Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.0137 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1141 | 0.0946 |
Mycobacterium leprae | Possible hydrolase | 0.0137 | 0 | 0.5 |
Mycobacterium ulcerans | glycosyl hydrolase | 0.0137 | 0 | 0.5 |
Loa Loa (eye worm) | trehalase | 0.0282 | 0.1141 | 0.0946 |
Brugia malayi | Trehalase family protein | 0.0282 | 0.1141 | 0.0053 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0282 | 0.1141 | 1 |
Trichomonas vaginalis | trehalase, putative | 0.0282 | 0.1141 | 1 |
Loa Loa (eye worm) | TRE-1 protein | 0.0282 | 0.1141 | 0.0946 |
Onchocerca volvulus | 0.0377 | 0.1892 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.1094 | 0.9407 |
Schistosoma mansoni | beta-galactosidase | 0.0602 | 0.3656 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.1094 | 0.9407 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0191 | 0.0425 | 0.0966 |
Echinococcus granulosus | beta galactosidase | 0.0602 | 0.3656 | 1 |
Brugia malayi | hypothetical protein | 0.0282 | 0.1141 | 0.0053 |
Brugia malayi | Trehalase family protein | 0.0282 | 0.1141 | 0.0053 |
Onchocerca volvulus | 0.0282 | 0.1141 | 0.5133 | |
Leishmania major | glycosyl hydrolase, putative | 0.0137 | 0 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0562 | 0.334 | 0.2522 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.1094 | 0.9407 |
Echinococcus multilocularis | beta galactosidase | 0.0602 | 0.3656 | 1 |
Onchocerca volvulus | 0.0282 | 0.1141 | 0.5133 | |
Onchocerca volvulus | 0.0282 | 0.1141 | 0.5133 | |
Onchocerca volvulus | Trehalase homolog | 0.0282 | 0.1141 | 0.5133 |
Loa Loa (eye worm) | hypothetical protein | 0.1217 | 0.8486 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0276 | 0.1094 | 0.0888 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1141 | 0.0946 |
Loa Loa (eye worm) | trehalase | 0.0282 | 0.1141 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1141 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1141 | 0.0946 |
Loa Loa (eye worm) | trehalase | 0.0282 | 0.1141 | 0.0946 |
Loa Loa (eye worm) | TRE-2 protein | 0.0282 | 0.1141 | 0.0946 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0562 | 0.334 | 0.3657 |
Trypanosoma brucei | glycosyl hydrolase, putative | 0.0137 | 0 | 0.5 |
Brugia malayi | Trehalase family protein | 0.0282 | 0.1141 | 0.0053 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0184 | 0.0371 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0184 | 0.0371 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.1094 | 0.9407 |
Onchocerca volvulus | 0.0282 | 0.1141 | 0.5133 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0191 | 0.0425 | 0.0966 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.1094 | 0.9407 |
Loa Loa (eye worm) | hypothetical protein | 0.0602 | 0.3656 | 0.4046 |
Onchocerca volvulus | 0.0282 | 0.1141 | 0.5133 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0276 | 0.1094 | 0.9407 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1141 | 0.0946 |
Trypanosoma cruzi | glycosyl hydrolase, putative | 0.0137 | 0 | 0.5 |
Brugia malayi | Trehalase family protein | 0.0282 | 0.1141 | 0.0053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.