Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.023 | 0.7817 | 1 |
Onchocerca volvulus | 0.0078 | 0.1881 | 0.2486 | |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0121 | 0.3566 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0186 | 0.6116 | 1 |
Brugia malayi | Matrixin family protein | 0.0078 | 0.1881 | 0.1879 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.3168 | 0.4744 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0043 | 0.0507 | 1 |
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.0121 | 0.3566 | 0.4185 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0096 | 0.2552 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3353 | 0.3892 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0121 | 0.3566 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1881 | 0.1879 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0121 | 0.3566 | 0.5454 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0639 | 0.0235 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0639 | 0.0181 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0078 | 0.1881 | 0.2448 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0639 | 0.0235 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0121 | 0.3566 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0043 | 0.0507 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0078 | 0.1881 | 0.1879 |
Loa Loa (eye worm) | matrixin family protein | 0.0174 | 0.5632 | 0.7011 |
Leishmania major | DNA polymerase eta, putative | 0.0043 | 0.0507 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.7817 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0078 | 0.1881 | 0.1879 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2552 | 0.2797 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3353 | 0.3892 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.7817 | 0.77 |
Onchocerca volvulus | 0.0111 | 0.3168 | 0.5064 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.294 | 0.3328 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.3566 | 0.4185 |
Onchocerca volvulus | Matrilysin homolog | 0.0174 | 0.5632 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.7817 | 0.77 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.0121 | 0.3566 | 0.3222 |
Onchocerca volvulus | Matrilysin homolog | 0.0078 | 0.1881 | 0.2486 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1881 | 0.1879 |
Brugia malayi | Hemopexin family protein | 0.0111 | 0.3168 | 0.364 |
Loa Loa (eye worm) | matrixin family protein | 0.019 | 0.6248 | 0.7854 |
Brugia malayi | Matrixin family protein | 0.0078 | 0.1881 | 0.1879 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0096 | 0.2552 | 0.2797 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.0121 | 0.3566 | 0.3222 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1881 | 0.1879 |
Mycobacterium ulcerans | hydrolase | 0.0096 | 0.2552 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0174 | 0.5632 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0121 | 0.3566 | 0.5 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.0121 | 0.3566 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0096 | 0.2552 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0078 | 0.1881 | 0.1879 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3353 | 0.3892 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0285 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.019 | 0.6248 | 0.7854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.