TDR Targets

Basic information

Technical information

TDR Targets ID: 821924
Name: 4-(2,4-dichlorophenoxy)-N-(2-ethoxyphenyl)but anamide
MW: 368.254 | Formula: C18H19Cl2NO3
H donors: 1 H acceptors: 1 LogP: 4.65 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccccc1NC(=O)CCCOc1ccc(cc1Cl)Cl
InChi: 1S/C18H19Cl2NO3/c1-2-23-17-7-4-3-6-15(17)21-18(22)8-5-11-24-16-10-9-13(19)12-14(16)20/h3-4,6-7,9-10,12H,2,5,8,11H2,1H3,(H,21,22)
InChiKey: VGGMHBQJNIPZRY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-(2,4-dichlorophenoxy)-N-(2-ethoxyphenyl)butyramide
ZINC01886722
CBMicro_006567
BIM-0006441.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0069	0.02	0.9105
Trichomonas vaginalis	tubulin, putative	0.0069	0.02	0.9105
Echinococcus granulosus	tubulin subunit beta	0.0069	0.02	0.2304
Schistosoma mansoni	tubulin subunit beta	0.0069	0.02	0.2304
Entamoeba histolytica	tubulin alpha chain, putative	0.0056	0.0113	0.5658
Schistosoma mansoni	tubulin subunit beta	0.0069	0.02	0.2304
Echinococcus multilocularis	Tubulin beta 2C chain	0.0069	0.02	0.2304
Echinococcus multilocularis	tubulin alpha chain	0.0056	0.0113	0.1304
Echinococcus multilocularis	sterol regulatory element binding protein	0.0063	0.0161	0.1855
Schistosoma mansoni	tubulin subunit alpha	0.0056	0.0113	0.1304
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Echinococcus multilocularis	Tubulin beta 2C chain	0.0069	0.02	0.2304
Trypanosoma cruzi	beta tubulin, putative	0.0069	0.02	0.2626
Trypanosoma brucei	beta tubulin	0.0069	0.02	0.2626
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0072	0.0219	1
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.0153	0.076	0.8774
Brugia malayi	Tubulin alpha-2 chain	0.0056	0.0113	0.1486
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0039	0.0001	0.0028
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Echinococcus granulosus	peroxisome assembly protein 26	0.0056	0.0113	0.1304
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0056	0.0113	0.5152
Mycobacterium tuberculosis	Probable histidinol dehydrogenase HisD (HDH)	0.1545	1	0.5
Brugia malayi	Tubulin alpha chain	0.0056	0.0113	0.1486
Trichomonas vaginalis	tubulin alpha chain, putative	0.0069	0.02	0.9105
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Trypanosoma brucei	alpha tubulin	0.0056	0.0113	0.1486
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0039	0.0001	0.0008
Echinococcus granulosus	Tubulin beta 2C chain	0.0069	0.02	0.2304
Echinococcus multilocularis	tubulin alpha 1C chain	0.0056	0.0113	0.1304
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Echinococcus multilocularis	tubulin beta 1 chain	0.0069	0.02	0.2304
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Trichomonas vaginalis	tubulin beta chain, putative	0.0056	0.0113	0.5152
Echinococcus multilocularis	Tubulin beta 2C chain	0.0069	0.02	0.2304
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.0153	0.076	1
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0072	0.0219	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0063	0.0161	0.1855
Trichomonas vaginalis	tubulin gamma chain, putative	0.0069	0.02	0.9105
Trichomonas vaginalis	tubulin beta chain, putative	0.0056	0.0113	0.5152
Echinococcus granulosus	beta tubulin	0.0069	0.02	0.2304
Entamoeba histolytica	tubulin alpha-1 chain	0.0056	0.0113	0.5658
Echinococcus multilocularis	protein patched	0.0063	0.0161	0.1855
Echinococcus multilocularis	tubulin alpha chain	0.0056	0.0113	0.1304
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.0153	0.076	1
Loa Loa (eye worm)	alpha-tubulin	0.0056	0.0113	0.1486
Trypanosoma brucei	alpha tubulin	0.0056	0.0113	0.1486
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0001	0.0008
Echinococcus granulosus	Protein patched homolog 1	0.0063	0.0161	0.1855
Echinococcus multilocularis	tubulin subunit beta	0.0069	0.02	0.2304
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0069	0.02	0.2304
Trypanosoma cruzi	alpha tubulin, putative	0.0056	0.0113	0.1486
Echinococcus multilocularis	tubulin alpha 1C chain	0.0056	0.0113	0.1304
Schistosoma mansoni	alpha tubulin	0.0056	0.0113	0.1304
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Loa Loa (eye worm)	tubulin beta-1 chain	0.0069	0.02	0.2626
