Detailed information for compound 821841

Basic information

Technical information
  • TDR Targets ID: 821841
  • Name: 4-amino-N'-[(2,4-dichlorophenyl)methoxy]-N,N- diethyl-1,2,5-oxadiazole-3-carboximidamide
  • MW: 358.223 | Formula: C14H17Cl2N5O2
  • H donors: 1 H acceptors: 2 LogP: 3.26 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=NOCc1ccc(cc1Cl)Cl)c1nonc1N)CC
  • InChi: 1S/C14H17Cl2N5O2/c1-3-21(4-2)14(12-13(17)19-23-18-12)20-22-8-9-5-6-10(15)7-11(9)16/h5-7H,3-4,8H2,1-2H3,(H2,17,19)/b20-14+
  • InChiKey: MSSSNGLSQBJNLB-XSFVSMFZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-N'-[(2,4-dichlorophenyl)methoxy]-N,N-diethyl-1,2,5-oxadiazole-3-carboxamidine
  • 4-amino-N'-(2,4-dichlorobenzyl)oxy-N,N-diethyl-furazan-3-carboxamidine
  • ZINC04579633
  • BIM-0006794.P001
  • 4-Amino-N'-(2,4-dichloro-benzyloxy)-N,N-diethyl-furazan-3-carboxamidine
  • BAS 00285733

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0018 0.0004 0.0416
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0411
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0004 0.0271
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.003 0.3609
Brugia malayi Cathepsin L-like precursor 0.0011 0 0.0032
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0018 0.0004 0.0414
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0019 0.0005 0.0541
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0003 0.0382
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0094
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0019 0.0005 0.0569
Brugia malayi isocitrate dehydrogenase 0.016 0.0081 1
Schistosoma mansoni cathepsin D (A01 family) 0.004 0.0016 0.1976
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0015 0.1633
Onchocerca volvulus 0.0017 0.0003 0.1255
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0003 0.1799
Echinococcus granulosus bloom syndrome protein 0.0043 0.0017 0.2111
Echinococcus granulosus lamin 0.0027 0.0009 0.1021
Trypanosoma cruzi aminopeptidase, putative 0.0018 0.0004 0.0416
Brugia malayi Isocitrate dehydrogenase 0.016 0.0081 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0007 0.3646
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0003 0.0411
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.001 0.1018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0126
Echinococcus multilocularis cysteine protease 0.0017 0.0003 0.0382
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0411
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0014 0.0002 0.0726
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0007 0.0371
Brugia malayi Hemopexin family protein 0.0016 0.0002 0.0307
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0035 0.0034
Echinococcus granulosus intermediate filament protein 0.0027 0.0009 0.1021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.004 0.0016 0.1912
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0003 0.023
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0003 0.1255
Echinococcus multilocularis isocitrate dehydrogenase 0.016 0.0081 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0004 0.0481
Brugia malayi Probable isocitrate dehydrogenase 0.0019 0.0005 0.0569
Leishmania major isocitrate dehydrogenase, putative 0.0019 0.0005 0.0166
Echinococcus multilocularis cysteine protease 0.0017 0.0003 0.0382
Schistosoma mansoni DNA helicase recq1 0.0018 0.0004 0.0451
Brugia malayi Peptidase family M1 containing protein 0.006 0.0027 0.3271
Loa Loa (eye worm) aminopeptidase N 0.0018 0.0004 0.0445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0004 0.0103
Echinococcus granulosus lamin dm0 0.0027 0.0009 0.1021
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0004 0.0451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.1799
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0018 0.0004 0.0414
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0019 0.0005 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0002 0.0221
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0005 0.0004
Schistosoma mansoni lamin 0.0027 0.0009 0.105
Brugia malayi hypothetical protein 0.0018 0.0004 0.0445
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.016 0.0081 1
Brugia malayi Probable isocitrate dehydrogenase 0.0019 0.0005 0.0569
Echinococcus multilocularis aminopeptidase N 0.006 0.0027 0.3251
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.016 0.0081 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0004 0.0451
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0007 0.0405
Onchocerca volvulus 0.0027 0.0009 0.3209
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0009 0.105
Schistosoma mansoni cathepsin D (A01 family) 0.004 0.0016 0.1976
Brugia malayi Bloom's syndrome protein homolog 0.0043 0.0017 0.2136
Loa Loa (eye worm) hypothetical protein 0.0076 0.0035 0.4336
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0003 0.0411
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.016 0.0081 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0018 0.0004 0.0416
Schistosoma mansoni isocitrate dehydrogenase 0.0019 0.0005 0.0569
Echinococcus multilocularis musashi 0.0027 0.0009 0.1023
Plasmodium vivax vivapain-2 0.0017 0.0003 0.023
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0018 0.0004 0.196
Onchocerca volvulus 0.0017 0.0003 0.1255
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0035 0.4229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0003 0.0411
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0018 0.0004 0.196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0018 0.0004 0.0445
Mycobacterium ulcerans histidinol dehydrogenase 1.8315 1 1
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0019 0.0005 0.2553
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0411
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0002 0.0221
