.044 0.4177
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.5389 0.8093
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0774 0.0696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0385 0.0557
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.3013 0.7029
Schistosoma mansoni tar DNA-binding protein 0.0196 0.5389 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.3013 0.7029
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.3404 0.7941
Echinococcus multilocularis GPCR, family 2 0.0049 0.0982 0.0982
Onchocerca volvulus 0.0051 0.1048 0.1115
Schistosoma mansoni hypothetical protein 0.0049 0.0982 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0598 0.0868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0673 0.0978
Brugia malayi TAR-binding protein 0.0196 0.5389 0.8093
Schistosoma mansoni tar DNA-binding protein 0.0196 0.5389 1
Brugia malayi MH2 domain containing protein 0.0238 0.6659 1
Brugia malayi glutathione reductase 0.0051 0.1048 0.1573
Brugia malayi Pre-SET motif family protein 0.0031 0.044 0.066
Schistosoma mansoni hypothetical protein 0.0036 0.058 0.1076
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0331 0.3138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0045 0.005
Brugia malayi Thioredoxin reductase 0.0051 0.1048 0.1573
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0331 0.0384
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0003 0.0005
Echinococcus granulosus intermediate filament protein 0.0027 0.0318 0.0318
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0002 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0331 0.0384
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.5972 0.8969
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0331 0.3138
Loa Loa (eye worm) hypothetical protein 0.0049 0.0982 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0376 0.0545
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0045 0.0045
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0003 0.0003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0045 0.5
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0045 0.0062
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0971 0.1459
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.1066 0.1241
Loa Loa (eye worm) hypothetical protein 0.0106 0.2687 0.4035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0598 0.0868
Giardia lamblia GTOR 0.0049 0.0971 1
Schistosoma mansoni lamin 0.0027 0.0318 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0376 0.0545
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.3404 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.8574 1
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.1048 0.1945
Echinococcus granulosus tar DNA binding protein 0.0196 0.5389 0.5389
Schistosoma mansoni intermediate filament proteins 0.0027 0.0318 0.0591
Echinococcus granulosus geminin 0.0171 0.4635 0.4635
Loa Loa (eye worm) hypothetical protein 0.0051 0.1048 0.1574
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0002 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0982 0.1475
Echinococcus multilocularis chromobox protein 1 0.007 0.1603 0.1603
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0971 0.0971
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0405 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0343 0.0496
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0318 0.0478
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0331 0.0384
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0003 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0331 0.3138
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0003 0.0005
Schistosoma mansoni chromobox protein 0.007 0.1603 0.2975
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.1048 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0982 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0301 0.0435
Plasmodium vivax glutathione reductase, putative 0.0051 0.1048 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0299 0.0433
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0673 0.0978
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.066
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0045 0.005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.3013 0.7029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.058 0.058
Echinococcus granulosus lamin 0.0027 0.0318 0.0318
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0003 0.0001
Echinococcus multilocularis lamin dm0 0.0027 0.0318 0.0318
Brugia malayi isocitrate dehydrogenase 0.0016 0.0003 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.058 0.1076
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0971 0.1131
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.5389 0.8093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0598 0.0868
Mycobacterium ulcerans hypothetical protein 0.0159 0.4286 1
Trichomonas vaginalis chromobox protein, putative 0.007 0.1603 0.2333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0301 0.0435
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0971 1
Schistosoma mansoni chromobox protein 0.007 0.1603 0.2975
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0971 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0045 0.0396
Echinococcus granulosus GPCR family 2 0.0049 0.0982 0.0982
Leishmania major trypanothione reductase 0.0051 0.1048 0.122
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0787 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0673 0.0978
Loa Loa (eye worm) glutathione reductase 0.0051 0.1048 0.1573
Echinococcus multilocularis chromobox protein 1 0.007 0.1603 0.1603
Loa Loa (eye worm) hypothetical protein 0.0026 0.0304 0.0456
Brugia malayi Pre-SET motif family protein 0.0215 0.5972 0.8969
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0045 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0673 0.0978
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0003 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0343 0.0496
Plasmodium falciparum glutathione reductase 0.0018 0.0045 0.0396
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.3801 0.4432
Trypanosoma brucei trypanothione reductase 0.0051 0.1048 0.122
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.8574 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0971 0.1131
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.0039 0.0685 0.1028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.4156 0.6241
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0045 0.005
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0674 0.0784
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0982 0.0982
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.044 0.0816
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Echinococcus multilocularis musashi 0.0027 0.0318 0.0318
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0045 0.0045
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0045 0.0396
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0318 0.0478
Brugia malayi intermediate filament protein 0.0027 0.0318 0.0478
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0045 0.005
Schistosoma mansoni hypothetical protein 0.0049 0.0982 0.1823
Schistosoma mansoni hypothetical protein 0.0171 0.4635 0.86
Trichomonas vaginalis set domain proteins, putative 0.0245 0.6865 1
Schistosoma mansoni hypothetical protein 0.0049 0.0982 0.1823
Schistosoma mansoni tar DNA-binding protein 0.0196 0.5389 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0045 0.005
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0001
Brugia malayi hypothetical protein 0.0027 0.0331 0.0497
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0045 0.0067

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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