Detailed information for compound 809889

Basic information

Technical information
  • TDR Targets ID: 809889
  • Name: 2-[2,6-dichloro-4-[[1-(4-ethylphenyl)-2,4,6-t rioxo-1,3-diazinan-5-ylidene]methyl]phenoxy]a cetic acid
  • MW: 463.268 | Formula: C21H16Cl2N2O6
  • H donors: 2 H acceptors: 5 LogP: 4.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)N1C(=O)NC(=O)C(=Cc2cc(Cl)c(c(c2)Cl)OCC(=O)O)C1=O
  • InChi: 1S/C21H16Cl2N2O6/c1-2-11-3-5-13(6-4-11)25-20(29)14(19(28)24-21(25)30)7-12-8-15(22)18(16(23)9-12)31-10-17(26)27/h3-9H,2,10H2,1H3,(H,26,27)(H,24,28,30)/b14-7+
  • InChiKey: KNWFHMPOBOUQKH-VGOFMYFVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[2,6-dichloro-4-[(E)-[1-(4-ethylphenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]phenoxy]acetic acid
  • 2-[2,6-dichloro-4-[[1-(4-ethylphenyl)-2,4,6-trioxo-hexahydropyrimidin-5-ylidene]methyl]phenoxy]acetic acid
  • 2-[2,6-dichloro-4-[(E)-[1-(4-ethylphenyl)-2,4,6-trioxo-hexahydropyrimidin-5-ylidene]methyl]phenoxy]acetic acid
  • 2-[2,6-dichloro-4-[[1-(4-ethylphenyl)-2,4,6-trioxo-5-hexahydropyrimidinylidene]methyl]phenoxy]acetic acid
  • 2-[2,6-dichloro-4-[(E)-[1-(4-ethylphenyl)-2,4,6-trioxo-5-hexahydropyrimidinylidene]methyl]phenoxy]acetic acid
  • 2-[2,6-dichloro-4-[[1-(4-ethylphenyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]methyl]phenoxy]acetic acid
  • 2-[2,6-dichloro-4-[(E)-[1-(4-ethylphenyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]methyl]phenoxy]acetic acid
  • 2-[2,6-dichloro-4-[(E)-[1-(4-ethylphenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]phenoxy]ethanoic acid
  • 2-[2,6-dichloro-4-[[1-(4-ethylphenyl)-2,4,6-trioxo-1,3-diazinan-5-ylidene]methyl]phenoxy]ethanoic acid
  • BIM-0008914.P001
  • CBMicro_008902
  • STK176799

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis basement membrane specific heparan sulfate 0.005 0.0069 0.0078
Echinococcus granulosus tyrosine protein kinase Fyn 0.0111 0.0559 0.063
Trichomonas vaginalis conserved hypothetical protein 0.1303 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0053 0.0097 0.0109
Loa Loa (eye worm) phosphatidylinositol 3 0.0231 0.1504 0.1912
Trichomonas vaginalis CMGC family protein kinase 0.0196 0.1231 0.091
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0261 0.1743 0.2791
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0133 0.0728 0.4264
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0816 0.6143 0.8918
Brugia malayi protein-tyrosine kinase 0.0104 0.0501 0.0728
Echinococcus granulosus twitchin 0.006 0.0153 0.0173
Echinococcus multilocularis cyclin dependent kinase 0.0091 0.0399 0.0449
Echinococcus granulosus tyrosine protein kinase Srms 0.0046 0.0039 0.0044
Echinococcus multilocularis rho associated protein kinase 0.0297 0.2026 0.2282
Echinococcus granulosus protein kinase shaggy 0.0196 0.1231 0.1387
Entamoeba histolytica protein kinase domain containing protein 0.0196 0.1231 0.1953
Schistosoma mansoni tyrosine kinase 0.0443 0.3187 0.3561
Entamoeba histolytica protein kinase, putative 0.0077 0.0282 0.0399
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0111 0.0559 0.063
Brugia malayi Immunoglobulin I-set domain containing protein 0.035 0.245 0.3556
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0786 0.5904 0.9608
Brugia malayi SH2 domain containing protein 0.0046 0.0039 0.0056
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0261 0.1743 0.2399
Entamoeba histolytica cell division protein kinase 2, putative 0.0091 0.0399 0.059
Brugia malayi Stress-activated protein kinase jnk-1 0.0466 0.3369 0.4891
Echinococcus multilocularis neuroglian 0.0054 0.0107 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1215 0.0893
Giardia lamblia Kinase, CMGC CDK 0.0091 0.0399 0.0142
Brugia malayi Fibronectin type III domain containing protein 0.005 0.0069 0.0101
Schistosoma mansoni cell adhesion molecule 0.0056 0.0117 0.0089
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0466 0.3369 0.3795
Brugia malayi Protein kinase domain containing protein 0.0046 0.0039 0.0056
Giardia lamblia Kinase, PLK 0.0194 0.1215 0.2676
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0353 0.0515
Brugia malayi Protein kinase domain containing protein 0.0046 0.0039 0.0056
Trichomonas vaginalis hypothetical protein 0.1303 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0069 0.0088
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1161 0.8879 1
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0039 0.0049
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0231 0.1504 0.1986
Trichomonas vaginalis conserved hypothetical protein 0.1303 1 1
Plasmodium vivax protein kinase Crk2 0.0091 0.0399 0.0519
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0816 0.6143 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0111 0.0559 0.063
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0069 0.0101
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1161 0.8879 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0194 0.1215 0.1764
Echinococcus granulosus Immunoglobulin 0.005 0.0069 0.0078
Echinococcus granulosus c src tyrosine kinase 0.0053 0.0097 0.0109
Loa Loa (eye worm) hypothetical protein 0.0457 0.3299 0.4195
