TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 436.46 | Formula: C23H24N4O5
H donors: 0 H acceptors: 4 LogP: 2.52 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCn1c(=O)cc(c2c1cccc2)OCC(=O)N1CCN(CC1)c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C23H24N4O5/c1-2-26-20-6-4-3-5-19(20)21(15-22(26)28)32-16-23(29)25-13-11-24(12-14-25)17-7-9-18(10-8-17)27(30)31/h3-10,15H,2,11-14,16H2,1H3
InChiKey: ALMIAUNFOWZRKD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0159	0.0193
Loa Loa (eye worm)	N-myristoyltransferase 2	0.1012	0.5947	1
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0177	0.0223
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0211	0.0323
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.005	0.0084
Loa Loa (eye worm)	latrophilin receptor protein 2	0.005	0.0222	0.034
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.005	0.0008
Echinococcus granulosus	chromobox protein 1	0.007	0.0343	0.0504
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0116	0.0124
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.005	0.0005
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0037	0.0145	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0567	0.0922
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0159	0.078
Trichomonas vaginalis	N-myristoyl transferase, putative	0.1012	0.5947	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.005	0.0222	0.0177
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.023	0.0314
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.005	0.0005
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.005	0.0084
Brugia malayi	steroid hormone receptor	0.0021	0.005	0.0084
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0048	0.0005
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.005	0.0012
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0065
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0048	1
Schistosoma mansoni	metabotropic glutamate receptor	0.0034	0.0128	0.0144
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.005	0.0084
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0045	0.5
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0034	0.0128	0.0083
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.023	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0021	0.005	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.009	0.0077
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.005	0.0005
Schistosoma mansoni	hypothetical protein	0.0108	0.0567	0.0887
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0048	0.0005
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0211	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0021	0.005	0.0051
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0046	0.0201	0.0267
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.023	0.0314
Echinococcus granulosus	dna polymerase eta	0.0021	0.0048	0.0005
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0065
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0048	0.0005
Brugia malayi	Pre-SET motif family protein	0.0032	0.0116	0.0195
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0116	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0021	0.005	0.0051
Schistosoma mansoni	ap endonuclease	0.002	0.0045	0.0004
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.014	0.0096
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.005	0.0051
Giardia lamblia	CDC72	0.1012	0.5947	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.005	0.0084
Trypanosoma cruzi	N-myristoyl transferase, putative	0.1012	0.5947	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0048	0.0005
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.005	0.0012
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0065
Trypanosoma brucei	protein kinase, putative	0.0051	0.023	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0159	0.0234
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.005	0.0084
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0211	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0116	0.0162
Entamoeba histolytica	hypothetical protein	0.0036	0.014	0.0161
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.005	0.0051
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.005	0.0008
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0211	0.0281
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.005	0.0012
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0048	0.0003
Schistosoma mansoni	ap endonuclease	0.002	0.0045	0.0004
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0343	0.0504
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0045	0.0059
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.005	0.0012
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.023	0.0314
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0048	0.0005
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.005	0.0224	0.0179
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.023	0.0314
Trypanosoma brucei	N-myristoyl transferase, putative	0.1012	0.5947	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.005	0.0008
Entamoeba histolytica	hypothetical protein	0.0036	0.014	0.0161
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0048	0.0005
Brugia malayi	hypothetical protein	0.0036	0.014	0.0236
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.005	0.0012
Onchocerca volvulus		0.0256	0.1446	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.005	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.005	0.0084
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.023	0.0314
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0048	0.0081
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.005	0.0012
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0048	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.005	0.0051
Loa Loa (eye worm)	glutamate receptor	0.0041	0.0168	0.0249
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0211	0.0167
Schistosoma mansoni	hypothetical protein	0.0036	0.014	0.0165
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.023	0.0314
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0065
Brugia malayi	Latrophilin receptor protein 2	0.005	0.0222	0.0373
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0048	0.0003
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.005	0.0005
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.005	0.0051
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.005	0.0222	0.0373
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0065
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.014	0.0165
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0048	0.0005
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0211	0.0285
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0048	0.0005
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0041	0.0168	0.0282
Echinococcus multilocularis	chromobox protein 1	0.007	0.0343	0.0299
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.005	0.0084
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.005	0.0051
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0048	0.0065
Plasmodium vivax	glycylpeptide N-tetradecanoyltransferase, putative	0.1012	0.5947	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0116	0.3833
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.023	0.0371
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0343	0.0544
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.005	0.0084
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.005	0.0084
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0034	0.0128	0.014
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0048	0.0065
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.023	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0021	0.005	0.0051
Echinococcus multilocularis	GPCR, family 2	0.005	0.0222	0.0177
Brugia malayi	nuclear receptor NHR-88	0.0021	0.005	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0108	0.0149
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.014	0.0161
