Detailed information for compound 807873

Basic information

Technical information
  • TDR Targets ID: 807873
  • Name: (5E)-5-[[3-bromo-5-methoxy-4-[2-(2-methylphen oxy)ethoxy]phenyl]methylidene]-3-methyl-2-sul fanylidene-1,3-thiazolidin-4-one
  • MW: 494.422 | Formula: C21H20BrNO4S2
  • H donors: 0 H acceptors: 1 LogP: 5.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C\2/SC(=S)N(C2=O)C)cc(c1OCCOc1ccccc1C)Br
  • InChi: 1S/C21H20BrNO4S2/c1-13-6-4-5-7-16(13)26-8-9-27-19-15(22)10-14(11-17(19)25-3)12-18-20(24)23(2)21(28)29-18/h4-7,10-12H,8-9H2,1-3H3/b18-12+
  • InChiKey: PQMKVAHOESRREO-LDADJPATSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5E)-5-[[3-bromo-5-methoxy-4-[2-(2-methylphenoxy)ethoxy]phenyl]methylene]-3-methyl-2-thioxo-thiazolidin-4-one
  • (5E)-5-[[3-bromo-5-methoxy-4-[2-(2-methylphenoxy)ethoxy]phenyl]methylene]-3-methyl-2-thioxo-4-thiazolidinone
  • (5E)-5-[3-bromo-5-methoxy-4-[2-(2-methylphenoxy)ethoxy]benzylidene]-3-methyl-2-thioxo-thiazolidin-4-one
  • BIM-0011014.P001
  • ZINC02966178

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aspartyl protease 0.0034 0.0482 0.1802
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0423 0.0415
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0008 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0482 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0103
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0423 0.1695
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0103
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0423 0.1695
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0008 0.5
Schistosoma mansoni biogenic amine receptor 0.0031 0.0423 0.0415
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Schistosoma mansoni hypothetical protein 0.0031 0.0423 0.0415
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0423 0.1695
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0423 0.0415
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Brugia malayi putative neuropeptide receptor 0.0031 0.0423 0.5184
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0025 0.0238 0.0939
Schistosoma mansoni neuropeptide receptor 0.0031 0.0423 0.0415
Echinococcus multilocularis g-protein coupled receptor 0.0031 0.0423 0.1695
Plasmodium falciparum plasmepsin VII 0.0034 0.0482 0.1802
Echinococcus granulosus neuropeptide s receptor 0.0031 0.0423 0.1695
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0423 0.1695
Brugia malayi putative neuropeptide receptor NPR1 0.0031 0.0423 0.5184
Brugia malayi G protein-coupled receptor 0.0031 0.0423 0.5184
Schistosoma mansoni hypothetical protein 0.0031 0.0423 0.0415
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Brugia malayi ORL1-like opioid receptor 0.0031 0.0423 0.5184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0031 0.0423 0.1695
Onchocerca volvulus 0.0034 0.0482 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Schistosoma mansoni opsin-like receptor 0.0031 0.0423 0.0415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Loa Loa (eye worm) TYRA-2 protein 0.0031 0.0423 0.1695
Echinococcus multilocularis G-protein coupled receptor, putative 0.0031 0.0423 0.1695
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0031 0.0423 0.1695
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0106 0.2454 0.93
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0031 0.0423 0.0415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Plasmodium falciparum plasmepsin VIII, putative 0.0034 0.0482 0.1802
Brugia malayi hypothetical protein 0.0034 0.0482 0.5913
Schistosoma mansoni amine GPCR 0.0031 0.0423 0.0415
Schistosoma mansoni neuropeptide receptor 0.0031 0.0423 0.0415
Brugia malayi Melatonin receptor type 1A 0.0031 0.0423 0.5184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Echinococcus multilocularis neuropeptide receptor A26 0.0031 0.0423 0.1695
Brugia malayi Tachykinin-like peptides receptor 99D 0.0031 0.0423 0.5184
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0031 0.0423 0.0415
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0031 0.0423 0.0415
Schistosoma mansoni memapsin-2 (A01 family) 0.0034 0.0482 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0423 0.1695
Plasmodium falciparum plasmepsin II 0.0106 0.2454 0.93
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0106 0.2454 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0423 0.0415
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0031 0.0423 0.0415
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0031 0.0423 0.1695
Leishmania major hypothetical protein, conserved 0.0025 0.0238 0.1849
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0423 0.1695
Brugia malayi Dopamine receptor 0.0031 0.0423 0.5184
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.089 0.7098
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0238 0.0873
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0482 0.0474
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0423 0.1695