Trichomonas vaginalis conserved hypothetical protein 0.1303 1 1
Onchocerca volvulus Tyrosine kinase homolog 0.0299 0.2046 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0194 0.1215 0.1488
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0457 0.3299 0.4789
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.062 0.4587 0.4389
Trichomonas vaginalis conserved hypothetical protein 0.1303 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0329 0.2284 0.3678
Plasmodium falciparum protein kinase 5 0.0091 0.0399 0.0519
Echinococcus granulosus c-Jun N-terminal kinases 0.0466 0.3369 0.3795
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0039 0.0049
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0196 0.1231 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0459 0.0109
Entamoeba histolytica serine/threonine protein kinase, putative 0.0194 0.1215 0.1927
Echinococcus multilocularis Immunoglobulin 0.005 0.0069 0.0078
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0399 0.0047
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0039 0.0049
Schistosoma mansoni tyrosine kinase 0.0471 0.3405 0.3808
Loa Loa (eye worm) hypothetical protein 0.005 0.0069 0.0088
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0053 0.0097 0.0109
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0039 0.0049
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0085 0.0353 0.0398
Echinococcus granulosus tyrosine protein kinase Src42A 0.0086 0.0357 0.0402
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0133 0.0728 0.2695
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0133 0.0728 0.082
Echinococcus granulosus cyclin dependent kinase 5 0.0091 0.0399 0.0449
Echinococcus granulosus roundabout 2 0.006 0.0155 0.0175
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0046 0.0039 0.0044
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0039 0.0049
Onchocerca volvulus 0.0196 0.1231 0.5941
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1215 0.0893
Echinococcus multilocularis c src tyrosine kinase 0.0053 0.0097 0.0109
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0133 0.0728 0.1129
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0133 0.0728 0.4264
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0085 0.0353 0.0398
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.008 0.0307 0.0346
Trypanosoma brucei polo-like protein kinase 0.0194 0.1215 0.6202
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0261 0.1743 1
Echinococcus granulosus tyrosine protein kinase shark 0.0471 0.3405 0.3835
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0196 0.1231 1
Echinococcus granulosus tyrosine kinase 0.0104 0.0501 0.0565
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0111 0.0559 0.063
Trypanosoma brucei cdc2-related kinase 3 0.0091 0.0399 0.0328
Schistosoma mansoni Neurotrimin precursor (hNT) 0.005 0.0069 0.0034
Loa Loa (eye worm) TK/ABL protein kinase 0.0046 0.0039 0.0049
Loa Loa (eye worm) SRC-1 0.0111 0.0559 0.0711
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0085 0.0353 0.0398
Echinococcus multilocularis tyrosine protein kinase Srms 0.0104 0.0501 0.0565
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0196 0.1231 0.1566
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0133 0.0728 0.0646
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0085 0.0353 0.0398
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0196 0.1231 0.1516
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0194 0.1215 0.9814
Loa Loa (eye worm) hypothetical protein 0.005 0.0069 0.0088
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0194 0.1215 0.1545
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0111 0.0559 0.063
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0086 0.0357 0.0402
Loa Loa (eye worm) hypothetical protein 0.0046 0.0039 0.0049
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0111 0.0559 0.063
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0816 0.6143 0.6002
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0457 0.3299 0.3715
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0194 0.1215 0.1369
Schistosoma mansoni vesicular amine transporter 0.005 0.0069 0.0034
Echinococcus granulosus tyrosine protein kinase Fyn 0.0111 0.0559 0.063
Trypanosoma cruzi cdc2-related kinase 3 0.0091 0.0399 0.0079
Giardia lamblia Kinase, CMGC GSK 0.0196 0.1231 0.2727
Echinococcus granulosus tyrosine protein kinase Fyn 0.0111 0.0559 0.063
Brugia malayi hypothetical protein 0.0046 0.0039 0.0056
Loa Loa (eye worm) hypothetical protein 0.0359 0.2521 0.3205
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0158 0.093 0.1791
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0196 0.1231 0.1349
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0104 0.0501 0.0565
Onchocerca volvulus Serine\/threonine kinase homolog 0.0194 0.1215 0.586
Echinococcus granulosus neuroglian 0.0054 0.0107 0.0121
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0056 0.0117 0.0132
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0261 0.1743 0.144
Trypanosoma brucei cdc2-related kinase 1 0.0091 0.0399 0.0328
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0353 0.0356
