Detailed information for compound 816312

Basic information

Technical information
  • TDR Targets ID: 816312
  • Name: BIM-0006245.P001
  • MW: 222.24 | Formula: C11H14N2O3
  • H donors: 2 H acceptors: 2 LogP: 0.66 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=O)C(=O)Nc1ccccc1
  • InChi: 1S/C11H14N2O3/c1-16-8-7-12-10(14)11(15)13-9-5-3-2-4-6-9/h2-6H,7-8H2,1H3,(H,12,14)(H,13,15)
  • InChiKey: UUETXVKASGRXHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CBMicro_006301
  • N-(2-methoxyethyl)-N'-phenyloxamide
  • N-(2-methoxyethyl)-N'-phenyl-oxamide
  • N-(2-methoxyethyl)-N'-phenyl-ethanediamide
  • STK168008

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis c src tyrosine kinase 0.0063 0.0355 0.0433
Echinococcus granulosus tyrosine protein kinase Fyn 0.021 0.3229 0.3216
Schistosoma mansoni protein kinase 0.0062 0.0337 0.0307
Echinococcus multilocularis tyrosine protein kinase Fyn 0.021 0.3229 0.3933
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0125 0.1563 0.1546
Schistosoma mansoni tyrosine kinase 0.0077 0.0629 0.0668
Echinococcus granulosus tyrosine kinase 0.0188 0.2812 0.2798
Entamoeba histolytica protein kinase, putative 0.0062 0.0337 0.0154
Echinococcus multilocularis epidermal growth factor receptor 0.0164 0.2327 0.2834
Loa Loa (eye worm) hypothetical protein 0.008 0.0696 0.0778
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0223 0.3498 0.3997
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0123 0.1539 0.5
Echinococcus granulosus Immunoglobulin 0.008 0.0696 0.0678
Brugia malayi Fibronectin type III domain containing protein 0.008 0.0696 0.0465
Echinococcus granulosus tyrosine protein kinase Src42A 0.021 0.3229 0.3216
Trichomonas vaginalis STE family protein kinase 0.0125 0.1563 1
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.1016 0.0999
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.1531 0.9739
Echinococcus granulosus mitogen activated protein kinase 14 0.0123 0.1539 0.1523
Loa Loa (eye worm) TK protein kinase 0.0166 0.2383 0.2717
Schistosoma mansoni protein kinase 0.0125 0.1563 0.1816
Echinococcus multilocularis hemicentin 1 0.0049 0.0087 0.0106
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0115 0.137 0.1552
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0064 0.0381 0.0415
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0242 0.3857 0.4698
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0063 0.0355 0.033
Echinococcus multilocularis tyrosine protein kinase Blk 0.0188 0.2812 0.3424
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0188 0.2812 0.2798
Echinococcus multilocularis mitogen activated protein kinase 11 0.0123 0.1539 0.1874
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.021 0.3229 0.3216
Schistosoma mansoni protein kinase 0.006 0.0305 0.0268
Loa Loa (eye worm) hypothetical protein 0.0121 0.1494 0.1694
Brugia malayi serine/threonine-protein kinase PAK 7 0.0223 0.3498 0.3794
Schistosoma mansoni Neurotrimin precursor (hNT) 0.008 0.0696 0.075
Schistosoma mansoni hypothetical protein 0.006 0.0305 0.0268
Echinococcus granulosus hemicentin 1 0.0049 0.0087 0.0068
Echinococcus multilocularis PAK box P21 Rho binding 0.0062 0.0337 0.041
Loa Loa (eye worm) TK/EGFR protein kinase 0.0164 0.2327 0.2652
Echinococcus multilocularis mitogen activated protein kinase 14 0.0123 0.1539 0.1874
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.0696 0.0465
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0065 0.0399 0.0486
Brugia malayi Protein kinase domain 0.0125 0.1563 0.1495
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0381 0.0361
Schistosoma mansoni cell adhesion molecule 0.0095 0.0984 0.1104
Echinococcus multilocularis insulin receptor 0.0065 0.0399 0.0486
Schistosoma mansoni tyrosine kinase 0.022 0.3429 0.4114
Trichomonas vaginalis STE family protein kinase 0.0125 0.1563 1
Echinococcus multilocularis Immunoglobulin 0.008 0.0696 0.0848
Echinococcus granulosus epidermal growth factor receptor 0.0164 0.2327 0.2312
Echinococcus multilocularis PAK box P21 Rho binding 0.006 0.0305 0.0371
Echinococcus multilocularis mitogen activated protein kinase 14 0.0123 0.1539 0.1874