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.1104 0.8824
Schistosoma mansoni growth hormone secretagogue receptor 0.0031 0.0423 0.0415
Echinococcus multilocularis orexin receptor type 2 0.0031 0.0423 0.1695
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0816 1
Leishmania major cathepsin L-like protease 0.0062 0.125 1
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0423 0.1695
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0482 0.0474
Plasmodium falciparum plasmepsin IV 0.0106 0.2454 0.93
Schistosoma mansoni amine GPCR 0.0031 0.0423 0.0415
Onchocerca volvulus 0.0031 0.0423 0.8745
Brugia malayi hypothetical protein 0.0031 0.0423 0.5184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0816 0.3301
Onchocerca volvulus 0.0031 0.0423 0.8745
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0482 0.1938
Plasmodium vivax aspartyl protease, putative 0.0034 0.0482 0.1802
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0482 0.1938
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0482 0.1802
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Brugia malayi follicle stimulating hormone receptor 0.0031 0.0423 0.5184
Echinococcus multilocularis neuropeptide FF receptor 2 0.0031 0.0423 0.1695
Echinococcus granulosus neuropeptide receptor 0.0031 0.0423 0.1695
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0423 0.0415
Plasmodium vivax aspartyl protease, putative 0.0113 0.2638 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0031 0.0423 0.0415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Brugia malayi hypothetical protein 0.0031 0.0423 0.5184
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Echinococcus granulosus g protein coupled receptor 0.0031 0.0423 0.1695
Brugia malayi hypothetical protein 0.0031 0.0423 0.5184
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0031 0.0423 0.0415
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0238 0.0873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0423 0.1695
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0423 0.0415
Schistosoma mansoni neuropeptide receptor 0.0031 0.0423 0.0415
Leishmania major cathepsin L-like protease 0.0062 0.125 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.125 1
Toxoplasma gondii aspartyl protease ASP3 0.0113 0.2638 1
Schistosoma mansoni histamine h1 receptor 0.0031 0.0423 0.0415
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0816 0.3301
Onchocerca volvulus 0.0031 0.0423 0.8745
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0423 0.0415
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0238 0.1849
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0816 0.0808
Leishmania major cathepsin L-like protease 0.0062 0.125 1
Plasmodium vivax aspartyl protease, putative 0.0113 0.2638 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Onchocerca volvulus 0.0031 0.0423 0.8745
Plasmodium falciparum plasmepsin VI 0.0106 0.2454 0.93
Echinococcus granulosus neuropeptide receptor A26 0.0031 0.0423 0.1695
Echinococcus granulosus g protein coupled receptor 0.0031 0.0423 0.1695
Echinococcus granulosus allatostatin A receptor 0.0031 0.0423 0.1695
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0031 0.0423 0.1695
Brugia malayi neuropeptide F receptor 0.0031 0.0423 0.5184
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0106 0.2454 0.2447
Entamoeba histolytica cysteine protease, putative 0.0016 0.0008 0.5
Brugia malayi hypothetical protein 0.0031 0.0423 0.5184
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0031 0.0423 0.1695
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0423 0.0415
Schistosoma mansoni biogenic amine receptor 0.0031 0.0423 0.0415
Plasmodium falciparum plasmepsin X 0.0113 0.2638 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0106 0.2454 1
Brugia malayi G-protein coupled receptor 0.0031 0.0423 0.5184
Brugia malayi neuropeptide F receptor 0.0031 0.0423 0.5184
Plasmodium falciparum plasmepsin IX 0.0113 0.2638 1
Onchocerca volvulus 0.0034 0.0482 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0423 0.1695
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0423 0.0415
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0423 0.0415
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Brugia malayi hypothetical protein 0.0031 0.0423 0.5184
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Brugia malayi hypothetical protein 0.0031 0.0423 0.5184
Brugia malayi RE15519p 0.0031 0.0423 0.5184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0423 0.0415
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0031 0.0423 0.1695
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0031 0.0423 0.5184
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0031 0.0423 0.1695
Echinococcus granulosus g-protein coupled receptor 0.0031 0.0423 0.1695
Brugia malayi hypothetical protein 0.0031 0.0423 0.5184
Onchocerca volvulus 0.0031 0.0423 0.8745
Schistosoma mansoni amine GPCR 0.0031 0.0423 0.0415