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0816 0.6143 0.6002
Trichomonas vaginalis conserved hypothetical protein 0.1303 1 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0085 0.0353 0.045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0261 0.1743 0.253
Entamoeba histolytica protein kinase, putative 0.0196 0.1231 0.1953
Loa Loa (eye worm) hypothetical protein 0.005 0.0069 0.0088
Loa Loa (eye worm) hypothetical protein 0.005 0.0069 0.0088
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0466 0.3369 0.4285
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0133 0.0728 0.0388
Echinococcus granulosus tyrosine protein kinase Src42A 0.0111 0.0559 0.063
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0039 0.0049
Echinococcus granulosus tyrosine protein kinase Blk 0.0104 0.0501 0.0565
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0091 0.0399 0.0519
Echinococcus granulosus tyrosine protein kinase Lyn 0.0117 0.0606 0.0682
Schistosoma mansoni tyrosine kinase 0.0111 0.0559 0.0589
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.008 0.0307 0.0346
Entamoeba histolytica protein kinase domain containing protein 0.0196 0.1231 0.1953
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0688 0.5128 0.8338
Giardia lamblia Kinase, CMGC GSK 0.0196 0.1231 0.2727
Onchocerca volvulus 0.0297 0.2026 0.9899
Schistosoma mansoni tyrosine kinase 0.0053 0.0097 0.0066
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0039 0.0049
Brugia malayi Protein kinase domain containing protein 0.0046 0.0039 0.0056
Loa Loa (eye worm) hypothetical protein 0.0056 0.0117 0.0149
Entamoeba histolytica hypothetical protein 0.0688 0.5128 0.8338
Echinococcus granulosus tyrosine kinase 0.0046 0.0039 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.1303 1 1
Schistosoma mansoni kinase 0.0101 0.0479 0.0497
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0133 0.0728 0.4264
Trypanosoma brucei protein kinase, putative 0.0196 0.1231 0.632
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0133 0.0728 0.4264
Schistosoma mansoni tyrosine kinase 0.0053 0.0097 0.0066
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0085 0.0353 0.0398
Brugia malayi intracellular kinase 0.0196 0.1231 0.1788
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0345 0.2411 0.35
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0111 0.0559 0.063
Schistosoma mansoni nephrin 0.0054 0.0107 0.0077
Loa Loa (eye worm) hypothetical protein 0.0085 0.0353 0.045
Echinococcus granulosus defective proboscis extension response 0.005 0.0069 0.0078
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0053 0.0097 0.0109
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0196 0.1231 0.1387
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0196 0.1231 0.1387
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0459 0.0109
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0133 0.0728 0.4264
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0133 0.0728 0.0646
Leishmania major phosphatidylinositol 3-kinase, putative 0.0133 0.0728 0.4264
Loa Loa (eye worm) TK protein kinase 0.0104 0.0501 0.0637
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0085 0.0353 0.0398
Brugia malayi cell division control protein 2 homolog 0.0091 0.0399 0.0579
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0039 0.0049
Loa Loa (eye worm) hypothetical protein 0.006 0.0155 0.0197
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0046 0.0039 0.0044
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0133 0.0728 0.082
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0399 0.0407
Trichomonas vaginalis CMGC family protein kinase 0.0196 0.1231 0.091
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1215 0.0893
Trypanosoma cruzi polo-like protein kinase, putative 0.0194 0.1215 0.1488
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0039 0.0049
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0261 0.1743 0.144
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0194 0.1215 0.1369
Echinococcus multilocularis cyclin dependent kinase 1 0.0091 0.0399 0.0449
Schistosoma mansoni tyrosine kinase 0.0111 0.0559 0.0589
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.2026 0.2248
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0816 0.6143 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0046 0.0039 0.0044
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0816 0.6143 0.6002
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0353 0.0356
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0111 0.0559 0.063
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0053 0.0097 0.0066
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1161 0.8879 1
Echinococcus multilocularis tyrosine kinase 0.0046 0.0039 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1215 0.0893
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0091 0.0399 0.0507
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0091 0.0399 0.0507
Onchocerca volvulus 0.0276 0.1864 0.9094
Echinococcus multilocularis tyrosine protein kinase HCK 0.0077 0.0282 0.0318
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0399 0.0407
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.062 0.4587 0.4389
