Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0232 | 0.2739 | 0.2739 |
Onchocerca volvulus | 0.0068 | 0.0078 | 0.0755 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0232 | 0.2739 | 0.2739 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.1031 | 0.1031 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0134 | 0.1137 | 1 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0127 | 0.1031 | 0.1031 |
Echinococcus multilocularis | 0.011 | 0.0758 | 0.6421 | |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.1031 | 0.9002 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0127 | 0.1031 | 0.9002 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0127 | 0.1031 | 0.1031 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0232 | 0.2739 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0127 | 0.1031 | 0.9002 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.1031 | 0.1031 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0127 | 0.1031 | 0.9002 |
Onchocerca volvulus | Putative nachr subunit | 0.0127 | 0.1031 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.1031 | 0.1031 |
Onchocerca volvulus | 0.0111 | 0.0771 | 0.7475 | |
Onchocerca volvulus | 0.0111 | 0.0771 | 0.7475 | |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0397 | 0.5424 | 0.5424 |
Onchocerca volvulus | 0.0111 | 0.0771 | 0.7475 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0134 | 0.1137 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0232 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0111 | 0.0771 | 0.0771 |
Onchocerca volvulus | 0.0127 | 0.1031 | 1 | |
Onchocerca volvulus | 0.0111 | 0.0771 | 0.7475 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0127 | 0.1031 | 0.9002 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0127 | 0.1031 | 0.1031 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.011 | 0.0758 | 0.5 |
Onchocerca volvulus | 0.0127 | 0.1031 | 1 | |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | Cytochrome P450 family protein | 0.0232 | 0.2739 | 0.2739 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0127 | 0.1031 | 0.9002 |
Onchocerca volvulus | 0.0127 | 0.1031 | 1 | |
Echinococcus granulosus | cytochrome P450 2K1 | 0.011 | 0.0758 | 0.6421 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0068 | 0.0078 | 0.0078 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0127 | 0.1031 | 0.1031 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0678 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0078 | 0.0078 |
Onchocerca volvulus | 0.0111 | 0.0771 | 0.7475 | |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0127 | 0.1031 | 0.9002 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0336 | 0.4432 | 1 |
Onchocerca volvulus | 0.0127 | 0.1031 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0068 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | LGC-31 protein | 0.0127 | 0.1031 | 0.1031 |
Onchocerca volvulus | 0.0127 | 0.1031 | 1 | |
Loa Loa (eye worm) | ACC-1 protein | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | Cytochrome P450 family protein | 0.0397 | 0.5424 | 0.5424 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0127 | 0.1031 | 0.9002 |
Trypanosoma brucei | cytochrome P450, putative | 0.0232 | 0.2739 | 1 |
Onchocerca volvulus | 0.0127 | 0.1031 | 1 | |
Brugia malayi | Cation transporter family protein | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0111 | 0.0771 | 0.0771 |
Schistosoma mansoni | cytochrome P450 | 0.011 | 0.0758 | 0.6421 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0127 | 0.1031 | 0.9002 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0068 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0068 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0336 | 0.4432 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Mycobacterium leprae | Conserved hypothetical protein | 0.011 | 0.0758 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0127 | 0.1031 | 0.9002 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0127 | 0.1031 | 0.9002 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Schistosoma mansoni | lipoxygenase | 0.0134 | 0.1137 | 1 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0127 | 0.1031 | 0.9002 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0127 | 0.1031 | 0.9002 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0232 | 0.2739 | 0.5392 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0127 | 0.1031 | 0.1031 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | ACC-1 protein | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0111 | 0.0771 | 0.0771 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.1031 | 0.1031 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0127 | 0.1031 | 0.1031 |
Onchocerca volvulus | 0.0111 | 0.0771 | 0.7475 | |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Entamoeba histolytica | hypothetical protein | 0.0068 | 0.0078 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0127 | 0.1031 | 0.1031 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0127 | 0.1031 | 0.9002 |
Schistosoma mansoni | lipoxygenase | 0.0093 | 0.0483 | 0.3827 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0127 | 0.1031 | 0.1031 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0127 | 0.1031 | 0.9002 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0068 | 0.0078 | 0.0078 |
Brugia malayi | Cytochrome P450 family protein | 0.0232 | 0.2739 | 0.2739 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0078 | 0.0078 |
Echinococcus multilocularis | nAChR subunit | 0.0127 | 0.1031 | 0.9002 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0127 | 0.1031 | 0.9002 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0758 | 0.6421 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0078 | 0.0078 |
Brugia malayi | cytochrome P450 | 0.011 | 0.0758 | 0.0758 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0127 | 0.1031 | 0.1031 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.1031 | 0.9002 |
Brugia malayi | Cytochrome P450 family protein | 0.011 | 0.0758 | 0.0758 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0232 | 0.2739 | 0.2739 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0127 | 0.1031 | 0.1031 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0127 | 0.1031 | 0.9002 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0127 | 0.1031 | 0.9002 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.1031 | 0.9002 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | cytochrome P450 | 0.011 | 0.0758 | 0.0758 |
Onchocerca volvulus | 0.0111 | 0.0771 | 0.7475 | |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Echinococcus granulosus | nAChR subunit | 0.0127 | 0.1031 | 0.9002 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0127 | 0.1031 | 0.1031 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.1031 | 0.9002 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0946 | 0.0946 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0127 | 0.1031 | 0.9002 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0771 | 0.0771 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0127 | 0.1031 | 0.9002 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0127 | 0.1031 | 0.1031 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0127 | 0.1031 | 0.9002 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0127 | 0.1031 | 0.9002 |
Onchocerca volvulus | 0.0111 | 0.0771 | 0.7475 | |
Onchocerca volvulus | 0.0068 | 0.0078 | 0.0755 | |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.1031 | 0.1031 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Mycobacterium leprae | putative cytochrome p450 | 0.011 | 0.0758 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Schistosoma mansoni | nAChR subunit | 0.0127 | 0.1031 | 0.9002 |
Leishmania major | cytochrome p450-like protein | 0.0232 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 0.9047 | 0.9047 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0127 | 0.1031 | 0.9002 |
Brugia malayi | Cation transporter family protein | 0.0127 | 0.1031 | 0.1031 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0312 | 0.4047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0127 | 0.1031 | 0.1031 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | Cation transporter family protein | 0.0127 | 0.1031 | 0.1031 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0111 | 0.0771 | 0.0771 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0078 | 0.0078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.