Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Mycobacterium ulcerans | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase 2 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Brugia malayi | glutaminase DH11.1 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Trichomonas vaginalis | glutaminase, putative | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0426 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0264 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0549 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.5044 | 0.5044 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0549 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0549 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0426 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0264 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0549 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.5044 | 0.5044 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0426 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0264 | 0.3546 | 0.3546 |
Mycobacterium ulcerans | glutaminase | 0.033 | 0.5044 | 0.5044 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0426 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0264 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0549 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0549 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.033 | 0.5044 | 0.5044 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0549 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0264 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0264 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0426 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0549 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0549 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0549 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0549 | 1 | 1 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0264 | 0.3546 | 0.3546 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0.5044 | 0.5044 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0264 | 0.3546 | 0.3546 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0549 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0426 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0426 | 0.7224 | 0.7224 |
Loa Loa (eye worm) | glutaminase | 0.033 | 0.5044 | 0.5044 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0264 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0426 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0426 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0264 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0549 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0264 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0549 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0426 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0549 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0426 | 0.7224 | 0.7224 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0264 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0264 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0426 | 0.7224 | 0.7224 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0108 | 0 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0426 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0264 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0264 | 0.3546 | 0.3546 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0426 | 0.7224 | 0.7224 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0549 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0549 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.0264 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0426 | 0.7224 | 0.7224 |
Onchocerca volvulus | Notchless protein homolog | 0.0108 | 0 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0264 | 0.3546 | 0.3546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.