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Brugia malayi	beta-tubulin, identical	0.0069	0.02	0.2626
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.0153	0.076	1
Plasmodium vivax	tubulin beta chain, putative	0.0069	0.02	1
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Echinococcus granulosus	tubulin alpha 1C chain	0.0056	0.0113	0.1304
Echinococcus granulosus	tubulin alpha 1C chain	0.0056	0.0113	0.1304
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Schistosoma mansoni	tubulin subunit beta	0.0069	0.02	0.2304
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Plasmodium vivax	tubulin alpha chain, putative	0.0056	0.0113	0.5658
Schistosoma mansoni	lipoxygenase	0.01	0.0405	0.4676
Echinococcus granulosus	Tubulin beta 2C chain	0.0069	0.02	0.2304
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Echinococcus granulosus	tubulin alpha chain	0.0056	0.0113	0.1304
Schistosoma mansoni	lipoxygenase	0.0169	0.0866	1
Loa Loa (eye worm)	tubulin alpha chain	0.0056	0.0113	0.1486
Loa Loa (eye worm)	hypothetical protein	0.0153	0.076	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0069	0.02	1
Loa Loa (eye worm)	alpha-tubulin	0.0056	0.0113	0.1486
Echinococcus granulosus	beta tubulin	0.0069	0.02	0.2304
Echinococcus multilocularis	Tubulin beta 2C chain	0.0069	0.02	0.2304
Schistosoma mansoni	tubulin subunit alpha	0.0056	0.0113	0.1304
Loa Loa (eye worm)	beta-tubulin	0.0069	0.02	0.2626
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Echinococcus multilocularis	tubulin subunit TubB	0.0056	0.0113	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0161	0.2114
Echinococcus multilocularis	beta tubulin	0.0069	0.02	0.2304
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0072	0.0219	1
Brugia malayi	alpha-tubulin	0.0056	0.0113	0.1486
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0072	0.0219	1
Echinococcus multilocularis	tubulin alpha chain	0.0056	0.0113	0.1304
Schistosoma mansoni	patched 1	0.0063	0.0161	0.1855
Trichomonas vaginalis	tubulin beta chain, putative	0.0056	0.0113	0.5152
Toxoplasma gondii	alpha-tubulin I, putative	0.0056	0.0113	0.5658
Echinococcus granulosus	tubulin alpha chain	0.0056	0.0113	0.1304
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0069	0.02	0.9105
Brugia malayi	tubulin alpha-2 chain	0.0056	0.0113	0.1486
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0153	0.076	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0069	0.02	0.2304
Echinococcus granulosus	Tubulin alpha 1 chain	0.0056	0.0113	0.1304
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Echinococcus granulosus	tubulin alpha chain	0.0056	0.0113	0.1304
Mycobacterium ulcerans	histidinol dehydrogenase	0.1545	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0039	0.0001	0.0008
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.0153	0.076	0.8774
Echinococcus multilocularis	tubulin alpha 3 chain	0.0056	0.0113	0.1304
Trypanosoma brucei	beta tubulin	0.0069	0.02	0.2626
Loa Loa (eye worm)	tubulin alpha chain	0.0056	0.0113	0.1486
Echinococcus granulosus	Niemann Pick C1 protein	0.0063	0.0161	0.1855
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Entamoeba histolytica	tubulin family protein	0.0069	0.02	1
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Loa Loa (eye worm)	tubulin alpha 2	0.0039	0.0001	0.0008
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Giardia lamblia	Alpha-tubulin	0.0056	0.0113	0.5152
Echinococcus granulosus	sterol regulatory element binding protein	0.0063	0.0161	0.1855
Echinococcus multilocularis	hypothetical protein	0.0056	0.0113	0.1304
Trichomonas vaginalis	tubulin beta chain, putative	0.0056	0.0113	0.5152
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0056	0.0113	0.5152
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.0153	0.076	1
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Echinococcus granulosus	Tubulin beta 2C chain	0.0069	0.02	0.2304
Plasmodium falciparum	alpha tubulin 2	0.0056	0.0113	0.5658
Schistosoma mansoni	alpha tubulin	0.0056	0.0113	0.1304
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0056	0.0113	0.5152