Echinococcus granulosus cyclin dependent kinase 1 0.0091 0.0399 0.0449
Echinococcus granulosus tyrosine protein kinase HCK 0.0077 0.0282 0.0318
Loa Loa (eye worm) hypothetical protein 0.0085 0.0353 0.0449
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0133 0.0728 0.0926
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0039 0.0049
Brugia malayi Protein kinase domain containing protein 0.0091 0.0399 0.0579
Loa Loa (eye worm) TK/KIN16 protein kinase 0.035 0.245 0.3115
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0399 0.0047
Echinococcus multilocularis cyclin dependent kinase 1 0.0091 0.0399 0.0449
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0111 0.0559 0.063
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.091 0.6888 0.876
Brugia malayi SH2 domain containing protein 0.0046 0.0039 0.0056
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0111 0.0559 0.063
Loa Loa (eye worm) phosphatidylinositol 3 0.1033 0.7864 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0104 0.0501 0.0565
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.005 0.0069 0.0034
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0133 0.0728 0.0779
Giardia lamblia Kinase, CMGC CDK 0.0091 0.0399 0.0142
Brugia malayi SRC-1 0.0111 0.0559 0.0812
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0091 0.0399 0.0507
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0133 0.0728 0.0388
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0457 0.3299 0.3715
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0133 0.0728 0.0779
Echinococcus multilocularis Zinc finger, PHD finger 0.0133 0.0728 0.082
Trypanosoma cruzi cdc2-related kinase 1 0.0091 0.0399 0.0079
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0085 0.0353 0.0513
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0091 0.0399 0.0519
Echinococcus granulosus cyclin dependent kinase 0.0091 0.0399 0.0449
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0261 0.1743 0.2791
Brugia malayi hypothetical protein 0.005 0.0069 0.0101
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0492 0.3572 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0816 0.6143 1
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.1215 0.1331
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1215 0.0893
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0133 0.0728 0.082
Schistosoma mansoni serine/threonine protein kinase 0.0466 0.3369 0.3768
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0261 0.1743 0.1927
Echinococcus granulosus tyrosine protein kinase ABL1 0.0046 0.0039 0.0044
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0085 0.0353 0.0398
Trypanosoma cruzi cdc2-related kinase 1 0.0091 0.0399 0.0079
Brugia malayi Protein kinase domain containing protein 0.091 0.6888 1
Trypanosoma cruzi cdc2-related kinase 3 0.0091 0.0399 0.0079
Echinococcus multilocularis Immunoglobulin 0.005 0.0069 0.0078
Plasmodium falciparum glycogen synthase kinase 3 0.0196 0.1231 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0261 0.1743 0.144
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0133 0.0728 0.1057
Entamoeba histolytica cell division protein kinase 2, putative 0.0091 0.0399 0.059
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0353 0.0356
Echinococcus multilocularis tyrosine protein kinase shark 0.0471 0.3405 0.3835
Onchocerca volvulus 0.0291 0.1979 0.9668
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0133 0.0728 0.1129
Echinococcus multilocularis cyclin dependent kinase 5 0.0091 0.0399 0.0449
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0091 0.0399 0.0449
Brugia malayi Protein kinase domain containing protein 0.0046 0.0039 0.0056
Loa Loa (eye worm) hypothetical protein 0.006 0.0155 0.0197
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0133 0.0728 0.0388
Echinococcus multilocularis protein kinase shaggy 0.0196 0.1231 0.1387
Loa Loa (eye worm) hypothetical protein 0.005 0.0069 0.0088
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0111 0.0559 0.063
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0111 0.0559 0.063
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0399 0.0047
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0196 0.1231 0.1566
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0091 0.0399 0.0519
Echinococcus granulosus tyrosine protein kinase Src64B 0.0111 0.0559 0.063
Brugia malayi Tyrosine-protein kinase abl-1 0.0053 0.0097 0.0141
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1215 0.0893
Brugia malayi Protein kinase domain containing protein 0.0046 0.0039 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.1215 0.0893
Loa Loa (eye worm) AGC/PKA protein kinase 0.0085 0.0353 0.045
Echinococcus granulosus rho-associated protein kinase 1 0.0297 0.2026 0.2282
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0353 0.0515
Echinococcus multilocularis roundabout 2 0.006 0.0155 0.0175
Loa Loa (eye worm) TK protein kinase 0.0077 0.0282 0.0359
Plasmodium vivax glycogen synthase kinase 3, putative 0.0196 0.1231 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0104 0.0501 0.0565

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.