Echinococcus granulosus	chromobox protein 1	0.007	0.0343	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0021	0.005	0.0051
Onchocerca volvulus		0.0031	0.0108	0.0417
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0045	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.005	0.0084
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0211	0.0167
Loa Loa (eye worm)	hypothetical protein	0.005	0.0222	0.034
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0048	0.0009
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.005	0.0005
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.005	0.0012
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0048	0.0005
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.023	0.0314
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0065
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0048	0.0065
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.005	0.0222	0.0177
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0159	0.0193
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0048	0.0009
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0048	0.0009
Plasmodium vivax	SET domain protein, putative	0.0032	0.0116	0.012
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0211	0.0281
Schistosoma mansoni	chromobox protein	0.007	0.0343	0.0508
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.005	0.0084
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0116	0.0124
Plasmodium falciparum	glycylpeptide N-tetradecanoyltransferase	0.1012	0.5947	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.005	0.0051
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.023	0.0186
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0158	0.0864	0.1453
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0158	0.0864	0.1453
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.023	0.0314
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.005	0.0008
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0048	1
Echinococcus granulosus	metabotropic glutamate receptor 5	0.005	0.0224	0.0302
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.023	0.0314
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.005	0.0012
Loa Loa (eye worm)	hypothetical protein	0.005	0.0224	0.0344
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.005	0.0012
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.005	0.0005
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0225	0.1261	0.2094
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.0048	0.0005
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.023	0.0355
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.005	0.0084
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.023	0.0186
Echinococcus granulosus	GPCR family 2	0.005	0.0222	0.0299
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0158	0.0864	0.1424
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.005	0.0222	0.0299
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0109	0.0108
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.023	0.0314
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.005	0.0008
Schistosoma mansoni	hypothetical protein	0.005	0.0222	0.0303
Schistosoma mansoni	hypothetical protein	0.005	0.0222	0.0303
Echinococcus granulosus	glycylpeptide N tetradecanoyltransferase	0.1012	0.5947	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.005	0.0012
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.005	0.0005
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.005	0.0005
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0048	0.0081
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.005	0.0051
Brugia malayi	metabotropic glutamate receptor type 2	0.002	0.0043	0.0072
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.005	0.0005
Leishmania major	DNA polymerase eta, putative	0.0021	0.0048	0.0005
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.005	0.0008
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0048	0.0005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.005	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.009	0.0077
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0116	0.0071
Brugia malayi	nuclear hormone receptor	0.0021	0.005	0.0084
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0065
Brugia malayi	latrophilin 2 splice variant baaae	0.0108	0.0567	0.0953
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0048	0.0048
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.005	0.0051
Brugia malayi	MAP kinase sur-1	0.0051	0.023	0.0387
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.005	0.0008
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.005	0.0012
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0065
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0048	0.0005
Brugia malayi	chromobox protein homolog 3	0.0039	0.0159	0.0267
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.005	0.0008
Entamoeba histolytica	glycylpeptide N-tetradecanoyltransferase, putative	0.1012	0.5947	1
Schistosoma mansoni	chromobox protein	0.007	0.0343	0.0508
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.005	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0048	0.0048
Trichomonas vaginalis	set domain proteins, putative	0.0256	0.1446	0.2373
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0045	0.0076
Brugia malayi	ecdysteroid receptor	0.0021	0.005	0.0084
Brugia malayi	Pre-SET motif family protein	0.0225	0.1261	0.2121
Loa Loa (eye worm)	hypothetical protein	0.0021	0.005	0.0051
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0177	0.0907
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0048	0.0065
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.023	0.0314
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0211	0.0285
Onchocerca volvulus		0.0044	0.0185	0.0964
Brugia malayi	Heterochromatin protein 1	0.007	0.0343	0.0576
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.005	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0021	0.005	0.0051
Schistosoma mansoni	hypothetical protein	0.005	0.0222	0.0303
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.023	0.0317
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0343	0.0504
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0177	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0864	0.1424
Schistosoma mansoni	N-myristoyltransferase	0.1012	0.5947	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0044	0.0185	0.024
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.023	1
Echinococcus multilocularis	chromobox protein 1	0.007	0.0343	0.0299
Leishmania major	N-myristoyl transferase, putative	0.1012	0.5947	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.005	0.0222	0.0299
Entamoeba histolytica	hypothetical protein	0.0036	0.014	0.0161
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.005	0.0084
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0048	0.0065
Echinococcus multilocularis	glycylpeptide N tetradecanoyltransferase	0.1012	0.5947	0.5928
Entamoeba histolytica	hypothetical protein	0.0036	0.014	0.0161
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0045	0.0042
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0116	0.0071
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0048	1
Trichomonas vaginalis	N-myristoyl transferase, putative	0.0665	0.3881	0.65
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.005	0.0012
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0048	1
Trypanosoma brucei	N-myristoyltransferase	0.1012	0.5947	1
Schistosoma mansoni	hypothetical protein	0.005	0.0222	0.0303
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0048	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.005	0.0084
Brugia malayi	N-myristoyltransferase 2	0.1012	0.5947	1
Trypanosoma cruzi	N-myristoyl transferase, putative	0.1012	0.5947	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0116	0.012
Trypanosoma brucei	unspecified product	0.0021	0.0048	0.0065
Schistosoma mansoni	coup transcription factor	0.0021	0.005	0.0012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 802176