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0169	0.0866	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0056	0.0113	0.5152
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.0153	0.076	0.8774
Schistosoma mansoni	alpha tubulin	0.0056	0.0113	0.1304
Echinococcus multilocularis	protein dispatched 1	0.0063	0.0161	0.1855
Echinococcus granulosus	tubulin alpha 3 chain	0.0056	0.0113	0.1304
Trypanosoma brucei	beta tubulin	0.0069	0.02	0.2626
Brugia malayi	Tubulin alpha-2 chain	0.0056	0.0113	0.1486
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0056	0.0113	0.1304
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Echinococcus multilocularis	peroxisome assembly protein 26	0.0056	0.0113	0.1304
Schistosoma mansoni	tubulin subunit beta	0.0069	0.02	0.2304
Giardia lamblia	Alpha-tubulin	0.0056	0.0113	0.5152
Echinococcus granulosus	Tubulin alpha 1 chain	0.0056	0.0113	0.1304
Trypanosoma brucei	alpha tubulin	0.0056	0.0113	0.1486
Echinococcus multilocularis	beta tubulin	0.0069	0.02	0.2304
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0169	0.0866	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0069	0.02	0.2626
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0161	0.733
Echinococcus granulosus	tubulin alpha chain	0.0056	0.0113	0.1304
Plasmodium falciparum	tubulin beta chain	0.0069	0.02	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0069	0.02	0.9105
Loa Loa (eye worm)	BEN-1 protein	0.0069	0.02	0.2626
Echinococcus granulosus	tubulin subunit TubB	0.0056	0.0113	0.1304
Toxoplasma gondii	beta tubulin	0.0069	0.02	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0056	0.0113	0.1304
Echinococcus granulosus	alpha tubulin	0.0056	0.0113	0.1304
Loa Loa (eye worm)	BEN-1 protein	0.0069	0.02	0.2626
Toxoplasma gondii	beta-tubulin, putative	0.0069	0.02	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0056	0.0113	0.1304
Echinococcus granulosus	Tubulin beta 2C chain	0.0069	0.02	0.2304
Entamoeba histolytica	tubulin family protein	0.0069	0.02	1
Trypanosoma brucei	alpha tubulin	0.0056	0.0113	0.1486
Brugia malayi	tubulin alpha chain - mouse	0.0056	0.0113	0.1486
Echinococcus multilocularis	tubulin alpha 3 chain	0.0056	0.0113	0.1304
Brugia malayi	CHE-14 protein	0.0063	0.0161	0.2114
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Echinococcus multilocularis	Tubulin beta 2C chain	0.0069	0.02	0.2304
Giardia lamblia	Beta tubulin	0.0069	0.02	0.9105
Echinococcus multilocularis	tubulin alpha chain	0.0056	0.0113	0.1304
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0056	0.0113	0.1486
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Loa Loa (eye worm)	tubulin beta chain	0.0069	0.02	0.2626
Plasmodium falciparum	alpha tubulin 1	0.0056	0.0113	0.5658
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0063	0.0161	0.2114
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Trypanosoma brucei	beta tubulin	0.0069	0.02	0.2626
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0056	0.0113	0.1304
Giardia lamblia	Beta tubulin	0.0069	0.02	0.9105
Echinococcus granulosus	tubulin beta 1 chain	0.0069	0.02	0.2304
Echinococcus multilocularis	tubulin alpha chain	0.0056	0.0113	0.1304
Brugia malayi	Tubulin beta-1 chain	0.0069	0.02	0.2626
Leishmania major	alpha tubulin	0.0056	0.0113	0.1486
Echinococcus granulosus	tubulin beta 4A class IVa	0.0069	0.02	0.2304
Echinococcus multilocularis	Niemann Pick C1 protein	0.0063	0.0161	0.1855
Schistosoma mansoni	tubulin subunit beta	0.0069	0.02	0.2304
Schistosoma mansoni	tubulin subunit alpha	0.0056	0.0113	0.1304
Loa Loa (eye worm)	tubulin beta-2A chain	0.0069	0.02	0.2626
Toxoplasma gondii	alpha tubulin TUBA1	0.0056	0.0113	0.5658
Echinococcus granulosus	Tubulin alpha 1 chain	0.0056	0.0113	0.1304
Plasmodium vivax	tubulin alpha chain, putative	0.0056	0.0113	0.5658
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0113	0.1486
Schistosoma mansoni	tubulin subunit beta	0.0069	0.02	0.2304
Leishmania major	beta tubulin	0.0069	0.02	0.2626
Echinococcus granulosus	tubulin alpha chain	0.0056	0.0113	0.1304
Trichomonas vaginalis	tubulin beta chain, putative	0.0056	0.0113	0.5152
Giardia lamblia	Beta tubulin	0.0069	0.02	0.9105

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 821924