Detailed information for compound 821809

Basic information

Technical information
  • TDR Targets ID: 821809
  • Name: 5-(2,4-dichlorophenyl)-N-prop-2-enylfuran-2-c arboxamide
  • MW: 296.149 | Formula: C14H11Cl2NO2
  • H donors: 1 H acceptors: 1 LogP: 4.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCNC(=O)c1ccc(o1)c1ccc(cc1Cl)Cl
  • InChi: 1S/C14H11Cl2NO2/c1-2-7-17-14(18)13-6-5-12(19-13)10-4-3-9(15)8-11(10)16/h2-6,8H,1,7H2,(H,17,18)
  • InChiKey: CDDPKDDXXLOVMP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-allyl-5-(2,4-dichlorophenyl)furan-2-carboxamide
  • N-allyl-5-(2,4-dichlorophenyl)-2-furancarboxamide
  • N-allyl-5-(2,4-dichlorophenyl)-2-furamide
  • 5-(2,4-dichlorophenyl)-N-prop-2-enyl-furan-2-carboxamide
  • CBMicro_007085
  • BIM-0007089.P001
  • ZINC05094343
  • Oprea1_523509

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PAN domain containing protein 0.0075 0.0096 0.0087
Plasmodium vivax plasmepsin IV, putative 0.0274 0.0906 0.1338
Loa Loa (eye worm) hypothetical protein 0.013 0.0318 0.0309
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0115 0.0259 1
Brugia malayi Trypsin family protein 0.013 0.0318 0.0309
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0428 0.1285
Brugia malayi Pepsin A precursor 0.0157 0.0428 0.0419
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.022 0.0683 0.2066
Plasmodium falciparum cysteine repeat modular protein 1 0.0383 0.1346 0.2572
Echinococcus multilocularis enteropeptidase 0.013 0.0318 0.2177
Brugia malayi hypothetical protein 0.013 0.0318 0.0309
Plasmodium falciparum plasmepsin IX 0.0399 0.1411 0.2755
Schistosoma mansoni memapsin-2 (A01 family) 0.0157 0.0428 0.1285
Brugia malayi PAN domain containing protein 0.0075 0.0096 0.0087
Echinococcus multilocularis glycoprotein Antigen 5 0.013 0.0318 0.2177
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.013 0.0318 0.0947
Loa Loa (eye worm) hypothetical protein 0.0075 0.0096 0.0087
Onchocerca volvulus 0.013 0.0318 0.1775
Brugia malayi PAN domain containing protein 0.0075 0.0096 0.0087
Onchocerca volvulus 0.0157 0.0428 0.2657
Plasmodium falciparum plasmepsin IV 0.0274 0.0906 0.1338
Loa Loa (eye worm) hypothetical protein 0.0114 0.0254 0.0245
Loa Loa (eye worm) hypothetical protein 0.0157 0.0428 0.0419
Echinococcus multilocularis integrin alpha 3 0.0115 0.026 0.1735
Trypanosoma brucei prolyl endopeptidase 0.0128 0.0313 1
Echinococcus granulosus transmembrane protease serine 3 0.013 0.0318 0.2177
Onchocerca volvulus 0.013 0.0318 0.1775
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0114 0.0254 0.0245
Loa Loa (eye worm) hypothetical protein 0.013 0.0318 0.0309
Loa Loa (eye worm) hypothetical protein 0.0075 0.0096 0.0087
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0 0.5
Plasmodium falciparum plasmepsin VI 0.0274 0.0906 0.1338
Echinococcus multilocularis transmembrane protease serine 3 0.013 0.0318 0.2177
Schistosoma mansoni integrin beta subunit 0.0181 0.0528 0.159
Brugia malayi Protein kinase domain containing protein 0.0383 0.1346 0.1338
Toxoplasma gondii prolyl endopeptidase 0.0128 0.0313 0.0665
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0032 0.007
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0274 0.0906 0.5
Brugia malayi aspartic protease BmAsp-1, identical 0.0157 0.0428 0.0419
Brugia malayi PAN domain containing protein 0.0075 0.0096 0.0087
Echinococcus granulosus calpain A 0.0059 0.0033 0.0007
Toxoplasma gondii aspartyl protease 0.0157 0.0428 0.1017
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.013 0.0318 0.2177
Echinococcus granulosus glycoprotein Antigen 5 0.013 0.0318 0.2177
Schistosoma mansoni hypothetical protein 0.013 0.0318 0.0947
Toxoplasma gondii kringle domain-containing protein 0.0383 0.1346 0.3828
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0428 0.1285
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.013 0.0318 0.0947