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.003
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0019 0.0005 0.0003
Loa Loa (eye worm) fibroinase 0.0017 0.0003 0.0411
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0018 0.0004 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0185
Loa Loa (eye worm) hypothetical protein 0.0053 0.0023 0.2857
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0003 0.0382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.1799
Schistosoma mansoni lamin 0.0027 0.0009 0.105
Onchocerca volvulus 0.0016 0.0002 0.0938
Entamoeba histolytica cysteine protease, putative 0.0017 0.0003 0.4934
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.0481
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0331
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.1799
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0026 0.323
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.0068
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0019 0.0005 0.0569
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0002 0.0185
Onchocerca volvulus 0.0017 0.0003 0.1255
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0022 0.2673
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0003 0.4934
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Echinococcus multilocularis bloom syndrome protein 0.0043 0.0017 0.2113
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0018 0.0004 0.0416
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0004 0.5
Plasmodium vivax vivapain-2 0.0017 0.0003 0.023
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0019 0.0005 0.0539
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0004 0.051
Mycobacterium ulcerans aminopeptidase N PepN 0.0018 0.0004 0.0002
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0019 0.0005 0.0541
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0032
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0019 0.0005 0.0569
Loa Loa (eye worm) peptidase family M1 containing protein 0.0048 0.002 0.2507
Mycobacterium tuberculosis Probable histidinol dehydrogenase HisD (HDH) 1.8315 1 1
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0035 0.4336
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0004 0.0422
Echinococcus multilocularis lamin 0.0027 0.0009 0.1023
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0411
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0001 0.0097
Onchocerca volvulus 0.006 0.0027 1
Onchocerca volvulus 0.0017 0.0003 0.1255
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.016 0.0081 1
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0007 1
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.003 0.3609
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0003 0.023
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0003 0.038
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0019 0.0005 0.0539
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0599
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0018 0.0004 0.0416
Onchocerca volvulus 0.0027 0.0009 0.3209
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0018 0.0004 0.0445
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0003 0.4934
Brugia malayi Cathepsin L-like precursor 0.0011 0 0.0032
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0307
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0004 0.0451
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0004 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0003 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Toxoplasma gondii isocitrate dehydrogenase 0.016 0.0081 1
Loa Loa (eye worm) ctsf protein 0.0017 0.0003 0.0411
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0331
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0001 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Loa Loa (eye worm) matrixin family protein 0.0024 0.0007 0.0895
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.016 0.0081 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0014 0.0002 0.0185
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0011 0 0.003
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0018 0.0004 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.1799
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.003 0.3609
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0411
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.016 0.0081 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0018 0.0004 0.0416
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.003 0.3609
Onchocerca volvulus 0.0017 0.0003 0.1255
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0018 0.0004 0.0414
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0018 0.0004 0.0414
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.016 0.0081 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0004 1
Toxoplasma gondii cathepsin CPL 0.0017 0.0003 0.023
Loa Loa (eye worm) hypothetical protein 0.0042 0.0017 0.2092
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0013 0.0001 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0005 0.0599
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0019 0.0005 0.0569
Echinococcus multilocularis lamin dm0 0.0027 0.0009 0.1023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Schistosoma mansoni intermediate filament proteins 0.0027 0.0009 0.105
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0003 0.0382
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.1017
Trypanosoma cruzi Aminopeptidase M1, putative 0.0018 0.0004 0.0416
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0003 0.0382
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0 0.0032
Onchocerca volvulus 0.0011 0 0.0098
Echinococcus granulosus aminopeptidase N 0.006 0.0027 0.3249
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0003 0.1255
Brugia malayi Peptidase family M1 containing protein 0.0018 0.0004 0.0445