Entamoeba histolytica protein kinase, putative 0.0125 0.1563 0.6051
Echinococcus multilocularis tyrosine protein kinase HCK 0.0166 0.2383 0.2903
Echinococcus multilocularis tyrosine protein kinase Fgr 0.021 0.3229 0.3933
Echinococcus granulosus insulin receptor 0.0065 0.0399 0.038
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0169 0.2425 0.2953
Giardia lamblia Kinase, STE STE20 0.0125 0.1563 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.0696 0.0778
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0064 0.0381 0.009
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0095 0.0984 0.0966
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0125 0.1563 0.1903
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0464 0.8211 0.8208
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.1016 0.1237
Loa Loa (eye worm) hypothetical protein 0.0123 0.1531 0.1737
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0163 0.2316 0.2301
Echinococcus granulosus neuroglian 0.0106 0.1207 0.1189
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.021 0.3229 0.3933
Schistosoma mansoni tyrosine kinase 0.0063 0.0355 0.033
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0464 0.8211 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0065 0.0399 0.038
Trichomonas vaginalis STE family protein kinase 0.0125 0.1563 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0063 0.0355 0.0433
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0125 0.1563 0.1546
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0381 0.0361
Echinococcus granulosus tyrosine protein kinase Fyn 0.021 0.3229 0.3216
Brugia malayi SRC-1 0.021 0.3229 0.3475
Loa Loa (eye worm) hypothetical protein 0.008 0.0696 0.0778
Loa Loa (eye worm) TK/ABL protein kinase 0.0242 0.3857 0.441
Onchocerca volvulus Tyrosine kinase homolog 0.0054 0.0186 1
Schistosoma mansoni tyrosine kinase 0.0097 0.1016 0.1143
Entamoeba histolytica protein kinase, putative 0.0062 0.0337 0.0154
Loa Loa (eye worm) hypothetical protein 0.013 0.1661 0.1886
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.006 0.0305 0.0328
Echinococcus granulosus fibroblast growth factor receptor 4 0.0464 0.8211 0.8208
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1109 0.1258
Loa Loa (eye worm) TK/INSR protein kinase 0.0065 0.0399 0.0436
Echinococcus granulosus tyrosine protein kinase ABL1 0.0242 0.3857 0.3845
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.137 0.1266
Echinococcus granulosus PAK box P21 Rho binding 0.006 0.0305 0.0286
Schistosoma mansoni tyrosine kinase 0.006 0.0307 0.027
Schistosoma mansoni wiskott-aldrich syndrome protein 0.006 0.0305 0.0268
Echinococcus multilocularis basement membrane specific heparan sulfate 0.008 0.0696 0.0848
Schistosoma mansoni tyrosine kinase 0.0164 0.2327 0.2758
Loa Loa (eye worm) SRC-1 0.021 0.3229 0.3689
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.008 0.0696 0.075
Brugia malayi Protein kinase domain containing protein 0.0065 0.0399 0.0112
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0046 0.0019 0.0024
Brugia malayi Tyrosine-protein kinase abl-1 0.0139 0.1854 0.1841
Loa Loa (eye worm) hypothetical protein 0.008 0.0696 0.0778
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0188 0.2812 0.3424
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0125 0.1563 0.1903
Echinococcus multilocularis tyrosine protein kinase Src64B 0.021 0.3229 0.3933
Loa Loa (eye worm) hypothetical protein 0.0095 0.0984 0.1108
Entamoeba histolytica p21-activated kinase 0.0125 0.1563 0.6051
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0163 0.2316 0.282
Echinococcus multilocularis tyrosine protein kinase Fyn 0.021 0.3229 0.3933
Echinococcus granulosus tyrosine protein kinase Lyn 0.0211 0.3261 0.3248
Brugia malayi P38 map kinase family protein 2 0.0123 0.1539 0.1467
Echinococcus multilocularis Immunoglobulin 0.008 0.0696 0.0848
Echinococcus granulosus defective proboscis extension response 0.008 0.0696 0.0678
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.021 0.3229 0.3933
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.1016 0.0999