Plasmodium vivax aspartyl proteinase, putative 0.0274 0.0906 0.1338
Onchocerca volvulus 0.013 0.0318 0.1775
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0383 0.1346 0.2572
Loa Loa (eye worm) integrin beta-2 0.0308 0.1041 0.1033
Echinococcus multilocularis prolyl endopeptidase 0.0128 0.0313 0.2142
Echinococcus multilocularis Mastin 0.013 0.0318 0.2177
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.0402 0.0393
Brugia malayi PAN domain containing protein 0.0075 0.0096 0.0087
Loa Loa (eye worm) hypothetical protein 0.0157 0.0428 0.0419
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Brugia malayi PAN domain containing protein 0.0075 0.0096 0.0087
Brugia malayi PAN domain containing protein 0.0075 0.0096 0.0087
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Loa Loa (eye worm) hypothetical protein 0.0083 0.0129 0.012
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0274 0.0906 0.0897
Echinococcus granulosus Mastin 0.013 0.0318 0.2177
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0428 0.1285
Loa Loa (eye worm) hypothetical protein 0.0075 0.0096 0.0087
Plasmodium falciparum plasmepsin I 0.0274 0.0906 0.1338
Brugia malayi PAN domain containing protein 0.0075 0.0096 0.0087
Onchocerca volvulus 0.013 0.0318 0.1775
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Trypanosoma cruzi prolyl endopeptidase 0.0128 0.0313 0.2329
Plasmodium falciparum plasmepsin X 0.0399 0.1411 0.2755
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.013 0.0318 0.0309
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.013 0.0318 0.0947
Loa Loa (eye worm) PAN domain-containing protein 0.0075 0.0096 0.0087
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.0313 0.0933
Echinococcus multilocularis tissue type plasminogen activator 0.0383 0.1346 1
Echinococcus multilocularis integrin alpha ps 0.0067 0.0066 0.026
Brugia malayi Trypsin family protein 0.013 0.0318 0.0309
Loa Loa (eye worm) integrin alpha pat-2 0.0232 0.0732 0.0724
Mycobacterium ulcerans hypothetical protein 0.013 0.0318 1
Onchocerca volvulus 0.013 0.0318 0.1775
Schistosoma mansoni hypothetical protein 0.013 0.0318 0.0947
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0032 0.007
Onchocerca volvulus Prolyl endopeptidase homolog 0.0128 0.0313 0.1738
Loa Loa (eye worm) aspartyl protease 6 0.0157 0.0428 0.0419
Loa Loa (eye worm) PAN domain-containing protein 0.0075 0.0096 0.0087
Loa Loa (eye worm) hypothetical protein 0.0075 0.0096 0.0087
Brugia malayi Integrin beta pat-3 precursor 0.0308 0.1041 0.1033
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Loa Loa (eye worm) hypothetical protein 0.0118 0.0271 0.0262
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0274 0.0906 0.2748
Plasmodium vivax aspartyl protease, putative 0.0399 0.1411 0.2755
Schistosoma mansoni integrin alpha-ps 0.0067 0.0066 0.0175
Echinococcus granulosus tissue type plasminogen activator 0.0383 0.1346 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0096 0.0087
Loa Loa (eye worm) hypothetical protein 0.013 0.0318 0.0309
Loa Loa (eye worm) hypothetical protein 0.0383 0.1346 0.1338
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.013 0.0318 0.2177
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.022 0.0683 0.2066
Brugia malayi prolyl oligopeptidase family protein 0.0128 0.0313 0.0304
Loa Loa (eye worm) hypothetical protein 0.0075 0.0096 0.0087
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0157 0.0428 0.0419
Echinococcus multilocularis calpain A 0.0059 0.0033 0.0007
Toxoplasma gondii aspartyl protease ASP1 0.0274 0.0906 0.2479
Loa Loa (eye worm) hypothetical protein 0.013 0.0318 0.0309
Plasmodium falciparum plasmepsin V 0.1037 0.3996 1
Trypanosoma cruzi hypothetical protein, conserved 0.0383 0.1346 1
Loa Loa (eye worm) trypsin family protein 0.013 0.0318 0.0309
Loa Loa (eye worm) hypothetical protein 0.0274 0.0906 0.0897
Loa Loa (eye worm) hypothetical protein 0.022 0.0683 0.0675