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.016 0.0081 1
Onchocerca volvulus Matrilysin homolog 0.0024 0.0007 0.2735
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.1799
Schistosoma mansoni blooms syndrome DNA helicase 0.0034 0.0012 0.1532
Chlamydia trachomatis endonuclease IV 0.0076 0.0035 0.5
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.016 0.0081 0.008
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.016 0.0081 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.003 0.3332
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.051
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0004 0.0003
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0003 0.023
Mycobacterium ulcerans epimerase 0.002 0.0005 0.0004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0004 0.0271
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0018 0.0004 0.0416
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0411
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0003 0.0382
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0019 0.0005 0.0569
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0014 0.0002 0.0155
Onchocerca volvulus 0.0017 0.0003 0.1255
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0032
Onchocerca volvulus 0.0018 0.0004 0.1359
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0411
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0003 0.038
Schistosoma mansoni unc-13 (munc13) 0.0019 0.0005 0.0569
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0007 0.0772
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0003 0.1255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Brugia malayi Matrixin family protein 0.0026 0.0008 0.1041
Leishmania major cathepsin L-like protease 0.0065 0.003 0.3356
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0035 0.4229
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.016
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0009 0.105
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0032
Onchocerca volvulus Matrix metalloproteinase homolog 0.0024 0.0007 0.2735
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.1799
Toxoplasma gondii isocitrate dehydrogenase 0.016 0.0081 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.105
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0009 0.105
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0003 0.0411
Leishmania major cathepsin L-like protease 0.0065 0.003 0.3356
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0004 0.0003
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.016 0.0081 1
Toxoplasma gondii endonuclease IV APN 0.0076 0.0035 0.4229
Mycobacterium ulcerans endonuclease IV 0.0076 0.0035 0.0034
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0005 0.1831
Onchocerca volvulus 0.0017 0.0003 0.1255
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0004 0.0481
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.1799
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0019 0.0005 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.1799
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.2269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Trichomonas vaginalis DNA helicase recq, putative 0.0043 0.0017 1
Entamoeba histolytica tartrate dehydrogenase, putative 0.0019 0.0005 0.7003
Entamoeba histolytica aminopeptidase, putative 0.0018 0.0004 0.5377
Loa Loa (eye worm) cysteine protease 0.0017 0.0003 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Schistosoma mansoni DNA helicase recq5 0.0018 0.0004 0.0451
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0094
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.016 0.0081 1
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0019 0.0005 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Mycobacterium ulcerans hypothetical protein 0.002 0.0005 0.0004
Brugia malayi intermediate filament protein 0.0027 0.0009 0.105
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0004 0.042
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0004 0.0479
Trypanosoma brucei isocitrate dehydrogenase, putative 0.016 0.0081 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0029 0.001 0.1041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0569
Loa Loa (eye worm) matrixin family protein 0.0026 0.0008 0.1041
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0004 0.0422
Toxoplasma gondii exonuclease III APE 0.0019 0.0004 0.0331
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0005 0.0004
Echinococcus granulosus cathepsin l1 0.0017 0.0003 0.038
Loa Loa (eye worm) hypothetical protein 0.0034 0.0013 0.1555
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0004 0.6225
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0003 0.0411
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0076 0.0035 0.0034
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0014 0.0002 0.0153
Leishmania major cathepsin L-like protease 0.0065 0.003 0.3356
Brugia malayi cathepsin L-like precursor 0.0011 0 0.0032
Loa Loa (eye worm) isocitrate dehydrogenase 0.016 0.0081 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0004 0.051
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0018 0.0004 0.0416
Trichomonas vaginalis DNA helicase recq1, putative 0.0043 0.0017 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.1799
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0004 0.042
Mycobacterium leprae conserved hypothetical protein 0.002 0.0005 0.0004
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.004 0.0016 0.191
Loa Loa (eye worm) RecQ helicase 0.0043 0.0017 0.2136
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.2269
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.016 0.0081 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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