Brugia malayi Dopamine receptor protein 1 0.0031 0.0423 0.5184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Brugia malayi sulfakinin receptor protein 0.0031 0.0423 0.5184
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0482 0.0474
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Onchocerca volvulus 0.0031 0.0423 0.8745
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0031 0.0423 0.1695
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0031 0.0423 0.8745
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Echinococcus granulosus G protein coupled receptor 139 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Brugia malayi GnHR receptor homolog 0.0031 0.0423 0.5184
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0106 0.2454 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0031 0.0423 0.8745
Brugia malayi G protein-coupled receptor F59B2.13 0.0031 0.0423 0.5184
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Echinococcus multilocularis neuropeptide s receptor 0.0031 0.0423 0.1695
Onchocerca volvulus 0.0031 0.0423 0.8745
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0816 0.0808
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0031 0.0423 0.1695
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0031 0.0423 0.1695
Echinococcus granulosus dro:myosuppressin receptor 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Plasmodium vivax aspartyl proteinase, putative 0.0106 0.2454 0.93
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0008 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0423 0.1695
Echinococcus granulosus serotonin receptor 0.0031 0.0423 0.1695
Schistosoma mansoni amine GPCR 0.0031 0.0423 0.0415
Brugia malayi hypothetical protein 0.0034 0.0482 0.5913
Echinococcus granulosus sex peptide receptor 0.0031 0.0423 0.1695
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0423 0.0415
Brugia malayi AKH receptor 0.0031 0.0423 0.5184
Echinococcus multilocularis G protein coupled receptor 139 0.0031 0.0423 0.1695
Echinococcus multilocularis serotonin receptor 0.0031 0.0423 0.1695
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0106 0.2454 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Echinococcus granulosus neuropeptide receptor 0.0031 0.0423 0.1695
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0106 0.2454 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Schistosoma mansoni amine GPCR 0.0031 0.0423 0.0415
Loa Loa (eye worm) melatonin receptor type 1A 0.0031 0.0423 0.1695
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0031 0.0423 0.1695
Echinococcus multilocularis allatostatin A receptor 0.0031 0.0423 0.1695
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0423 0.1695
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0482 0.0474
Echinococcus granulosus 7TM GPCR rhodopsin 0.0031 0.0423 0.1695
Echinococcus granulosus somatostatin receptor 0.0031 0.0423 0.1695
Brugia malayi hypothetical protein 0.0031 0.0423 0.5184
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0103
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0423 0.1695
Echinococcus granulosus alpha 1A adrenergic receptor 0.0031 0.0423 0.1695
Echinococcus multilocularis somatostatin receptor 0.0031 0.0423 0.1695
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0423 0.0415
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0031 0.0423 0.1695
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0031 0.0423 0.5184
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0482 0.5913
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0423 0.1695
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0423 0.1695
Onchocerca volvulus 0.0031 0.0423 0.8745
Brugia malayi Dopamine receptor protein 2 0.0031 0.0423 0.5184
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0423 0.1695
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0423 0.1695
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0423 0.1695
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0423 0.0415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.125 1
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0482 0.5913
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0423 0.1695
Brugia malayi hypothetical protein 0.0031 0.0423 0.5184
Plasmodium falciparum plasmepsin III 0.0034 0.0482 0.1802
Brugia malayi hypothetical protein 0.0025 0.0238 0.2918
Brugia malayi Pepsin A precursor 0.0034 0.0482 0.5913
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0816 0.3301
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0423 0.1695
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Brugia malayi Serotonin receptor 0.0031 0.0423 0.5184
Schistosoma mansoni opsin-like receptor 0.0031 0.0423 0.0415
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0423 0.1695
Echinococcus multilocularis sex peptide receptor 0.0031 0.0423 0.1695
Echinococcus granulosus peptide allatostatin:somatostatin 0.0031 0.0423 0.1695
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0423 0.0415