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0274 0.0906 0.6648
Schistosoma mansoni cathepsin D (A01 family) 0.0858 0.3271 1
Brugia malayi Trypsin family protein 0.022 0.0683 0.0675
Echinococcus granulosus enteropeptidase 0.013 0.0318 0.2177
Brugia malayi Trypsin-like protease protein 5 0.013 0.0318 0.0309
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0157 0.0428 0.1017
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.0313 0.0933
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Brugia malayi Trypsin family protein 0.013 0.0318 0.0309
Plasmodium vivax aspartyl protease, putative 0.0399 0.1411 0.2755
Loa Loa (eye worm) PAN domain-containing protein 0.0075 0.0096 0.0087
Schistosoma mansoni hypothetical protein 0.0383 0.1346 0.4099
Toxoplasma gondii aspartyl protease ASP3 0.0399 0.1411 0.4027
Plasmodium vivax plasmepsin V, putative 0.1037 0.3996 1
Echinococcus granulosus integrin alpha ps 0.0067 0.0066 0.026
Toxoplasma gondii aspartyl protease ASP5 0.088 0.3361 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0428 0.1285
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Brugia malayi PAN domain containing protein 0.0075 0.0096 0.0087
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.013 0.0318 0.2177
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.013 0.0318 0.0947
Plasmodium falciparum plasmepsin II 0.0274 0.0906 0.1338
Onchocerca volvulus 0.0157 0.0428 0.2657
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Loa Loa (eye worm) PAN domain-containing protein 0.0075 0.0096 0.0087
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0128 0.0313 0.2329
Echinococcus granulosus integrin beta 2 0.0228 0.0717 0.5216
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.013 0.0318 0.2177
Schistosoma mansoni integrin alpha 0.015 0.0402 0.1205
Schistosoma mansoni cercarial elastase (S01 family) 0.013 0.0318 0.0947
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.013 0.0318 0.0947
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0274 0.0906 0.2479
Loa Loa (eye worm) hypothetical protein 0.013 0.0318 0.0309
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0428 0.1285
Loa Loa (eye worm) PAN domain-containing protein 0.0075 0.0096 0.0087
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.2518 1 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0274 0.0906 0.6648
Brugia malayi Eukaryotic aspartyl protease family protein 0.0157 0.0428 0.0419
Onchocerca volvulus 0.009 0.0158 0.0496
Leishmania major hypothetical protein, conserved 0.0383 0.1346 1
Echinococcus multilocularis integrin beta 2 0.0228 0.0717 0.5216
Brugia malayi Kringle domain containing protein 0.0383 0.1346 0.1338
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0428 0.1285
Loa Loa (eye worm) hypothetical protein 0.022 0.0683 0.0675
Onchocerca volvulus 0.0383 0.1346 1
Brugia malayi hypothetical protein 0.0157 0.0428 0.0419
Onchocerca volvulus 0.022 0.0683 0.4697
Echinococcus multilocularis integrin alpha ps 0.0067 0.0066 0.026
Loa Loa (eye worm) TK/ROR protein kinase 0.0383 0.1346 0.1338
Loa Loa (eye worm) hypothetical protein 0.0075 0.0096 0.0087
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.013 0.0318 0.0947
Brugia malayi hypothetical protein 0.0157 0.0428 0.0419
Brugia malayi aspartic protease BmAsp-2, identical 0.0157 0.0428 0.0419
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0428 0.1285
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0428 0.1285
Echinococcus granulosus prolyl endopeptidase 0.0128 0.0313 0.2142
Loa Loa (eye worm) hypothetical protein 0.0128 0.0313 0.0304
Schistosoma mansoni cathepsin D (A01 family) 0.0858 0.3271 1
Brugia malayi PAN domain containing protein 0.0075 0.0096 0.0087
Echinococcus granulosus integrin alpha 3 0.0115 0.026 0.1735

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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