Detailed information for compound 820014

Basic information

Technical information
  • TDR Targets ID: 820014
  • Name: 4-fluoro-N-(2-phenylpropyl)naphthalene-1-carb oxamide
  • MW: 307.361 | Formula: C20H18FNO
  • H donors: 1 H acceptors: 1 LogP: 4.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccccc1)CNC(=O)c1ccc(c2c1cccc2)F
  • InChi: 1S/C20H18FNO/c1-14(15-7-3-2-4-8-15)13-22-20(23)18-11-12-19(21)17-10-6-5-9-16(17)18/h2-12,14H,13H2,1H3,(H,22,23)
  • InChiKey: DGNGZJCEHLGQBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-fluoro-N-(2-phenylpropyl)-1-naphthalenecarboxamide
  • 4-fluoro-N-(2-phenylpropyl)-1-naphthamide
  • Oprea1_360366
  • BAS 00729484
  • 4-Fluoro-naphthalene-1-carboxylic acid (2-phenyl-propyl)-amide
  • Oprea1_033888
  • BIM-0013671.P001
  • CBMicro_013755

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.019 0.1123 0.7119
Onchocerca volvulus 0.0044 0.0014 0.0088
Toxoplasma gondii aspartyl protease 0.019 0.1123 0.179
Onchocerca volvulus Cathepsin L homolog 0.0044 0.0014 0.0088
Toxoplasma gondii cathepsin CPL 0.0044 0.0014 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Schistosoma mansoni hypothetical protein 0.0251 0.1578 0.1566
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0495 0.3424 1
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.0014 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Brugia malayi aspartic protease BmAsp-1, identical 0.019 0.1123 0.7119
Brugia malayi Protein kinase domain containing protein 0.0251 0.1578 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0251 0.1578 0.203
Onchocerca volvulus Cathepsin F homolog 0.0044 0.0014 0.0088
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0041
Brugia malayi Cathepsin L-like precursor 0.0044 0.0014 0.0088
Loa Loa (eye worm) TK/ROR protein kinase 0.0251 0.1578 0.4608
Plasmodium falciparum plasmepsin I 0.0495 0.3424 0.4427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Onchocerca volvulus 0.0044 0.0014 0.0088
Plasmodium falciparum plasmepsin IV 0.0495 0.3424 0.4427
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.1123 0.1111
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.0014 0.5
Brugia malayi hypothetical protein 0.019 0.1123 0.7119
Brugia malayi aspartic protease BmAsp-2, identical 0.019 0.1123 0.7119
Brugia malayi hypothetical protein 0.019 0.1123 0.7119
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0495 0.3424 0.5456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Schistosoma mansoni cathepsin D (A01 family) 0.1364 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.1123 0.1111
Loa Loa (eye worm) hypothetical protein 0.019 0.1123 0.3281
Plasmodium vivax aspartyl protease, putative 0.027 0.1727 0.2224
Onchocerca volvulus 0.0044 0.0014 0.0088
Plasmodium falciparum plasmepsin VIII, putative 0.019 0.1123 0.144
Plasmodium falciparum plasmepsin X 0.027 0.1727 0.2224
Onchocerca volvulus 0.0251 0.1578 1
Plasmodium falciparum plasmepsin III 0.019 0.1123 0.144
Onchocerca volvulus 0.0044 0.0014 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Schistosoma mansoni memapsin-2 (A01 family) 0.019 0.1123 0.1111
Onchocerca volvulus 0.0044 0.0014 0.0088
Plasmodium vivax aspartyl protease, putative 0.027 0.1727 0.2224
Loa Loa (eye worm) aspartic protease BmAsp-1 0.019 0.1123 0.3281
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.019 0.1123 0.179
Plasmodium falciparum plasmepsin IX 0.027 0.1727 0.2224
Onchocerca volvulus 0.0044 0.0014 0.0088
Plasmodium falciparum plasmepsin VI 0.0495 0.3424 0.4427
Plasmodium vivax plasmepsin IV, putative 0.0495 0.3424 0.4427
Toxoplasma gondii kringle domain-containing protein 0.0251 0.1578 0.2514
Brugia malayi Cathepsin L-like precursor 0.0044 0.0014 0.0088
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0495 0.3424 0.3415
Loa Loa (eye worm) cysteine protease 0.0044 0.0014 0.0041
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.1123 0.1111
Toxoplasma gondii aspartyl protease ASP3 0.027 0.1727 0.2752
Onchocerca volvulus Cathepsin L homolog 0.0044 0.0014 0.0088
Brugia malayi Cathepsin L-like precursor 0.0044 0.0014 0.0088
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0044 0.0014 0.0041
Plasmodium falciparum plasmepsin VII 0.019 0.1123 0.144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Loa Loa (eye worm) hypothetical protein 0.0251 0.1578 0.4608
Loa Loa (eye worm) hypothetical protein 0.019 0.1123 0.3281
Brugia malayi Pepsin A precursor 0.019 0.1123 0.7119
Loa Loa (eye worm) fibroinase 0.0044 0.0014 0.0041
Toxoplasma gondii aspartyl protease ASP1 0.0495 0.3424 0.5456
Echinococcus multilocularis tissue type plasminogen activator 0.0251 0.1578 0.4586
Brugia malayi Cathepsin L-like precursor 0.0044 0.0014 0.0088
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.0014 0.0088
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0495 0.3424 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.1123 0.1111
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.1123 0.1111
Entamoeba histolytica cysteine protease, putative 0.0044 0.0014 0.5
Plasmodium falciparum plasmepsin II 0.0495 0.3424 0.4427
Loa Loa (eye worm) hypothetical protein 0.0495 0.3424 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Loa Loa (eye worm) aspartyl protease 6 0.019 0.1123 0.3281
Plasmodium falciparum cysteine repeat modular protein 1 0.0251 0.1578 0.203
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0495 0.3424 1
Toxoplasma gondii aspartyl protease ASP5 0.0872 0.6276 1
Plasmodium vivax aspartyl proteinase, putative 0.019 0.1123 0.144
Plasmodium falciparum plasmepsin V 0.1062 0.7717 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.019 0.1123 0.7119
Plasmodium vivax aspartyl proteinase, putative 0.0495 0.3424 0.4427
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0014 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Echinococcus granulosus tissue type plasminogen activator 0.0251 0.1578 0.4586
Onchocerca volvulus 0.019 0.1123 0.7119
Loa Loa (eye worm) ctsf protein 0.0044 0.0014 0.0041
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.1123 0.1111
Onchocerca volvulus 0.0044 0.0014 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0251 0.1578 1
Brugia malayi Kringle domain containing protein 0.0251 0.1578 1
Plasmodium vivax plasmepsin V, putative 0.1062 0.7717 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0044 0.0014 0.5
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.1123 0.1111
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0495 0.3424 1
Leishmania major hypothetical protein, conserved 0.0251 0.1578 1
Brugia malayi Cathepsin L-like precursor 0.0044 0.0014 0.0088
Plasmodium vivax aspartyl protease, putative 0.019 0.1123 0.144
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.019 0.1123 0.1111
Brugia malayi Cathepsin L-like precursor 0.0044 0.0014 0.0088

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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