Echinococcus granulosus mitogen activated protein kinase 11 0.0123 0.1539 0.1523
Trichomonas vaginalis STE family protein kinase 0.0125 0.1563 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0696 0.0778
Echinococcus granulosus tyrosine protein kinase Fyn 0.021 0.3229 0.3216
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.021 0.3229 0.3933
Echinococcus multilocularis roundabout 2 0.0121 0.1494 0.1819
Echinococcus multilocularis tyrosine protein kinase Srms 0.0188 0.2812 0.3424
Brugia malayi Furin-like cysteine rich region family protein 0.0164 0.2327 0.2403
Echinococcus granulosus tyrosine protein kinase Blk 0.0188 0.2812 0.2798
Schistosoma mansoni hypothetical protein 0.006 0.0305 0.0268
Echinococcus granulosus tyrosine protein kinase Src42A 0.0169 0.2425 0.241
Schistosoma mansoni nephrin 0.0106 0.1207 0.1378
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0125 0.1563 0.1546
Echinococcus multilocularis neuroglian 0.0106 0.1207 0.1469
Schistosoma mansoni protein kinase 0.0125 0.1563 0.1816
Schistosoma mansoni tyrosine kinase 0.0077 0.0629 0.0668
Schistosoma mansoni tyrosine kinase 0.0097 0.1016 0.1143
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.1544 0.1472
Loa Loa (eye worm) hypothetical protein 0.008 0.0696 0.0778
Schistosoma mansoni tyrosine kinase 0.021 0.3229 0.3868
Schistosoma mansoni tyrosine kinase 0.0063 0.0355 0.033
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0123 0.1539 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0063 0.0355 0.0336
Entamoeba histolytica protein kinase, putative 0.0062 0.0337 0.0154
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0125 0.1563 0.1903
Schistosoma mansoni tyrosine kinase 0.0077 0.0629 0.0668
Echinococcus granulosus roundabout 2 0.0121 0.1494 0.1477
Echinococcus granulosus tyrosine protein kinase HCK 0.0166 0.2383 0.2369
Brugia malayi protein-tyrosine kinase 0.0188 0.2812 0.2979
Schistosoma mansoni hypothetical protein 0.006 0.0305 0.0268
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.006 0.0305 0.0286
Echinococcus multilocularis tyrosine protein kinase Fyn 0.021 0.3229 0.3933
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.006 0.0305 0.0286
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0123 0.1539 1
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0123 0.1539 0.1746
Brugia malayi hypothetical protein 0.008 0.0696 0.0465
Echinococcus multilocularis tyrosine protein kinase Abl 0.0139 0.1854 0.2258
Echinococcus granulosus tyrosine protein kinase Src64B 0.021 0.3229 0.3216
Brugia malayi Immunoglobulin I-set domain containing protein 0.049 0.8721 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0123 0.1539 0.1874
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0064 0.0381 0.0415
Loa Loa (eye worm) TK protein kinase 0.049 0.8721 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0123 0.1539 0.5
Echinococcus granulosus contactin 0.0049 0.0087 0.0068
Schistosoma mansoni tyrosine kinase 0.008 0.0691 0.0744
Echinococcus multilocularis tyrosine protein kinase Src42A 0.021 0.3229 0.3933
Schistosoma mansoni tyrosine kinase 0.021 0.3229 0.3868
Loa Loa (eye worm) hypothetical protein 0.0096 0.1008 0.1136
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0063 0.0349 0.033
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.006 0.0305 0.0371
Entamoeba histolytica protein kinase, putative 0.0166 0.2383 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.021 0.3229 0.3216
Echinococcus granulosus twitchin 0.0108 0.1239 0.1222
Echinococcus granulosus c src tyrosine kinase 0.0063 0.0355 0.0336
Loa Loa (eye worm) TK protein kinase 0.0188 0.2812 0.3209
Schistosoma mansoni tyrosine kinase 0.0065 0.0399 0.0384
Schistosoma mansoni vesicular amine transporter 0.008 0.0696 0.075
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0064 0.0381 0.0358
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0464 0.8211 1
Schistosoma mansoni tyrosine kinase 0.0464 0.8211 1
Schistosoma mansoni tyrosine kinase 0.0065 0.0399 0.0384

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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