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Brugia malayi hypothetical protein 0.0031 0.0423 0.5184
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0238 0.0873
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0103
Onchocerca volvulus 0.0031 0.0423 0.8745
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0423 0.1695
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0031 0.0423 0.1695
Plasmodium falciparum plasmepsin V 0.0034 0.0482 0.1802
Brugia malayi larval opioid receptor 0.0031 0.0423 0.5184
Brugia malayi Serotonin receptor 0.0031 0.0423 0.5184
Schistosoma mansoni opsin-like receptor 0.0031 0.0423 0.0415
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.125 1
Brugia malayi G-protein coupled receptor 0.0031 0.0423 0.5184
Schistosoma mansoni cathepsin D (A01 family) 0.0383 1 1
Onchocerca volvulus 0.0031 0.0423 0.8745
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0816 0.3301
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0103
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.125 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0482 0.0474
Schistosoma mansoni biogenic amine receptor 0.0031 0.0423 0.0415
Echinococcus granulosus tachykinin peptides receptor 99D 0.0031 0.0423 0.1695
Schistosoma mansoni neuropeptide receptor 0.0031 0.0423 0.0415
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0034 0.0482 0.1802
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0423 0.0415
Onchocerca volvulus 0.0031 0.0423 0.8745
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0423 0.1695
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0031 0.0423 0.1695
Echinococcus granulosus fmrfamide receptor 0.0031 0.0423 0.1695
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0031 0.0423 0.0415
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0031 0.0423 0.1695
Schistosoma mansoni hypothetical protein 0.0031 0.0423 0.0415
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0482 0.0474
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0482 0.5913
Schistosoma mansoni myosin xvIII 0.0031 0.0423 0.0415
Onchocerca volvulus 0.0031 0.0423 0.8745
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Echinococcus granulosus neuropeptide FF receptor 2 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0034 0.0482 0.1938
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0423 0.0415
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0816 0.3301
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Schistosoma mansoni hypothetical protein 0.0031 0.0423 0.0415
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0423 0.1695
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0031 0.0423 0.5184
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0238 0.1849
Plasmodium vivax plasmepsin V, putative 0.0034 0.0482 0.1802
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Echinococcus multilocularis serotonin receptor 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0034 0.0482 0.1938
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Brugia malayi Cathepsin L-like precursor 0.0016 0.0008 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0423 0.1695
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0031 0.0423 0.5184
Echinococcus granulosus orexin receptor type 2 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Onchocerca volvulus 0.0031 0.0423 0.8745
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0031 0.0423 0.0415
Schistosoma mansoni adenoreceptor 0.0031 0.0423 0.0415
Onchocerca volvulus 0.0031 0.0423 0.8745
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0423 0.0415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0423 0.1695
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Echinococcus granulosus hypothetical protein 0.0031 0.0423 0.1695
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0238 0.0873
Onchocerca volvulus 0.0031 0.0423 0.8745
Onchocerca volvulus 0.0031 0.0423 0.8745
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0423 0.0415
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0482 0.0474
Echinococcus granulosus 7tm_1 domain containing protein 0.0031 0.0423 0.1695
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.125 1
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0423 0.1695
Plasmodium falciparum plasmepsin I 0.0106 0.2454 0.93
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0423 0.1695
Onchocerca volvulus 0.0031 0.0423 0.8745
Schistosoma mansoni neuropeptide f receptor 76f 0.0031 0.0423 0.0415
Plasmodium vivax plasmepsin IV, putative 0.0106 0.2454 0.93
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0031 0.0423 0.0415
Loa Loa (eye worm) hypothetical protein 0.0031 0.0423 0.1695
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0816 0.0808
Toxoplasma gondii aspartyl protease ASP1 0.0106 0.2454 0.93
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0031 0.0423 0.5184
Echinococcus granulosus g protein coupled receptor 0.0031 0.0423 0.1695

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.