Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0549 | 0.9735 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0175 | 0.018 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0037 | 0.0319 | 0.0328 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.005 | 0.0566 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0029 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0061 | 0.0764 | 0.0764 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0175 | 0.018 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0037 | 0.0319 | 0.0328 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0037 | 0.0319 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0037 | 0.0319 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0319 | 0.0319 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0549 | 0.9735 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0175 | 0.0175 |
Brugia malayi | leucyl aminopeptidase | 0.0037 | 0.0319 | 0.0328 |
Entamoeba histolytica | protein kinase, putative | 0.0549 | 0.9735 | 0.5 |
Entamoeba histolytica | protein kinase , putative | 0.0549 | 0.9735 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0029 | 0.0175 | 0.018 |
Leishmania major | glutaminyl cyclase, putative | 0.0037 | 0.0319 | 0.0328 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0175 | 0.018 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0037 | 0.0319 | 0.0328 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0037 | 0.0319 | 0.0328 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0549 | 0.9735 | 1 |
Leishmania major | protein kinase, putative | 0.0549 | 0.9735 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0037 | 0.0319 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0319 | 0.5643 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.005 | 0.0566 | 1 |
Trypanosoma brucei | aurora B kinase | 0.0549 | 0.9735 | 1 |
Schistosoma mansoni | protein kinase | 0.0549 | 0.9735 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Giardia lamblia | Aurora kinase | 0.0549 | 0.9735 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0037 | 0.0319 | 0.0319 |
Trypanosoma brucei | cytochrome P450, putative | 0.0029 | 0.0175 | 0.018 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0549 | 0.9735 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0319 | 0.5643 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0549 | 0.9735 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0549 | 0.9735 | 0.9981 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0175 | 0.018 |
Loa Loa (eye worm) | AUR protein kinase | 0.0549 | 0.9735 | 0.9735 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.6516 | 0.6516 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0549 | 0.9735 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.0319 | 0.5 | |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.055 | 0.9753 | 1 |
Brugia malayi | FXNA | 0.0037 | 0.0319 | 0.0328 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0175 | 0.0175 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0549 | 0.9735 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0037 | 0.0319 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0319 | 0.0319 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0037 | 0.0319 | 0.0328 |
Brugia malayi | Peptidase family M28 containing protein | 0.0037 | 0.0319 | 0.0328 |
Toxoplasma gondii | hypothetical protein | 0.0037 | 0.0319 | 0.0328 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0549 | 0.9735 | 1 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0037 | 0.0319 | 0.0327 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0037 | 0.0319 | 0.0328 |
Echinococcus granulosus | aurora kinase A | 0.0549 | 0.9735 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0549 | 0.9735 | 0.9735 |
Brugia malayi | nicalin | 0.0037 | 0.0319 | 0.0328 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0037 | 0.0319 | 0.0328 |
Echinococcus granulosus | twitchin | 0.0021 | 0.0039 | 0.004 |
Loa Loa (eye worm) | AUR protein kinase | 0.0549 | 0.9735 | 0.9735 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0549 | 0.9735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0319 | 0.0319 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0037 | 0.0319 | 0.0327 |
Trichomonas vaginalis | AGC family protein kinase | 0.0549 | 0.9735 | 1 |
Toxoplasma gondii | aurora kinase | 0.0549 | 0.9735 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0549 | 0.9735 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0549 | 0.9735 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0029 | 0.0175 | 0.3098 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0037 | 0.0319 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0549 | 0.9735 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.908 | 0.908 |
Mycobacterium leprae | putative cytochrome p450 | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0549 | 0.9735 | 0.5 |
Schistosoma mansoni | nicalin (M28 family) | 0.0037 | 0.0319 | 0.0328 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0037 | 0.0319 | 0.0328 |
Brugia malayi | Cytochrome P450 family protein | 0.0061 | 0.0764 | 0.0784 |
Brugia malayi | serine/threonine kinase 12 | 0.0549 | 0.9735 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0319 | 0.0328 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.036 | 0.6269 | 0.644 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0037 | 0.0319 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0549 | 0.9735 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0549 | 0.9735 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0549 | 0.9735 | 0.9981 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0037 | 0.0319 | 0.0328 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.