Detailed information for compound 816884

Basic information

Technical information
  • TDR Targets ID: 816884
  • Name: 2,5-dichloro-N-(2-methoxy-5-nitrophenyl)benze nesulfonamide
  • MW: 377.2 | Formula: C13H10Cl2N2O5S
  • H donors: 1 H acceptors: 4 LogP: 3.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NS(=O)(=O)c1cc(Cl)ccc1Cl)[N+](=O)[O-]
  • InChi: 1S/C13H10Cl2N2O5S/c1-22-12-5-3-9(17(18)19)7-11(12)16-23(20,21)13-6-8(14)2-4-10(13)15/h2-7,16H,1H3
  • InChiKey: LVEDUOGXGSFLNW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,5-dichloro-N-(2-methoxy-5-nitro-phenyl)benzenesulfonamide
  • BIM-0011564.P001
  • AG-690/11635591
  • ZINC00854672
  • 2,5-Dichloro-N-(2-methoxy-5-nitro-phenyl)-benzenesulfonamide
  • BAS 00627797
  • STK029948
  • CBMicro_011773

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.018 0.0445 0.0442
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0037 0.0025
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0023 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0037 0.0025
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0969 0.2794 0.9284
Mycobacterium ulcerans beta-lactamase 0.0038 0.0023 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0003 0.0003
Echinococcus granulosus carbonic anhydrase 0.1339 0.3897 0.3897
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.1339 0.3897 0.3894
Entamoeba histolytica ankyrin, putative 0.0075 0.0132 0.0245
Loa Loa (eye worm) hypothetical protein 0.2605 0.7665 0.7665
Brugia malayi beta-lactamase family protein 0.0038 0.0023 0.0019
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0023 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0019
Brugia malayi beta-lactamase family protein 0.0038 0.0023 0.0019
Schistosoma mansoni carbonic anhydrase-related 0.1339 0.3897 0.3894
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0023 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.4735 1
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0043 0.0037 0.0048
Onchocerca volvulus 0.0072 0.0124 0.1825
Echinococcus multilocularis carbonic anhydrase 0.1339 0.3897 0.3894
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0019
Plasmodium falciparum carbonic anhydrase 0.1339 0.3897 1
Schistosoma mansoni hypothetical protein 0.0038 0.0022 0.0019
Echinococcus granulosus geminin 0.018 0.0445 0.0445
Echinococcus granulosus dynactin 5 p25 0.0075 0.0132 0.0132
Entamoeba histolytica acetyltransferase, putative 0.0075 0.0132 0.0245
Mycobacterium ulcerans carbonic anhydrase 0.1621 0.4735 1
Mycobacterium ulcerans transferase 0.0072 0.0124 0.0237
Onchocerca volvulus 0.0038 0.0023 0.0288
Brugia malayi Putative carbonic anhydrase 5 precursor 0.3389 1 1
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0035 0.0012 0.0022
Onchocerca volvulus 0.0038 0.0023 0.0288
Echinococcus multilocularis carbonic anhydrase 0.1339 0.3897 0.3894
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1339 0.3897 0.3894
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1041 0.3008 1
Loa Loa (eye worm) hypothetical protein 0.1339 0.3897 0.3894
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.0571 0.0568
Mycobacterium ulcerans lipase LipD 0.0038 0.0023 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0124 0.0215
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1339 0.3897 0.3894
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0023 0.001
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.3389 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1339 0.3897 0.3894
Echinococcus multilocularis geminin 0.018 0.0445 0.0442
Mycobacterium ulcerans carbonic anhydrase 0.1549 0.4521 0.9547
Trichomonas vaginalis set domain proteins, putative 0.0253 0.0663 0.1359
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0019
Echinococcus multilocularis carbonic anhydrase 0.1339 0.3897 0.3894
Echinococcus multilocularis carbonic anhydrase II 0.3389 1 1
Mycobacterium leprae PROBABLE TRANSFERASE 0.0072 0.0124 0.0225
Mycobacterium leprae Probable transmembrane transport protein 0.0252 0.066 0.1417
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0075 0.0132 1
Plasmodium vivax sulfate transporter, putative 0.0035 0.0012 0.4497
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0019
Entamoeba histolytica carbonic anhydrase, putative 0.1549 0.4521 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0023 0.0049
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.3389 1 1
Schistosoma mansoni carbonic anhydrase-related 0.1339 0.3897 0.3894
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0646 0.0643
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0023 0.0019
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1339 0.3897 0.3894
Leishmania major carbonic anhydrase family protein, putative 0.1549 0.4521 0.4509
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0023 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0037 0.0025
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0252 0.066 0.2135
Onchocerca volvulus Putative sulfate transporter 0.0219 0.0559 0.8424
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0043 0.0037 0.0032
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0022 0.0019
Echinococcus granulosus carbonic anhydrase 0.1339 0.3897 0.3897
Brugia malayi Pre-SET motif family protein 0.0223 0.0571 0.0568
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0022 0.0022
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.3389 1 1
Loa Loa (eye worm) hypothetical protein 0.1339 0.3897 0.3894
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0023 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0023 0.0019
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1549 0.4521 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.0637 0.206
Schistosoma mansoni carbonic anhydrase 0.1339 0.3897 0.3894
Loa Loa (eye worm) beta-lactamase 0.0038 0.0023 0.0019
Schistosoma mansoni carbonic anhydrase 0.1549 0.4521 0.4519
Trichomonas vaginalis conserved hypothetical protein 0.1621 0.4735 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0019
Trypanosoma brucei carbonic anhydrase-like protein 0.3389 1 1
Chlamydia trachomatis sulfate transporter 0.0035 0.0012 0.5
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0646 0.0643
Leishmania major hypothetical protein, conserved 0.0043 0.0037 0.0014
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.3389 1 1
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0075 0.0132 1
Echinococcus granulosus carbonic anhydrase II 0.3389 1 1
Leishmania major carbonic anhydrase-like protein 0.3389 1 1
Onchocerca volvulus 0.0219 0.0559 0.8424
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0023 0.001
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0833 0.2387 0.7922
Mycobacterium ulcerans hypothetical protein 0.0043 0.0037 0.0053
Schistosoma mansoni carbonic anhydrase-related 0.1339 0.3897 0.3894
Mycobacterium ulcerans hypothetical protein 0.0038 0.0023 0.0022
Toxoplasma gondii hypothetical protein 0.1339 0.3897 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.3389 1 1
Onchocerca volvulus 0.0038 0.0023 0.0288
Echinococcus granulosus carbonic anhydrase 0.1339 0.3897 0.3897
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0072 0.0124 0.0215
Schistosoma mansoni hypothetical protein 0.018 0.0445 0.0442
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0075 0.0132 0.0368
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1339 0.3897 0.3894
Brugia malayi hypothetical protein 0.0038 0.0022 0.0019
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0023 0.0022
Brugia malayi beta-lactamase 0.0038 0.0023 0.0019
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1339 0.3897 0.3894
Loa Loa (eye worm) carbonic anhydrase 3 0.3389 1 1
Onchocerca volvulus 0.0253 0.0663 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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